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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
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Search results for , issue "Vol. 6 No. 1 (2021)" : 7 Documents clear
Health-related quality of life: chronic kidney disease patients in Riau Ferdy Firmansyah; Tiara Tri Agustini
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.14806

Abstract

Chronic Kidney Disease (CKD) can have an impact on quality of life which affects physical, mental health, functional status, and independence. The high prevalence of CKD will have an impact on the quality of life. The purpose of this study was to see the effect of the characteristics of CKD patients on the utility index score and to determine the dimensional correlation to the utility value measured using the SF-6D questionnaire. The study was conducted with an observational approach using a cross-sectional design in the CKD population in the city of Pekanbaru. The SF-6D questionnaire was administered to 122 patients to measure utility index scores. The difference in utility index scores based on patient characteristics was tested using Mann Whitney and Kruskal Wallis, while the correlation between domains and utility scores was used Pearson Correlation 0.61 ± 0.07. Score utility measured using the SF-6D instrument can distinguish utility values ​​based on education and comorbidities. There is a strong correlation (> 0.797) between vitality and mental domains with the SF-6D utility index.
Antihyperlipidemic activity and mechanism test of cashew nut shell extract in male wistar rat induced by high-cholesterol foods Era Rahmi; Poppy Dharsana
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.15077

Abstract

Nutshell is a waste of cashew nuts product which is known to contain phytosterols was tested as an antihyperlipidemic agent with two methods:  induction of hyperlipidemia and inhibition of cholesterol absorption method. In induction of hyperlipidemia, animals were induced using high cholesterol foods and induction agents (cholesterol, cholic acid, and propylthiouracil). After that were treated using simvastatin and cashew nut shell extract. Total cholesterol value was measured periodically after therapy, then aorta was isolated to examine the histology of aorta. In inhibition cholesterol absorption method, rats were given PTU and then were given ezetimibe and extracted orally. After that, all the animals were induced with exogenous cholesterol. Cholesterol level in the serum and feces was measured as well as to see the effects of inhibition of cholesterol absorption. For hyperlipidemia induction method, extract had different significance compared to the control group after 8 weeks of therapy. Atherogenic index of plasma (IAP) values of low-dose extract and high dose extract was significantly different compared to the control group. Histology of rats aorta for extract was significantly different in thickness compared to the control group. In the inhibition of cholesterol absorption method, extract 250mg/kg bw (group EKBKM 250) and 500  mg/kg bw (group EKBKM 500) inhibit the increase of total blood cholesterol within one hour after  induction and significantly different compared to the control group. N-hexane extract cashew nut shells 500mg/kg have antihyperlipidemic effects, one of them is inhibition of cholesterol absorption.
Analysis of BPJS patient satisfaction levels against pharmaceutical services in outpatient pharmacy installation of Anwar Medika Hospital Ahmad Zulfikar Badri; Khurin In Wahyuni; Puspita Raras Anindita
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.13862

Abstract

Good pharmaceutical services are directly oriented in using drugs, aiming to ensure the safety, effectiveness, and rationality of drug use by applying science and function in patient's care. Patients who have insurance are also entitled to get good service or quality, one of the government's insurance, namely BPJS. This study analyzes patient satisfaction with services seen from 5 dimensions, namely the dimensions of reliability, responsiveness, assurance, empathy, and tangibility. This research is an observational type with the cross-sectional method and was carried out by purposive sampling. Data collection was carried out in March-April 2020 using a questionnaire. Data analysis was carried out descriptively by comparing the satisfaction and expectation values ​​, which were then related to the range value to obtain the patient's satisfaction level. The results of this study of 51 respondents obtained an average level of satisfaction value of 0.85 (high) from the five dimensions, namely reliability of 0.86 (high), the responsiveness of 0.68 (sufficient), assurance of 0.90 (high), empathy is 0.94 (high), and reality is 0.91 (high).
Analysis of antioxidant activity of carrots (Daucus carrota L.) using FRAP and CUPRAC methods Aprilya Sri Rachmayanti; Nurmaya Effendi; Andi Muflihunna
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.13981

Abstract

Carrot antioxidant activity analysis has been carried out. Carrot juice was analyzed qualitatively by the FRAP method using FRAP reagent and by the CUPRAC method using copper (II) chloride solution, neucuproine solution, ammonium acetate buffer solution, and distilled water. Quantitatively, the mixture of sample solutions using the FRAP and CUPRAC methods was analyzed using a UV-Vis spectrophotometer at a wavelength of 596 nm for the FRAP method and 452 nm for the CUPRAC method, using Trolox solution as the standard curve. The results obtained were that each sample A and B's antioxidant activity using the FRAP method was 0.5186 µM TR/g and 0.8857 µM TR/g samples. Meanwhile, samples A and B's antioxidant activity using the CUPRAC method was 0.1160 µM TR/g sample and 0.1762 µM TR/g sample.
Behavioral factor analysis of the accuracy in using gastritis drugs at the Puskesmas Arjuno in Malang City with the Health Belief Model (HBM) approach Firdha Julianty Sukma; Ika Ratna Hidayati; Liza Pristianty
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.14173

