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Bayu Brahma
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Dki jakarta
INDONESIA
Indonesian Journal of Cancer
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 562 Documents
Investigation of Genital System Cancers Prevalence in Isfahan, Iran Zahra Tolou-Ghamari
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (775.748 KB) | DOI: 10.33371/ijoc.v13i2.631

Abstract

Background: Previous publication reported a significant disparity of genital cancer incidence between genders. The aim of this study is to investigate period prevalence (PP) and incidence (Irs) of genital cancer in Isfahan/Iran. Methods: Information equivalent to those collected by the USA Surveillance, Epidemiology, and End Results (SEER) program was obtained from the Isfahan Cancer Registry. Period prevalence (PP) was calculated per 100.000 persons. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition) and recorded by topography code. Results: Between the years 2011 to 2015, among all registered cases (3024 cases), 60% applied to the male genital system. The mean (SD) age at diagnosis was higher for men 69.4 (14.7) than women 57.8 (15) (t-test; P<0.006). The calculated PP was significantly (Chi-squared test; P<0.001) higher in males (71.5) than females (49.6) per 100.000 in Isfahan Province. Conclusions: The PP for ovarian cancer in female and prostate cancer in male was higher than for other genital tumors. To facilitate early diagnosis for better management, we recommend that health-care plans for Isfahan Province/Iran place a greater focus on pharmacotherapy and environmental factors in cancer control.
Pregnancy Associated Breast Cancer di Rumah Sakit Onkologi Surabaya 2006 2014 JACOBUS OCTOVIANUS; SAVITRI KUNTARI; ARIO DJATMIKO
Indonesian Journal of Cancer Vol 9, No 2 (2015): April-Juni 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.646 KB) | DOI: 10.33371/ijoc.v9i2.377

Abstract

ABSTRACTPregnancy associated breast cancer (PABC) is the most common malignancy in gestation. Due to its high aggressiveness, PABC needs a specific management right from diagnosis process to therapy. The objective of this study is to find out the PABC profile in Rumah Sakit Onkologi Surabaya from 2006-2014. A descriptive study using PABC Medical Record datafrom 2006 until 2014. There were 21 PABC patients of whom 11 was diagnosed on 31-40 years old (52.38%); 16 PABC patients with multiparity (76.19%); 14 (66.67%) PABC diagnosed at 1 year post partum; 18 USG and 6 Mammography examinations, both revealed 100% sensitivity in diagnosing PABC; 14 patients (66,67%) in stadium III-IV; 9 patients (42,86%) with T4 tumor size; 9 patients (42,86%) with axillary lymphnode metastasis ; 4 patients (19,05%) with distant metastasis; 10 patients (47,62%) with Invasive Ductal Carcinoma (IDC); 14 patients (66,67%) grade III; and 8 patients (38,10%) with angioinvasion. Positive ER/PR in 11 patients (52,38%) and positive Her-2 in 10 patients (47,62%). PABC prognosis were: 8 patients (38,10%) in good condition, while 5 patients (23.81%) had distant metastasis, and 4 patients (19,05%) passed away. Twenty one babies born healthy (100%). The aggressiveness of PABC can be seen from the percentage of patients in advanced stage and has worse prognosis.Keywords: breast cancer, pregnancyABSTRAKPregnancy Associated Breast Cancer (PABC) merupakan keganasan yang paling sering ditemukan pada kehamilan. Karena agresivitas yang tinggi, PABC memerlukan penanganan yang khusus, baik saat penegakan diagnosis maupun tindakan terapi. Penelitian ini bertujuan mengetahui profil PABC di Rumah Sakit Onkologi Surabaya sejak 2006-2014. Studi deskriptif ini menggunakan data rekam medis pasien PABC sejak 2006 hingga 2014. Hasil penelitian menunjukkan kasus PABC sebanyak 21 pasien. Jumlah PABC tertinggi ditemukan pada usia 31-40 tahun, yaitu 11 pasien (52,38%); 16 pasien (76,19%) PABC didapatkan pada multiparitas; 14 pasien (66,67%) pada 1 tahun post-partum. Pada 18 pemeriksaan USG dan 6 pemeriksaan mammografi memiliki tingkat sensitivitas 100%; 14 pasien (66,67%) pada stadium III-IV; 9 pasien (42,86%) tumor T4; 12 pasien (57,14%) metastasis ke kelenjar getah bening; 4 pasien (19,05%) metastasis jauh; 10 pasien (47,62%) Invasive Ductal Carcinoma (IDC); 14 pasien (66,67%) pada grade III; 8 pasien (38,10%) memiliki angioinvasion; 11 pasien (52,38%) memiliki ER/PR positif; dan 10 pasien (47,62%) memiliki Her-2 positif. Pada follow up didapatkan 8 pasien (38,10%) berada dalam kondisi baik, 5 pasien mengalami metastasis jauh (23,81%), dan 4 pasien meninggal (19,05%). Dua puluh satu bayi terlahir sehat (100%). Kesimpulannya, agresivitas PABC dapat dilihat dari besarnya persentase pasien yang datang pada stadium lanjut dan prognosis yang buruk.Kata Kunci: kanker payudara, kehamilan
Rabdomiosarkoma Pada Anak: Gambaran Klinis di 2 Institusi Anky Tri Rini; Kusumaning Edhy; Djajadiman Gatot; Endang Windiastuti; Yanto Ciputra
Indonesian Journal of Cancer Vol 2, No 2 (2008): Apr - Jun 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1676.103 KB) | DOI: 10.33371/ijoc.v2i2.40

Abstract

Rabdomiosarkoma (RMS) merupakan keganasan jaringan lunak yang banyak terjadi pada anak umur 1 sampai 5 tahun dan remaja. Sekitar 15 % anak dengan RMS datang dalam keadaan metastasis dan prognosisnya tidak ada perbaikan dalam 15 tahun terakhir.Penelitian ini untuk mengetahui keluaran terapi serta pengembangan selanjutnya Penelitian dilakukan secara retrospektif dari data pada catatan medis 30 pasien yang diterapi di RS Cipto Mangunkusumo (RSCM), Jakarta bulan Juni 2000 sampai Juli 2006 dan 11 pasien di RS Kanker Dharmais (RSKD), Jakarta bulan Januari 2003 sampai Desember 2007. Data dikumpulkan untuk melihat gambaran klinis dan keluaran terapi.Terdapat 30 pasien RMS di RSCM tahun 2000-2006 dan 11 di RSKD tahun 2003-2007. Perbandingan antara laki-laki dan perempuan adalah 2:1 (RSCM) dan 1:1,7 (RSKD).Kebanyakan menyerang anak umur antara 1 bulan sampai 5 tahun (43,3 % & 43,5 %) dengan median antara 6-7 tahun. Gambaran patologi terbanyak yaitu embrional (70% & 54,5%). Lokasi primer terbanyak pada bagian kepala dan leher (43,3% & 27,3%). Didapatkan stadium lanjut sebesar 80% & 45,5%. Sebagian besar metastasis ditemukan pada sumsum tulang (85,7% & 33,3%). Keluaran terapi didapatkan yang masih dalam terapi 66,7% & 27,3%, meninggal 30% & 18,2% dan lost to folloiv up 3,3% & 54,5%.RMS kebanyakan didapatkan pada anak umur 1 bulan sampai 5 tahun. Gambaran histologi tipe embrional dan lokasi primer pada kepala dan leher merupakan yang tersering. Pada umumnya, pasien datang dalam stadium lanjut tetapi jika datang pada stadium awal akan memberikan hasil yang lebih baik.Kata kunci: Rabdomiosarkoma, epidemiologi klinik, keluaran terapi.
Jun Activation Domain-binding Protein 1 Antisense (p27Kip1) Induces Apoptosis of an Oral Tongue Cancer Cell Supriatno -
Indonesian Journal of Cancer Vol 5, No 1 (2011): Jan - Mar 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.445 KB) | DOI: 10.33371/ijoc.v5i1.88

