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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 562 Documents
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Multimodality Diagnosis of Laryngeal Cancer in “Dharmais” National Cancer Hospital (DNCH) Dian Cahyanti; Syahrizal Syarif; Septiawati -; Evlina Suzanna
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.1021

Abstract

Background: Almost 95% of laryngeal cancers are squamous cell carcinoma. Most of them come from the supraglottic and glottic regions. Globally from 1990 to 2017, there was an increase in the incidence of laryngeal cancer by 58.67%. Patients with suggestive grievances of laryngeal cancer symptoms are usually advised to do a further examination. The use of multimodality diagnosis is helpful for the diagnosis of cancer. Diagnostic procedures in diagnosing laryngeal cancer can be made by history and physical examination, clinical (laryngoscopy), and supporting examination (radiology and biopsy). This study aims to determine the distribution of the demographic (gender, age, domicile, marital status, and educational level), clinical distribution (voice changes, respiratory disorders, pain, dizziness, cough, lump on the neck, and others), and modalities of diagnosis (anamnesis, clinical examination, radiology, and biopsy) in laryngeal cancer.Methods: Descriptive study and a routine data-based study was conducted by collecting data on cancer patients who were diagnosed with laryngeal cancer from 2003 to 2007 by the microscopic either in Dharmais National Cancer Hospital (DNCH) or other hospitals. The study sample was 53 out of a total of 68 cases of laryngeal cancer who had been diagnosed with malignancy histopathologically at DNCH or in other hospitals with epithelial or non-epithelial types with completed medical records. Results: The glottic region is the most common subsite, that is, 52.8%, and squamous cell carcinoma (SCC) is the most common histopathological type of laryngeal cancer. In most of the cases, either males or females presented with a change in the voice of 68.8% and 80% respectively. In 6 out of 12 cases have not been examined microscopically before, while 7.5%.of the cases have done the diagnostic procedure completely in DNCH. Conclusions: The most common subsite and histopathological type of laryngeal cancer is glottis and SCC. The most common clinical feature in both sexes is voice changes. Most cases have not been examined according to the standard diagnosis procedure completely.
Sexual Rehabilitation of Cancer Patients: A Less Noticed Domain in Cancer Care Abhijeet Dhawalram Faye
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.929

Abstract

Background: Sexual problems are associated with almost all types of cancers, especially those of the genital regions. Sexual problems can occur due to cancer itself or due to its treatment (chemotherapy, radiotherapy, or surgery) across all the stages of cancer and its management.Methods: The researcher reviewed the current research status of this less-discussed issue. 115 articles were identified using predefined keywords in Pubmed, Pubmed Central, Embase, and Google Scholar databases from January 1, 2000, to March 31, 2022. First, the articles were screened based on the abstracts followed by checking for the availability of their full-text versions. A total of 28 articles fulfilling the inclusion criteria were finally selected and analyzed. Results: Common sexual problems found in men were erectile dysfunction, decreased libido, dry ejaculation, and performance anxiety. On the other hand, women usually complained of reduced intimacy, lack of sexual desire, vaginal dryness, pain during intercourse, lack of sexual sensation, and reduced self-esteem for sexual activities. There is a significant prevalence of sexual problems with effects on marital relationships in cancer patients. Psychiatric disorders were found to be associated with a higher prevalence of sexual dysfunction ranging from 70 to 90% compared to the general population. Up to 50% and 40% of female and male patients with depression (a common occurrence in cancer) respectively may have sexual dysfunctions. Conclusions: Management of these problems is necessary, as it can be a contributing factor to the poor quality of life. Communication and discussion about sexual health from patients as well as the healthcare provider side are needed. The urgency of seeking a specialist’s help such as a psychiatrist or a sex therapist is also discussed. The researcher reviewed common sexual problems, causes, and treatment modalities, and suggested a few recommendations for making sexual health a part of routine cancer check-ups.
A Rare Clinical Entity of Krukenberg Tumor: A Case Report in Margono Soekarjo Hospital of Purwokerto Aditya Eka Octavian; M Yamsun; Gita Nawangtantrini
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.931

Abstract

Introduction: Krukenberg Tumor is an ovarian tumor that originated from other organ metastases such as gastric, colorectal, pylorus, appendix, colorectal, or breasts. This study aims to report an incidence of a Krukenberg tumor found in a-36year- old woman who has finished her therapy at Margono Soekarjo Hospital.Case Presentation: This case reports the incidence of a Krukenberg tumor found in a-36-year old woman with the main complaint of a burning sensation in her stomach and the existence of a mass in the right and under the Arcus Costae. The patient underwent metastasectomy and biopsy. Histopathological examinations show that the features of Krukenberg tumor originated from a gaster. The patient then underwent chemotherapy for 6 cycles, radiotherapy 20 times, and some evaluation. This case had been observed for 12 months since the first time the patient came to the hospital.Conclusions: Krukenberg tumor is a rare tumor of the ovary which is characterized by poor prognosis. This case depicts the finding of Krukenberg tumor with gastric clinical features. The combination of metastasectomy and chemotherapy can be done in such a case to improve patient survival rates.
Various Clinical Overviews in Pelvic Cavity Cancer In “Dharmais” National Cancer Hospital (DNCH) Evlina Suzanna; Asri C Adisasmita; Pradnya Sri Rahayu; Grace Shalmont
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.1022

Abstract

Background: Pelvic cavity is formed by the bones of pelvic organs where there are many system organs. Pelvic cavity cancer incidence in Jakarta from 2005 to 2007 was 13.96/100.000 population. In “Dharmais” National Cancer Hospital (DNCH), the frequency in 1993-2007 was 26% of all cancer. The purpose of the research is to find an overview of epidemiological (age group, gender, domicile, educational, marital status, tumor location) and clinical (symptoms and stage) cancer pelvic cavity. Methods: This cross-sectional study used the medical records of patients registered with DNCH as new cases and diagnosed by microscopic examination during 2005-2007. The study population is a case of cancer with the diagnosis of the location of the primary tumor in the pelvic cavity area. The sample calculation used a precision formula and obtained a minimum sample of 323. The data collection used questionnaires and obtained 326 cases. The data were analyzed using SPSS 26.0 with Chi-square test (α = 0.05).Results: Pelvic cavity cancer is a major problem in females (91.1%) with peak ages 45-59. Variations of clinical features in males and females were 24 and 35 symptomatic. In males, the most common clinical feature is dark/blood stool (41.38%), generally on rectal cancer, followed by weight loss (20.69%) which overlaps at five organs. In females, the most common clinical features are vaginal bleeding (43.77%), and vaginal spotting (13.47%), which occurs in cervix cancer, followed by abdominal pain (13.47%) that overlaps in six organs. Conclusions: Cancer, especially primary tumors of the pelvic cavity, is not a “silent killer” disease because the clinical picture can appear at an early stage. This study also provides a common clinical picture in patients with primary tumors in the pelvic cavity even though they are in one cavity. The clinical picture that appears is specific according to the primary tumor. In addition, some symptoms are possessed by various organs, so they are nonspecific.
The Effectiveness of Laughter Yoga to Improve Individual and Peer Happiness Among Cancer Patients Yesiana Dwi Wahyu Werdani
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.940

Abstract

Background: Cancer therapy during the pandemic causes physical and psychological problems. It impacts happiness in their lives. Laughter yoga is an intervention that can increase happiness. The purpose of this study is to prove that laughter yoga can increase the achievement of individual and peer happiness in cancer patients undergoing therapy in a pandemic situation. Methods: This was a quasi-experimental with a non-equivalent control group design. The total sample was 40 cancer patients at the Indonesia Cancer Foundation East Java selected through the inclusion and exclusion criteria. In the implementation, 20 people belong to the intervention group (IG) and 20 other people belong to the control group (CG). The IG provided laughter yoga 2x/a week for 4 weeks with 14 steps, while CG only through daily activities. Both groups conducted pre-test and post-tests using The Subjective Happiness Scale. The scale consists of two indicators: individual happiness and peers’ happiness. In addition, the calculation of the two indicators is done separately. The instrument has been tested for its validity and reliability. The data were normally distributed (Shapiro-Wilk test p > 0.05). Statistical test was conducted using paired t-test (p < 0.05) to test the pre-post data in both groups and independent sample t-test (p < 0.05) to test the effectiveness of the intervention compared to the control group.Results: Demographic data of respondents was homogenous. The mean score of individual and peer happiness before and after intervention in the IG increased. It means that respondents had better happiness. Meanwhile, in the CG there was a stagnation score of individual and peer happiness. Paired t-test in the IG showed that individual and peers’ happiness got the same p-value < 0.001 each. In the CG, individual happiness records p = 1.000 and peers’ happiness p = 0.083. Statistical tests conducted by Independent t-test to compare IG and CG had the p = 0.012 for individual happiness and p = < 0.001 for peers’ happiness.Conclusions: Laughter yoga has a significant effect to enhance individual and peer happiness compared to respondents who only carry out normal daily activities, especially for cancer patients undergoing therapy during the COVID-19 pandemic.
Multiple Bone Metastases as the Initial Presentation of Occult Breast Carcinoma in a Kidney Transplant Recipient Marina Kljajić; Guy Alush; Nikolina Bašić-Jukić
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.945

Abstract

Introduction: Due to their immunosuppressive medication regimen, solid organ transplant recipients have an increased risk of developing cancer, which might jeopardize their survival. Specifically, cardiovascular disease and malignancy are the two leading causes of death in kidney transplant recipients. In solid organ recipients, cutaneous malignancies, lymphomas, and Kaposi’s sarcomas also appear to be the most prevalent cancer forms. Thus, carcinoma of unknown primary origin is a clinical entity that diagnosing requires a high level of suspicion and thorough reviewing of laboratory, radiological, and clinical findings. Further, susceptible patients, such as immunocompromised ones, should merit a careful analysis of findings and detailed analytic rationale. We, therefore, present the following case report demonstrating the importance of follow-up of specific suspicious serum markers in transplant patients. To our knowledge, this study is the first case to report an occult breast carcinoma as the initial presentation in a patient with a kidney transplant.Case Presentation: In the following case, the primary indication for malignancy was elevated alkaline phosphatase (ALP), a common finding in patients with chronic renal failure. Once noticed in a scheduled post-transplantation follow-up, further diagnostic tests, such as a broader serum panel, sternal puncture, and mammography, were ordered and returned normal. Subsequently, CT was ordered and revealed lytic and sclerotic bone changes. Afterward, serum tumor markers were ordered together with gynecological ultrasound and PET-CT. Finally, an iliac bone marrow biopsy confirmed a breast cancer diagnosis of unknown primary origin, causing the elevated ALP.Conclusions: This case report presents a uniquely difficult diagnostic challenge as an expected elevated value of ALP in a kidney transplant recipient was the only diagnostic clue for occult breast carcinoma. We discuss further the vigilance that physicians must exert when dealing with kidney transplant recipients and the implication of carcinoma of unknown primary in this population.
Morphological Changes and Apoptosis of Buccal Mucosa Basal Epithelium in Heads and Necks during Cancer Radiotherapy Christiana Cahyani Prihastuti; A. Haris Budi Widodo; Nabila Prandita Bagasworo; Arundito Widikusumo; Dody Novrial; Daniel Joko Wahyono; Tirta Wardana
Indonesian Journal of Cancer Vol 17, No 1 (2023): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i1.944

Abstract

Background: Radiotherapy is generally used to treat head and neck malignancy through high radiation, focusing on killing cancer cells. However, some adverse effects in oral mucosal tissue, including cell morphology changes and apoptosis, are commonly found. This study aims to determine the morphological changes and apoptosis of buccal mucosa epithelium after radiotherapy in head and neck cancer (HNC) patients.Methods: This study involved 8 subjects of patients diagnosed with HNC. Buccal mucosal smear samples were collected using cytobrush two times, before and after radiotherapy, with a dose of 70 Gy in 7 weeks. The specimens were prepared and stained using Feulgen and Rosenbeck technique. Observations were made using a light microscope with a count per 1000 epithelial cells. Statistical analysis was performed using statistical software with Pearson’s correlation test and significance t-test (p < 0.05) between irradiated and non-irradiated samples.Results: Data analysis showed significant changes in cell morphological damage and apoptosis in patients before and after radiotherapy. It increases in the number of micronuclei (p = 0.001), broken egg (p = 0.001), binuclei (p = 0.003), pyknosis (p = 0.033), karyorrhexis (p = 0.020), and karyolysis (p = 0,004). Conclusions: The effects of radiation reflect morphological changes and apoptosis in the buccal mucosa basal epithelium in HNC patients.
Incidental Findings of Duodenal-Type Follicular Lymphoma by Endoscopic Screening: A Case Report Herman Saputra; Ni Putu Sriwidyani; Putu Erika Paskarani; Silvia Khosasi
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.965

Abstract

Introduction: Follicular Lymphoma (FL) is a B-cell neoplasm arising from the germinal center. Gastrointestinal FL is a rare case, accounting for less than 4% of all primary lymphoma of the gastrointestinal tract. Duodenal-type Follicular Lymphoma (DTFL) was included in an entity of primary intestinal FL. However, in the 2017 World Health Organization (WHO) Classification, this entity was included in a specific variant called DTFL. In this article, we report a case of DTFL in a 56-year-old man which was incidentally found during upper gastrointestinal endoscopy Case Presentation: : We report a case of incidentally found DTFL in a 56-year-old man during an endoscopy. The endoscopic finding showed a small, hypertrophic, or nodular lesion on part two duodenum. Microscopic evaluation of duodenal mucosa consists of proliferative atypical lymphoid cells arranged in follicular architecture. The lesion was confined to the lamina propria. The atypical lymphoid cells were dominated by monotonous centrocyte-like cells, small-sized, with scant cytoplasm, and cleaved nuclei. There were some scattered larger centroblast-like cells with multiple nucleoli. No mantle zone and tingible body macrophage were found. The immunohistochemical evaluation showed positivity for CD 20, CD 10, Bcl-6, and Bcl-2 in the follicular structure. CD 21 was dominantly stained at the periphery of the follicular structure, and Ki-67 was low. Conclusions: According to clinical data, endoscopic findings, and histopathological and immunohistochemical findings, the patient was diagnosed with DTFL. 
Comparative Prostate Cancer Detection Rate of Transrectal Ultrasonography Guided versus Finger Guided Prostate Biopsy Rizki Abri Laksono; Tanaya Ghinorawa; Aria Danurdoro
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.689

Abstract

Background: Prostate biopsy was used to diagnose and establish a therapy for prostate cancer (PCa). Instead of using conventional finger-guided prostate biopsy (FGPB) to approximate prostatic architecture, transrectal ultrasonography-guided biopsies of the prostate (TRUSGB) have become more popular nowadays because of offer direct visualization. However, the lack of availability of transrectal ultrasound probes in less-developed regions raises concerns regarding the need to diagnose patients with PCa. Moreover, different conclusions have been found from prior studies that examined the efficacy of both methods. This study aims to compare the accuracy of TRUSGB to FGPB in prostate cancer.. Methods: This study was done retrospectively from 50 medical records of PCa in the Urology Division of Sardjito Hospital from January 2009 until December 2013. Patients’ age, PSA value, digital rectal examination, and histopathological examination were analyzed. Results: The mean age was 65.18 ± 7.76 years in FGPB and 67.52 ± 10.79 years in TRUSGB group. The median PSA was 65.01 (range: 16.33–114.72) ng/mL in FGPB and 71.75 (range: 19.86– 123.47) ng/mL in TRUSGB. Abnormal DRE was found in 75.75% of patients in FGPB group and 70.58% in TRUSGB. Comparable cancer detection rates were found in the FGPB and TRUSGB groups (45.45% vs. 52.94%) (p = 0.136).Conclusions: The cancer detection rates for FGPB and TRUSGB procedures are comparable. This supports using FGPB as the first-line diagnostic technique, especially in low-resource situations where ultrasonography is unavailable.
Left Hindquarter Amputation due to High-Grade Pleomorphic Sarcoma of the Groin: A Case Report M. Zaki Abdul Hafiz; Bayu Brahma; Rian Fabian Sofyan
Indonesian Journal of Cancer Vol 17, No 2 (2023): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i2.957

Abstract

Introduction:Hindquarter amputation or known as hemipelvectomy is a surgical technique that is primarily used for the eradication of malignant primary soft tissue and bone tumors of the pelvis, hip, and upper thigh regions. Occasionally, hindquarter amputation has been employed in the treatment of severe trauma, metastases, and infection. This case report aims to give a lesson in the case of the High-Grade Pleomorphic Sarcoma of the Groin because this is a very rare case and most patients are not willing to undergo amputation.Case Presentation: A 54-year-old male patient came with a complaint of a lump in the thigh. Initially, the lump was as big as a marble and has been getting bigger since last year. The size of the lump was approximately 30 x 30 x 30 cmConclusions: The most common indications for amputation in patients with the primary localized disease were extensive involvement of the limb-girdle, multiple muscle compartment involvement, multifocality, and unsuitability for limb-sparing surgery, typically due to lack of a salvage option. Hindquarter amputation was used as a treatment for 13% of all pelvic bone sarcomas where there is a realistic chance of control of symptoms or long-term survival.comas.

Page 38 of 57 | Total Record : 562

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