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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 10 Documents
 1 
Search results for , issue "Vol. 9, No. 3" : 10 Documents clear
Faktor Penentu Permeasi Transdermal:Tinjauan Berdasarkan Hukum Fick I Binarjo, Annas
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Abstract

Transdermal drug delivery may be an alternative to overcome the problems of oral administration, such as fluctuations drugconcentration in the blood. Only several drugs have a good transdermal permeation ability, thus some efforts are needed to improve it. Transdermal permeation follows pasive diffusion mechanism. Therefore, Fick Law I must be concidered in improving transdermal permeation of the drug. This review aims to determine the factors associated with the transdermal permeation based on Fick's law I. Chemical compounds to enhance transdermal permeation (Chemical penetration enhancers) can be used to increase the diffusion coefficient (D), the partition coefficient (k), the rate of drug in the donor compartment (Cd), membrane thickness (h), and extensive contact of drug with the skin (S).
Studi Disolusi Terbanding Tablet Komparator dan Generik Glibenklamida 5 MG Menggunakan Parameter Difference Factor (f2) dan Similarity Factor (f1) Sutriyo, Sutriyo; Aeni, Siti Nur; Sundarsih, Sundarsih
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Dissolution testing is an essential requirement for the development, establishment of in Vitro dissolution and in Vivo performance (I VIV R), registration and quality control Of solid oral dosage forms. The objective of the present study was to compare dissolution profile of glibenclamide 5 mg tablet between generic and inovator product from commercial market, using independent model. Samples of glibenclamide 5 mg tablets was used on the batch number are the Same design for each other product. The dissolution test were perfoming using USP 23 apparatus 2, in pH 7,40 buffer phosphate, employing 900 ml of dissolution medium at a temperature of 37 ±0,5 ˚C and an agitation rate of 75 rpm with spesification performed at 15, 30, 45, 60 and 120 minutes. Comparison between dissolution profiles was achieved using a difference factor (f1) and simmilarity factor (f2) methods in inovator product and generic \ product. The results showed that dissolution profiles of product B (generic) has similar with product A (inovator) where difference factor (f1) value is 5,53% and simmilarity factor (f2) is 99,29 %
Uji Aktivitas Penghambatan Enzim Alfaglukosidase Pada Beberapa Tanaman Suku Euphorbiaceae Elya, Berna; Katrin, Katrin; Bangun, Anastasia
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Abstract

