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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
 1 
Search results for , issue "Vol. 5 No. 1 (2020)" : 7 Documents clear
Plant cyanogenic glycosides: an overview Dwi Hartanti; Arinda Nur Cahyani
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.10047

Abstract

The cyanogenic glycosides have consisted of α-hydroxy nitrile aglycone and a sugar moiety that producing hydrogen cyanide (HCN) during the hydrolysis process. This HCN-producing property underlines the toxicity of the plants commonly associated with these compounds in humans and animals. However, new evidence shows that the toxicity of these compounds is lower than those theoretically caused by the equivalent released HCN. In order to provide a deeper understanding of cyanogenic glycosides, an overview of these compounds is given in this article. It covers the chemistry, distribution, biosynthesis, toxicity, determination, as well as extraction and isolation of the compounds. 
Knowledge of sunlight exposure toward obesity in geriatric Amelia Lorensia; Rivan Virlando Suryadinata; Nurul Fitrianingsih
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.11454

Abstract

Indonesia gets good sun exposure every year. Sunlight is a major source of vitamin D., but studies show that tropical countries still have a high prevalence of vitamin D deficiency. Geriatrics and obesity are some of the factors that can lead to vitamin D deficiency. Lack of information and knowledge about the effects of vitamin D deficiency, concerns about skin cancer from sunburn, and some current trends that want white skin cause them to limit sun exposure. Based on the high prevalence of geriatric and obesity data in Indonesia and the decline of functional status in geriatrics, which is a person's ability to perform daily physical activity, thus limiting himself to outdoor physical activities to expose the sun. Researchers conducted research to see the knowledge of sun exposure. This study was conducted to analyze vitamin D deficiency risk factors by the cross-sectional method to 88 obesity geriatrics and 88 non-obesity geriatrics based on knowledge of sun exposure. Test the risk factor aspects of knowledge using the odds ratio. The result of the odds ratio test of the knowledge aspect is 0.725, so it can be concluded that good knowledge of sun exposure has the same risk in both groups of respondents (obesity and non-obesity).
The relationship of self-stigma with the quality of living people with HIV/AIDS (PLWHA) in WPA Turen District Dani Kurniawanto; Tri Nurhudi Sasono; Galuh Kumalasari
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.12657

Abstract

Stigma is something that unacceptable or usually condescending and degrading. Stigma and discrimination cause inhibition of HIV/AIDS prevention and treatment in the community, thus impacting psychologically and decreasing the quality of life of PLWHA. To find out the relationship between self-stigma and the quality of life of people living with HIV/AIDS (PLWHA), a study in the AIDS Concerned Residents (ACR) District of Turen. It uses a correlational analytic design with a cross-sectional approach. The number of respondents is 22 PLWHA in Turen Concerned Residents (ACR), and methods of sampling in this study are using a purposive sampling technique. From 22 respondents, the result of self-stigma on PLWHA was low, with a percentage (54.5%) and the quality of life of PLWHA living in ACR Kec. Turn is excellent, with a percentage (54.5%). The results of statistical tests show that the value of p = 0.108 and the significance level of 0.05 also obtained p > 0.05, meaning that there is no significant relationship between self-stigma and the quality of life of PLWHA. This study shows that there is no significant relationship between self-stigma and the quality of life of PLWHA. With the existence of ACR, people and HIV-AIDS sufferers in Turen District have started to eliminate existing stigma and have a good quality of life.
The effect of additional therapy of Curcuma longa and Boswellia serrata on NSAIDs on functional activity in osteoarthritis patients Rizaldy Taslim Pinzon; Jessica Herwanto
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.12677

Abstract

Osteoarthritis (OA) is a chronic disease that causes joint pain, stiffness, and swelling. The knee is the most affected joint in osteoarthritis. A typical therapy that often used for osteoarthritis patients is NSAIDs, but a previous study showed that satisfactory pain control could not be achieved with NSAIDs alone, so that additional analgesic therapy is needed. Some previous studies showed the extracts of Curcuma longa and Boswellia serrata were promising in reducing pain and do not cause serious side effects in osteoarthritis patients. This research aims to measure the effect of additional therapy Curcuma longa and Boswellia serrata to NSAIDs on functional activities in knee osteoarthritis patients. The type of this research is cross-sectional, involving 71 patients. This study uses secondary data taken from previous RCT studies by completing questionnaires to determine the WOMAC score of osteoarthritis patients at Bethesda Hospital and Panti Rapih Hospital in Yogyakarta. Data were analyzed statistically using the licensed SPSS program with the Wilcoxon test and the Mann-Whitney test. The reduction of WOMAC scores was superior in the NSAIDs group with Curcuma longa and Boswellia serrata after being given therapy for four weeks but not significant (p = 0.372). The giving of additional therapy Curcuma Longa and Boswellia serrata to NSAIDs is not superior compared to NSAIDs in increasing functional activities in osteoarthritis patients. 
Formulation and evaluation of hand sanitizer gel containing infused of binahong leaf (Anredera cordifolia) as antibacterial preparation Dyah Rahmasari; Esti Hendradi; Uswatun Chasanah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13008

Abstract

Hand sanitizer gel is one of the alternative methods for hand hygiene when soap and water are not available. Binahong leaf (Anredera cordifolia) is a natural herb that has phenolic, flavonoids, saponins, and the steroid-terpenoids compound, which is potentially used as the active ingredient in the hand sanitizer gel. The primary purpose of this research was to determine the antibacterial potential and physicochemical properties of a hand-sanitizer gel containing binahong leaves’ infusion against Staphylococcus aureus. The efficacy of this formulation was tested against a bacterial strain using the disc diffusion method and determined by measuring the inhibition zone of each preparation. The testing of physicochemical properties includes the organoleptic test, pH, viscosity, and gel spreadability. The physicochemical characteristics of the gel showed excellent properties for all formulas. The antibacterial test showed that hand sanitizer gel containing an infusion of binahong’s leaves has an inhibition zone (6.02 mm; 6.24 mm; 6.55 mm), almost close to a positive control (9.15 mm). In conclusion, the formulated hand sanitizer gel possesses the antibacterial potential to inhibit S. aureus.
In vitro testing of emulgel with a combined extract of Sansevieria trifasciata Prain. and Curcuma longa Linn. against the Candida albicans Uswatun Chasanah; Ayudya Rizky Permatasari
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13185

Abstract

Content of flavonoids in Sansevieria trifasciata Prain. and curcumonoids in Curcuma Longa Linn. can inhibit the growth of the fungi Candida albicans in the wound. An innovative formulation was made that form a combination of antifungal extracts S. trifasciata and C. longa in the form of emulgel, which is easy to absorb and can moisturize the skin. The purpose is to determine the effect of antifungal activity of emulgel preparations using S. trifasciata extract with a concentration of 0%; 5%; and 10%, and C. longa 10% against C. albicans. S. trifasciata and C. longa extracts are formulated into emulgel in three formulas, F1 (C. longa 10%); F2 (S. trifasciata 5%; C. Longa 10%); and F3 (S. trifasciata 10%; C. Longa 10%). Antifungal activity was tested using the diffusion well method. The results of antifungal activity research showed inhibition zone diameter, inhibitory activity, and effectiveness. There were no significant differences in formula 1, formula 2, formula 3, but there were significant differences with positive controls. Variation the concentration of S. trifasciata 5% and 10% has no significant effect on the inhibitory zone of the C. albicans, but the three emulgel of S. trifasciata and C. Longa extract had antifungal activity on the growth of C. albicans.
Evaluation of variations in the response of hypertensive patients in the outpatient installation of the UPT Puskesmas, Babat Lamongan District Primanitha Ria Utami; Riana Prastiwi Handayani; Sheila Sheila
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13956

Abstract

Hypertension has long been a health problem that can have severe impacts on society. Measurement of blood pressure is one of the determinants of antihypertensive treatment's success, which can be seen from the reduction in the patient's blood pressure towards achieving the target blood pressure. Less than optimal blood pressure control is the most common risk factor for CVD and cerebrovascular disease. The role of the selection of antihypertensive therapy in each patient's condition is individual. Each patient will vary in response to various types of antihypertensive treatment. The research design carried out was retrospective descriptive with the observation of variations in answer to the use of antihypertensives in outpatient hypertension patients at the Babat Health Center with an examination period from January to December 2019. The study was divided into two groups, namely the positive and negative response groups. Patient characteristics data (age, sex, and treatment regimen) were statistically tested with the chi-square test to see whether there was a difference in eating or not between the two groups. It is said a positive response if the patient's blood pressure has decreased after three months of using antihypertensives. Harmful if after three months of antihypertensive use, there is no change in blood pressure or increased blood pressure. The evaluation was carried out on patients with negative responses, what factors were the causes. The results of patient characteristics, p> 0.05, were not significant differences between the two groups. There are variations in the negative response caused by the therapy regimen that is not optimal, lifestyle, and metabolism of antihypertensive drugs that are different for each individual.

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