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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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Peutz–Jeghers Syndrome which Develops into Descending Sigmoid Colon Adenocarcinoma Abdul Mughni; Albert Eko Hendrawijaya; Meira Dewi Kusuma
Indonesian Journal of Cancer Vol 16, No 2 (2022): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Peutz–Jeghers Syndrome (PJS) is an autosomal dominant hereditary condition mainly characterized by hamartomatous gastrointestinal (GI) polyps. Medical treatment is often sought due to complications that arise from the polyps. PJS polyps tend to be accompanied by freckling or hyperpigmentation on the lips, buccal mucosa, vulva, fingers, and toes. PJS is also associated with an increased risk for colorectal or extraintestinal tumors. Case Presentation: A 24-year-old female complained about a lump in her abdomen and constipation. The physical examination found hyperpigmentation on the lips and a hard and mobile mass on the left quadrant abdomen. We found a descending-sigmoid colon tumor with multiple polyps on all colon mucous and performed total colectomy and ileorectal anastomosis on the laparotomy operation. Two months later, Esophagogastroduodenoscopy revealed multiple polyps on Duodenum 1, II, and gaster. The colon tumor pathology result showed welldifferentiated adenocarcinoma. Conclusions: Peutz–Jeghers Syndrome (PJS) can develop into malignant intestinal tumors that require surgery for resection of the tumor.

Skull Ganglioneuroblastoma: A Case Report M RADHIAN ARIEF; SAMSUL ASHARI; HILMAH MAHYUDDIN
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i2.92

Ganglioneuromas and ganglioneuroblastomas are tumors of the sympathetic nervous system that originate from neural crest sympathogonia, which are completely undifferentiated cells of the sympathetic nervous system. Along with neuroblastomas, ganglioneuromas and ganglioneuroblastomas are collectively known as neuroblastic or neurogenic tumors. Ganglioneuroblastoma is an intermediate tumor, a tumor that is between benign (slow-growing and unlikely to spread) and malignant (fast-growing, aggressive, and likely to spread). We report a rare case of skull ganglioneuroblastoma in a 4 months old child who came with a progressive increasing mass volume in the forehead. No other neurologic deficit was found. Serial Brain CT Scan was performed and showed progressive increasing of the mass volume. Comprehensive management was carry out for this patient.

Perjalanan Klinis Pasien Leukemia Limfoblastik Akut dengan Kromosom Ph-Positif (Philadelphia Chromosome) Sri Mulatsih; Serasiamy Ritonga
Indonesian Journal of Cancer Vol 3, No 4 (2009): Oct - Dec 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Penderita leukemia limfoblastik akut (LLA) dengan kromosom philadelphia secara umum mempunyai luaran terapi yang buruk. Dilaporkan perjalanan klinis penderita LLA anak dengan Ph-positif. Pasien laki-laki usia 6 tahun, datang dengan jumlah leukosit 102.000/ul. Hasil pemeriksaan fusi gena menunjukkan Ph-positif (BCR-ABL tipe LLA), sehingga pasien didiagnosis sebagai LLA risiko tinggi. Pasien berhasil mencapai remisi fase induksi, namun mengalami relaps saat fase reinduksi (minggu 17), sehingga diulang terapi dari awal. Dalam fase rumatan awal, penderita mengalami sepsis, batuk-batuk, dan ada massa di punggung. Diagnosis saat itu adalah adanya keganasan sekunder malignant peripheral nerve sheath tumor, dengan penyebaran ke paru dan hati. Pasien meninggal karena gagal napas akibat metastasis paru.Kata kunci: leukemia, philadelphia, kromosom