Diabetes mellitus (types 1 and 2) is recognized as a serious global health problem that characterized by hyperglycemia. Type 2 diabetes is more common in diabetic populations. In type 2 diabetes mellitus, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. Avoiding the adverse effects of current agents, it is still necessary to search alternative for better options. Plants have been a rich source of α-glucosidase inhibitors. In this research, screenings based on chemotaxonomic approach to determine the class of chemical constituents and to know α-glucosidase inhibiting activity of some plants from Euphorbiaceae. The simplisia powder was extracted using ethanol 80% by reflux. Measurement of inhibitory activity of α-glucosidase performed using a spectrophotometer UV-VIS. In vitro assays of α-glucosidase activity showed 14 extracts had IC50 values of between 2.34 µg/mL and 64.78 µg/mL, which were lower than that of acarbose (117.20 µg/mL). Leaves extract from Antidesma celebicum had the highest α-glucosidase inhibiting activity with an IC50 of 2.34 µg/mL. The results of phytochemical screening in 15 extracts generally contain glycosides, terpenoids/ sterols, tannins, saponins and alkaloids.
Uji Stabilitas Fisik Losio Yang Mengandung Fraksi Diklorometana Ekstrak Metanol Kulit Buah Manggis (Garcinia mangostana L.) Apriyanti, Elis; Jufri, Mahdi; Elya, Berna
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Mangosteen pericarp (Garcinia mangostana L.) contains some of xanthones derivates which have antioxidant activity.Those compounds prevent formation of free radicals that cause premature aging. Dichloromethane fraction from methanol extract of mangosteen pericarp has very strong antioxidant activity. Dicholomethane fraction of mangosteen pericarp was formulated into lotion dosage form with different concentration 0.01; 0.05; and 0.25%.. Physical stability of lotion was evaluated by cycling test, centrifugal test, and stored the lotions at low temperature (4±2˚C), room temperature (27±2˚C), dan high temperature (40±2˚C). The result showed that the lotions stable at each strorage condition and cycling test. However, the result of centrifugal test showed separation phase of lotions.
Preparasi, Karakterisasi dan Evaluasi Pelepasan Obat dari Beads Kalsium Alginat Deksametason dengan Metode Gelasi Ionik Aulia, Christye; Djajadisastra, Joshita
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Inflammatory Bowel Disease (IBD) is a disease of inflammation in the colon. Targeted delivery systems for the treatment of IBD is designed to increase the drug concentration in the local tissue. Dexamethasone is a drug having anti-inflammatory and antifibrosis effects which is used to repair scar tissue arising from postoperative IBD. This research purpose to create calciumalginate beads dexamethasone to be released only in the colon. Beads were made by using sodium-alginate and Ca2+ as crosslinker by ionic gelation method, with ratio between sodium alginate-dexamethasone (3:1). A concentration of solution sodium alginate 3 % b/v with variation concentration of crosslinker is 2% (formula 1), 3% (formula 2), and 4% (formula 3). Beads were characterized and drug release determined. The results obtained were spherical beads with a size range between 630 > 800 µm with the greatest encapsulation efficiency obtained from the beads formula 1 with the amount of 98.14% and after coated with Eudragif ® S100 using a fluid bed dryer apparatus, beads of formula 4 was obtained with an encapsulation efficiency of 67, 78%. Beads formula 1 were only released in stomach pH and not able to hold up the release of the active substance in colonic pH, whereas beads of formula 4 releasing dexamethason gradually more than 8 hours in colonic pH, and has a better release profile for the active substance.
Characterisation and Antibacterial Activity of Green Tea Extract-Enriched Solid Goat’s Milk Soap Chasanah, Uswatun; Ermawati, Dian; Utami, Dwi Putri; Hayati, Angela Nora
Pharmaceutical Sciences and Research Vol. 9, No. 3
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Solid goat’s milk soap is organic and beneficial for the health and appearance of the skin. One of the components in green tea known to display antibacterial activities is epigallocatechin gallate (ECGC). In this study, the effects of solid goat’s milk soap containing 1%, 2%, and 4% green tea extract on the growth of Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis were examined. The soap was characterized for its organoleptic, pH, free fatty acid, alkalinity, water content, foam stability, and hardness. In addition, an in vitro antimicrobial test was performed utilising the well-diffusion method. The findings revealed that all the soap formulas matched the SNI 3533-2016 standards for water content, free fatty acid content, and free alkali content, and that they also had similar pH, foam stability, and hardness. The solid goat’s milk soap showed antibacterial activities against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, but the effect of the green tea extract on the soap did not increase these.
Formulation of Pectin-Based Double Layer-Coated Tablets Containing Dexamethasone and Probiotics for Inflammatory Bowel Disease Sagita, Erny; Winata, Ronaldo Ongki; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 9, No. 3
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Abstract

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition in the colon that includes ulcerative colitis and Crohn’s disease. Dexamethasone is a steroid anti-inflammatory drug that can be used in IBD therapy. This study aims to obtain an optimum formulation of a dexamethasone drug delivery system for IBD treatment and to investigate its release profile based on an in vitro dissolution test. Dexamethasone was formulated as a double-coated tablet in combination with a probiotic L. acidophilus and B. longum mixture (1:1). The core tablets were produced using the wet granulation method, after which they were coated with pectin 4% b/v on the inner coat and a mixture of Eudragit L100 and S100 (1:4) on the outer coat. Three different core tablet formulas were prepared by varying the concentration of probiotics at 0%, 16% and 40% (F1, F2, and F3, respectively). The cumulative drug release of F1, F2 and F3 in HCl 0.1 N pH 1.2 for 2 hours were 42.92 ± 1.55%, 39.41 ± 4.10%, and 39.39 ± 1.63%, respectively, while in the phosphate buffer pH 6.8 they were 102.83 ± 1.56%, 105.08 ± 1.70%, and 98.81 ± 3.37% respectively, after 12 hours. From the results, we conclude that all formulas could be promising candidates for developing colon-targeted drug delivery.
Antiproliferative Activity of Philippine Marine Sediment-Derived Actinomycetes Maglonzo, Jon Ray M; Sabido, Edna M; Salibay, Cristina C; Dalisay, Doralyn S; Saludes, Jonel P
Pharmaceutical Sciences and Research Vol. 9, No. 3
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The Philippine archipelago is rich in marine biodiversity and resources that are widely unexplored. Its marine sediments harbor marine microbes that possess secondary metabolites with potent bioactivities. This study aims to determine the antiproliferative activity of the crude extracts of selected Actinomycete isolates (DSD011, DSD017, and DSD042) from Islas de Gigantes, Carles, Iloilo. The antiproliferative screening was done using Saccharomyces cerevisiae as a model organism. Crude extracts of isolates that are active in inhibiting the growth of S. cerevisiae were determined using the broth microdilution method. Afterward, the active extract was tested using antiproliferative and budding yeast assays. With the antiproliferative model, only DSD011 was found to inhibit the growth of S. cerevisiae. The percentage of live and dead cells in DSD011 was comparable to those treated with Triton X (positive control). Further, the budding yeast analysis showed that DSD011 induced G1 cell cycle arrest of nearly 50% of S. cerevisiae cells. Thus, DSD011, a marine sediment-derived Actinomycete, serves as a potential source of naturally occurring bioactive compounds with antiproliferative properties.
The Potential Application of Clitoria ternatea for Cancer Treatment Purnamayanti, Anita; Budipramana, Krisyanti; Gondokesumo, Marisca Evalina
Pharmaceutical Sciences and Research Vol. 9, No. 3
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Abstract

