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A SIMPLE SYNTHESIS OF NICKEL OXIDE NANOTUBE USING HIGH VOLTAGE ELECTROLYSIS Pramana, Yanatra Budi; Setiawan, Bramianto; Prihono, Prihono; Utomo, Yitno; Subandowo, Marianus; Budipramana, Krisyanti
Jurnal Neutrino:Jurnal Fisika dan Aplikasinya Vol 13, No 1 (2020): October
Publisher : Department of Physics, Maulana Malik Ibrahim State Islamic University of Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/neu.v13i1.10224

Recently, the development of nanoparticle nickel oxide has increased due to their potential application such as biosensors, catalysts, solar cells, supercapacitors, and batteries. In this work, the addition of CTAB for nickel oxide nanoparticle synthesis using electrolysis was investigated. Â The nickel plates were used as anode and cathode in the electrolysis process. The process was operated at a constant voltage of 60 V for 30 minutes. The XRD result showed conformity with the Nickel oxide diffraction pattern. Meanwhile, the impurity from nickel hydroxide peaks still appeared. From FTIR characterization also indicates the band of Ni-O stretching vibration. The morphology characterization of nickel oxide using Scanning Electron Microscopy (SEM) showed the nanotube structure, while Transmission Electron Microscopy showed the nanoparticle size from 250.44 to 325.60 nm in length. On the other hand, the transformation of Ni(OH)2 to NiO has been shown using TGA characterization.

The Inhibition of 15-Lipoxygenase by Blechnum orientale Leaves and its Glycoside-flavonoid Isolates: In Vitro and In Silico Studies Rissyelly Rissyelly; Syaikhul Aziz; Frangky Sangande; Agung Wibawa Mahatva Yodha; Krisyanti Budipramana; Elfahmi Elfahmi; Sukrasno Sukrasno
HAYATI Journal of Biosciences Vol. 29 No. 3 (2022): May 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.3.353-359

Fern is one of the groups of primitive plants rich in secondary metabolites that are commonly used to treat various diseases, including antioxidant, anti-hyaluronidase, anti-inflammation, and respiratory disease but less investigated. Flavonoid is one of the secondary metabolites abundantly present in ferns. This study aims to isolate major compounds found in Blechnum orientale act as 15-lipoxygenase (15-LOX) inhibitors. Inhibition of lipoxygenase decrease the production of leukotriene that induces bronchoconstriction in asthma. Isoquercitrin (Quercetin-3-O-β-glucopyranoside) and trifolin (kaempferol-3-O-β-D-galactoside) have been successfully isolated from Blechnum orientale. Further in silico study was performed to explain the binding mode between flavonoid pyranoside or galactoside and flavonoid aglycone in the 15-LOX cavity and their amino acid residues interaction. Isoquercitrin binds with Ile663, Ile400, Leu408, Leu597, Ala404, and Arg403 in the 15-LOX cavity as a lipoxygenase inhibitor. Trifolin binds the same amino acids as isoquercetin with addition His366, Gln596, and Phe175. Both isoquercitrin and trifolin act as competitive inhibitors against lipoxygenase enzymes.

Electrochemical Synthesis of Nickel Hydroxide Ni(OH)2 Nanoparticles Solution for Detecting Mercury (Hg) Yanatra Budi Pramana; Djoko Adi Walujo; Marianus Subandowo; Indah Nurhayati; Fauziatul Fajaroh; Krisyanti Budipramana
JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Vol 5, No 2 (2021)
Publisher : State University of Malang or Universitas Negeri Malang (UM)

Nickel hydroxide Ni(OH)2 nanoparticles were used as sensors for mercury (Hg) in water using a UV-Vis spectrophotometer instrument. The synthesis of Ni(OH)2 nanoparticles was carried out by electrochemical method using nickel plates as anode and cathode and the process was operated at constant voltage of 25 V for 30 minutes. In this study, 2 variations of the concentration of Ni(OH)2 nanoparticles were used, namely (5 mL and 4 mL) to detect mercury at concentrations of 0 ppm, 10 ppm, 20 ppm, 30 ppm, 40 ppm, and 50 ppm. Changes in the absorbance value of Ni(OH)2 nanoparticles will be observed. From the observations, there was a decrease in the absorbance value of Ni(OH)2 nanoparticles along with the increase in mercury concentration. The decrease in the absorbance value of Ni(OH)2 nanoparticles is directly proportional to the amount of mercury concentration. The detection limit value was obtained at a volume of 5 mL and 4 mL are 42 ppm, and 75.8 ppm.