Abstract

Jun activation domain-binding protein (Jab1) berperan sebagai koaktivator dari aktivator protein 1 yang terlibat dalam degradasi cyclin-dependent kinase inhibitor p27Kip1. Efek Jab1 antisense (Jab1-AS) diujikan pada sel kanker lidah manusia Supris-Clone 1 (Sp-C1). Tujuan penelitian ini adalah menganalisis hambatan sel SP-C1 dengan perlakuan Jab1-AS. Hasil penelitian menunjukkan bahwa Jab1-AS meningkatkan apoptosis yang ditandai dengan meningkatnya fase awal apoptosis (33,5%) dan fase lambat apoptosis (17,6%). Selain data tersebut, diketahui peningkatan aktivitas proteolitik caspase-3 dan caspase-9 pada sel yang diperlakukan dengan Jab1 AS. Kesimpulannya, Jab1 AS dapat meningkatkan apoptosis sel kanker lidah manusia (Sp-C1). Target pada molekul Jab1 dapat memberikan harapan baru sebagai pendekatan terapeutik untuk jenis kanker tersebut.Kata kunci: Jab1, apoptosis, antisense, kanker lidah manusia (Sp-C1).
Uji Diagnosis Ultrasonografi Strain Ratio Elastography Dihubungkan dengan Histopatologi pada Palpable Mass Payudara di RSUP Dr. Hasan Sadikin, Bandung HARI SOEKERSI; FERDI MAHADIAN
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1549.614 KB) | DOI: 10.33371/ijoc.v11i2.503

Abstract

ABSTRACT Strain ratio elastography ultrasound of palpable mass of the breast is one of ultrasound examination based on semiquantitative analysis, is currently widely used to assess tissue stiffness that vary. Strain ratio elastography ultrasound is expected to be able to establish a quick and proper diagnosis to get the right therapy resulting in lower morbidity and mortality in breast carcinoma. Strain ratio elastography ultrasound have been more useful on the morphology of lesions such as suspicious atypical benign (BIRADS 3), suspected malignant (BIRADS 4), suggestive of malignancy (BIRADS 5). The aim of this study to determine the results of the diagnostic tests strain ratio elastography ultrasound associated with histopathology in palpable breast mass in Dr. Hasan Sadikin General Hospital. This research is an analytic observational study and a diagnostic test of strain ratioelastographyultrasound associated with histopathology in palpable breast mass with a model to assess the validity of cross sectional. Sampling was conducted prospectively and performed in the Department of Radiology Dr. Hasan Sadikin General Hospital Bandung from November 2016 to January 2017. Data analysis using univariate analysis and bivariate analysis and Chi Square test. Results, the subject of study are 32 female patients, the youngest are 21 years old and the oldest are 72 years old. The results of diagnostic tests strain ratio elastography ultrasound in differentiating palpable breast mass after being confirmed by histopathology in Dr. Hasan Sadikin General Hospital Bandung with a sensitivity 81.5%, specificity 80.0%, accuracy of 81.3%, PPV 95.7% and NPV 44.4%. Conclusion: strain ratio elastography ultrasound has value of sensitivity and specificity that is high enough in differentiating palpable breast mass after being confirmed by histopathology in Dr. Hasan Sadikin General Hospital Bandung.ABSTRAK Ultrasonografi (USG) strain ratio elastography pada palpable mass payudara yang merupakan salah satu turunan dari pemeriksaan USG berdasarkan analisis semikuantitatif, saat ini banyak digunakan untuk menilai kekakuan jaringan yang bervariasi. Dengan USG strain ratio elastography diharapkan dapat mendiagnosis dengan tepat dan cepat untuk mendapatkan terapi yang tepat sehingga menurunkan angka morbiditas serta mortalitas pada karsinoma payudara. USG strain ratio elastography lebih bermanfaat pada morfologi lesi-lesi atipikal seperti curiga jinak (BIRADS 3), curiga ganas (BIRADS 4), atau sugestif keganasan (BIRADS 5). Histopatologi merupakan baku emas untuk mendiagnosis palpable mass dan non palpable mass payudara. Penelitian ini bertujuan mengetahui hasil uji diagnosis USG strain ratio elastography dihubungkan dengan histopatologi pada palpable mass payudara di RSUP Dr. Hasan Sadikin, Bandung. Penelitian ini merupakan studi observasional analitik dan merupakan suatu uji diagnosis dari USG strain ratio elastography dihubungkan dengan histopatologi pada palpable mass payudara dengan model cross sectional untuk menilai validitas. Pengambilan sampel dilakukan secara prospektif dan dilakukan di Departemen Radiologi/ RSUP Dr. Hasan Sadikin, Bandung, dari November 2016 sampai Januari 2017. Data dianalisis menggunakan analisis univariabel dan bivariabel menggunakan uji Chi square. Hasil penelitian menunjukkan subjek penelitian sebanyak 32 penderita wanita, usia termuda 21 tahun, dan usia tertua 72 tahun. Hasil uji diagnosis USG strain ratio elastography dalam membedakan palpable mass payudara setelah dikonfirmasi dengan histopatologi di RSUP Dr. Hasan Sadikin, Bandung, menunjukkan sensitivitas 81,5%; spesifisitas 80,0%; akurasi 81,3%; PPV 95,7%; dan NPV 44,4%. Penelitian ini menyimpulkan bahwa USG strain ratio elastography memiliki nilai sensitivitas dan spesifisitas yang cukup tinggi dalam membedakan palpable mass payudara setelah dikonfirmasi dengan histopatologi di RSUP Dr. Hasan Sadikin, Bandung.
The Profile of Cervical Cancer Patients at Soedarso Hospital Sari Eka Pratiwi; Heru Fajar Trianto; Nabilah Nurul Fatinah; Muhammad In’am Ilmiawan; Iit Fitrianingrum; Desriani Lestari
Indonesian Journal of Cancer Vol 16, No 1 (2022): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.619 KB) | DOI: 10.33371/ijoc.v16i1.845

Abstract

Background: The prevalence and mortality rates of cervical cancer differ by region with the highest rates found in Latin America, Southeast Asia, and Africa. In Indonesia, cervical cancer is the second-largest contributor to the latest cases in 2020. In West Kalimantan, over 20,000 women were diagnosed with cervical cancer in 2014. This study aims to describe the characteristics of cervical cancer patients in West Kalimantan. Methods: A descriptive observational study was conducted on patients from 2017 to 2019 according to the Soedarso Hospital database. All medical records were reviewed and analyzed to obtain the variable data; they were age, ethnics, origin, stage of cervical cancer, histopathology types, and hemoglobin (Hb) level. Results: Cervical cancer patients for the 2017–2019 period totaled 147 people with 30 deaths. In this study, 97 patients from 2017 to 2019 met the inclusion criteria. Cervical cancer was found from the age of 27 years with a peak at the age of 41–60 years. Most patients came from Pontianak and Kubu Raya cities (45.4% and 14.4%, respectively) with the most ethnic groups being Malays (41.2%). A total of 43.3% of patients had a parity amount of more than five times. Most patients came at stage IIIb (45.4%). The patients present with moderate to severe anemia with the lowest Hb level of around 2.3 g/dL. Based on histopathology, the type of squamous cell carcinoma ranks the highest (70.1%).  Conclusions: Cervical cancer incidence reaches the peak at adults to elderly. The amount of parity seems to contribute to the incidence of cervical cancer in West Kalimantan. Most patients came at an advanced stage and the type of squamous cell carcinoma with moderate to severe anemia
SUPLEMEN: Registrasi Kanker Berbasis Rumah Sakit di Rumah Sakit Kanker "Dharmais" Pusat Kanker Nasional Pusat Kanker, 1993-2007 EVLINA SUZANNA; TIARLAN SIRAIT; PRADNYA SRI RAHAYU; GRACE SHALMONT; ELFIRA ANWAR; RIZKA ANDALUSIA; HARJATI -; SONAR SONI PANIGORO
Indonesian Journal of Cancer Vol 6, No 4 (2012): Oct - Dec 2012
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v6i4.299

Abstract

http://indonesianjournalofcancer.org/2012/2012-no4-oct-dec/205-registrasi-kanker-berbasis-rumah-sakit-di-rumah-sakit-kanker-qdharmaisq-pusat-kanker-nasional-1993-2007?catid=95%3Asupplement
Sebaran Kanker di Indonesia, Riset Kesehatan Dasar 2007 MAKASSARI DEWI
Indonesian Journal of Cancer Vol 11, No 1 (2017): Jan-Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (493.456 KB) | DOI: 10.33371/ijoc.v11i1.494

