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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 10 Documents
 1 
Search results for , issue "Vol. 4, No. 3" : 10 Documents clear
Epidemiologi Dan Diagnosis Dengue Di Indonesia Zilhadia, Zilhadia
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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Abstract

Dengue fever/DF and dengue hemorrhagic fever/DHF is a global public health problem that occured in tropical and subtropical region. Epidemic dengue occurs every years, and it continues to be a major health problem in Indonesia. Due to its asymptomatic nature, a reliable, rapid and accurate dengue diagnosis is needed. Dengue diagnosis method based on molecular dengue virus properties and it will be developed by researcher. Dengue rapid test isnewly method. This article explaine about dengue epidemiology, molecular dengue virus properties, clinical diagnosis, serology diagnosis and progress research of dengue virus.
Identifikasi Interaksi Kimia Fisika Pada Kombinasi Antibiotika Amoksisilina Trihidrat - Kalium Klavulanat Dengan Kalorimeter Larutan Dan Rekristalisasi Nugrahani, Ilma; Asyarie, Sukmadjaja; N.S, Sundani; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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Abstract

Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.
Formulasi dan Uji Kestabilan Fisik Suspensi Topikal yang Mengandung Ekstrak Nerii Folium sebagai Antibakteri dalam Sediaan Anti Jerawat Djajadisastra, Joshita; Munim, Abdul; Hidayah, Octaviarini
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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Nerium oleander is one of the plants that can be developed to be a herbal medicine because the leaf extract has an antibacterial activity against some microorganisms and empirically had been used to solve the acne problem. The anti acne formulation should not make the acne worse because of mistaken to choose the dosage form. The suspension dosage form (has no oil content makes the acne worse) containing the dried leaf extract of Nerium oleander in 97% alcohol was chosen to be formulated by varying respectively carbomer, sodium carboxy methyl cellulose and tragacanth as a suspending agent. The concentration of Nerii folium extract in the suspension was based on the Minimal Inhibitory Concentration of the extract against Propionibacterium acnes and Staphylococcus. The evaluation of the formula was done by physical stability test including organoleptic test (color and odor), pH, volume of sedimentation, mean particle diameter size, viscosity stored in low temperature of 4oC, room tperature of 28oC, and high temperature of 40oC, cycling test and mechanical test.The results showed that suspension with sodium carboxy methyl cellulose as the suspending agent has better physical stability than carbomer or tragacanth.
Sintesis dan Uji Aktivitas Antibakteri N,N'-Divanilidenaetilendiamina Hayun, Hayun; Munim, Abdul; Hariria, Dini; Aunillah, Ulfah
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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The study of synthesis and antibacterial activity test of N,N'-divanilidene-ethylendiamine was performed. N,N'-divanilidene-ethylendiamine was synthesized by reacting vaniline with ethylendiamine in ethanol pH 1, and the structure was elucidated based on IR and 1H-NMR spectra data. Antibacterial activity test was performed using minimum inhibition concentration method (MIC) against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, and Escherichia coli ATCC 25922. The results showed that N,N'-divanilidene-ethylendiamine has antibacterial activity with MIC of 2 mg/mL against the the bacteria.
Determination of Ethanol In Employee's Blood Who Work In "X" Alcoholic Beverage Industry Using 1-Propanol as an Internal Standard by Gas Chromatography Harmita, Harmita; Mansur, Umar; Rahmadani, Suchi
Majalah Ilmu Kefarmasian Vol. 4, No. 3
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Abstract