Pembuatan Biodiesel Dari Biji Nyamplung Menggunakan Metode Tranesterifikasi Dengan Penambahan Toluena Zulfikar Ainunsidiq, Mohammad; Huda, Miftakul; Ayu Titisari, Manik; Budi Pramana, Yanatra; Budipramana, Krisyanti
STIGMA: Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa Vol 16 No 2 (2023)
Publisher : Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/stigma.16.2.8170.55-59

The purpose of this study was to determine the effect of the addition of toluene on the quality of biodiesel from nyamplung seeds, including: viscosity, density, flash point. The method used is esterification using H2SO4 and then transesterification using NaOH. Biodiesel is then added to toluene. The ratio of the addition of toluene to the volume of biodiesel is 2%, 3%, 4% and 5% (%v/v). The final step is to analyze biodiesel which includes analysis of density, viscosity, and flash point. From this research, which gave the best results by adding 3% toluene, the density, viscosity and flash point values met the standards of the Indonesian Biodiesel Forum. Namely a density value of 0,8415gr/ml, a viscosity of 4,7cSt, and a flash point of 62 °C.

Hubungan Profil Status Vitamin D dengan Keparahan Merokok pada Perokok Aktif Dewasa Lorensia, Amelia; Jalmav, Marthy Meliana; Amilia, Eva; Budipramana, Krisyanti
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 4 No. 1 (2023): Juni
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v4i1.135

Cigarettes are one of the addictive substances in the form of nicotine, which can cause dependence for the wearer. In Indonesia, the number of smokers continues to increase every year. The prevalence of adult smokers consisted of men (67.4%), women (4.5%) from 36.1% of the population. The mortality rate due to smoking is expected to continue to increase because there is a significant relationship between the degree of smoking and the severity of COPD. COPD is a disease that attacks the lungs, one of the causes of which is cigarette smoke. The higher the level of knowledge of active smokers, the lower the risk of a person getting COPD. Therefore, research is needed regarding the level of knowledge of chronic respiratory diseases related to active smokers. This study aims to determine the level of knowledge of chronic respiratory disease in active smokers in Pungging Mojokerto District. The method used is a quantitative cross-sectional design with purposive sampling and analyzed descriptively. The results showed that the level of knowledge of active smokers in the District of Pungging Mojokerto on chronic respiratory disease there are 3 levels of categories. Of the three categories, the highest level of knowledge was obtained in the moderate category (50.82%), high category (44.26%), and low category (3.28%).

The Potential Application of Clitoria ternatea for Cancer Treatment Purnamayanti, Anita; Budipramana, Krisyanti; Gondokesumo, Marisca Evalina
Pharmaceutical Sciences and Research Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The Clitoria ternatea flower, known as bunga telang in Indonesia, is commonly mixed with food and beverages to provide a natural blue colour. Aside from its popular culinary use, it is a traditional medicine in Indonesia for diseases in the eyes, urinary tract and skin, as well as functioning as an anti-toxin. Furthermore, recent advances in science and technology have revealed that the C. ternatea flower contains a high level of polyphenol compounds that possess anticancer activity, including saponins, tannins, steroids, triterpenoids, kaempferol, and quercetin. This review aims to identify and analyse recent articles regarding the phytochemical activities of C. ternatea flower extract as an anticancer agent. The literature on main databases from 2011 to 2021 was searched systematically using the keywords “Anticancer activity of Clitorea ternatea” and “Phytochemical activities of Clitorea ternatea flower extract against cancer cells”. The various extracts of C. ternatea flower display a moderate cytotoxic, IC50 = 21 µg/mL - 200 µg/mL, for many cancer cell lines, such as MCF-7, MDA-MB-231, CaoV-3, HEp-G2 in aquadest extract and the DLA cell line in petroleum ether extract. The bioactive compounds responsible for the anticancer effect include ternatins, delphinidin, kaempferol, quercetin, sitosterol, and tocopherols. In addition, there have been no reports of any toxic effect on normal cells (Hs27) and oral consumption in mice. According to many studies, the extract is active on multi-molecular targets, with the most conclusive effect on polymerase enzymes, whose inhibition can be an important therapeutic strategy to treat hyperproliferation in cell cancer. Therefore, the findings suggest a potential application of C. ternatea for cancer treatment.

RP-HPLC Method Validation for Purity Assay of α-Mangostin Isolate Ratih, Ratih; Budipramana, Krisyanti; Firmansyah, Adang
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.6108

The quality of natural products regarding the purity of their active compounds, such as α-mangostin isolate from mangosteen pericarp, may vary depending on cultivation, harvest season, and isolation process. Thus, extensive isolation procedures are involved in obtaining a certain level of purity of the active compounds. Studies on the yield of α-mangostin isolate and its effectiveness as an active compound in health care have been reported. The quality parameter of the isolate as the intended active compound can be indicated by its purity level. Measuring the purity of the active compound is proposed to define the grade α-mangostin isolate as a starting material or even reference standard. The higher the purity level of α-mangostin isolate, the greater its potential as a reference standard candidate. Therefore, a selective analytical method is required to measure the purity level accurately. For this reason, a rapid analytical method to ensure α-mangostin isolate was developed and validated to confirm its purity. Separation condition semployed an X-Terra® C18 column 5 μm, 4.6 x 150 mm under an isocratic system with a mobile phase composition of MeCN:water (85:15) at a flowrate of 0.5 mL/ min and a detector wavelength of 243 nm were selected. Acceptable validation parameters of linearity in the range of 2.6 –52 μg/mL with r2 = 0,9994, Vx0 = 2.64%; accuracy 96.38 – 100.99%; precision 1.36%; and LOD/LOQ = 4.6 μg/mL/ 13.7μg/mL were achieved. The validated method was successfully applied to the purity assay α-mangostinisolate with a run time of less than 9 minutes.

Formulasi dan Evaluasi Sabun Wajah yang Mengandung Ekstrak Etanol Jamur Shiitake (Lentinus edodes) Putranti, Astridani Rizky; Wijaya, Yeremia Tanu; Budipramana, Krisyanti
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 2 (2024): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i2.7032

Jamur shiitake (Lentinus edodes) kaya akan polisakarida, selenium, dan vitamin sehingga banyak digunakan sebagai salah satu komposisi kosmetik kulit dan rambut. Salah satu kosmetik yang banyak menggunakan jamur shiitake adalah sabun wajah. Penelitian ini bertujuan untuk mengekstraksi jamur shiitake dengan beberapa konsentrasi alkohol, yaitu 96% (F1), 75% (F2), dan 50% (F3) menggunakan ultrasonik. Selanjutnya, formula tersebut dievaluasi karakteristik fisikokimianya meliputi pemeriksaan organoleptis, pH, berat jenis, daya sebar, uji busa, laju alir, dan uji hedonik. Formula terbaik adalah F3 dengan karakteristik warna putih krim, tekstur homogen, aroma enak, pH 10,55, berat jenis 0,25 g/ml, daya sebar 11,4 cm, stabilitas 100%, dan viskositas 233,8 cps. Uji hedonik formula F3 dilakukan terhadap 20 responden dengan parameter organoleptis, aroma, kekentalan, uji busa, dan efek melembabkan kulit. Hasil uji hedonik dari para responden dengan nilai tertinggi dari sabun wajah diperoleh dari parameter efek melembabkan kulit, diikuti dengan organoleptis dan efek busa. Shiitake mushrooms (Lentinus edodes) are rich in polysaccharides, selenium, and vitamins that are beneficial for skin and hair cosmetics. These compounds induce shiitake mushrooms to be widely used as raw materials for cosmetics, one of which is facial wash. The purpose of this study is to extract shiitake mushroom using various ethanol concentration 96% (F1), 75% (F2), and 50% (F3) with ultrasonic assisted extraction (UAE) method. Next, the formulas were evaluated for physicochemical characteristics, including organoleptic testing, pH, specific gravity, spreadability, foam test, flow properties, and hedonic test. F3 showed the best formula with evaluated characteristics of creamy white color, homogeneous texture, aromatic, pH value 10.55, specific gravity 0.25 g/ml, spreadability of 11.4 cm, 100% foam stability, and flow properties of 233.8 cps. Hedonic testing of F3 facial wash was conducted on 20 respondents with acceptance parameters including organoleptic, scent, viscosity, foam test, and moisturizing effect. The highest hedonic test result score was shown from the parameter of the ability of shiitake mushroom extract facial wash to moisturize the skin, followed by organoleptic and foam effect. Submitted: 12-11-2024, Revised: 09-12-2024, Accepted: 11-12-2024, Published regularly: December 2024