Peran Asam Klorogenat Terhadap Ekspresi Gen; miRNA 146 A, Caspase 3, Cyclin D1, dan Kematian Sel Kanker Hepatoseluler Model Cell Lines Hep-G2 ASEP SUKOHAR; HENING HERAWATTI; ARIEF B WITARTO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Chlorogenic acid (CA) is the active compound isolated from medicinal plants, can be used as a chemopreventive agents of hepatocellular cancer (HCC). It works as an exogenous antioxidant and inhibit growth of cancer cells through the inhibition of free radicals. The purpose of this study is to know mechanism of CA in inhibition to growth of Hep-G2 through apoptosis stimulation. In vitro study was performed Hep-G2 cells. The samples were divided into the control group treatment and experiment group expose to 727, 500 and 250 ?M and 3 times repetition. Expression of miRNA 146 A, caspase 3 and cyclin D1 examined by RT-PCR CFX-96. Samples were analysed at 0, 8, 18, and 24 hours after exposure CA. The data were statistically tested by repeated measurement, pearson, and multivariate regression. The results showed that cell death of Hep-G2 were increase as the dose increase and time, at 8 hours after exposure CA cell death of Hep-G2 increased as much as 35,68, 37,75, 40,86%. At 18 hours cell death of Hep-G2 increased as much as 54,56, 56,48, and 59,73%. At 24 hours cell death of Hep-G2 increased as much as 67,73, 69,37, and 72,16%. The lowest expression miRNA 146 A in group 24 hours after exposure at doses of 727 ?M CA (0,85), followed by 500 ?M (1,28) and the highest expression at a dose of 250 ?M (1,61). The result of repeated measurement test: miRNA 146 A and caspase 3 at 8th and 18th hours was significantly different to the 24th with p<0.05. The expression of caspase 3 increase from 0-24 hours, the highest expression of caspase 3 in group 18 hours after exposure at doses CA at 750 ?M (3,86). After 18 hours, expression caspase 3 decreased and the lowest in group 24 hours after exposure: at a dose of 250 ?M (1,52). Expression of cyclin D1 decrease from 0-24 hours with the highest expression at 0 hours (4,35) at a dose of 250 ?M and the lowest expression at 24 hours after exposure to CA (0,32) at a dose of 727 AK ?M.

Deteksi Dini Karsinoma Sel Basal SUKMAWATI TANSIL TAN; MAHMUD GHAZNAWIE; GABRIELA REGINATA
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTBasal Cell Carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasize. BCC is more common in the elderly. Etiopathogenesis associated with BCC is genetic, environmental, and most often is exposure to ultraviolet light. Clinically, there are five types of BCC, which are nodular, superficial, morpheaform, pigmented, and fibroepitelioma Pinkus. Early detection of skin cancer can be done with self skin examination. Definitive diagnosis of malignancy is determined by anatomical pathology examination. However, for very early BCC lesion, it’s difficult to determine with hematoxylin eosin staining. Therefore, it is uses Ber-EP4 staining which is specific and highly sensitive for early BCC growing as budding in basal layer of the epidermis and follicles. This finding is particularly significant in the development of molecular pathology and clinical management of BCC lesions or suspected BCC. ABSTRAKKarsinoma Sel Basal (KSB) merupakan neoplasma ganas dari sel yang tidak mengalami keratinisasi pada lapisan basal epidermis, bersifat invasif lokal, agresif, destruktif, dan jarang bermetastasis. KSB lebih sering terjadi pada usia lanjut. Etiopatogenesis yang berkaitan dengan KSB adalah genetik, lingkungan, dan yang paling sering adalah paparan sinar ultraviolet. Secara klinis, terdapat lima tipe KSB, yaitu nodular, superfisial, morpheaform, pigmented, dan fibroepitelioma Pinkus. Deteksi dini kanker kulit dapat dilakukan dengan pemeriksaan kulit sendiri (SAKURI). Diagnosis pasti keganasan ditentukan dengan pemeriksaan patologi anatomi. Namun, untuk lesi sangat dini KSB sulit ditentukan dengan pewarnaan hematoksilin eosin. Oleh karena itu, digunakanlah pewarnaan Ber-EP4 yang bersifat spesifik dan sangat sensitif untuk KSB dini yang tumbuh sebagai tunas di lapisan basal epidermis dan folikel. Temuan ini sangat berarti dalam pengembangan patologi molekuler dan penanganan klinis lesi KSB atau yang dicurigai KSB.