Ethanol not only caused drunk, but also in certain amount it can caused death. Because of the side effect of ethanol was dangerous if there sufficient concentration in blood and the penetration which is relatively easy so it was important to know how much ethanol in blood, especially on official employee in alcoholic beverage industry. A gas chromatography method using a capillary column CBP-10 and flame ionization detector (FID) has been developed and validated for the detection and quatification of ethanol in blood. Gas chromatography was performed in isothermal mode with column temperature 60oC. Helium was used as carrier gas with flow rate 1.0 mL/min. Quantification was performed with the uses of 1-propanol as an internal standard (IS). The method was linear in the concentration range of 0.001-0.8% v/v with coefficient of corelation 0.9998. The lower limit of quantification (LLOQ) was found to be 0.001% v/v. This method was validated with precisions (CV) 0.53-3.47% and accuracies (% diff) 3.86-7.46%. Result of ethanol recovery varied from 96.14-107.46%. The result of validation method fulfilled for the given criteria.
Pengujian Aktivitas Antibakteri Sabun Cair dari Ekstrak Kulit Daun Lidah Buaya Sari, Rafika; Ferdinan, Ade
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Aloe vera is one of the typical plants found in Pontianak, West Kalimantan. This plant’s leaf peel is nontoxic and can be used as an antibacterial and anti-inflammatory agent. Nowadays, Aloe vera is one among 10 most popular plants in the world that have a potency to be developed as medicinal plant. This study aimed to determine antibacterial activity of the extract of Aloe vera leaf peel in liquid soap formulation against several pathogenic bacteria. Aloe vera leaf peel extract was prepared with maceration using ethanol. Then, it was formulated into a liquid soap. The soap was evaluated for its organoleptic, pH value, specific gravity, and foam height. Antibacterial activity assay of the liquid soap was carried out using diffusion method. The results showed that the characteristic of the liquid soap was viscous, yellowish white colored, and had distinctive smell of Aloe vera. The pH values on the day 0, 7 and 14 were 8; 8,9; and 9,4; respectively. The specific gravity was 1,033 g/ml. The foam height on minute 5, 10 and 15 were 76.92%, 19.23% and 19.23%, respectively. The liquid soap from the extract of Aloe vera leaf peel was found to have antibacterial activity against Gram positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Bacillus cereus) and Gram negative bacteria (Salmonella typhimurium, Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli).
Formulasi, Uji Stabilitas Fisik, dan Uji Aktivitas Secara In Vitro Sediaan Spray Antibau Kaki yang Mengandung Ekstrak Etanol Daun Sirih (Piper betle L.) Iswandana, Raditya; Sihombing, Lidya KM
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

Betel leaf has long been proven and widely used in Indonesia for its antibacterial activities. Betel leaf 80% ethanolic extract has high compatibility to be made as a widely used pharmaceutical product, including spray. In 2014 American Podiatric Medical Association, studied a significant increase of foot odor prevalence between our citizens. One of the reasons of foot odor is caused by bacteria, mostly by Bacillus subitilis. This study focused on creating a pharmaceutical product with a strong antibacterial that showed minimum bactericidal concentration (MBC) towards bacteria that caused foot odor. Spray product was chosen because of the great pleasant experience for the user. The study tested various concentrations of betel leaf 80% ethanolic extract, to study its antibacterial activity. Furthermore, stability testing towards its physical property on 8-week storage in three different temperature; room temperature (28±2 ºC), high temperature (40±2 ºC), and low temperature (4±2 ºC), was also conducted. All formulae showed great physical stability profile on organoleptic parameters. Betel leaf 80% ethanolic extract, in the Formula 3 showed minimum bactericidal concentration (MBC) in 2 mm area with the Formula that contained ≥ 2 mg/ml ethanolic extract.
Penentuan Nilai FICI Kombinasi Ekstrak Etanol Kulit Daun Lidah Buaya (Aloe vera (L) Burm.f) dan Gentamisin Sulfat Terhadap Bakteri Escherichia coli A’lana, Lu’lu’; Sari, Rafika; Apridamayanti, Pratiwi
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

