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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 215 Documents
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Abses Tiroid pada Pasien dengan Infeksi HIV: Laporan Kasus Diah Pradnya Paramita; Made Ratna Saraswati
MEDICINUS Vol. 39 No. 5 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/kyr4be95

Abstract

Thyroid abscess is a rare infectious condition as the thyroid gland is completely enclosed by a fibrous capsule, has an iodine-rich environment, an abundant blood supply, and effective lymphatic drainage. Thyroid abscess occurs more frequentlyin patients with pre-existing thyroid anatomical abnormalities or immunocompromised conditions. Underlying thyroid diseases, such as thyroid nodules or thyroid malignancy, represent important predisposing factors. Only approximately 8% of thyroid abscess cases have been reported in the adult population. Case report: A 71-year-old man presented presenting with right-sided neck pain, fever, and odynophagia for seven days prior to admission. Physical examination revealed a 7 × 5 cm mass in the right cervical region with a smooth surface, firm-rubbery consistency, movement with swallowing, and tenderness on palpation. Thyroid ultrasonography demonstrated a cystic lesion with a solid component and internal echoes. Fine-needle aspiration biopsy revealed polymorphonuclear inflammatory cells consisting of neutrophils and lymphocytes. The patient was also newly diagnosed with human immunodeficiency virus (HIV) infection and had subclinical hypothyroidism. A history of thyroid nodules may represent a significant risk factor for the development of thyroid abscess. In this case, the administration of broad-spectrum systemic antibiotics resulted in a favourable clinical response.
Faktor yang Berhubungan dengan Penyebab Admisi dan Kematian Pasien Systemic Lupus Erythematosus (SLE) di RSUP Prof. dr. I.G.N.G. Ngoerah, Denpasar Ni Kadek Ariesta Dwijayanthi; Pande Ketut Kurniari
MEDICINUS Vol. 39 No. 5 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6553mv58

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with high mortality. Epidemiological data on SLE related mortality in Indonesia remain limited, therefore, this study was conducted to identify the characteristics of patients with SLE who died. This study used a cross-sectional design with total sampling based on medical record data of SLE patients who died during hospitalization at RSUP Prof. dr. I.G.N.G Ngoerah, Denpasar from August 2022 to October 2024. Data were analyzed using SPSS version 22.The mortality of SLE patients at RSUP Prof. dr. I.G.N.G Ngoerah, Denpasar during this study period were 45 patients. The female-to-male patient ratio was 10:1, with a mean age of 34.96 (±11.50) years, history of hospitalizations of 2,27 (±1.09) times in the last 3 months, and the length of hospitalization of 6.40 (±3.48) days. Approximately 55% of patients died within less than 3 months after the diagnosis of SLE was established. Most patients (73.33%) experienced infections, and40% patients had cardiovascular and 55.55% had renal comorbidities. Vasculitis and neuropsychiatric SLE (NPSLE) were associated with severe disease activity. While worsening SLE activity was a major factor in patient admission, deaths were primarily attributed to infections (19 cases; 42.22%) and comorbid complications (17 cases; 37.78%).Cardiovascular disease was associated with hospital admissions due to comorbid complications (p=0.05) and with increased SLE disease activity at admission (p=0.02). Infection remains the leading cause of mortality in SLE and also a contributing factor to delays in initiating high-dose corticosteroid administration. Cardiovascular disease appears to be a comorbidity that progresses and worsens earlier in SLE patients. Multidisciplinary management of infectious andcardiovascular comorbidities may reduce mortality and morbidity in SLE.
Pendekatan Diagnosis pada Pasien dengan Primary Sclerosing Cholangitis (PSC): Sebuah Laporan Kasus I Putu Aris Govindha Putra; I Ketut Mariadi
MEDICINUS Vol. 39 No. 5 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/pznw5k98

Abstract

Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disorder of unknown etiology, characterized by inflammation, fibrosis, and narrowing of the intrahepatic and/or extrahepatic bile ducts. The discovery of commonclinical manifestations of cholestasis, whose etiology is difficult to determine, makes PSC cases a challenge for clinicians. We reported the case of a 20-year-old female who presented with the chief complaint of jaundice lasting 6 months.Symptoms included pruritus, tea-colored urine, pale stools, decreased appetite and body weight, and the appearance of bruising without trauma. The patient underwent several examinations, including laboratory tests, ultrasound, CT scan,and magnetic resonance cholangiopancreatography (MRCP), which showed a blockage and narrowing of the bile ducts. The first endoscopic retrograde cholangiopancreatography (ERCP) included biliary stent placement, but the complaints persisted, so a repeat ERCP was performed, revealing a biliary tract stricture. The initial diagnosis was PSC with severe acute cholangitis and coagulopathy. Patient was treated with antibiotics, steroids, and ursodeoxycholic acid (UDCA). In clinical practice, the recognition and confirmation of the diagnosis, as well as the management of PSC remain challenging. This case highlights the importance of early recognition and suspicion as well as comprehensive treatment of PSC to prevent further complications.
Resistensi Insulin sebagai Poros Disfungsi Ovulasi pada Polycystic Ovary Syndrome Raymond R. Tjandrawinata
MEDICINUS Vol. 39 No. 5 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/wnqbb620

Abstract

Insulin resistance in polycystic ovary syndrome (PCOS) is intrinsic in nature and not merely a consequence of obesity. Postreceptorphosphorylation abnormalities, particularly excessive serine phosphorylation of the insulin receptor and insulin receptor substrate, impair the activation of PI3K/Akt pathway, resulting in compensatory hyperinsulinemia. This conditionstimulates CYP17A1 expression in ovarian theca cells, suppresses hepatic synthesis of sex hormone-binding globulin, and creates a hormonal milieu that disrupts follicular maturation, ultimately leading to oligo-anovulation. The improvementin ovulation reported with the use of glucagon-like peptide-1 (GLP-1) receptor agonists is better understood as an indirect consequence of systemic metabolic improvement. The bioactive fraction DLBS3233 acts at a more downstream level,restoring tyrosine phosphorylation and glucose transporter-4 (GLUT-4) expression by modulating peroxisome proliferatoractivated receptor (PPAR)-γ. Positioning insulin resistance as the central pathophysiological axis enables a more precisetherapeutic approach aligned with the physiological mechanisms underlying ovulatory dysfunction in PCOS.
Pentingnya Mendeteksi Hiperammonia Transien pada Bayi Baru Lahir (Transient Hyperammonemia of the Newborn/THAN) Juliani Dewi
MEDICINUS Vol. 39 No. 5 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/me592623

Abstract

Ammonia is a byproduct of nitrogen metabolism. In healthy individuals, ammonia is transported and metabolized under tight regulation to maintain low plasma concentrations. Increased ammonia production or insufficient ammonia detoxificationmay cause hyperammonemia. Transient hyperammonemia of the newborn (THAN) is often underdiagnosed, although it may lead to coma and death, particularly in premature infants. Acute hyperammonemia is an emergency condition thatmay cause cerebral edema, seizures, coma, severe neurological damage, and death. Ammonia levels can be measured using either an automated analyzer or dry slide. With early detection and prompt, appropriate treatment, the prognosis ofTHAN is excellent, without neurological sequelae.

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