Abstract

This study aims to analyze the behavioral factors according to the Health Belief Model (HBM) theory, which affects the accuracy in using gastritis drugs at Arjuno Health Center, Malang City. This research is a non-experimental study with an analytical observational research design. The instrument used a valid and reliable questionnaire. There were two variables used, the independent variables, namely the factors of the theory of the HBM (Perceived susceptibility, Perceived severity, Perceived Benefits, Perceived barriers, and Self Efficacy), and the dependent variable is the proper usage of gastric drugs. The number of samples used int this study was 80 respondents. The regression test results on each factor of HBM theory on the accuracy of using gastritis drugs (p < 0.05) means significantly affected the accuracy of using gastritis drugs except for perceived barriers, which is a significant value of 0.301 > 0.05. This result is relevant to the theory which states that the higher perceived barriers, the correct use of drug will be lower. Then for the Anova test, all independent variables were tested with the dependent variable and the results  means that there is an influence between the HBM theory and the accuracy of using gastritis drugs. If measured simultaneously, factors from the HBM affect the accuracy in using gastritis drugs with a significant effect of 64.9%.
Comparison of blood pressure reduction between treatments of steeping red ginger rhizome (Zingiber officinale R.) and steeping binahong leaves (Anredera cordifolia (Ten.) Steenis) in healthy people with hypertension risk Djelang Zainuddin Fickri; Arista Wahyu Ningsih; Martina Kurnia Rohmah; Khurin In Wahyuni; Novita E. Winarni; Pahri
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.16304

Abstract

The potency of red ginger rhizome (Zingiber officinale R.) and binahong leaves (Anredera cordifolia (Ten.) Steenis) has been known to have an antihypertensive effect and can be used in herbal medicine. This study compared the impact of steeping red ginger rhizome and steeping binahong leaves on blood pressure reduction in healthy people with hypertension risk. The research design is a Comparative Quasy Experiment to measure pre-test and post-test blood pressure on treating 3 gr/200 ml steeping the red ginger rhizome (S1) and 3 gr/200 ml steeping binahong leaves (S2). The number of respondents was 64 according to the inclusion criteria and had obtained ethical clearance. The data were processed statistically. The experiment showed that the S1 group had a significant difference in systolic blood pressure reduction compared with the control treatments, but there was no significant difference in diastolic blood pressure reduction compared with controls. Meanwhile, in the S2 group, there was a significant difference in systolic blood pressure reduction compared with the control treatments, but there was no significant difference in diastolic blood pressure reduction compared with controls. Between the treatment of S1 and S2, there was no significant difference in systolic blood pressure reduction, which means that both red ginger and binahong seed had the same effect on systolic blood pressure. Treatment of steeping red ginger rhizome and steeping binahong leaves has a similar effect on systolic blood pressure reduction.
Cost-effectiveness of esomeprazole and pantoprazole as prophylaxis stress-related mucosal disease therapy in Intensive Care Unit Ferina Damayanti; Endang Darmawan; Setiawan Didik
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

High risk of bleeding in a patient with a critical condition in an Intensive Care Unit (ICU) resulting requirement use needs prophylaxis for decrease bleeding incident during ICU is entirely accurate. This research is to determine the cost and effectiveness of esomeprazole and pantoprazole as Stress Related Mucosal Disease (SRMD) in the hospital ICU in Surakarta. This research is a retrospective cohort study. The subject is about all inpatients in ICU with the age of 18 to 65 who get esomeprazole and pantoprazole as stress ulcers prophylaxis during December 2016 – December 2018 that meets the criteria inclusion and exclusion criteria. Subjects on this research are 166 patients, where each group esomeprazole therapy (83 patients) and pantoprazole (83 patients). The effectiveness of treatment was observed based on the minor and major bleeding. Furthermore, the cost of therapy is calculated based on the total price paid by the patient for prophylaxis therapy on SRMD and treatment bleeding SRMD that count as Incremental cost-effectiveness ratio (ICER) value. The research result shows that no real difference between patients treated with esomeprazole (88%) and pantoprazole (80,7%) as prophylaxis therapy SRMD (p = 0.286). The use of esomeprazole can save money by IDR 13,456,368.00 (ICER) compared to pantoprazole for each cost reduction in the event of bleeding.

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