Efektivitas Art Therapy dalam Mengurangi Kecemasan pada Remaja Pasien Leukemia Shinta Natalia Adriani; Monty Satiadarma
Indonesian Journal of Cancer Vol 5, No 1 (2011): Jan - Mar 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Leukemia adalah jenis kanker yang paling banyak dialami oleh anak-anak di bawah usia 16 tahun. Ketika remaja, didiagnosis menderita leukemia, ada beberapa reaksi emosional yang menyertainya, salah satunya adalah kecemasan. Kecemasan pada remaja penderita leukemia ini diukur dengan Hamilton Rating Scale for Anxiety (HRS-A), Revised Childrens Manifest Anxiety Scale (RCMAS), dan melihat gejala kecemasan dari segi fisik, kognitif, serta tingkah laku. Penelitian ini menggunakan metode kualitatif untuk menggambarkan kecemasan remaja penderita leukemia dan metode kuantitatif untuk melihat efektivitas art therapy dalam mengurangi kecemasan pada remaja penderita leukemia. Subjek dalam penelitian ini adalah 5 remaja penderita leukemia dengan 2 subjek diberikan art therapy. Teknik pengambilan sampel dengan menggunakan metode purposive sampling. Pemberian art therapy pada subjek 1 sebanyak 22 sesi dan subjek 2 sebanyak 24 sesi. Dalam penelitian ini, art therapy telah terbukti efektif mengurangi kecemasan pada remaja penderita leukemia dengan menunjukkan perubahan ke arah yang positif pada keduanya. Keberhasilan art therapy ini juga dipengaruhi oleh dukungan dari keluarga dan lingkungan.Kata kunci: Terapi seni, Kecemasan, Remaja, Leukemia

Multidisciplinary Management of a Rare Case of a Huge LowGrade Chondrosarcoma of the Lumbar Spine: A Case Report Samuel Jason Rolando Tua; Hendy Rachmat Primana; Agus Hadian Rahim; Ahmad Ramdan; Herry Herman
Indonesian Journal of Cancer Vol 14, No 4 (2020): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Chondrosarcoma is the second most common primary bone sarcoma and arising in the spine. It is estimated to be 2% to 12% in incidence from various series. The use of neoadjuvant and adjuvant chemotherapy for chondrosarcomas is controversial. Low- and intermediate-grade chondrosarcomas respond poorly to chemotherapy. Although not much data on the efficacy of chemotherapy in the treatment of high-grade chondrosarcomas, it should be considered in any young patient with a high-grade tumor. Radiation is recommended when anything other than wide excision is performed for chondrosarcoma of any grade.Case Presentation: A 24-year old female presented to the clinic with a chief complaint of persistent low back pain and a lump in her back. Initially, the lump was the size of a tennis ball three years ago. At the time of the examination, the lump was at the size of a volleyball about 65 x 63 x 58 centimeters. Systemic and general examinations were unremarkable. There were no comorbid conditions. From the results of the Clinicopathological Conference conducted by neurologists, pathologists, radiologists, orthopedic spine and oncology surgeons, it is advisable to conduct investigations such as x-rays, CT scans, MRI, biopsy, and surgery is recommended for evaluation of expansion of chondrosarcoma, evolving the spinal cord, and for resection of tumors.Conclusion: Early diagnosis and complete resection of tumor and treatment of relevant symptoms represent a viable treatment for this rare disorder to achieve increased life expectancy, low recurrence of tumor, and improvement of quality of life.

Lateral Forehead Flap in Neglected Giant Basal Cell Carcinoma of the Nose: A Case Report Jonathan Kevin; Renate Parlene Marsaulina; Alberta Jesslyn Gunardi; Irena Sakura Rini
Indonesian Journal of Cancer Vol 13, No 4 (2019): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Neglected basal cell carcinoma (BCC) of the nose can grow into giant BCCs, rare cases with extensive nasal defects. Such large defects would require complex reconstruction such as free flaps or multiple local flaps. Lateral forehead flap may provide a simpler alternative with good functional and cosmetic results.Case Presentation: We present a case of a 76-year-old man with neglected giant BCC of nose extending to right lower eyelid and upper lip. Wide excision of the tumor leaves a 12cm x 10cm defect. Reconstruction was performed using lateral forehead flap and donor site was covered with split-thickness skin graft from thigh. The second surgery was done after four months to create nostrils and wider eye-opening. Six months later, flap was viable and there was no sign of recurrence. Nasal reconstruction is planned to further improve cosmetics. In this case, neglect is due to low social-economic status and adaptation to painless tumors. The use of lateral forehead flap allows for simpler and faster surgery suitable for elderly. Delayed reconstruction was needed to ensure optimal tissue healing. Conclusions: Neglected BCC causes disfigurement with remarkable morbidity, requiring complex reconstruction. The lateral forehead flap is a simple and reliable reconstruction method for extensive nasal defects with good functional and cosmetic outcomes.

Gambaran Makna Hidup Remaja Penderita Leukemia Widianita P.L. -; Hera Lestari Mikarsa; Fenny Hartiani
Indonesian Journal of Cancer Vol 3, No 1 (2009): Jan - Mar 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Remaja penderita leukemia membutuhkan waktu pengobatan yang panjang dan memberikan efek samping secara fisik serta psikologis pada penderitanya. Dampak psikologis dirasakan saat menghadapi kematian. Remaja yang menghadapi kematian mengalami konflik berkepanjangan selama masa penyesuaian diri. Hal ini menimbulkan depresi. Adanya depresi membuat mereka merasa tidak memiliki makna dalam hidupnya.1 Makna hidup adalah hal-hal yang terjadi dalam kehidupan sehari-hari yang dianggap sangat penting dan berharga serta memberikan nilai khusus bagi individu sehingga layak dijadikan tujuan hidup.2 Penelitian menunjukkan bahwa kedua remaja penderita leukemia memiliki kebermaknaan hidup. Adanya orang terdekat dan keinginan untuk membahagiakan mereka membuat kedua partisipan merasa berarti dan tetap memiliki motivasi untuk sembuh. Usaha kedua partisipan untuk membahagiakan orang-orang terdekat mereka adalah dengan berusaha mencapai cita-cita. Usaha mereka dalam mencapai cita-cita tampak dalam kegiatan yang mereka lakukan.Kata kunci: makna hidup, leukemia

Validitas Diagnostik Fine Needle Aspiration Biopsy Kelenjar Getah Bening Inguinal yang Teraba pada Karsinoma Penis di RSUP Sanglah, Denpasar Suarsana -; Sastrodihardjo -; Gde Oka
Indonesian Journal of Cancer Vol 3, No 4 (2009): Oct - Dec 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Penelitian ini bertujuan untuk mengetahui validitas diagnostik dari pemeriksaan fine-needle aspiration biopsy (FNAB) dalam mendeteksi metastasis karsinoma penis pada kelenjar getah bening inguinal yang teraba. Untuk itu, semua penderita yang bersedia dan secara klinis didiagnosis sebagai karsinoma penis disertai kelenjar getah bening inguinal yang teraba dilakukan tindakan FNAB serta biopsi pada kelenjar getah bening inguinal. Selanjutnya, spesimen biopsi diperiksa secara histopatologi. Kemudian dilakukan uji diagnostik terhadap 36 penderita karsinoma penis dengan stage I (0), stage II (13), stage III (19), dan stage IV (4). Hasil FNAB pada kelenjar getah bening yang teraba memiliki sensitivitas sebesar 92,31%; spesifisitas 86,36%; positive likelihood ratio 6,77; dan negative likelihood ratio sebesar 0,09. Kesimpulannya, FNAB adalah sebuah modalitas diagnostik yang valid dan akurat dalam mendeteksi metastasis karsinoma penis pada kelenjar getah bening inguinal yang teraba. Karena modalitas ini sederhana, mudah, cepat, dan murah maka FNAB dapat digunakan sebagai uji diagnostik rutin dalam mendeteksi adanya metastasis karsinoma penis pada kelenjar getah bening inguinal yang teraba.Kata kunci: FNAB, karsinoma penis, kelenjar getah bening inguinal yang teraba, sensitivitas, spesifisitas, positive likelihood ratio, negative likelihood ratio.

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Home Page

OAI Link

Editorial Team

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Contact Name Bayu Brahma

Contact Email journal.cancer@gmail.com

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Journal Mail Official admin@indonesianjournalofcancer.or.id

Editorial Address National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location Kota adm. jakarta barat, Dki jakarta INDONESIA

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Abstract

Contact Name
Bayu Brahma

Contact Email
journal.cancer@gmail.com

Phone
+628176389956

Journal Mail Official
admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA