cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Saleha Sungkar
Contact Email
ejki.fkui@ui.ac.id
Phone
+6282123550275
Journal Mail Official
ejki.fkui@ui.ac.id
Editorial Address
Departemen Parasitologi FKUI Jl. Salemba Raya No. 6 Jakarta Pusat
Location
Kota depok,
Jawa barat
INDONESIA
eJournal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23381426     EISSN : 23386037     DOI : http://doi.org/10.23886/ejki
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
eJournal Kedokteran Indonesia (eJKI) is a general medical journal, published quadrimester (April, August, December) by Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. eJKI aims to published the manuscript of students (Bachelor of Medicine (S.Ked), study Program of Medical Profession, magister/specialist, doctoral, and fellow). The journal is a general medical journal that covering all areas of biomedical science, basic medical science, clinical science, medical technology, and medical education. The journal accepts editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. This work was supported by Faculty of Medicine, Universitas Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 128 Documents
 9   10   11   12   13 
6-Gingerol Reduces Tumor Necrosis Factor-Alpha Levels in the Brain of Metabolic Syndrome Rats Kenneth Ren; Tommy Alfie Fibisono; Adilla Zakia Herjawan; Vivian Soetikno
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1439.1

Abstract

Metabolic syndrome (MetS), with its associated abnormalities, is linked with oxidative stress and inflammation in the brain, leading to cognitive decline. As a natural compound with promising antioxidant properties derived from ginger, 6-gingerol (6G) could be a potential therapeutic candidate. This study aimed to investigate the effects of 6G on alleviating inflammation, oxidative stress, and insulin signaling in the brain tissue of MetS rats. Male Sprague-Dawley Rats were randomized into five groups: normal control, negative control, and three groups receiving increasing doses of 6G for 8 weeks. A high-fat diet and a low-dose streptozotocin injection induced MetS. Brain tissues were analyzed for tumor necrosis factor (TNF-ɑ), interleukin-1 (IL-1β), malondialdehyde (MDA), glutathione peroxidase (GPx), glucagon-like peptide (GLP-1), and GLP-1 receptor (GLP-1R) levels. The study was conducted at the Pharmacokinetics Laboratory Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, in January-February, 2023. TNF- levels were significantly higher in the MetS group compared to the normal-control group (95% CI: -4.4 – -74.9; p = 0.024), whereas there were no significant differences in IL-1, MDA, GPx, GLP-1, and GLP-1R levels between the MetS and normal-control groups. Administration of 6G at 50 mg/kg/day significantly reduced TNF levels compared with the MetS group (95% CI: -12 to -82; p = 0.006), whereas 6G at 100 and 200 mg/kg/day did not improve all parameters. The present findings suggest that 6G, particularly at a dose of 50 mg/kg, may exert anti-inflammatory effects in MetS-induced brain inflammation. However, the importance of dose optimization for the potential translational application of 6G remains to be further researched.
Urethral Hypermobility and Levator Ani Ballooning in Primigravida: A Preliminary Report Gita Nurul Hidayah; Ayyada Khairunnisa; Muhammad Syah Nadir Chan; Fernandi Moegni; Firda Hanan Bahjah; Alfa Putri Meutia; Budi Iman Santoso
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1488.1

Abstract

Pelvic floor dysfunction (PFD) has been develop even before first delivery, with clinical manifestations frequently include pelvic organ prolapse (POP) and urinary incontinence (UI). This study aimed to characterize ultrasound-defined urethral hypermobility in strictly primigravid women during late pregnancy. This cross-sectional study included primigravid women (18–35 years) at  36 weeks gestation undergoing transperineal ultrasound. Urethral hypermobility was defined by alternating threshold, bladder neck descent (BND) >20.8 mm, or retrovesical angle (RVA) >141.5°, or urethral rotational angle (URA) >19.43°. Among 32 participants, urethral hypermobility was identified in 15 (46.9%) and levator ani ballooning in 2 (6.3%). RVA during Valsalva was potentially significant differ in women with hypermobility than in those without (138.3 ± 26.3° vs. 92.5 ± 33.2°, p<0.001). No significant differences were found in URA or BND.  Dynamic urethral support changes are identifiable before the first delivery, with the most interesting finding was RVA during Valsalva potentially significant between groups.
Pengaruh Konsentrasi dan Lama Perendaman Carbol Fuchsin pada Hasil Pewarnaan Modifikasi Ziehl-Neelsen untuk Deteksi Cyclospora cayetanensis Yuni Wulandari; Dewi Inderiati; Ika Puspa Sari
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1502.1

Abstract

Cyclospora cayetanensis merupakan protozoa penyebab siklosporiasis yang memerlukan diagnosis laboratorium secara cepat dan akurat. Metode pewarnaan modifikasi Ziehl-Neelsen umum digunakan untuk mendeteksi ookista C. cayetanensis dalam spesimen feses, namun variasi penyerapan zat warna sering kali berpotensi menyebabkan kesalahan identifikasi. Penelitian eksperimental dengan rancangan posttest-only ini bertujuan untuk menganalisis pengaruh variasi konsentrasi (0,3%; 1%; 4%) dan lama perendaman (10 menit, 15 menit, 20 menit) Carbol Fuchsin dengan tiga kali pengulangan terhadap hasil pewarnaan. Penelitian dilaksanakan di Laboratorium Departemen Parasitologi Fakultas Kedokteran Universitas Indonesia pada Maret–April 2025. Hasil analisis statistik menunjukkan bahwa konsentrasi Carbol Fuchsin berpengaruh signifikan terhadap persentase ookista terwarna (ANOVA dua arah, p < 0,000) dan kualitas latar belakang pewarnaan (uji Kruskal-Wallis, p = 0,004). Sebaliknya, lama perendaman Carbol Fuchsin tidak berpengaruh signifikan terhadap persentase ookista terwarna (p = 0,234) maupun kualitas latar belakang (p = 0,128). Tidak ditemukan interaksi signifikan antara konsentrasi dan lama perendaman (p=0,183). Kesimpulannya, konsentrasi Carbol Fuchsin memengaruhi keberhasilan pewarnaan ookista C. cayetanensis, dengan kombinasi konsentrasi 1% dan lama perendaman 10 menit sebagai variasi optimal untuk meningkatkan kejelasan visual dan meminimalkan risiko misidentifikasi.
Behavioral Intervention for Lifestyle Modification in Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease Marinda Asiah Nuril Haya; Dwina Prawitasari; Syifa Nur Azizah; Dian Kusumadewi
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1557.1

Abstract

A 19-year-old female student presented to the university clinic following a hospital diagnosis of grade 1 fatty liver disease. She exhibits grade 2 obesity, dyslipidemia, hyperuricemia, and elevated liver transaminases, with a family history of obesity and type 2 diabetes mellitus. Given the patient's challenges in adhering to diet and exercise recommendations, this evidence-based care report explores whether behavioral interventions, compared with standard care, more effectively improve outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) among young adults. A literature search conducted via PubMed® and Scopus® on June 23, 2026 identified three systematic reviews, three randomized controlled trials, and one cohort study relevant to the clinical inquiries. Findings consistently show that behavioral interventions outperform standard care in weight management, reduction of liver enzymes, and improvements in lipid profiles, though results for lipid changes remain heterogeneous. One study with a three-year follow-up demonstrated improvements in the hepatic steatosis index (HSI) and fatty liver index (FLI), suggesting long-term benefits. Evidence further highlights the role of eHealth strategies, including mobile applications and adherence reminders, in sustaining lifestyle changes. Overall, structured behavioral programs supported by professional coaching and digital monitoring yield significant clinical benefits for young adults with MASLD.
Efektivitas Terapi Kombinasi Insulin-Glukosa-Salbutamol versus Insulin-Glukosa dalam Manajemen Hiperkalemia Jason Alexander Tjoa; Adeline Pasaribu; Erni Juwita Nelwan
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1155.%p