Abstract

ABSTRACTCancer is one of the leading causes of death in the world. It takes an evidence-based strategy to address the increasing incidence of cancer in the world. To control the increase of cancer in Indonesia required control strategies of the key riskfactors associated with the incidence of cancer. Currently the data on the distribution of cancer in Indonesia is still limited. Key risk factors for cancer can be known from the existing types of cancer. By knowing the distribution of cancerthat is expected to become a factor in the prevention of cancer in Indonesia. The purpose of this paper is to describe the distribution of cancer in Indonesia by the community in 2007. The data used is data survey of basic health research(Riskesdas) 2007. Design this study was a descriptive cross-sectional. The analysis showed that from 768 635 respondents there were 4647 (0.6%) respondents who had cancer. Central Java province was the province with the highest number of cancer patients (23.6%). Cervical and ovarian cancer as well as breast cancer were the most commonly found as many as 927 (20%) of respondents to cervical and ovarian cancer, and as many as 746 (16%) of respondents had breast cancer. Cervical and ovarian cancer were most commonly found in adults, with the status ofmarried, live in urban areas and have low education status. Breast cancer was most common in women aged adult, married status, living in urban, low educational status and low economic status.ABSTRAKKanker merupakan salah satu penyebab kematian utama di dunia. Dibutuhkan strategi berbasis bukti untuk mengatasi meningkatnya kejadian kanker di dunia. Untuk mengontrol peningkatan kanker di Indonesia diperlukan strategipengendalian faktor risiko kunci yang berhubungan dengan kejadian kanker. Saat ini, data tentang sebaran kanker di Indonesia masih terbatas. Faktor risiko kunci kanker dapat diketahui dari jenis kanker yang ada. Dengan mengetahuisebaran kanker yang ada diharapkan dapat menjadi salah satu acuan dalam penanggulangan kanker di Indonesia. Tujuan dari tulisan ini adalah untuk menggambarkan sebaran kanker di Indonesia berdasarkan komunitas pada tahun2007. Data yang digunakan adalah data surveI Riset Kesehatan Dasar (Riskesdas) 2007. Desain studi ini adalah deskriptif cross-sectional. Hasil analisis menunjukkan bahwa dari 768.635 responden, 4.647 (0,6%) responden di antaranya menderita kanker. Jawa Tengah merupakan provinsi dengan jumlah penderita kanker tertinggi (23,6%). Kanker serviks uteri dan ovarium serta kanker payudara merupakan jenis kanker yang paling banyak ditemukan, yaitu 927 (20%) responden untuk kanker serviks uteri dan ovarium serta 746 (16%) responden kanker payudara. Kanker serviks uteri dan ovarium paling banyak ditemukan pada usia dewasa, dengan status menikah, hidup di perkotaan, dan memiliki status pendidikan rendah. Kanker payudara paling banyak ditemukan pada wanita usia dewasa, status menikah, tinggal di perkotaan, status pendidikan rendah, dan status ekonomi rendah.
Parotid Gland Metastasis From Breast Cancer: A Case Report Bob Andinata; Dewi Iriani; Adlina Karisyah
Indonesian Journal of Cancer Vol 14, No 3 (2020): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1801.197 KB) | DOI: 10.33371/ijoc.v14i3.723

Abstract

Introduction: Breast cancer metastasis at the parotid gland is uncommon. There were only 21 cases reported until the recent year, and none of them came from Indonesia. The reports showed that breast cancer metastasis is more often found at the liver, lung, bone, and brain. Therefore, any masses found on the parotid are usually considered as a double primer.Case Presentation: We report a case of a woman, firstly diagnosed with luminal A stage IIA breast cancer at 39 years old. The patient had undergone breast-conserving therapy (BCT), followed by adjuvant hormonal therapy before being diagnosed with bone metastasis four years later. She also complained about a painful mass on her left upper neck. Ultrasonography and CT-scan resulted in insignificant abnormality. After a year with increasing painful mass, we performed FNAB. The result showed metastatic adenocarcinoma with a suspicious breast cancer origin. We did total parotidectomy with facial nerve preservation to alleviate the pain. Pathology results showed a confirmed diagnosis of breast cancer metastasis. The patient was given radiotherapy as local control and was scheduled to receive chemotherapy as systemic therapy.Conclusions: Parotid mass with a clinical symptom in the patient with the history of breast cancer should be evaluated firstly by imaging and may be followed by cytology or pathology evaluation to confirm whether it is primary or secondary malignancy. If the parotid metastasis from breast cancer is confirmed, we should consider adding systemic therapy after completing the local control.
Pati Resistan serta Perannya dalam Penghambatan Proliferasi dan Induksi Apoptosis Sel Kanker Kolon ENDANG YULI PURWANI
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.744 KB) | DOI: 10.33371/ijoc.v8i4.363

Abstract

Resistant starch (RS) is starch fraction which is not digested by human starch degrading enzyme, and it will thus undergo bacterial fermentation in the colon. The main fermentation products are Short Chain Fatty Acid (SCFA): acetate, propionate and butyrate. The Fermentation products were able to inhibit the proliferation and to induce apoptosis of colon cancer cell. The apoptosis occured through mitochondrial pathway by changing the expression of pro-apoptosis related gene of Bax toward antiapoptosis related gene of Bcl-2.

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