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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

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Published by The Indonesian Society for Digestive Endoscopy

ISSN : 14114801 EISSN : 23028181 DOI : -

Core Subject : Health,

Medicine & Pharmacology

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.

Arjuna Subject : Kedokteran - Ilmu Pencernaan

Articles 771 Documents

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Gastric Amyloidosis Achmad Fauzi; Fajar Raditya; Ari Fahrial Syam; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 3, December 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/73200686-89

Amyloidosis occurs as secondary to rheumatoid arthritis, inflammatory bowel disease and other diseases and also associated with familial Mediterranean fever. Outcomes are worse if there are cardiac or gastrointestinal manifestations. A 57 year-old female was admitted to our hospital with clinical manifestations of nausea, vomiting, epigastric pain, odynophagia, dysphagia and chronic diarrhea. She has also history of rheumatoid arthritis for 10 years. Upper gastrointestinal endoscopy revealed hyperemia in the whole region of gastric mucosa and lower gastrointestinal endoscopy showed hyperemia with erosion in colonic and ileal mucosa. Histopathologic examination of the gastric biopsy showed the deposition of amyloid materials in the mucosa. We report a case of gastric amyloidosis secondary to rheumatoid arthritis. Keywords: gastric amyloidosis, rheumatoid arthritis, dyspepsia

Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies Mutiara Nindya Sari; Clarissa Agdelina; Darlene Bahri; Nadya Regina Permata; Joue Abraham Trixie
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 2 (2021): VOLUME 22, NUMBER 2, August 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Background: There are a lot of theories about how Hepatitis B Virus (HBV) infection affects many diseases, one of them is Diabetes Mellitus (DM). However, the relation remains controversial between DM and HBV as an infection. This study aims to evaluate HBV infection as a risk factor for developing DM.Method: A systematic review was performed using medical search engines such as Pubmed, ScienceDirect and GoogleScholar. References until February 2021 that met the inclusion criteria were reviewed. The primary outcome was the prevalence of DM. Authors also perform Subgroup analyses based on study type. The extracted data were analyzed using RevMan 5.4 application.Results: A total of 20 studies were analyzed with 245,468,411 subjects included. In which divided into two groups, patients with HBV infected group and non infected HBV group. Authors found that there is a statistically difference between patients with HBV infected groups and non infected HBV groups on the primary outcome which is the prevalence of DM (OR 1.24; 95% CI, 1.10-1.41; p = 0.0006). Authors also found the same results based on study type both in case-control (OR = 1.76; 95% CI: 1.08-2.85; p = 0.02) and cross-sectional (OR = 1.40; 95% CI: 1.05-1.85; p = 0.02) studies. Meanwhile in Cohort studies the results show no statistically significant difference between the two groups (OR = 1.07; 95% CI: 0.87-1.33; p = 0.52). Conclusion: HBV infected patients have a higher risk of developing DM than patients without HBV infection.

Diagnostic Approach to Gastroesophageal Reflux Disease: The Role of GERD Questionnaire and PPI Test Ummu Habibah; Achmad Fauzi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 16, No 2 (2015): VOLUME 16, NUMBER 2, August 2015
Publisher : The Indonesian Society for Digestive Endoscopy

Gastroesophageal Reflux Disease (GERD), according to American College of Gastroenterology (ACG), is symptoms or mucosal damage produced by abnormal reflux of gastric contents into the esophagus. In most patients with GERD, showed no abnormalities in the endoscopic picture. This is what underlies the importance of a diagnostic tool in the form of assessment for the degree of severity of the disease based on symptoms, response to therapy and effect on the patients’ quality of life. This diagnostic tool is then formulated in the form of a questionnaire (GERD Questionnaire). Response to treatment with proton pump inhibitor (PPI) drugs is also often used to support the diagnosis of this disease.DIAMOND study is a large study which aim to assess the accuration of the questionnaire and use of PPI test. Diagnostic method with questionnaire modality and followed by PPI test have sensitivity and specificity value, which are relatively similar to the symptoms-based diagnoses performed by general practitioners or gastroenterologist, as well as when compared to endoscopy and esophageal pH monitoring. Although the diagnosis by methods of questionnaires and PPI test is not the most ideal test in term of accuracy, but these tests are not expensive, readily available and worked mainly on primary health care. These test methods are favored compared to other tests.