The combined use of natural materials and antibiotic compound is one of treatment that can be done against infections caused by bacteria. This combination is expected to be more potent to inhibit the bacteria with lower side effects. FICI (Fractional Inhibitory Concentration Index) is an index that can indicate the activity of a combination of natural ingredients and antibiotic compounds. FICI would indicate that the combination has a synergistic effect, additive, indifferent or antagonistic. The aim of this study is to determine the FICI to the combination of Aloe vera leaves skin (Aloe vera (L.) Burm.f.) ethanol extract and gentamicin sulphate againts Escherichia coli. FICI was determined by disc diffusion method. Combination of Aloe vera leaves skin (Aloe vera(L.) Burm.f.) ethanol extract and gentamicin sulphate with concentration of 1.25 mg/mL + 2,5 µg/mL was not form zone of inhibition; while the concentration of 2.5 mg/ml + 5 µg/ mL formed zone of inhibition of 6.95 mm; 6.75 mm; and 6.65 mm. The results showed that the combination of Aloe vera leaves skin (Aloe vera (L.) Burm.f.) ethanol extract and gentamicin sulphate against the Escherichia coli has the indifference effect on Escherichia coli, and FICI to this combination is 2.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Gaharu (Aquilaria microcarpa Baill.) Terhadap Bakteri Staphylococcus aureus dan Proteus mirabilis Sari, Rafika; Muhani, Mutiara; Fajriaty, Inarah
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

Leaves agarwood (Aquilaria microcarpa Bail) is one of the natural materials that can be used as an antibacterial. This study aims to determine the content type of secondary metabolites and antibacterial activity against Staphylococcus aureus and Proteus mirabilis by the method of Kirby-Bauer disc diffusion. Simplicia leaves agarwood macerated with ethanol 96%. Results of phytochemical screening of ethanol extract of leaves agarwood contain flavonoids, phenols, tannins, saponins and steroids. Furthermore, the TLC for the assertion of their chemical compounds in extracts of leaves agarwood using a mobile phase of butanol: acetic acid: water (4: 1: 5) with the stationary phase silica gel GF254 with spotting FeCl3 5% for phenolic and AlCl3 5% for flavonoids later in UV detection at 254nm and 366nm. Control positive used is siprofloksasin 50 μg while control negative used is DMSO 20 % . Based on the results of the average diameter zone obstruent extract ethanol leaves agarwood in staphylococcus aureus by concentration of the 300 mg / ml, 400 mg / ml, 500 mg / ml is 12.50 mm, 13,51 mm, 15,80 mm. while in proteus mirabilis by concentration of the 300 mg / ml, 400 mg / ml, 500 mg / ml is 12,10 mm, 13,26 mm, 15.19 mm. This shows that extracts ethanol leaves agarwood having activity on Gram positive and Gram negative.
Pengembangan Metode Analisis Agen Pengatur Keasaman Pakan Ternak Menggunakan Metode Kromatografi Cair Kinerja Tinggi Asih, Ninis Kurnia; Harmita, Harmita; Maggadani, Baitha Palanggatan
Pharmaceutical Sciences and Research Vol. 4, No. 3
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Abstract

Quantitative analysis of organic acid in acidifier product is needed to maintain product effectiveness in repressing microbial growth and lowering feed and gastrointestinal tract pH. The aim of this research is determining the level of formic and lactic acid in two acidifiers from the market. Analysis were performed using reversed phase High Performance Liquid Chromatography (HPLC) with LiChrospher® 100 RP-18 column (250 x 4.0 mm, 5μm, Merck), buffer potassium dihydrogenphosphate 50 mM-TEA 0,5% pH 4,00 as mobile phase and flow rate 0,6 mL/min. Wavelength used in the analysis was 214 nm. Validation methods provide results of recovery by 98.02%-101.97% for formic acid and 97.09%-102.78% for lactic acid, RSD <0.59% for formic acid and 1.28% for lactic acid, LOD 63.05 µg/mL for formic acid 4.55 µg/mL for lactic acid, LOQ 210.16 µg/mL for formic acid and LOD 15.18 µg/mL for lactic acid. The analysis method gives linearity in the range of 439.2 -1764.61 µg/mL for formic acid with correlation coefficient (r) 0.9992 while lactic acid linearity range was 47.88 µg/mL-193.44 g/mL with a correlation coefficient (r) 0.9994. Conformity product A to its label provides the results of 108.19%-109.82% formic acid and 156.88%-167.90% lactic acid whereas the result for product B were 101.65%-109.95% formic acid and 151.10%-172.82% lactic acid.

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