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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 562 Documents
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Free Tissue Transfer in Patients with Hematologic Malignancies: A Case Series Azmi Ritana; Dewi Aisiyah Mukarramah; Muhammad Irsyad Kiat; Kasih Rahardjo Djarot; Irena Sakura Rini; Resti Mulyasari; Oskar Ady Widarta
Indonesian Journal of Cancer Vol 16, No 4 (2022): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v16i4.913

Abstract

Introduction: Free tissue transfer performed in patients with hematologic malignancies has several considerable challenges. Studies that report the challenges and outcomes related to these patients have been rather limited. This study presents the outcome of free tissue transfer as the reconstructive option for patients with hematologic malignancies. This study reports our experience regarding the perioperative evaluation, management, and outcomes of five patients with hematological malignancies that underwent free tissue transfer at Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia. Case Presentation: Five patients with hematologic malignancies, aged 26 to 60 years, who underwent free tissue transfer at Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia from January 2017 to February 2020 were included. The outcomes such as flap survival, complications, and mortality were reviewed. There were three patients with NonHodgkin lymphoma (NHL), one patient with peripheral T-cell lymphoma, and one patient with acute myeloid leukemia (AML). All patients received free tissue transfer with flap modalities such as radial free forearm flap and anterolateral thigh. One patient had a postoperative complication of vein compromise and was treated with negative pressure wound therapy (NPWT), which resulted in partial flap necrosis. Dehiscence was also found in one patient, and the patient underwent reoperation. Then, a myocutaneous trapezius flap was applied. There was no total flap loss, no donor site morbidity, and no mortality. Conclusions: This study has shown that free tissue transfer was a reliable reconstructive option for patients with hematologic malignancies. Flap survival and minimal complications can be achieved by optimizing the patient’s condition preoperatively, performing the meticulous nontraumatic surgical technique, closely monitoring potential post-operative complications, and implementing a multidisciplinary approach with the hematooncologists.
Resection of Anaplastic Meningioma via Combined Craniofacial Approach Yosafat Kurniawan Sugiarto; Arwinder Singh; Muhammad Firdaus; Oskar Ady Widarta; Farilaila Rayhani
Indonesian Journal of Cancer Vol 16, No 4 (2022): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v16i4.910

Abstract

Introduction: Meningiomas are common and mostly benign intracranial tumors but may show a histological progression to malignancy. The mechanism of malignant transformation remains unclear. Malignant meningiomas usually bear a high recurrence rate and unfavorable prognosis; hence, multiple surgical resections are required for the treatmentCase Presentation: A 41-year-old woman with a prior history of craniotomy at another center six years ago with Meningioma Grade 1 presented to our institution with new neurological symptoms. The magnetic resonance image demonstrated a large frontal base mass that extended to the nasal cavity with diffuse contrast enhancement and extensive surrounding edema. A craniofacial approach combined with a bifrontal approach was performed in multistage tumor resection. The tumor and the infiltrated dura were radically removed. The histopathology demonstrated an Anaplastic Meningioma. The patient also underwent radiation therapy.Conclusion:  Treatment of recurrent meningioma with anaplastic histology remains challenging because recurrence rates remain high with a poor prognosis.
A Case Report of Breast Fibromatosis Mimicking Breast Cancer Dwirani Rosmala Pratiwi; Dyah Fauziah; Rizkie T Trisnawaty; Cindy Angelina Limantara
Indonesian Journal of Cancer Vol 16, No 4 (2022): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v16i4.919

