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eJournal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23381426     EISSN : 23386037     DOI : http://doi.org/10.23886/ejki
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
eJournal Kedokteran Indonesia (eJKI) is a general medical journal, published quadrimester (April, August, December) by Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. eJKI aims to published the manuscript of students (Bachelor of Medicine (S.Ked), study Program of Medical Profession, magister/specialist, doctoral, and fellow). The journal is a general medical journal that covering all areas of biomedical science, basic medical science, clinical science, medical technology, and medical education. The journal accepts editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. This work was supported by Faculty of Medicine, Universitas Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 118 Documents
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Correlation of Hematological Profiles and Parasite Density of Malaria Patients from Low Endemic Areas in North Sulawesi, Indonesia Senduk, Evy Beatrix; Tuda, Josef Sem Berth; Kurniawan, Agnes; Diptyanusa, Ajib
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1196.1

Abstract

North Sulawesi province is an area with low malaria endemicity. Variations in hematological profiles of malaria patients can serve as indicators for malaria diagnosis. This study aimed to determine correlation of hematological profile and parasite density of malaria patients. The cross-sectional study utilized medical record data from Kandou Hospital, Budi Mulia Hospital, and Tuda Hospital in North Sulawesi Province. The study was conducted from October 2022 to June 2023. In the current study, a total of 65 patient medical records were analyzed. Among them, 28 patients (43.1%) were infected with Plasmodium falciparum, and 37 patients (56.9%) were infected with P. vivax, with 20% of cases belonged to age group of <12 years. Hematological profiles showed moderate to severe thrombocytopenia in falciparum malaria cases and mild to severe thrombocytopenia in vivax malaria cases, while normal leukocyte count was observed in the majority of cases in both groups. Sex (p=0.014) and thrombocytopenia (p=0.034) showed a statistically significant association with malaria infections in this study. Anemia, thrombocytopenia and leukocyte counts did not show a statistically significant association with the degree of parasitemia in patients with falciparum and vivax malaria (r <0.40; p >0.05). The results of current study can be used as additional predictive variables for patients suspected of having malaria in similar populations.
Urethral Mobility Ultrasound: A Comparable Diagnostic Method for Urethral Hypermobility in Indonesian Women with Stress Urinary Incontinence Hidayah, Gita Nurul; Hidayat, Fery; Angelina, Jessica; Moegni, Fernandi
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1254.1

Abstract

Urethral hypermobility is the primary mechanism of stress urinary incontinence. In Indonesia, the prevalence of SUI (stress urinary incontinence) is approximately 13% (the other 16% had mixed urinary incontinence). To diagnose urethral hypermobility, the Q-tip test is performed, but it can provoke discomfort. Urethral mobility ultrasonography (UMU) has emerged as a non-invasive, more comfortable alternative, with high accuracy. This study reports the concordance of the evaluations in Indonesian women with SUI, to evaluate the accuracy of UMU compared with the Q-tip test in diagnosing urethral hypermobility among Indonesian women with SUI. A cross-sectional study was conducted at the outpatient clinic of RSUPN Dr Cipto Mangunkusumo and at the Jakarta Urogynecology (JUN) Centre-YPK Mandiri Hospital during the January – December 2024 period. Thirty-six SUI women without symptomatic pelvic organ prolapse (POP) completed the study. Each subject underwent a Q-tip test and ultrasonographic evaluation of urethral mobility. Ultrasonographic assessment of urethral mobility demonstrated high sensitivity (92.6%) but low specificity (33.3%) compared to the Q-tip test. The positive predictive value (PPV) of UMU was 80.6%, while the negative predictive value (NPV) was 60%. The concordance value was 77.8%. 16.67% of patients reported discomfort and pain during the Q-tip test and required medication to manage their symptoms. In those women, the Qtip test was negative but may reflect bias/false negatives, which can affect ultrasound specificity. With 80.6% PPV, 60% NPV, and 77.8% concordance, UMU may serve as a practical alternative to the Q-tip test in daily clinical practice.
Implementasi Optimalisasi Strategi Pelayanan Stroke Hiperakut Berbasis Wilayah sebagai Perwujudan Keadilan Sosial dalam Menekan Angka Kecacatan dan Kematian di Indonesia Hidayat, Rakhmad
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1260.1

Abstract

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The Effectiveness of Combined Acupuncture and Pharmacotherapy in Improving Cognitive Function in Alzheimer’s Disease Clarissa Oktavia; Asti Meidianti; Adiningsih Srilestari
eJournal Kedokteran Indonesia Vol. 14 No. 1 (2026): Vol 14, No. 1 - April 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1208.1

Abstract

Alzheimer’s Disease (AD) merupakan penyakit neurodegeneratif kronis dan progresif yang ditandai oleh penurunan fungsi kognitif dan memori. Walaupun farmakoterapi secara luas digunakan, manfaatnya terbatas karena efek samping. Akupunktur merupakan terapi adjuvan yang aman, namun bukti mengenai efikasi kombinasi terapi tersebut masih diragukan. Tujuan artikel ini menilai efektivitas kombinasi terapi akupunktur manual dengan donepezil dalam memperbaiki fungsi kognitif pada AD.: Seorang laki-laki berusia 70 tahun dengan penurunan fungsi kognitif progresif, skor MMSE 20/30 dan MoCA-Ina 19/30, telah mendapat donepezil 5 mg per hari selama tiga bulan, namun perbaikan fungsi kognitif masih terbatas. Apakah kombinasi akupunktur manual dan donepezil lebih efektif dibandingkan donepezil saja dalam memperbaiki fungsi kognitif pada pasien AD derajat ringan–sedang? Pencarian literatur dilakukan pada Pubmed, Cochrane, dan Scopus pada Maret 2025 menggunakan kerangka PICO. Seleksi artikel dan penilaian kritis dilakukan secara independen oleh dua penelaah menggunakan Covidence. Studi yang terinklusi meliputi empat systematic review/meta-analysis (SR/MA) dan satu randomized controlled trial (RCT). Pencarian dilakukan tanpa pembatasan periode publikasi. Lima artikel terinklusi (4 SR/MA dan 1 RCT) menunjukkan efektivitas kombinasi terapi yang lebih baik dibandingkan donepezil saja dalam memperbaiki skor Mini-Mental State Examination (MMSE) pada pasien Alzheimer. Namun, hanya tiga dari lima artikel yang melaporkan derajat keparahan penyakit secara jelas. Kombinasi akupunktur manual dan donepezil berpotensi memberikan manfaat tambahan terhadap fungsi kognitif pada pasien AD derajat ringan-sedang.    The Effectiveness of Combined Acupuncture and Pharmacotherapy in Improving Cognitive Function in Alzheimer’s Disease Abstract  Alzheimer’s Disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Although pharmacotherapy is widely used, its benefit is limited by adverse effects. Acupuncture has emerged as a safe adjuvant treatment, yet evidence regarding the efficacy of this combined therapeutic approach remains inconclusive. To evaluate the effectiveness of the combination of manual acupuncture with donepezil in improving cognitive function in AD. A 70-year-old man with progressive cognitive decline, a MMSE score of 20/30, and a MoCA-Ina score of 19/30 had been treated with donepezil 5 mg daily for three months, but cognitive improvement remained limited. Is the combination of manual acupuncture and donepezil more effective than donepezil alone in improving cognitive function in patients with mild-to-moderate Alzheimer’s disease (AD)? A literature search was conducted in PubMed, Cochrane, and Scopus in March 2025 using the PICO framework. Article selection and critical appraisal were performed independently by two reviewers using Covidence. The included studies consisted of four systematic reviews/meta-analyses (SR/MAs) and one randomized controlled trial (RCT). No publication date restrictions were applied. Five articles (4 SR/MA and 1 RCT) showed that combination therapy was more effective than donepezil alone in improving MMSE scores in Alzheimer patient. However, only three of the five studies clearly reported disease severity. The combination of manual acupuncture and donepezil may provide additional benefit for cognitive function in mild to moderate AD.
Penggunaan Unfractionated Heparin terhadap Kadar Red Blood CellDistribution Width dan D-dimer pada Pasien Kritis Murdia Murdia; Muhammad Fuad; Muhammad Riswan
eJournal Kedokteran Indonesia Vol. 14 No. 1 (2026): Vol 14, No. 1 - April 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1224.1

Abstract

Pasien penyakit kritis merupakan kelompok dengan presentasi klinis yang heterogen. Kelompok ini berisiko mengalami berbagai komplikasi lanjut, termasuk kejadian tromboemboli, yang dapat muncul akibat perjalanan alamiah penyakit yang berat, komplikasi penyakit komorbid, atau intervensi medis yang diberikan. Penelitian ini bertujuan mengkaji pengaruh penggunaan unfractionated heparin (UFH) terhadap kadar red blood cell distribution width (RDW) dan D-dimer pada kelompok tersebut di Rumah Sakit Dr. Zainoel Abidin Banda Aceh. Penelitian ini merupakan studi analitik observasional retrospektif dengan desain pre-post menggunakan data rekam medis 36 subjek berisiko tinggi tromboemboli vena (skor Padua ≥4). Data dikumpulkan pada periode 1 September 2024 hingga 31 Juli 2025, meliputi karakteristik subjek, terapi unfractionated heparin, serta kadar RDW dan D-dimer sebelum dan sesudah terapi. Hasil menunjukkan penurunan kadar RDW sebesar 5,27% dan D-dimer sebesar 30,2% setelah penggunaan UFH, dengan nilai signifikansi masing-masing P<0,000 dan P=0,004. Tidak ditemukan komplikasi perdarahan akibat penggunaan UFH. Penelitian ini mendukung penggunaan UFH sebagai agen tromboprofilaksis pada pasien dengan penyakit kritis.   Effect of Unfractionated Heparin on Red Blood Cell Distribution Width and D-dimer Levels in Critically Ill Patients Abstract Critically ill patients represent a heterogeneous group with diverse clinical presentations. This group is at risk of developing various complications, including thromboembolic events, which may arise from the severe natural course of the underlying disease, comorbid conditions, or medical interventions. This study aimed to assess the effect of unfractionated heparin (UFH) on red blood cell distribution width (RDW) and D-dimer levels in critically ill patients at Dr. Zainoel Abidin Hospital, Banda Aceh. This study was a retrospective observational analytic study with a pre-post design using medical record data from 36 subjects at high risk of venous thromboembolism (Padua score ≥4). Data were collected during the period from 1 September 2024 to 31 July 2025, including subject characteristics, unfractionated heparin therapy, and RDW and D-dimer levels before and after treatment. The results showed a 5.27% reduction in RDW levels and a 30.2% reduction in D-dimer levels after UFH administration, with statistical significance of p < 0.001 and p = 0.004, respectively. No bleeding complications were observed following UFH use. This study supports the use of UFH as a thromboprophylactic agent in critically ill patients
Brief Report: Evaluation of Ziehl-Neelsen Slide Restaining with 0.4% Malachite Green for Identifying Cyclospora cayetanensis Oocysts Sri Wahdini; Raphael Salim; Ika Puspa Sari; Agnes Kurniawan
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1249.1

Abstract

Cyclospora cayetanensis oocysts are typically identified using Ziehl-Neelsen acid-fast staining. However, slides that have been stored for extended periods often experience color fading, reducing visual clarity and unsuitable for training and educational purposes. This study aimeds to evaluate the effectiveness of re-staining with 0.4% malachite green in enhancing the contrast and visualization of Cyclospora oocysts on faded slides. This study used a quantitative experimental laboratory design. Ten positive slides stored at the Clinical Parasitology Laboratory, Universitas Indonesia, were selected based on the degree of fading and   thickness of staining. Each slide was (destained with methanol, then??) restained with 0.4% malachite green for 30 seconds. After drying, the slides were examined under a light microscope, and oocysts were manually counted.  Restaining restored the background to a bluish-green color, improving visual contrast and facilitating oocyst identification. Restaining Ziehl-Neelsen slides by adding 0.4% malachite green is a simple and effective method for enhancing visualization and accurate counting of C. cayetanensis oocysts.
Rehabilitation in Juvenile Myasthenia Gravis: Strategies and Challenges in Enhancing Pediatric Patient Quality of Life zulfahmidah zulfahmidah; Nila Mayasari
eJournal Kedokteran Indonesia Vol. 14 No. 1 (2026): Vol 14, No. 1 - April 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1140.1

Abstract

Juvenile Myasthenia Gravis (JMG) is a rare autoimmune disorder characterized by impaired neuromuscular transmission, resulting in fatigable weakness and significant functional limitations in pediatric patients. Despite growing recognition of rehabilitation's importance in JMG management, there remains a critical need to synthesize current evidence and establish standardized approaches. This comprehensive review examines the pathophysiology of JMG, focusing on autoantibody-mediated disruption of acetylcholine receptors (AChR) and muscle-specific kinase (MuSK) at the neuromuscular junction. We evaluate evidence-based rehabilitation strategies including (1) tailored exercise programs combining resistance (30-50% 1RM) and aerobic training; (2) targeted bulbar and respiratory interventions; and (3) integrated psychosocial support. The analysis highlights emerging technologies such as telerehabilitation and robotic exoskeletons while identifying persistent challenges in care accessibility and disease variability. Current evidence demonstrates rehabilitation's crucial role in optimizing functional outcomes for JMG patients, though significant knowledge gaps remain. The review underscores the urgent need for JMG-specific clinical trials, precision rehabilitation approaches, and standardized care protocols. Future research should prioritize biomarker-guided interventions and technology-enhanced therapies to advance pediatric JMG management globally.
Integrasi Presisi Morfometri dan Fotometri dalam Bedah Rekonstruksi Mikrotia-Atresia: Paradigma Baru Menuju Kualitas Hidup Inklusif Trimartani Koento
eJournal Kedokteran Indonesia Vol. 14 No. 1 (2026): Vol 14, No. 1 - April 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1499.1

Abstract

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Page 12 of 12 | Total Record : 118

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