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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Kesehatan Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Majalah Farmaseutik Jurnal farmasi UIN Alauddin Makassar Jurnal Kesehatan Tambusai Jurnal Kesehatan Saintika Meditory Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Pharmaceutical Reports
Nurmaya Effendi
Fakultas Farmasi Universitas Muslim Indonesia, Makassar
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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IDENTIFIKASI AKTIVITAS IMUNOGLOBULIN M (IG.M) EKSTRAK ETANOLIK DAUN CEPLUKAN (Physalis Minima Linn.) PADA MENCIT Effendi, Nurmaya; Widiastuti, Harti
Jurnal Kesehatan Vol 7, No 2 (2014): Jurnal Kesehatan
Publisher : Kesehatan Masyarakat UIN Alauddin Makassar

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Abstract

Sistem imun adalah sistem yang sangat penting bagi tubuh untuk menghindari dan melawan berbagai penyakit (Abbas et al, 2007). Keseimbangan sistem imun dapat dipengaruhi oleh faktor internal dalam tubuh dan faktor eksternal yang perlu dipertahankan untuk menjaga tubuh agar tetap sehat (Ma’at, 2010). Sistem imun ini berkaitan erat dengan adanya antibodi. Antibodi merupakan protein immunoglobulin yang disekresi oleh sel B yang terfiksasi oleh antigen. Tanaman ceplukan (Physalis minima Linn.) termasuk famili Solanaceae merupakan tanaman yang tidak banyak diketahui orang bahwa dapat menyembuhkan berbagai penyakit. Tujuan penelitian ini adalah untuk mengetahui kemampuan ekstrak etanol daun ceplukan (Physalis minima Linn.) untuk meningkatkan aktivitas IgM.Daun ceplukan kering dimaserasi dengan etanol. Ekstrak etanolik cair yang diperoleh dikentalkan dengan rotavavor dan kemudian disuspensikan dengan Na-CMC sebagai pembawa. Ekstrak diberikan secara oral kekelompok mencit uji dengan menggunakan kontrol negatif Na-CMC dan selanjutnya diimunisasi dengan suspensi sel darah merah domba secara intraperitonial dan setelah lima hari selanjutnya darah mencit diambil secara intrakardial. Darah mencit selanjutnya digumpalkan, serumnya lalu diencerkan dengan PBS dan diuji lagi dengan sel darah merah domba, dan setelah diinkubasi selanjutnya diamati pengenceran tertinggi darah yang dapat mengaglutinasi sel darah domba.Hasil penelitian menunjukkan bahwa ekstrak etanolik daun Ceplukan (Physalis minima Linn.) konsentrasi 4%, 8% dan 12% b/v dapat meningkatkan aktivitas Ig.M dengan titer imunoglobulin rata-rata masing-masing sebesar 1/32, 1/128 dan 1/64 sedangkan kelompok perlakuan kontrol, rata-rata titer imunoglobulinnya hanya 1/8. Kata Kunci : sistem imun, antibiotik, ceplukan, IgM
ANALISIS KADAR PENGAWET NATRIUM BENZOAT PADA PRODUK MINUMAN BERKARBONASI DENGAN METODE HPLC Rahmawati, Rahmawati; Kosman, Rachmat; Effendi, Nurmaya; Ismayani, Nur
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

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Abstract

It has been worked a research about the analysis of sodium benzoate content of carbonated beverages which is in Makassar market using High Performance Liquid Chromatography (HPLC) reverse phase. In this research, the analysis was conducted on four brands of carbonated beverages products. The results of analysis are sample A contains 47,6907 mg/kg, sample B 152,9348 mg/kg, sample C 271,4082 mg/kg, and sample D 357,3797 mg/kg of sodium benzoate. The four samples appropriate Permenkes No. 722/Menkes/Per/IX/1988 are <600 mg/kg.  Key words : Natrium Benzoate, HPLC, Carbonated Beverages
Radiolabeled curcumin as β amyloid imaging and tumor targeting imaging agents Nurmaya Effendi
Jurnal Fitofarmaka Indonesia Vol 8, No 3 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i3.708

Abstract

Curcumin, a polyphenolic compound, derived from the rhizomes of Curcuma longa L. Curcumin shows potential pharmacological action against numerous disorders, including cancer, neurodegenerative, and infection diseases. Curcumin-based molecular imaging agents could be useful for early detection of Alzheimer Disease and tumor and monitor the progress of therapy. Radiolabeled curcumin and its derivatives become promising compounds as imaging agents. In this review, radiolabeled curcumin bearing radionuclides including fluorine-18, Technetium-99m, Iodine-125, and Gallium-68 are reviewed as an effort to develop curcumin-based probes not only for β amyloid imaging but also for tumor imaging.
ANALISIS AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK DAUN YODIUM (Jatropha multifida L.) DENGAN METODE CUPRIC ION REDUCING ANTIOXIDANT CAPACITY (CUPRAC) St Maryam; Randi Pratama; Nurmaya Effendi; Tadjuddin Naid
Jurnal Fitofarmaka Indonesia Vol 2, No 1 (2015): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (606.636 KB) | DOI: 10.33096/jffi.v2i1.185

Abstract

The research had been conducted about the analysis of antioxidant activity of yodium (Jatropha multifida L.) leaves using cupric ion reducing antioxidant capacity to determine the existance of antioxidant activity and to measure the antioxidant capacity in yodium (Jatropha multifida L.) leaves ethanolic extract using CUPRAC method. It was experimental research using CUPRAC method to prove the existance of antioxidant activity of yodium (Jatropha multifida L.) leaves. It was started by extracting the leaves using maseration using ethanol 96% solvent. The resulted extracts were analyzed quantitatively and qualitatively by adding CuCl2 solution, neucuproin, NH4Ac buffer system which were measured in UV-Visible spectrophotometer and analyzed at a wavelength of 450 nm. Based on data analysis, it was found that the askorbat acid equivalent (AAE) presentage of yodium (Jatropha multifida L.) leaves was 0.7385 ± 0.0521 mg L-1 AA g-1 extract.
Analysis of antioxidant activity of carrots (Daucus carrota L.) using FRAP and CUPRAC methods Aprilya Sri Rachmayanti; Nurmaya Effendi; Andi Muflihunna
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.13981

Abstract

Carrot antioxidant activity analysis has been carried out. Carrot juice was analyzed qualitatively by the FRAP method using FRAP reagent and by the CUPRAC method using copper (II) chloride solution, neucuproine solution, ammonium acetate buffer solution, and distilled water. Quantitatively, the mixture of sample solutions using the FRAP and CUPRAC methods was analyzed using a UV-Vis spectrophotometer at a wavelength of 596 nm for the FRAP method and 452 nm for the CUPRAC method, using Trolox solution as the standard curve. The results obtained were that each sample A and B's antioxidant activity using the FRAP method was 0.5186 µM TR/g and 0.8857 µM TR/g samples. Meanwhile, samples A and B's antioxidant activity using the CUPRAC method was 0.1160 µM TR/g sample and 0.1762 µM TR/g sample.
VALIDASI METODE PENETAPAN KADAR GABAPENTIN TERDERIVATISASI SECARA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DAN APLIKASINYA DALAM SEDIAAN KAPSUL Nurmaya Effendi
As-Syifaa Jurnal Farmasi Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i1.122

Abstract

Gabapentine, is a new antiepileptic drug which has a structural analogue of neurotransmitter γ-aminobutyric acid (GABA). Gabapentine inhibits calcium uptake of gated calcium channels presinaps in the brain. This research aimed to develop and validate a new HPLC method with UV detection for determination of gabapentine in capsule. The method is based on the reaction of gabapentine with 1-fluoro-2,4-dinitrobenzen (FDNB) in acetonitrile which carried out in the presence of borate buffer (pH = 9,5) at 65oC for 20 minutes, which formed a yellow colored product with the absorption at 367 nm. The product was separated by HPLC using A Zorbax ODS (Agilent) column (250 x 4.6 mm, 5 µm) was utilized as stationary phase and 50 mM acetate buffer (pH 3.7) : methanol : acetonitril (25 : 30 : 45 v/v/v) as mobile phase, with flow rate 0.8 mL/min, and the detection at 367 nm.The purposed method was validated by means of accuracy, precision, linearity, selectivity, LOD and LOQ, and the complied with the requirement for validity. The method has been succesfully applied for the determination of gabapentine in capsule with LOD = 1.05 µg/mL and LOQ = 3.49, linear quantitative response curve was generated over a concentration range of 3.49 - 100 µg/mL with the correlation coefficient of 0.99996 and recovery range of 97.27 – 104.24% with RSD 2.63%.Keywords : gabapentin, FDNB, HPLC, validation
UJI KOEFISIEN FENOL FORMULASI DESINFEKTAN DENGAN VARIASI KONSENTRASI BENZALKONIUM KLORIDA Nurmaya Effendy
As-Syifaa Jurnal Farmasi Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i2.94

Abstract

A research on The Phenol Coefficient Test Formulation of Disinfectant with vary Concentration Of Benzalkonium Chloride to microorganisms test Salmonella thyposa and Staphylococcus aureus ATCC 25922 has been done. This research was conducted to know concentration of  solution disinfectant with certain dilution which effective to destroy the pathogen microorganisms. Microbiology’s test was done with dilution methods to know dilution lower which can delay the growth of test microorganisms and Coefficient Phenol methods (Rideal-Walker Test) to know dilution of disinfectant which concentrate on five variations such as benzalkonium chloride, 0.05%; 0.1%; 0.2%; 0.4%; 0.8%, with used NB media (Nutrient Broth) which incubated for 2 x 24 hours. Result of research show that count of phenol coefficient every that concentration of Benzalconium chloride are 0.4; 0.8; 1.4; 2.2; 5.4 for Salmonella thyposa and 0.4; 0.8; 1.6; 5.4; 11.8 for Staphylococcus aureus ATCC 25922. Because count of coefficient phenol are large than 0.05 according to the appointment of Ditjen POM, and then formula which standarized can as desinfectant. From dilution and properties of antimicrobe, that benzalkonium chloride 0.8% with dilution 1:108 that is very effective to two that pathogen bacteries to be as an used active agent disinfectant floor cleaner.Keywords : Phenol coefficient test, benzalkonium chloride, disinfectant, floor cleaner
ISOLASI DAN KARAKTERISASI SENYAWA BIOAKTIF EKSTRAK DIETIL ETER DAUN MIANA (Coleus scutellarioides (L) Benth) YANG AKTIF TERHADAP BEBERAPA MIKROBA UJI Nurmaya Effendi
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.110

