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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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Konsep Boutique Hospital, Sebuah Pilihan dalam Penanganan Kanker di Indonesia (Tata Laksana Penanganan Kanker Payudara Terpadu di Rumah Sakit Ongkologi Surabaya, Sebuah Ilustrasi) Sri Redjeki A; Lies Mardiyana; Anggraheny -
Indonesian Journal of Cancer Vol 3, No 2 (2009): Apr - Jun 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Berbeda dengan penyakit lain, penanganan kanker membutuhkan kekhususan. Penanganan awal adalah kunci paling menentukan prognosis selanjutnya. Dengan demikian, kualitas pelayanan, dalam hal ini -diagnostik yang tepat, tindakan akurat, pemilihan teknologi yang tepat- adalah hal yang tak dapat ditawar. Kesalahan tindakan pertama berakibat irreversible. Untuk itu, diperlukan tata laksana yang tepat dan kerja sama tim dokter yang solid. Penderita kanker memerlukan pendekatan yang lebih humanistik karena problem psikisnya berbeda. Biaya pengobatan penyakit kanker tergolong mahal. Kesadaran akan kendali biaya harus selalu ada dalam setiap pengambilan keputusan medik. Pada 20 April 1995, RS Onkologi Surabaya hadir membawa konsep Boutique Hospital. Rumah sakit ramping yang sesuai dengan kebutuhan penanganan penyakit kanker dan kondisi masyarakat pengakses. Tulisan ini adalah laporan ilmiah mengenai bagaimana RS Onkologi Surabaya melakukan kendali mutu dan kendali biaya dalam penanganan kanker payudara.Kata kunci: Boutique hospital, kendali mutu, kendali biaya, kanker payudara

Transfusi pada Pasien Kanker: Manfaat dan Risiko Noorwati Sutandyo
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Transfusi darah pada pasien kanker biasanya diperlukan pada terapi radiasi, terapi operasi, kemoterapi, terapi suportif/ paliatif. Walaupun saat ini transfusi darah diyakini lebih aman dibandingkan dengan masa-masa sebelumnya, namun transfusi juga masih memiliki banyak risiko, antara lain peristiwa yang menyimpang (adverse events), baik berupa peristiwa imunologik maupun non imunologik yang berpotensi fatal. Peristiwa imunologik antara lain berupa reaksi transfusi, alloimunisasi, transfussion-related acute lung injury (TRALI), dan transfussion-associated immunomodulation (TRIM), sedangkan peristiwa non-imunologik antara lain meliputi kelebihan beban volume, hemodilusi, dan infeksi. Selain itu, human error sering dikaitkan juga sebagai salah satu faktor risiko yang berakibat fatal. Dengan mengingat berbagai keterbatasan dan risiko yang dapat terjadi, maka perlu dipertimbangkan pemberian transfusi sesuai manfaat dan indikasinya.

The Proportion of Radiation Pneumonitis among Lung Cancer Patients in Persahabatan Hospital Dini Rizkie Wijayanti; Jamal Zaini; Achmad Hudoyo; Aziza Ghanie; Westi ATW
Indonesian Journal of Cancer Vol 14, No 2 (2020): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background : Radiation-induced pulmonary toxicity occurs in patients with lung cancer who received irradiation. The objective of this study was to determine the proportion of radiation pneumonitis among lung cancer patients that were exposed to radiation treatment in Persahabatan Hospital. There is no data about proportion of radiation pneumonitis in Indonesia.Methods: This was a retrospective study conducted in Persahabatan Hospital during June 2013– July 2015 using the medical record of lung-cancer patients who received irradiation.Results: 33 lung-cancer patients fulfilled the inclusion criteria. Most of them were male (66.7%), in age ≥ 51 years (63.6%), had a smoking history (75.8%) with moderate Brinkman Index (60%), were given irradiation doses of 3,000–4,000 (60.6%) with irradiation fractions of 10–19 (60.6%), had no history of chemotherapy (54.5%), and were diagnosed with adenocarcinoma (66.7%) and stage-IV cancer (84.84%). The proportion of radiation pneumonitis based on chest X-ray (CXR) was 39.4%; which consisted of hazy ground-glass opacities, hazy ground-glass opacities, and fibrosis, and only fibrosis. There were significant differences in age, radiation doses, and history of chemotherapy with the proportion of radiation pneumonitis (p < .05).Conclusion: The proportion of radiation pneumonitis based on CXR was 39.4%. There were significant differences in age, radiation doses, and history of chemotherapy with the proportion of radiation pneumonitis.

Survival Analysis of Patients with Luminal and Non-Luminal Subtype Breast Cancer Receiving Vinorelbine Therapy at Sanglah General Hospital, Denpasar, Bali Dewa Putu Satria Juristiasa; Putu Anda Tusta Adiputra; Dewa Made Sukrama
Indonesian Journal of Cancer Vol 16, No 2 (2022): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Breast cancer is the most common type and lethal cancer affecting women. Meanwhile, vinorelbine is one of the chemotherapy agents used for luminal and non-luminal breast cancer. Therefore, this study aims to determine the survival difference between patients with luminal and non-luminal subtype breast cancer treated with vinorelbine.Methods: This study was a retrospective cohort. Women with breast cancer treated with vinorelbine were classified based on estrogen receptor (ER), progesteron receptor (PR), human epidermal growth factor receptor-2 (HER-2) markers, and subtypes. The subjects were followed up to chemotherapy visits with vinorelbine recorded in the medical record. The survival analysis between subtypes was analyzed by the Kaplan-Meier curve.Results: : One hundred women were obtained with a mean age of 52.36 ± 10.45 years. Based on immunohistochemistry, 60% were ER-positive, 53% were PR positive, and 57% were HER-2- positive. Based on the subtype, 67% were luminal, while 33% were non-luminal. All subjects had a mean survival duration of 155.38 days (95% CI 128.05-182.71). The stratified survival analysis showed a significant difference in survival duration based on HER-2 marker and subtype. The subjects with HER-2 positive survived longer with a mean of 203.37 days (190.72–216.02) than those with HER-2 negative with a mean of 90.10 days (65.68-114.53) (p<0.001). In addition, the subjects with the luminal subtype survived longer with a mean of 174.84 (142.72-206.94) than those with non-luminal with a mean of 90.10 (65.68-114.53) (p = 0.04).Conclusion: There was a significant difference in survival duration between women with breast cancer treated with vinorelbine chemotherapy who were HER-2 positive, HER-2 negative, and luminal and non-luminal subtypes.

Pemeriksaan Paps Smear dengan Metode Thinprep Lenny Sari
Indonesian Journal of Cancer Vol 2, No 2 (2008): Apr - Jun 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Pemeriksaan melalui metode ThinPrep telah diakui oleh FDA (The US Food and Drug Administration) untuk menggantikan pemeriksaan Pap's smear konvensional sejak tahun 1996 untuk mendeteksi sel atipik, lesi prakanker dan kanker serviks sesuai dengan Sistem pelaporan Pap's smear melalui Bethesda Sistem. Penelitian menyebutkan metode ThinPrep Pap test secara signifikan lebih efektif dibanding metode Pap smear konvensional dalam mendeteksi lesi prakanker Low Grade Squamous Intraepithelial Lesion (LSIL) ataupun kelainan lebih lanjut. Hasil negatif palsu dari Pap smear konvensional terjadi karena kesalahan pada pengambilan bahan/sample dan pada pembuatan sediaan. Pada Pap smear konvensional hanya sebagian sel yang diapuskan pada gelas objek yang menghasilkan apusan yang tidak monolayer serta sebagian dari sel-sel kemudian ikut terbuang dengan sikat endoserviks. ThinPrep Pap test akan menghasilkan kualitas spesimen yang lebih baik secara signifikan dibandingkan dengan Pap smear konvensional dan disamping itu proses skrining menjadi lebih cepat serta dapat dilakukan pemeriksaan lebih lanjut terhadap HPV ataupun pembuatan cell block.Kata kunci : Konvensional Pap's smear, Thin Prep Pap tes

Correlation of CD133 and SOX2 Expression with Regional Lymph Nodes Metastatic Status in Invasive Breast Carcinoma of No Special Type Dyah Fauziah; Sutrisno Sutrisno; Gondo Mastutik
Indonesian Journal of Cancer Vol 15, No 1 (2021): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: CD133 overexpression can increase cell proliferation, migration, and epithelialmesenchymal transition that promotes metastasis. CD133 expression is induced by hypoxiainduced factor (HIF) which requires SOX2 binding in the promoter region. SOX2 is an embryonal transcription factor that plays a role in the development of malignancy. The study aimed to analyze the expression of CD133 and SOX2 with regional lymph nodes (LN) metastatic status in invasive breast carcinoma of no special type (NST). Methods: The study was a cross-sectional design. Forty-five samples were retrieved from pathology archives in Dr. Soetomo Hospital from January to December 2018. Samples were divided into 2 groups, with and without regional LN metastasis. Immunohistochemistry with CD133 and SOX2 was applied to all samples. CD133 expression was assessed by immunoreactive score, and SOX2 expression was assessed by the percentage of tumor positive cells.Results: There was no significant difference in CD 133 expression between invasive breast carcinoma of NST with and without regional LN metastases (P = .990). A positive correlation was found in SOX2 expression between breast carcinoma with and without regional LN metastasis (P = .000; rs = .518). There was no correlation between CD133 and SOX2 expression (P = .082), which means that the high expression of CD133 did not affect SOX2 expression.Conclusions: CD133 expression was not significantly different in breast carcinoma with and without LN metastasis. The high expression of SOX2 was found significantly correlated with regional LN metastasis. SOX2 expression may become a potential prognostic marker in invasive breast carcinoma of NST. regional LN metastasis

Nutritional Status and Quality of Life in Breast Cancer Patients in Karawaci General Hospital ANDREE KURNIAWAN; NATA PRATAMA HARDJO LUGITO
Indonesian Journal of Cancer Vol 10, No 1 (2016): Jan - Mar 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTCancer is related to a deterioration of nutritional status and quality of life (Qol), but the extent of these conditions in patients with breast cancer has not been studied well. Malnutrition is prevalent among cancer patients and maybe correlated with altered quality of life. The aim of this study is to evaluate the association of QoL and nutritional status after breast cancer diagnosed. Nutritional status was evaluated with Patient Generated Subjective Global Assessment and QoL using Short form 36 (SF-36) and also with the specific module for breast cancer patients. A consecutive sampleof twenty two patients diagnosed with breast cancer was evaluated. The associations of QoL with stadium and nutrition status were evaluated using T-test analysis. The mean of body mass index was 21.3 kg/m2. Fifty percent patient have menopause. Most patients were stage II (77.3%), the others stage III (18.2%) and stage I (4.5%). Sixty eight point two percent had risk of malnutrition. The stadium of tumor was significantly related to physical functioning (p < 0.000), physical limitation (p < 0.024), emotional limitation (p < 0.013), well-being (p < 0.020), health changes (p < 0.010). Thestatus of nutrition was significantly related to physical functioning (p < 0.001), loss of energy (p < 0.010) and general health (p <0.005). For Conclusion, the status of nutrition breast cancer patients were related to QoL especially physical functioning, loss of energy and general health after they were diagnosed.ABSTRAKKanker sangat terkait dengan perburukan status nutrisi dan kualitas hidup. Namun demikian, belum banyak studi yang yang melaporkan masalah nutrisi dan kulitas hidup pada kanker payudara. Malnutrisi sering ditemukan pada kanker dan mungkin terkait dengan perubahan kulaitas hidup. Tujuan penelitian ini adalah untuk mengevaluasi hubungan antara kualitas hidup dengan status nutrisi setelah kanker payudara terdiagnosis. Evaluasi status nutrisi dilakukan dengan Patient Generated Subjective Global Assessment dan kualitas hidup dengan Short form 36 (SF-36) sertakarakteristik pada kanker payudara. Sampel diambil dengan teknik konsekutif terhadap 22 pasien yang terdiagnosis kanker payudara. Hubungan kualitas hidup dengan stadium kanker dan status nutrisi dinilai menggunakan analisis T-test. Indeks massa tubuh rata-rata adalah 21,3 kg/m2. Lima puluh pasien telah menopause. Terbanyak adalah stadium 2 (77,3%), stadium 3 (18,2%), dan stadium 1 (4,5%). Enam puluh dua koma dua persen berisiko malnutrisi. Stadium tumor secara bermakna berhubungan dengan fungsi fisik (p <0,000), keterbatasan fisik (p<0,024), keterbatasan emosi(p<0,013), rasa nyaman (p<0,020), dan perubahan kesehatan (p<0,000). Status nutrisi berhubungan secara bermakna dengan fungsi fisik (p<0,001), kehilangan energi (p<0,010), dan kesehatan secara umum (p<0,005). Simpulan, status nutrisi pasien kanker payudara berhubungan dengan kualitas hidup, terutama fungsi fisik, kehilangan energi, status kesehatan umum setelah mereka terdiagnosis.

Hubungan antara Ekspresi mRNA Gen Epidermal Growth Factor Receptor (EGFR) dengan Penurunan Kadar ?-hCG Serum Pasca-evakuasi Mola Hidatidosa Komplit LAURENS DAVID PAULUS; YUDI MULYANA HIDAYAT; SUPRIADI GANDAMIHARJA
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

In 2008, the incidence of hydatidiform mole that occurred in West Java around 1:28. Malignant transformation of Complete Hydatidiform Mole (CHM) is influenced by many factors, among others, is the expression of the epidermal growth factor receptor (EGFR). This study uses Historical Cohort to retrieve CHM patients data and trophoblastic tissue paraffin block in 2007-2012, and perform examination of Polymerase chain reaction.Results of the study: 40 CHM patients, 24 with EGFR (-) and 16 with EGFR (+), at 12 weeks monitoring post evacuation using the Mochizuki regression curve was not obtained persistent mole in the group with EGFR (-), while the group of EGFR (+), all showed an increase in ?-hCG levels. Relative risk (RR) of 3.4 in the CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 6th week and RR of 13.0 in CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 8th week. The conclusion of this study demonstrate the suitability of the hypothesis that the higher mRNA gene expression of EGFR, the slower decrease in serum levels of ?-hCG after CHM evacuation and expression EGFR (+) may be a predictor of the occurrence of persistent mole.Pada 2008, insiden mola hidatidosa (MH) yang terjadi di Jawa Barat sekitar 1:28. Transformasi keganasan dari mola hidatidosa komplit (MHK) dipengaruhi oleh banyak faktor, antara lain ekspresi Epidermal Growth Factor Receptor (EGFR). Penelitian ini menggunakan metode historical cohort dengan mengambil data dan parafin block jaringan trofoblas pasien MHK tahun 2007?2012, dan dilakukan pemeriksaan POLYMERASE CHAIN REACTion. Hasil penelitian menunjukkan dari 40 pasien MHK, 24 di antaranya EGFR (-) dan 16 EGFR (+) pada 12 minggu pascaevakuasi menggunakan kurva regresi Mochizuki. Tidak didapatkan mola persisten pada kelompok EGFR (-), sedangkan kelompok EGFR (+) semuanya menunjukkan peningkatan ?-hCG (mola persisten). Risiko relatif (RR) sebesar 3,4 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-6 dan RR sebesar 13,0 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-8. Hasil penelitian ini menunjukkan kesesuaian dengan hipotesis bahwa semakin tinggi ekspresi EGFR maka semakin lambat penurunan kadar ?-hCG serum pasca-evakuasi MHK. Ekspresi EGFR dapat menjadi prediktor terjadinya mola persisten.

Small Cell Neuroendocrine Carcinoma in Head and Neck Sondang Nora Harahap; Daan Khambri
Indonesian Journal of Cancer Vol 15, No 4 (2021): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Poorly differentiated neuroendocrine carcinomas (NECs) originating from the eye are rare and very highly malignant diseases with a poor prognosis. Small cell NEC of the head and neck is a rare disease and highly aggressive. Early recognition and treatment are crucial for reducing morbidity and mortality. Case Presentation: A 19-year-old male visited our oncology surgery outpatient department due to the progressive neck mass enlargement originating from the eye. The patient was previously diagnosed with invasive choroid malignant melanoma of the left eye which had metastasized to the lymph nodes of the left neck. He underwent a surgical removal/exenteration of the left eye. The result showed that the patient’s survival with poorly differentiated tumors was about 14% while patients with well-differentiated NEC had a survival rate of 34%. It also indicates that the prognosis of these tumors is very poor with a total of over 90% of patients having distant metastatic disease. Histopathological examination showed the tumor tissue and its immunohistochemistry with positive streaks of CD56, NSE, Synaptophysin, and Ki67 suggested small cell NEC.Conclusions: it is crucial to establish an early diagnosis of these tumors to reduce morbidity and mortality. No optimal treatment for such disease has yet been established.

Gambaran Computed Tomografi Scan Toraks Teratoma Kistik Paru DETI NURBAETI; AZIZA G ICKSAN; HERIAWATY HIDAYAT
Indonesian Journal of Cancer Vol 8, No 2 (2014): April-Juni 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v8i2.304

Pulmonary cystic teratoma is a very rare disease, composed of tissues from more than one germ cell line. Pulmonary cystic teratoma commonly involve the upper lobe of the left lung, most follow a benign course and are incidental findings during routine chest X-rays. Proper diagnosis is needed to determine adequate treatment in order to reduce symptoms and improve quality of life. We report a twenty six years old man with clinical symptom hemoptysis, chest pain and dyspnea since one month before admission. The chest X-ray showed a large opacity of the entire right hemithorax, there is no calcification. On enhanced chest CT examination, we found an encapsulated cystic mass on the upper and middle of the right lung with peripheral enhancement. Histopathological examination confirmed an infected cyst with cystic teratoma. The main purpose of this report is to emphasize the importance of enhanced chest CT in evaluating patient suspected pulmonary cystic teratoma.

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Bayu Brahma

Contact Email journal.cancer@gmail.com

Phone +628176389956

Journal Mail Official admin@indonesianjournalofcancer.or.id

Editorial Address National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

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Abstract

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Abstract

Abstract

Abstract

Contact Name
Bayu Brahma

Contact Email
journal.cancer@gmail.com

Phone
+628176389956

Journal Mail Official
admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA