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UPT Publikasi Ilmiah, Universitas Islam Bandung. Jl. Tamansari No. 20, Bandung 40116, Indonesia, Tlp +62 22 420 3368, +62 22 426 3895 ext. 6891
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Bandung Conference Series: Pharmacy
Published by Universitas Islam Bandung
ISSN : -     EISSN : 28282116     DOI : https://doi.org/10.29313/bcsp.v2i2
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Bandung Conference Series: Pharmacy (BCSP) menerbitkan artikel penelitian akademik tentang kajian teoritis dan terapan serta berfokus pada Farmasi dengan ruang lingkup Airlock system Kanker, Alcohol, Antelmintik, Antigastritis drugs, Antioksidan, Artemia franciscana, Ascaris suum, Cacing babi (Ascaris suum Goeze), Contact Bioautography TLC, Daun cincau hijau (Cyclea barbata Miers), Daun kelor (Moringa oleifera Lam), Diabetes mellitus, DPPH Flavonoid, Fenilpropanolamin, Fermentasi, Flavonoid, Flavonol,Iles-iles, Isolasi, Lichen, Malassezia furfur, Metode Brine Shrimp Lethality Test (BSLT), Obat antidiabetes (OAD) Propionibacterium acnes, Obat tradisional, Parkia Speciosa Antibakteri, Pektin, Propionibacterium Acnes, Pseudoefedrin, Saccharomyces Cerevisiae, Spektrofotometri uv sinar tampak, Staphylococcus epidermidis, uji aktivitas antibakteri, Uji sitotoksik, Usnea baileyi. Prosiding ini diterbitkan oleh UPT Publikasi Ilmiah Unisba. Artikel yang dikirimkan ke prosiding ini akan diproses secara online dan menggunakan double blind review minimal oleh dua orang mitra bebestari.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 1 Documents
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Search results for , issue "561 - 570" : 1 Documents clear
Studi Literatur Potensi Ekstrak Jahe Merah sebagai Agen Antiinflamasi Jihram Achmad Fauzi Febrian; Budi Prabowo Soewondo; Ratih Aryani
Bandung Conference Series: Pharmacy 561 - 570
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25204

Abstract

Abstract. Inflammation is a physiological response to tissue injury or infection; however, prolonged inflammation contributes to the development of various chronic diseases. Long-term use of conventional anti-inflammatory drugs is associated with adverse effects, prompting the exploration of natural products as alternative therapeutic agents. Red ginger (Zingiber officinale var. rubrum) is a medicinal plant rich in bioactive compounds with promising anti-inflammatory properties. This study aimed to evaluate the potential of red ginger extract as an anti-inflammatory agent based on its phytochemical constituents, molecular mechanisms, and biological efficacy reported in previous studies. A literature review was conducted following the PRISMA guidelines by searching articles from PubMed, Scopus, ScienceDirect, SpringerLink, Wiley Online Library, and Google Scholar. The collected data were analyzed using a narrative synthesis approach. The findings demonstrated that major bioactive compounds, including 6-gingerol, 6-shogaol, paradol, and zingerone, suppress inflammatory pathways such as NF-κB, MAPK, and PI3K/Akt, reduce the expression of COX-2, iNOS, TNF-α, IL-1β, and IL-6, and enhance antioxidant defense through the Nrf2/HO-1 pathway. Evidence from in vitro, in vivo, and clinical studies indicates that red ginger effectively attenuates inflammatory responses. Therefore, red ginger extract has considerable potential as a phytopharmaceutical candidate for anti-inflammatory therapy, although further extract standardization and clinical studies are required. Abstrak. Inflamasi merupakan respons fisiologis tubuh terhadap cedera atau infeksi, namun inflamasi yang berlangsung berkepanjangan dapat memicu berbagai penyakit kronis. Penggunaan obat antiinflamasi konvensional dalam jangka panjang diketahui berpotensi menimbulkan efek samping sehingga mendorong pengembangan bahan alam sebagai alternatif terapi. Jahe merah (Zingiber officinale var. rubrum) merupakan tanaman obat yang kaya senyawa bioaktif dan berpotensi sebagai agen antiinflamasi. Penelitian ini bertujuan mengkaji potensi ekstrak jahe merah sebagai agen antiinflamasi berdasarkan kandungan fitokimia, mekanisme molekuler, serta efektivitasnya berdasarkan berbagai penelitian. Metode yang digunakan adalah studi literatur dengan mengacu pada pedoman PRISMA melalui penelusuran artikel dari PubMed, Scopus, ScienceDirect, SpringerLink, Wiley Online Library, dan Google Scholar. Data dianalisis menggunakan metode sintesis naratif. Hasil kajian menunjukkan bahwa senyawa utama jahe merah, seperti 6-gingerol, 6-shogaol, paradol, dan zingerone, mampu menghambat jalur NF-κB, MAPK, dan PI3K/Akt, menurunkan ekspresi COX-2, iNOS, TNF-α, IL-1β, IL-6, serta meningkatkan aktivitas antioksidan melalui jalur Nrf2/HO-1. Berbagai penelitian in vitro, in vivo, dan uji klinis menunjukkan efektivitas jahe merah dalam menekan respons inflamasi. Dengan demikian, ekstrak jahe merah berpotensi dikembangkan sebagai kandidat fitofarmaka antiinflamasi, meskipun masih diperlukan standardisasi ekstrak dan uji klinis lebih lanjut.

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