Abstract

Has been conducted research Isolation and characterization of compounds Bioaktif Leaf Extract Diethyl Ether Miana (Coleus scutellarioides (L) Benth) is active against some microbes Test. Maceration extraction is done with diethyl ether. Diethyl ether extracts obtained isolated by method column chromatography with using silica gel as absorbent and hexane-ethyl acetate as dilution fluid, and obtained six fractions. Fraction III-9 was isolated by Preparatif Thin Layer Chromatography (KLTP) and obtained ten tapes.Isolates fraction III-9 identified by chemical reaction with ammonia vapor, aluminum chloride and boric citro, and showed a positive reaction to the flavonoid class of compounds. Data ultraviolet-visible spectroscopy showed a maximum wavelength of 420 nm, while the infrared spectroscopy showed the existence of functional groups - C = C -; - OH; - CH3; and - CH - alifatis and - CH - aromatic. Isolates fraction III-9 with KLT-bioautgraphy was active against  microbial testing Staphylococcus aureus, Candida albicans and Salmonella thyposaKey Words : Leaf Extract Diethyl Ether Miana, Maceration, KLT-Bioautography
ANALISIS KANDUNGAN LOGAM BERAT MERKURI (Hg) DAN TIMBAL (Pb) PADA KOSMETIK LIPSTIK YANG BEREDAR DI KOTA MAKASSAR DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Nurmaya Effendi; Mamat Pratama; Husna Kamaruddin
As-Syifaa Jurnal Farmasi Vol 6, No 1 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.114 KB) | DOI: 10.33096/jifa.v6i1.36

Abstract

Lipstick is a lip cosmetic that almost every day is used by the most women. Lipstick should be safe and does not contain hazardous materials as it can go ingested with food or drink consumed. One of hazardous contaminants in lipstick is contained heavy metals, such as lead and mercury. Based on these considerations, the cosmetic lipstick should be safe and do not contain harmful ingredients, One of the parameters to determine the lipstick cosmetics are safe or not from the content of the metals in contained. To determine the metals Pb and Hg contamination in cosmetics lipsticks do research by doing destruction samples and proceed with the analysis of the metal content using atomic absorption spectrophotometry. The results showedthat inallfour samplesstudiedlipstickall containmercury(Hg) levelseachwithA0.0460 µg/g, B0.0425 µg/g, C0.0345 µg/g, andD0,0431 µg/g, as wellasfor lead(Pb) levelseachwithA6.1628 µg/g, B3.5041 µg/g, C56.6496 µg/g, andD6.0324 µg/g.
Pengembangan dan Profil Farmakokinetik Senyawa Turunan Pirazolo-(3,4-D)-Pirimidin Sebagai Inhibitor Mer Secara Insilico Nursalam Hamzah; Nurmaya Efendi; Muh. Hidayat
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 2 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i2.2207

Abstract

The Mer receptor is an important target for development of molecular probes in oncology because just expressed by T cell Acute Leukemia Lymphboblastic and not expressed by T-cell normal and a ATP kinase competitive inhibitor. The purpose of this research is development derivate Pyrazolo-[3,4-D]-pyrimidin then choose candidate active and selective chemicals for Mer receptor to be a treatment for acute leukemi lymphoblastic by insilico. Procedures are began with modelingand geometry optimization of molecular structure which made by HyperChem 8.0. Geometry optimization was performed by Ab initio method. QSAR descriptors were calculated by MOE 2009. The next step is determine pharmacokinetic profile with AdmetSAR and DemPred. Based on pharmacokinetic predictions overall koefisian compounds have the same choice 1.0000 on human intestinalabsorption can be absorbed properly. the most well permeabiltas Caco2 cells are compounds 008 and 115. Compounds 008 and 115 also has the lowest coefficient on thepenetration of blood brain barrier. Compounds 008 and 115 have the smallest volume of distribution is 2.400352 L / kg means that the volume of the compounds 008 and 115.Compounds with the best clearance of compounds 001 and 111 with a clearan  of 2.058811 ml / min / kg.
Co-Authors Andi Muflihunna Aprilya Sri Rachmayanti Aulia Fikriyani Hamka Aulia Fikriyani Hamka Dewi Yuliana Hamsinah Hamsinah Harti Widiastuti Hasnaeni Hasnaeni Husna Kamaruddin Kasmah Kasmah Mamat Pratama Muh. Hidayat Muzakkir Baits Nur Ismayani, Nur Nursalam Hamzah Rachmat Kosman, Rachmat Rahmawati, Rahmawati Randi Pratama St Maryam St. Maryam Sulfiani Sulfiani Sulfiani Sulfiani Syabrina Salsabilah Gili Tadjuddin Naid