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Bayu Brahma
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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 5 Documents
 1 
Search results for , issue "Vol 10, No 2 (2016): April - June 2016" : 5 Documents clear
Deteksi Dini Karsinoma Sel Basal SUKMAWATI TANSIL TAN; MAHMUD GHAZNAWIE; GABRIELA REGINATA
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1248.004 KB) | DOI: 10.33371/ijoc.v10i2.428

Abstract

ABSTRACTBasal Cell Carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasize. BCC is more common in the elderly. Etiopathogenesis associated with BCC is genetic, environmental, and most often is exposure to ultraviolet light. Clinically, there are five types of BCC, which are nodular, superficial, morpheaform, pigmented, and fibroepitelioma Pinkus. Early detection of skin cancer can be done with self skin examination. Definitive diagnosis of malignancy is determined by anatomical pathology examination. However, for very early BCC lesion, it’s difficult to determine with hematoxylin eosin staining. Therefore, it is uses Ber-EP4 staining which is specific and highly sensitive for early BCC growing as budding in basal layer of the epidermis and follicles. This finding is particularly significant in the development of molecular pathology and clinical management of BCC lesions or suspected BCC. ABSTRAKKarsinoma Sel Basal (KSB) merupakan neoplasma ganas dari sel yang tidak mengalami keratinisasi pada lapisan basal epidermis, bersifat invasif lokal, agresif, destruktif, dan jarang bermetastasis. KSB lebih sering terjadi pada usia lanjut. Etiopatogenesis yang berkaitan dengan KSB adalah genetik, lingkungan, dan yang paling sering adalah paparan sinar ultraviolet. Secara klinis, terdapat lima tipe KSB, yaitu nodular, superfisial, morpheaform, pigmented, dan fibroepitelioma Pinkus. Deteksi dini kanker kulit dapat dilakukan dengan pemeriksaan kulit sendiri (SAKURI). Diagnosis pasti keganasan ditentukan dengan pemeriksaan patologi anatomi. Namun, untuk lesi sangat dini KSB sulit ditentukan dengan pewarnaan hematoksilin eosin. Oleh karena itu, digunakanlah pewarnaan Ber-EP4 yang bersifat spesifik dan sangat sensitif untuk KSB dini yang tumbuh sebagai tunas di lapisan basal epidermis dan folikel. Temuan ini sangat berarti dalam pengembangan patologi molekuler dan penanganan klinis lesi KSB atau yang dicurigai KSB.
Internal Genital Organ-preserving Radical Cystectomy: A Case Report FINA WIDIA; GERHARD R SITUMORANG; AGUS RIZAL A.H HAMID; CHAIDIR A MOCHTAR
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.53 KB) | DOI: 10.33371/ijoc.v10i2.429

Abstract

ABSTRACTAdenocarcinoma of the bladder is usually managed by radical cystectomy. However, recent literature shows that internal genital organ-preserving radical cystectomy is feasible in selected cases in order to get a better impact on patient’s psychology, sexuality and potential fertility. Here, we report a 32-year-old woman with adenocarcinoma of the bladder who was managed with internal genital organ-preserving radical cystectomy. The patient was never had any child and the radiologic examination (MRI) showed no involvement of internal genitalia organ. This procedure aims to maintain fertility potential of the patient. Intraoperatively, no adhesion was found between the tumor and internal genitalia organ. The internal genitalia organ was successfully preserved during the radical cystectomy. ABSTRAKTata laksana adenokarsinoma kandung kemih umumnya berupa sistektomi radikal. Akan tetapi, penelitian terbaru menunjukkan bahwa preservasi organ internal genitalia dapat diterapkan pada kasus-kasus tertentu dengan tujuan untuk mempertahankan potensi seksual dan fertilitas pasien. Saat ini kami melaporkan seorang perempuan berusia 32 tahun dengan adenokarsinoma kandung kemih yang menjalani sistektomi radikal dengan tetap mempertahankan organ genitalia interna. Pasien merupakan nulipara dan pada pemeriksaan radiologi MRI tidak didapatkan infiltrasi tumor pada organ genitalia interna. Prosedur operasi dilakukan dengan tujuan mempertahankan potensi fertilitas. Intraoperatif, tidak didapatkan perlengketan antara tumor dan organ genitalia interna. Organ genitalia interna berhasil dipreservasi selama prosedur sistektomi radikal.
Korelasi antara Ekspresi Tumor Infiltrating Lymphocytes CD4 dan CD8 dengan Kanker Ovarium Tipe Epitel Stadium Lanjut yang Bebas Penyakit dan Kekambuhan SITI SALIMA
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1446.711 KB) | DOI: 10.33371/ijoc.v10i2.424

Abstract

ABSTRACTEpithelial ovarian cancer has the high incidence and mortality. One of them is because of high of recurrency in ovarian cancer. The recurrence rate is probably related to the immunological system through the role of TILs CD8 and CD4. This study is a retrospective case-control. Subjects were paraffin block of ovarian epithelial advanced stage patient who come to the hospital Dr Hasan Sadikin with the period 2012 to 2014, which already had completed therapy.There were 22 samples, consisting of 12 cases of ovarian cancer were free of disease and 10 cases of recurrence ovarian cancer. Statistical analysis using unpaired t test found significant difference the levels of TILs CD8 between recurrence ovarian cancer and disease-free, mean ovarian cancer with disease free is 20,9112,70, and mean of recurrence ovarian cancer 5,9006,081 (p<0,05) but the expression of TILs CD4 showed no significant difference by using Mann Whitney test. Positive correlation between the expression levels of TILs CD8 with ovarian cancer whose disease-free, usingstatistical test of correlation eta, and has a fairly strong correlation strength based on criteria Guilford. There is a positive correlation between the expression levels of TILs CD8 with disease free of ovarian cancer, which means that the higher the expression TILs CD 8 shows the higher the number of ovarian cancer were free of disease, and the recurrence rate would be lower.ABSTRAKKanker ovarium tipe epitel mempunyai insidensi dan angka kematian yang tinggi. Tingginya angka mortalitas pada kanker ovarium salah satunya berhubungan dengan tingginya angka kekambuhan. Angka kekambuhan ini mungkin berkaitan erat dengan sistem imunologi melalui peran Tumor Infiltrating Lymphocytes (TILs) CD8 dan CD4. Penelitian ini menggunakan studi analitik retrospektif case control dengan mengambil data dan blok parafin jaringan kanker ovarium tipe epitel stadum lanjut pada periode 2012-2014, yang terdiri dari kanker ovarium stadium lanjut yang telah dilakukan terapi lengkap. Kemudian dilakukan pemeriksaan imunohistokimia. Hasil penelitian menunjukkan dari 22 subjek penelitian terdiri dari 12 kasus merupakan kanker ovarium tipe epitel stadium lanjut bebas penyakit dan 10 kasus kanker ovarium tipe epitel stadium lanjut yang mengalami kekambuhan. Terdapat perbedaan yang bermakna tingkat ekspresi TILs CD8 antara kanker ovarium tipe epitel stadium lanjut yangbebas penyakit dan yang mengalami kekambuhan, kelompok bebas penyakit rata-rata sebesar 20,9112,70, sedangkanpada kelompok kekambuhan rata-rata sebesar 5,9006,081, dengan nilai p<0,05. Sebaliknya, ekspresi TILs CD4 tidak menunjukkan perbedaan yang bermakna. Selain itu, juga didapatkan korelasi positif antara tingkat ekspresi TILs CD8 dengan kanker ovarium yang bebas penyakit. Dengan menggunakan uji statistik korelasi eta, didapatkan nilai r untuk nilai korelasi CD8 sebesar 0,607, sedangkan nilai p=0,000 (p<0,05). Penelitian ini menyimpulkan bahwa semakin tinggi tingkat ekspresi TILs CD8, semakin tinggi angka kanker ovarium yang bebas penyakit dan semakin rendah kejadian kanker ovarium yang mengalami kekambuhan.
Hubungan antara Ekspresi Ki-67 dan Kaspase-3 dengan Respons Kemoterapi Neoajuvan pada Pasien Karsinoma Serviks Stadium IB2 dan IIA2 di Rumah Sakit Dr. Hasan Sadikin, Bandung I MADE WIDYALAKSANA MAHAYASA; MARINGAN DIAPARI LUMBAN TOBING; ALI BUDI HARSONO
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1302.96 KB) | DOI: 10.14414/ijoc.v10i2.425

Abstract

ABSTRACTCervical carcinoma is the second ranks cancer in women in developing countries. This study was a retrospective cohortstudy of the relationship between the role of Ki-67 expression and caspase-3 on tumor shrinkage response in cervical carcinoma stage IB2 and IIA2. A total of 41 cases have been done NACT with Cisplatin, Vincristine and Bleomycin. All samples showed expression in immunohistochemical staining for Ki-67 and caspase-3. Meanwhile, Pearson correlation analysis found no correlation between the expression levels of Ki-67 and caspase-3 with a diminution oftumor mass (p>0.05). While the correlation between the ratio of Ki-67 expression and caspase-3 with a significant diminution of tumor mass is obtained p 0.042, R-0.319, means that the higher the Ki-67 expression levels compared caspase-3 expression level then the response of the tumor mass size reduction will be better.ABSTRAKKarsinoma serviks merupakan kanker kedua terbanyak pada wanita di negara berkembang. Penelitian ini merupakan penelitian kohort retrospektif yang mempelajari hubungan antara peran ekspresi Ki-67 dan kaspase-3 terhadap respons pengecilan tumor pada karsinoma serviks stadium IB2 dan IIA2. Sebanyak 41 kasus telah dilakukan KTNA dengan Cisplatin, Vincristin, dan Bleomycin (PVB).Hasil penelitian menunjukkan seluruh sampel ekspresi pada pewarnaan imunohistokimia untuk Ki-67 dan kaspase-3. Sedangkan analisis korelasi Pearson tidak didapatkan korelasi antara tingkat ekspresi ki-67 dan kaspase-3 dengan pengecilan massa tumor dan nilai p>0,05. Sedangkan korelasi antara rasio ekspresi Ki-67 dan kaspase-3 dengan pengecilan massa tumor didapatkan bermakna dengan nilai p = 0,042 (p<0,05), R-0,319. Artinya, semakin tinggi proliferasi (tingkat ekspresi Ki-67) dibandingkan dengan apoptosis (tingkat ekspresi kaspase-3) maka respons pengecilan tumor akan semakin baik pada karsinoma serviks stadium IB2 dan IIA2
Gambaran Mikrobiologi pada Ruang Isolasi Imunitas Menurun dan Ruang Operasi (Studi di Rumah Sakit Kanker “Dharmais” Jakarta, 2013-2014) NI PUTU ARYADNYANI; EVA AYU MAHARANI; DEWI ASTUTI; DEMAK LUMBAN TOBING
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.274 KB) | DOI: 10.33371/ijoc.v10i2.427

Abstract

ABSTRACTPatients treated at the ward in a hospital can get nosocomial infection through exposure of microbes that contaminate air and medical equipments. This study was conducted to determine the amount of air microbes and to identify bacterium found on a swab equipments at Isolation room on decrease immunity and operating theatre in “Dharmais” Cancer Hospital Jakarta. This study uses secondary data on a periode of 2013-2014. The amount of microbial colonies that meet the threshold value in accordance with a predetermined on Kepmenkes RI No. 1204 / Menkes / SK / X / 2004 on a Hospital Environmental Health Requirements in RIIM is at 100%, while at OK is 13:33%. Types of microbes found in the RIIM were E. gergoviae, A. baumanni, S. liquefaciens, C. freundii, Y. enterocolitica, C. diversus and fungi while the types of microbes found in the OK room were A. haemolyticus, M. morganii, A. baumanni, E. coli, A. Iwoffli, K. oxytoca, C. diversus, K. ozaenae, P. stuartii, S. marcescens, Y. enterocolitica, and fungi. ABSTRAKPasien yang dirawat di ruang rawat inap sebuah rumah sakit bisa mendapat infeksi nosokomial melalui paparan dengan mikroba udara maupun yang mengontaminasi peralatan medis. Penelitian ini dilakukan untuk mengetahui jumlah koloni mikroba udara dan identifikasi bakteri pada swab peralatan di Ruang Isolasi Imunitas Menurun (RIIM) dan ruang operasi (OK) di RS Kanker “Dharmais”, Jakarta. Penelitian ini menggunakan data sekunder periode 2013-2014. Jumlah koloni mikroba yang memenuhi nilai ambang batas sesuai dengan yang telah ditetapkan pada Kepmenkes RI nomor 1204/Menkes/SK/X/2004 tentang Persyaratan Kesehatan Lingkungan Rumah Sakit pada RIIM adalah sebesar 100%, sedangkan pada OK sebesar 13,33%. Jenis mikroba yang ditemukan pada ruang RIIM adalah E. gergoviae, A. baumanni, S. liquefaciens, C. freundii, Y. enterocolitica, C. Diversus, dan jamur, sedangkan jenis mikroba yang ditemukan pada ruang operasi adalah A. haemolyticus, M. morganii, A. baumanni, E.coli, A. Iwoffli, K. oxytoca, C. diversus, K. ozaenae, P. stuartii, S. marcescens, Y. enterocolitica, dan jamur.

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