Abstract

Introduction: Breast Fibromatosis is a rare benign stromal tumor that accounts for 0.2% of all breast tumors. The clinical presentation and imaging features may mimic a malignant tumor. We reported a case of breast fibromatosis mimicking breast cancer.Case Presentation: A 22-years-old woman with a palpable breast lump was present and being examined. The ultrasound and mammography features suggested malignancy. Magnetic Resonance Imaging (MRI) and Multislice Computerized Tomography (MSCT) evaluation showed invasion of a tumor to muscle without intrathoracic involvement. A core biopsy was performed with the pathologic conclusion suspected as a phyllodes tumor with a differential diagnosis as mammary fibromatosis. The pathology result of intraoperative examination favor for fibromatosis. A wide excision procedure with a free margin could be achieved. The histopathological examination revealed spindle cells tumor infiltrating into muscle tissue. The result of immunohistochemistry examination excluded metaplastic carcinoma and Phyllodes tumor. Therefore, it confirmed a diagnosis of breast fibromatosis.Conclusions: Breast fibromatosis is a rare benign tumor of the breast that can mimic malignancy. This entity should be considered as one of the differential diagnoses in a patient with a breast lump. A pre-operative tissue diagnostic is mandatory to prevent radical treatment for this nonmalignant case.
Predictors of Quality of Life of Family Caregiver in A Community Setting: Breast and Cervical Cancer Impacts Ni Putu Wulan Purnama Sari; Agustina Chriswinda Bura Mare
Indonesian Journal of Cancer Vol 16, No 4 (2022): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v16i4.820

Abstract

Background: There is a growing trend for those with a terminal illnesses to be cared for by their families at home. Globally, there is a growing governmental policy to engage caregivers, families, and communities in the healthcare delivery system. Family caregivers (FCG) have taken responsibility for the day-to-day care of their ill loved ones at home. A cancer diagnosis is a major event for the person diagnosed and also for his or her family and caregivers. The caregiving activity has a significant impact on FCG’s quality of life (QOL). This study aimed to analyze the best predictor of FCG’s QOL of female cancer patients in a community setting.Methods: This cross-sectional study involved five Public Health Centers (PHCs) among 63 PHCs in Surabaya (7.94%), Indonesia, which were selected by one-stage cluster random sampling. There were 60 FCGs of female cancer patients who participated in this study (n = 60). The Caregiver Quality of Life – Cancer (CQOLC) was a valid and reliable instrument that was used to collect the data. Linear regression and one-way ANOVA tests were used in data analysis (α < .05). Ethical clearance was issued.Results: Most respondents were middle-aged married men with sufficient educational background and still actively working with sufficient income. Their QOL was mostly at a moderate level (Mean ± SD = 62.57 ± 16.23). Burden (p < 0.000), disruptiveness (p = 0.001), and financial concern (p < 0.000) were significantly different between the low, moderate, and high FCG’s QOL. The best predictor of FCG’s QOL of female cancer patients in a community setting was disruptiveness (R2 = 0.622; p < 0.000) compared to burden (R2 = 0.531; p < 0.000) and financial concern (R2 = 0.184; p = 0.001), especially when other family members have not shown interest in caregiving (R2 = 0.539; p < 0.000). Conclusions: FCG’s QOL of female cancer patients in a community setting is at a moderate level. Disruptiveness, burden, and financial concern could predict FCG’s QOL significantly. The other family members’ disinterest in caregiving which belongs to the disruptiveness domain is the best predictor of FCG’s QOL of female cancer patients in a community setting, which accounted for 53.9% variance of QOL in this population
The Benefits of Physical Activity to Reduce Mortality in Postmenopausal Breast Cancer Patients: A Literature Review Thomas Jaya Gumilang; Budi Hernawan
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.917

Abstract

Background: Breast cancer cases are more commonly diagnosed in postmenopausal women and the risk increases with age. Along with an increased vulnerability to breast cancer, increasing age also carries a higher risk of other health problems. Postmenopausal breast cancer patients frequently have one or more pre-existing comorbid conditions at the time of diagnosis. Higher physical activity can reduce breast cancer-specific and overall mortality. However, the vast majority of early breast cancer survivors experience a decrease in physical activity. This study aimed to determine the relationship between physical activity and the reduction of Breast Cancer-Specific Mortality (BCSM) and overall mortality in postmenopausal breast cancer survivors.Methods: This research uses a literature review design by conducting a journal search through Google Scholar, PubMed, and ScienceDirect. The keywords used are (“Physical activity” or Exercise) and (“Breast Cancer” or “Breast Neoplasm”) and (Mortality) and (“Post-menopause”).Results: Seven studies were included in this review. A total of 6276 deaths were reported. Only 3 out of 6 studies reported that there is a significant benefit between physical activity and reduction in breast cancer-specific mortality. Contrarily, all studies reported that there is a significant benefit between physical activity and overall mortality reduction, but at a certain intensity level. Conclusions: Our data suggest that physical activity, whether pre-diagnosis or post-diagnosis, is associated with a better prognosis of breast cancer in postmenopausal women.
Sunlight Exposure and Protection Behavior as Prevention of Skin Cancer in Nursing Students Raden Nabilah Putri Fauziyyah; Maria Komariah; Yusshy Kurnia Herliani
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.921