Abstract

Hiperkalemia merupakan kondisi medis dengan kadar kalium serum >5,0 mEq/L yang dapat menyebabkan komplikasi serius, termasuk aritmia dan kematian. Terapi insulin-glukosa merupakan salah satu terapi utama untuk menurunkan kadar kalium serum melalui pergeseran kalium ke intraseluler. Penambahan agonis β2 seperti salbutamol diduga memberikan efek tambahan melalui mekanisme yang berbeda. Laporan kasus berbasis bukti ini bertujuan membandingkan efektivitas terapi kombinasi insulin-glukosa-salbutamol dibandingkan dengan insulin-glukosa saja dalam menurunkan kadar kalium pada pasien hiperkalemia. Penelusuran literatur dilakukan pada PubMed, Cochrane, dan ScienceDirect. Studi yang diinklusi merupakan studi dengan desain meta-analisis, tinjauan sistematis, randomized controlled trial, atau studi observasional yang membandingkan terapi insulin-glukosa dengan kombinasi insulin-glukosa dan salbutamol pada pasien berusia 15–59 tahun dengan hiperkalemia (>5,0 mEq/L). Dari 89 studi, didapatkan satu studi meta-analisis dan satu studi observasional yang memenuhi kriteria eligibilitas. Studi meta-analisis melaporkan bahwa terapi kombinasi insulin-glukosa-salbutamol menurunkan kadar kalium sebesar 0,45 mmol/L (95% CI: 0,18–0,71; p<0,05) lebih banyak dibandingkan dengan insulin-glukosa saja. Studi observasional retrospektif menunjukkan bahwa terapi kombinasi ini menurunkan kadar kalium sebesar 0,33 mmol/L (95% CI: 0,08–0,57; p=0,009) lebih banyak dibandingkan dengan terapi insulin-glukosa saja. Terapi kombinasi insulin-glukosa-salbutamol lebih efektif dalam menurunkan kadar kalium serum dibandingkan terapi insulin-glukosa saja.
Analisis Tingkat Self-Management terhadap Kategori Tekanan Darah pada Pasien Hipertensi di Fasilitas Pelayanan Primer Syarifah Nurul Yanti Rizki Syahab Asseggaf; Mistika Zakiah; Ridha Ulfah; Triyana Harlia Putri; Jenny Firda Len; Aura Qatrunnada; Fahim Zuhudan; Syech Indah Adivanefi
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1380.%p

Abstract

Hipertensi merupakan salah satu penyakit kronis dengan prevalensi tinggi dan menjadi faktor risiko utama berbagai penyakit kardiovaskular. Salah satu faktor yang berperan dalam keberhasilan pengendalian tekanan darah adalah self-management, yaitu kemampuan individu dalam mengelola penyakitnya melalui kepatuhan terhadap pengobatan, pemantauan kondisi kesehatan, serta penerapan perilaku hidup sehat. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Penelitian dilakukan pada pasien hipertensi di Puskesmas Kampung Dalam dan Puskesmas Saigon, Kecamatan Pontianak Timur, Kalimantan Barat, selama periode Oktober-Desember 2024. Sebanyak 388 responden direkrut menggunakan teknik accidental sampling. Tingkat self-management diukur menggunakan Hypertension Self-Management Behavior Questionnaire (HSMBQ), sedangkan kategori tekanan darah ditentukan berdasarkan klasifikasi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). Analisis hubungan antara kedua variabel dilakukan menggunakan uji korelasi Spearman.Hasil penelitian menunjukkan bahwa sebagian besar responden berusia 51-55 tahun (36,3%), berjenis kelamin perempuan (78,6%), dan memiliki tingkat self-management yang baik (59,3%). Kategori tekanan darah terbanyak adalah hipertensi derajat 1 (44,1%), diikuti hipertensi derajat 2 (36,3%). Hasil uji korelasi Spearman menunjukkan tidak terdapat hubungan yang bermakna antara tingkat self-management dan kategori tekanan darah (r = 0,037; p = 0,465). Tingkat self-management tidak berhubungan secara signifikan dengan kategori tekanan darah pada pasien hipertensi dalam penelitian ini. Temuan ini menunjukkan perlunya mempertimbangkan faktor lain, seperti kepatuhan terapi, dukungan keluarga, gaya hidup, dan faktor lingkungan, dalam upaya meningkatkan pengendalian tekanan darah pada pasien hipertensi.
Spinal Paradox in Suspected Thoracolumbar Metastatic Epidural Spinal Cord Compression from Recurrent HER2-Positive Breast Cancer Bima Diokta Alparisi; Sucipto Sucipto; Yossi Maryanti; Daril Al Rasyid; Novia Aiko; Riki Sukiandra; Desby Juananda; Agus Tri Joko; M. Ihsan
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1392.%p

Abstract

Metastatic epidural spinal cord compression is a neurological emergency. Thoracolumbar involvement can produce overlapping cord and nerve-root findings, complicating localisation when degenerative lumbar disease coexists. This report describes the clinical-radiological correlation of mixed upper and lower motor neuron signs in a patient with suspected thoracolumbar metastatic epidural spinal cord compression due to recurrent HER2-positive breast cancer. A 56-year-old woman with recurrent HER2-positive left breast carcinoma developed progressive back pain, severe paraparesis, asymmetric sensory impairment, and bladder–bowel dysfunction. Examination demonstrated predominantly flaccid weakness, diminished reflexes, and bilateral extensor plantar responses. MRI showed L1 vertebral collapse and T12–L2 epidural extension compressing the distal spinal cord and conus medullaris, alongside L5–S1 disc protrusion. Mastectomy-bed ultrasonography was classified as BI-RADS 5, and biopsy reportedly supported locoregional recurrence. Spinal metastatic involvement remained clinically and radiologically suspected. Anatomical findings suggested combined spinal cord and nerve-root involvement. However, a patient-specific pathophysiological mechanism could not be confirmed. Treatment included corticosteroids, zoledronic acid, supportive care, and rehabilitation. Partial motor recovery and improvement in bladder and bowel control were reported, although objective follow-up measurements were unavailable. This case highlights the importance of clinical-radiological correlation in patients presenting with mixed upper and lower motor neuron signs. Progressive weakness and sphincter dysfunction in breast cancer survivors should prompt urgent spinal imaging and multidisciplinary evaluation, even when flaccid weakness predominates.
Association Between Macronutrient and Dietary Fiber Intake and Fat Mass Index Among Adults with Obesity Ika Handayani Siswanto; Erfi Prafiantini; Sri Widia A. Jusman
eJournal Kedokteran Indonesia Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1509.%p

Abstract

Obesity has become a global public health challenge and is recognized as a complex chronic disease associated with numerous non-communicable diseases. Dietary factors, including macronutrient composition and dietary fiber intake, are considered important determinants of adiposity. However, evidence regarding their association with Fat Mass Index (FMI) in adults with obesity remains limited. This study aimed to determine the association between macronutrient intake, including energy, carbohydrate, protein, and fat intake, as well as dietary fiber intake, and Fat Mass Index among adults with obesity. A cross-sectional study was conducted between February and May 2026 among 100 adults with obesity. Dietary intake was assessed using non-consecutive 2-day dietary recalls. Body composition was measured using bioelectrical impedance analysis (BIA), and FMI was calculated as fat mass (kg) divided by height squared (m²). Spearman correlation analysis was used to evaluate unadjusted associations, while multiple linear regression analysis adjusted for age, sex, physical activity, and total energy intake was performed to examine independent associations with FMI. In unadjusted analyses, energy, carbohydrate, protein, fat, and dietary fiber intake were not significantly associated with BMI or FMI (all p > 0.05). However, after adjustment for age, sex, physical activity, and total energy intake, protein intake was positively associated with FMI (B = 0.053; 95% CI: 0.009–0.098; p = 0.020). Carbohydrate, fat, and dietary fiber intake were not significantly associated with FMI. Sex remained a significant predictor of FMI in all regression models (p < 0.001). Macronutrient and dietary fiber intake were not associated with BMI or FMI in the unadjusted analysis. After controlling for potential confounders, protein intake showed a positive association with FMI. These findings suggest that adiposity in adults with obesity is influenced by multiple factors beyond short-term nutrient intake.

Page 13 of 13 | Total Record : 128

 9   10   11   12   13 

Filter by Year

2021 2026


Reset
Filter By Issues
All Issue Vol. 14 No. 2 (2026): Vol 14, No. 2 - Agustus 2026 Vol. 14 No. 1 (2026): Vol 14, No. 1 - April 2026 Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025 Vol. 12 No. 1 (2024): Vol 12, No. 1 - April 2024 Vol. 11 No. 3 - Desember 2023 Vol. 11 No. 2 - Agustus 2023 Vol 11, No. 1 - April 2023 Vol 10, No. 3 - Desember 2022 Vol. 10 No. 2 - Agustus 2022 Vol 10, No. 1 - April 2022 Vol 9, No. 3 - Desember 2021 Vol 9, No. 2 - Agustus 2021 Vol 9, No. 1 - April 2021 More Issue