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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 12 Documents
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Search results for , issue "Vol. 5, No. 2" : 12 Documents clear
Antimicrobial and Cytotoxic Properties of the Ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri Karim, Firmansyah; Putra, Masteria Yunovilsa; Hadi, Tri Aryono; Abrar, Muhammad
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

The aim of this research is to investigate antimicrobial and cytotoxic activity from Indonesian ascidians. Extracts prepared from the Indonesian ascidians Lissoclinum patella, Oxycoryna fascicularis, Didemnum molle and Botryllus schlosseri were assessed for anti-microbial and cytotoxic properties. Antibacterial activity of the extracts was tested against two Gram-positive bacteria, viz. Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923, and three Gram-negative bacteria, viz. Escherichia coli ATCC 25922, Vibrio cholerae ATCC 14035 and Pseudomonas aeruginosa ATCC 101454 using the disk diffusion test. Antifungal activity was also tested against Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404. The minimum inhibitory concentrations (MICs) of potential ascidian extracts were determined by the microdilution technique. Cytotoxicity of the extracts was assessed using the brine shrimp lethality bioassay. By comparing the inhibition zones in the disk diffusion test, the most active anti-bacterial activity against Gram-positive bacteria (S. aureus and B. subtilis) was found in the crude extracts of Oxycoryna fascicularis and Didemnum molle. Lissoclinum patella extract showed the highest activity against the Gram-negative bacteria E. coli and V. cholerae. The LC50 values of the crude extracts of Lissoclinum patella, Didemnum molle, Botryllus schlosseri, and Oxycoryna fascicularis were 74.3, 97.2, 114.7 and 132.9 μg/ml, respectively. In our study, the most promising species for anti-microbial and cytotoxic properties are Lissoclinum patella and Didemnum molle.
Potensi Anthelmintik Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L.) pada Cacing Ascaridia galli dan Raillietina tetragona secara In Vitro Robiyanto, Robiyanto; Kusuma, Ria; Untari, Eka Kartika
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Arumanis mango (Mangifera indica L.), a medicinal plant, is allegedly potential as an anthelmintic agent. This research aimed to investigate the in vitro anthelmintic activity of ethanolic extract of arumanis mango leaves against Ascaridia galli and Raillietina tetragona; know the effect of increasing extract concentration; and calculate the LC50 and LT50 value of the extract. The extract concentrations tested were 5, 25 and 50 (mg/ml) with normal control (NaCl 0,9%) and positive control (mebendazole 5 mg/ml). The time and number of worm deaths were observed and analyzed statistically using One Way Anova SPSS, Post hoc (LSD) and Probit. The results showed that ethanolic extract had anthelmintic activity in which concentration of extract at 25 mg/ml and 50 mg/ml had death time and number of death worms similar to mebendazole 5 mg/ml for A. galli (p=0.466 and p=0.760) and R. tetragona (p=0.093 and p=0.566); the increasing of extract concentration was linear with the increase of its anthelmintic activity; and LC50 dan LT50 value of the extract for A. galli were 2,6 mg/ml and 15,2 hours, while for R. tetragona were 3,1 mg/ml and 2,5 hours. As a conclusion, arumanis mango leaves is potential to be developed as an anthelmintic traditional medicine.

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