Abstract

Background: Skin cancer ranks fifth in the world. Melanoma, a type of skin cancer, ranks 23rd in Indonesia. Meanwhile, deaths caused by skin cancer are more than half of the number of new cases in Indonesia. Indonesia is a country that lies across the equator. It makes Indonesia have longer exposure to sunlight and a higher UV index. This study aims to describe the sunlight exposure level and protection behavior among nursing students.Methods: The samples of this study were 248 respondents from the Faculty of Nursing, Universitas Padjadjaran, who were recruited with a convenience sampling technique. Data were collected using a modified Sun Exposure Behaviour Inventory (SEBI). The data were processed using SPSS statistical software to determine behavioral descriptions and exposure to sunlight. Then, the result of the data analysis was performed with descriptive analysis (frequency and percentage).Results: The result of this study showed that most of the respondents (84.3%) always used longsleeved clothes to cover their shoulders. Most respondents (85.9%) used sunscreen with a Sun Protection Factor (SPF) of 15 or more, and more than half of the respondents (68.5%) used sunscreen that can protect from Ultraviolet A (UVA) and Ultraviolet B (UVB). Most respondents (76.2%) never spent time under natural or artificial Ultraviolet Radiation (UVR) to get the desired brown skin. More than half of the respondents (66.9%) had never sunbathed in the last 12 months. Conclusions: More than half of the respondents had adequate protective behavior against sun exposure and had moderate sun exposure. Using sunscreens with a higher SPF has shown a stronger preventive effect. Therefore, regular use of sunscreen can decrease the risk of skin cancer.
Real-Time MRI-guided Radiation Therapy for Locally Advanced Pancreatic Tail Cancer in Contact with The Colon Yukihiro Hama; Etsuko Tate
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.947

Abstract

Introduction: Curative radiation therapy for locally advanced pancreatic ductal adenocarcinoma (PDAC) is difficult when the tumor is in contact with the colon. In this regard, MRI-guided radiation therapy (MRgRT) provides real-time MRI during radiation therapy, resulting in highdose radiation delivery to the target while avoiding surrounding organs at risk (OARs), such as the intestinal tract. Case Presentation: A 94-year-old woman with locally advanced PDAC in the pancreatic tail underwent high-dose (72 Gy/30 fractions) real-time hypo-fractionated MRgRT to avoid irradiation of the colon. Three months after MRgRT, her serum CA 19-9 level normalized, and the tumor regressed completely. No adverse event or recurrence was noted during the six-month follow-up period.Conclusions: High-dose hypo-fractionated MRgRT may be a treatment option for a patient with locally advanced PDAC of the pancreatic tail, which is in contact with the colon.
Comparison of Electrons and Photons Treatment Plans in Medulloblastoma Patients Muhammad Usman Ghani; Aasia Razzaq; Nauman Amjad; Ismat Fatima
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.949

Abstract

Background: The treatment of medulloblastoma involves surgery, radiotherapy, and adjuvant chemotherapy. In radiotherapy, craniospinal irradiation (CSI) is prescribed, where two lateral cranial fields and one or two spinal beams are applied in CSI. Different multi-field techniques (coplanar and/or noncoplanar) are used to register the prescribed dose. The purpose of this study was to assess plan quality in terms of dose coverage of the spine with both photon and electron beam therapy and the sparing of organs at risks (OARs).Methods: Ten pediatric patients (ages 6 to 10 years) were immobilized in the prone position for simulation. The Clinical Target Volume (CTV) of the organ under treatment, Planning Target volume (PTV) of the organ under treatment, and OARs were contoured. Prowess Panther (v4.71) was used for dose computations. Two lateral parallel-opposed 6 MV photon cranial fields with the spinal beam(s) (either 6 Photons or 21 MeV electrons) were used in planning. Electron beams were added posteriorly on the spine with parallel-opposed cranial fields. The treatment plans were computed for 3600 c Gy in 21 fractions.Results: For comparable conformity number of electron versus photons beam plans (0.68 ± 0.41 versus 0.66 ± 0.47, is not significantly different at p < 0.05) and homogeneity index (1.22 ± 0.03 versus 1.25 ± 0.04, is significantly different at p < 0.05), the photon doses were higher for underlying OARs (heart, liver, and thyroid) and were lower for partially in-field organs (lungs and kidneys) compared to electrons.Conclusions: The underlying organs i.e., thyroid, heart, and liver receive a lesser dose in case of electrons, while partially in-field organs are exposed more compared to photons mainly due to the ballooning effect in electrons. The study shows that both electrons and photons can be used for CSI. However, the electron may be preferred due to its better sparing of underlying structures.
A Preliminary Study on Cancer Patients’ Quality of Life during the COVID-19 Pandemic Ririn Afrian Sulistyawati; Santoso Santoso; Lalu Muhammad Panji Azali; Galih Setia Adi
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.938

Abstract

Background: Cancer patients are 3.5 times more susceptible to COVID-19 than patients without cancer. The increasing number of COVID-19 patients is likely to impact cancer patients’ quality of life (QoL) significantly. This study aims to analyze the QoL of cancer patients during the COVID-19 pandemic. Methods: The method used is quantitative with a cross-sectional research design. In this study, 60 respondents were selected using the Consecutive Sampling Technique. The patient’s QoL was measured once by utilizing The World Health Organization Quality of Life Brief Version (WHOQOL BREF) instrument. The QoL of cancer patients was shown in mean and standard deviation, and the correlation between respondent characteristics and QoL was analyzed with Spearman.Results: The results showed that the average QoL of the respondents in the physical health was 30.36 ± 7.72, the intermediate psychological was 25.88 ± 9.14, the average social relationship was 59.90 ± 13.04, and the mean environment was 56.7 ± 10.93.Conclusions: Respondents’ low QoL during the COVID-19 pandemic for all domains. This study implies the importance of paying attention to every domain of the QoL of cancer patients, especially during the COVID-19 pandemic.
Cases of CHOP Chemotherapy - Unresponsive Primary Cutaneous Diffuse of Large B-Cell Lymphoma in Abdul Wahab Sjahranie Regional Public Hospital: A Case Presentation and Brief Review of Literature Viky Hibatu Wafi; Zainal Abidin
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.953

Abstract

Introduction: Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) is a variety of B-cell neoplasms that are present in the skin with no evidence of extra-cutaneous disease at the time of diagnosis or even after 6 months of the diagnosis. Cutaneous B-cell Lymphoma (CBCL) comprises 25 to 35% of all primary cutaneous lymphomas. Due to the relative rarity of PCDLBCL, there are no completed randomized trials to clarify the optimal treatment. Reported therapy options include radiotherapy, multiagent chemotherapy, chemotherapy, polychemotherapy with rituximab, and rituximab as a single agent.Case Presentation: Several red nodular lesions on the back developed over 10 months are found in a 40-year-old woman. The first Incision biopsy revealed these lesions were malignant roundcell tumors. After being treated with 10 cycles of chemotherapy regimens comprising cyclophosphamide, doxorubicin, vincristine, dan prednisone (CHOP), there was a progressive response as several red nodular lesions are getting larger and turned into an ulcerated wound. Wide excisions and skin flaps were done. Anatomical pathology examination showed diffuse non-Hodgkin lymphoma, a large B cell that belongs to intermediate malignancy, as immunohistochemistry was positive for CD20 and CD45. The patient was then diagnosed with primary cutaneous diffuse large B-cell lymphoma and given rituximab, a CD20-targeted therapy. The patient was allowed to be discharged on the second day after surgery.Conclusions: This case report presents cases of CHOP chemotherapy-unresponsive PCDLBCL in Abdul Wahab Sjahranie Regional Public Hospital of Samarinda, East Kalimantan.

Page 37 of 57 | Total Record : 562

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