The Clitoria ternatea flower, known as bunga telang in Indonesia, is commonly mixed with food and beverages to provide a natural blue colour. Aside from its popular culinary use, it is a traditional medicine in Indonesia for diseases in the eyes, urinary tract and skin, as well as functioning as an anti-toxin. Furthermore, recent advances in science and technology have revealed that the C. ternatea flower contains a high level of polyphenol compounds that possess anticancer activity, including saponins, tannins, steroids, triterpenoids, kaempferol, and quercetin. This review aims to identify and analyse recent articles regarding the phytochemical activities of C. ternatea flower extract as an anticancer agent. The literature on main databases from 2011 to 2021 was searched systematically using the keywords “Anticancer activity of Clitorea ternatea” and “Phytochemical activities of Clitorea ternatea flower extract against cancer cells”. The various extracts of C. ternatea flower display a moderate cytotoxic, IC50 = 21 µg/mL - 200 µg/mL, for many cancer cell lines, such as MCF-7, MDA-MB-231, CaoV-3, HEp-G2 in aquadest extract and the DLA cell line in petroleum ether extract. The bioactive compounds responsible for the anticancer effect include ternatins, delphinidin, kaempferol, quercetin, sitosterol, and tocopherols. In addition, there have been no reports of any toxic effect on normal cells (Hs27) and oral consumption in mice. According to many studies, the extract is active on multi-molecular targets, with the most conclusive effect on polymerase enzymes, whose inhibition can be an important therapeutic strategy to treat hyperproliferation in cell cancer. Therefore, the findings suggest a potential application of C. ternatea for cancer treatment.
Phytochemical Analysis, Antioxidant and Cytotoxic Activity of Lannea egregia Engl. & K. Krause Stem Bark Extracts Akoro, Seide M; Omotayo, Mutiat A; Ogundare, Oyinlade C; Akpovwovwo, Stemon A; Bello, Gbemileke P
Pharmaceutical Sciences and Research Vol. 9, No. 3
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This study investigates the phytochemical contents, antioxidants and cytotoxic activities of Lannea egregia Engl. & K. Krause stem bark extracts. Secondary metabolites were extracted using n-hexane, ethyl acetate, and ethanol by successive maceration. The concentrated extracts were subjected to preliminary phytochemical screening using standard procedures. The crude flavonoid was obtained from the plant material using Harborne’s method and then profiled using high-performance liquid chromatography (HPLC). The antioxidant activities of the plant extract were assessed using reducing power assay and DPPH scavenging activity, while the cytotoxic activity was determined using the brine shrimp lethality assay. The crude extract of n-hexane or LEHe (0.86%), ethyl acetate or LEEa (1.42%), ethanol or LEEt (3.32%), and flavonoid or LEF (9.7+-0.01%) were obtained from the plant material, with flavonoids, anthraquinone, terpenoids, and tannins detected. The ethyl acetate extract and the crude flavonoid have the highest and comparable DPPH radical scavenging activity at IC50 of 22.98 ± 0.07 μg/mL and 22.48 ± 1.02 μg/mL respectively, the greatest reducing property being exhibited by the ethanol extract. The most cytotoxic activity was observed in the n-hexane extract at LC50 of 8.70 ± 0.58 μg/mL. HPLC detected catechin, p-coumaric acid, ferulic acid, rutin, apigenin, kaempferol and quercetin. In conclusion, Lannea egregia stem bark extracts possess antioxidant and cytotoxic activities and could be explored for new drugs in the management of cancer.

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