A Review of Fungal-Derived Natural Dyes: Chemical Diversity and Multifaceted Health Benefits Budipramana, Krisyanti; Setiawan, Vendra; Ratih, Ratih; Budi Pramana, Yanatra
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.1047

Various industrial sectors, from food and drug production to textiles, have widely used pigments or dyes as coloring agents. Generally, we can distinguish between two types of coloring agents: synthetic and natural. Currently, the use of synthetic colorings is a topic of debate due to their potential health risks, toxicity, and environmental pollution. This prompts a deeper exploration of natural resources as a more secure substitute for coloring agents. Plants, animals, microbes, and fungi can all provide natural coloring agents. Besides animals and microbes, some challenges in developing plants as major sources of natural coloring agents include variations in production or harvest times, strongly influenced by season, weather, and the intensity of sunlight. These factors influence not only the stability of the produced color but also its physicochemical properties, such as solubility and pH. Moreover, overexploitation of plants has an impact on ecosystem imbalances and leads to extinction. Among natural resources, pigments or dyes from fungi have shown their potential to address these challenges. This review focuses on the potential of various microfungi that produce natural dyes, especially from Monascaceae, Trichocomaceae, and Nectriaceae, as well as the classification based on their chemical structure. Furthermore, we describe their diverse biological impacts as antioxidants, antibiotics, antidiabetics, anticancer agents, and anti-cholesterol agents, along with their health advantages.

A Review of Fungal-Derived Natural Dyes: Chemical Diversity and Multifaceted Health Benefits Budipramana, Krisyanti; Setiawan, Vendra; Ratih, Ratih; Budi Pramana, Yanatra
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.1047

Various industrial sectors, from food and drug production to textiles, have widely used pigments or dyes as coloring agents. Generally, we can distinguish between two types of coloring agents: synthetic and natural. Currently, the use of synthetic colorings is a topic of debate due to their potential health risks, toxicity, and environmental pollution. This prompts a deeper exploration of natural resources as a more secure substitute for coloring agents. Plants, animals, microbes, and fungi can all provide natural coloring agents. Besides animals and microbes, some challenges in developing plants as major sources of natural coloring agents include variations in production or harvest times, strongly influenced by season, weather, and the intensity of sunlight. These factors influence not only the stability of the produced color but also its physicochemical properties, such as solubility and pH. Moreover, overexploitation of plants has an impact on ecosystem imbalances and leads to extinction. Among natural resources, pigments or dyes from fungi have shown their potential to address these challenges. This review focuses on the potential of various microfungi that produce natural dyes, especially from Monascaceae, Trichocomaceae, and Nectriaceae, as well as the classification based on their chemical structure. Furthermore, we describe their diverse biological impacts as antioxidants, antibiotics, antidiabetics, anticancer agents, and anti-cholesterol agents, along with their health advantages.

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