Lower Gastrointestinal Bleeding due to Multiple Polyps in Ileum Ivo Novita Sah Bandar; Ari Fahrial Syam; Chudahman Manan; Marcellus Simadibrata; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 3, NUMBER 3, December 2002
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/33200299-101

The causes of lower gastrointestinal bleeding (hematochezia) are amyloidosis, anal fissure, angiodysplastic lesions, coagulation disorder, colitis, colon cancer, colorectal polyps, Crohn’s disease, diverticulitis, haemorrhoids, etc. This was a case of lower gastrointestinal bleeding due to colonic inflammatoric polyp. This inflammatoric polyps were caused by infection/inflammation and improved after antibiotic and NSAID therapy. Key Words : Colonic inflammatoric polyp, hematochezia.

Symptoms and Diagnostic Yields of Colonoscopy in St Vincentius Hospital Singkawang West Borneo 2017-2018 Frandy Frandy; Prionggo Mondrowinduro
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 1 (2019): VOLUME 20, NUMBER 1, April 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Colonoscopy is the gold standard procedure which is widely used in the diagnosis and treatment of colonic mucosal disorder. Colonoscopy examination which is included in the referral system of the social insurance administration organization has been available at St Vincentius Hospital Singkawang since March 2017 to support diagnosis of lower gastrointestinal diseases. Patients were from Singkawang City and 3 surrounding districts (Sambas, Bengkayang, and Mempawah) that close to the Malaysian border. The purpose of this study is to evaluate symptom and diagnosis yield of patient who underwent colonscopy at St. Vincentius Hospital, Singkawang from March 2017 to April 2018.Method: This was a retrospective descriptive study by using secondary data of patient’s medical records at St Vincentius Hospital Singkawang in March 2017 - April 2018. Every patient is included as a sample (total sampling).Results: Total numbers are consisted 78 colonoscopies, with 163 cases of lower gastrointestinal disease. Three major findings of colonoscopy were internal hemorrhoids (64%), colon mass (30%), and inflammatory bowel disease (IBD) (26%). Indications of patient to underwent colonoscopy were hematochezia 38%, chronic diarrhea 19%, chronic constipation 18%, anemia 12%, abdominal pain 6%, screening neoplasia 3% and unexplained weight lost 3%.Conclusion: Hematochezia is the most common indication of patients to underwent colonoscopy at Singkawang and its surrounding districts. The most common finding of colonoscopy was hemorrhoid.

The Prevalence and Factors Associated with Drug-induced Hepatitis in HIV-positive Tuberculosis Patients Gurmeet Singh; Ceva Wicaksono Pitoyo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Introduction: Tuberculosis (TB) have demonstrated a global increase since 1990 along with the increase of world’s population and the transmission of human immunodeficiency virus (HIV). Anti- tuberculosis drugs are very effective, but it may cause drug-induced hepatitis (DIH). The aim of this study was to assess the prevalence and association of several risk factos with the occurence of drug-induced hepatitis in HIV-positive tuberculosis patients. Method: We conducted a retrospective case-control study based on medical records of HIV-positive TB patients who seek medical attention to HIV Referral Center at Cipto Mangunkusumo Hospital between July 2008 and December 2010. Overall, we enrolled 168 medical records with 42 cases and 126 controls. Chi-square and logistic regression test analysis were conducted for analyzing risk factors of drug-induced hepatitis in HIV-positive tuberculosis patients. Results: Drug-induced hepatitis were found in 42 (8.04%) patients.The prevalence of DIH was highest among 35 (25.2%) male patients, aged 35 years old in 32 (26.0%) patients, with albumin level 3.5 g% in 10 (11.2%) patients, body mass index (BMI) 18.5 kg/m2 in 14 (18.4%) patients, CD4+ count 100 cells/mm3 in 29 (24.4%) patients, and those who received rifampicin (R), isoniazid (H), and pirazinamid (Z) regiments for their anti-tuberculosis drugs 24 (31.2%) patients. No risk factors were found to have statistically significant association with DIH. Conclusion: The prevalence of DIH is quite high. Although no risk factor was found statistically significant, but evaluation and liver biochemical examination should be carried out regularly in patients with DIH risk factors. Keywords: drug-induced hepatitis, tuberculosis, human immunodeficiency virus

Diagnostic Tests for Helicobacter pylori Infection Tonny Loho
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200816-23

Helicobacter pylori is a spiral-shaped Gram negative bacterium, has 4-6 flagella, live in microaerophillic condition, has urease, oxidase and catalase enzymes. Helicobacter pylori (H. pylori) infection is etiologically involved in dyspepsia, gastric ulcer, duodenal ulcer, gastric adenocarcinoma and primary gastric B-cell lymphoma. Transmissions of H. pylori is by fecal-oral and oral-oral.4 Diagnostic tests for H. pylori infection can be divided into 2 categories, invasive and non invasive methods. Invasive methods to diagnose H. pylori infection are performed by endoscopy and biopsy. Gastric biopsies are then tested with culture, histologic assessment, urease test and PCR test. Non-invasive methods to diagnose H. pylori infections consist of urea breath test (UBT), 15NH + excretion test, serologic detection of IgG and IgA in the blood, fecal antigen detection and fecal PCR detection. All these tests have its own advantages and limitations. But non-invasive tests have several advantages compared to invasive tests as cheaper, more convenient and easier to perform. To apply these tests accurately, it is very important to understand the principle of the test, how to perform the test, the sensitivity, specificity, positive predictive value, negative predictive value and to recognize all the sources of error which can happen with each test and accurate interpretation. Keywords: Helicobacter pylori infection, diagnostic tests, invasive methods, non-invasive methods

COVID-19 in A Liver Cirrhosis Patient Sasmithae, Lia
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

The COVID-19 pandemic is a novel disease and posed a great challenge in the current healthcare system. The exact impact of the COVID-19 virus on the liver is still unknown. However, in a patient with chronic liver disease, most COVID-19 infections will affect the survival rate and initiate liver decompensation. This study reported a 50-years-old man who complained about bloody vomit and black tarry stool with COVID-19 infection. Physical examination findings included hematemesis, pale conjunctiva, ascites, collateral vein; and from the rectal toucher, there was melena. There was no fever, cough, or shortness of breath. The laboratory and radiological examinations showed that there were normochromic normocytic anemia, hypoalbuminemia, slightly increased ALT/AST, HBsAg (+), and abdominal ultrasound findings were liver cirrhosis with ascites. The patient was screened for the COVID-19 antigen swab test (+), further confirmed by the COVID-19 PCR swab test (+). The treatment given for hematemesis and melena was Gastric Cooling; the patient was fasted, then received somatostatin PPI drip, Vitamin K injection, PRC transfusion, lactulose, ceftriaxone, ascites fluid puncture, and albumin transfusion. After the bleeding resolved, the patient received spironolactone and propranolol. The treatments for COVID-19 were Azithromycin, Favivirapir, Vitamin D, Vitamin K, and Zinc. The patient was hospitalized for 11 days and then improved. Conclusion: This study reported a case of a 50 years-old man with ruptured esophageal varices due to liver cirrhosis with concomitant COVID-19 infection and improved with comprehensive therapy despite the limited facilities at the hospital.

Expression of Hepcidin and Growth Differentiation Factor 15 (GDF-15) Levels in Thalassemia Patients with Iron Overload and Positive Anti Hepatitis C Virus Nuri Dyah Indrasari; Ina Susianti Timan; Pustika Amalia
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 2 (2016): VOLUME 17, NUMBER 2, August 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Thalassemia patients who undergo life-long recurrent blood transfusion will experience iron overload in various organs including the liver and possibly suffer from chronic hepatitis C infection which may lead to liver impairment. The liver produces hepcidin, a hormone which plays role in the regulation of iron level in the blood. Various factors may influence hepcidin level in the blood. Chronic hepatitis C causes iron overload and liver impairment. Liver impairment and haemolytic anaemia due to haemoglobinopathy will suppress hepcidin production. Anaemia stimulates growth differentiation factor 15 (GDF-15) to increase erythropoiesis and suppress hepcidin production. Iron overload causes increase in hepcidin level. Presence of factors which decrease or increase hepcidin production will express various levels of hepcidin. This study aimed to identify the expression of hepcidin and GDF-15 levels in thalassemia patients with iron overload and positive anti-HCV. Information on hepcidin and GDF-15 levels are beneficial in the management of iron overload in thalassemia with positive anti-HCV.Method: This study was a descriptive analytic study in thalassemia patients who had received recurrent blood transfusion ≥ 12 times, suffered from iron overload (transferrin saturation 55% and ferritin 1,000 ng/mL), which consisted of 31 individuals with positive anti-HCV and 27 individuals with negative anti-HCV. This study was performed in Thalassemia Centre Department of Child Health and Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, in October 2011–January 2012. Serum hepcidin and GDF-15 examinations were performed using enzyme-linked immunosorbent assay (ELISA) method. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) examinations were performed using colorimetry method. Data on ferritin and transferrin saturation were obtained from medical records in the last 3 months. Data was analysed using SPSS Windows version 17 software.Results: Characteristics of subjects in this study included ferritin level, transferrin saturation, AST, and ALT were 5,289 (SD 2,492) ng/mL, 96.7 (SD 9.2)%, 41.8 (SD 26.7) U/L, and 50.6 (24.9) U/L, respectively. It was obtained that the hepcidin levels were within the normal limits with median of 51.5 (19-166) pg/mL, while GDF-15 levels were higher than the normal range with median of 1,936 (643-2,475) pg/mL. There was no significant difference of hepcidin and GDF-15 levels between positive and negative anti-HCV groups, with p value of 0.842 and 0.115, respectively.Conclusion: We obtained that the hepcidin levels were within normal limits and GDF-15 levels were higher than the normal range. There was no significant difference of hepcidin and GDF-15 levels between positive and negative anti-HCV group.

Specific Subjective Symptoms for Gastroesophageal Reflux Disease in Ulcer Like Dyspepsia Poerniati Koes Andrijani; Chudahman Manan; Marcellus Simadibrata; Parlindungan Siregar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 5, ISSUE 1, April 2004
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/5120047-14

Background: The Aim of study is to identify specific subjective symptoms for gastroesophageal reflux disease (GERD), GERD proportion in ulcer like dyspepsia and the correlation between specific subjective symptoms for GERD and endoscopic examination Result in ulcer like dyspepsia Methods: A cross-sectional study was conducted in 67 patients with ulcer like dyspepsia. The patient’s history of illness was taken, and physical and endoscopic examinations were performed. A questionnaire on dyspepsia symptoms was completed. Data analysis was performed to identify the correlation between subjective symptoms and endoscopic examination results using chi-square test. T test was performed to determine the correlation between dyspepsia scores and endoscopic results. Result: Subjective symptoms that correlated with endoscopic results were severe epigastric pain (p=0.080) and the absence of bloating (p=0.055). Dyspepsia scores did not correlate with endoscopic examination results (p=0.725). Conclusion: Specific subjective symptoms for GERD in clinical dyspepsia-like ulcer were severe epigastric pain and absence of bloating. The proportion of such symptoms in ulcer like dyspepsia could assist clinical diagnosis of GERD. Keywords: GERD, symptom, dyspepsia

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Murdani Abdullah

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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Murdani Abdullah

Contact Email ina.jghe@gmail.com

Phone +6285891498517

Journal Mail Official ina.jghe@gmail.com

Editorial Address Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Murdani Abdullah

Contact Email
ina.jghe@gmail.com

Phone
+6285891498517

Journal Mail Official
ina.jghe@gmail.com

Editorial Address
Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA