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Abd. Kakhar Umar
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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Volume 5 Issue 1" : 5 Documents clear
Efficacy and Safety of Tenofovir in Preventing Perinatal Hepatitis B in Jakarta Muzakar, Cholid; Sandhiutami, Ni Made Dwi; Ramadaniati, Hesty Utami; Sriyono, Bimantoko Hadi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

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Abstract

Vertical transmission of hepatitis B virus (HBV) remains a major public health challenge in Indonesia, particularly among pregnant women with high viral loads. Tenofovir disoproxil fumarate (TDF) has been recommended to prevent perinatal transmission; however, local data regarding its efficacy and safety remain limited. This study aimed to evaluate Analyzing the effectiveness and safety of TDF in HBsAg-reactive pregnant women and its relationship with the infant's HBsAg status is necessary. An observational cohort study was conducted on 103 HBsAg-reactive pregnant women at five referral health facilities in Jakarta. Maternal effectiveness was measured by changes in SGPT and SGOT levels before and after therapy using the Wilcoxon test. Safety was assessed based on adverse events, pregnancy complications, and renal function using the chi-square test. Infant effectiveness was analyzed based on HBsAg status and tested using multivariate logistic regression. TDF significantly reduced SGPT and SGOT levels (p < 0.001). No significant association was found between TDF duration and adverse events, complications, or renal impairment (p > 0.05). Ninety-one-three percent of infants were HBsAg non-reactive, and 93.2% received complete hepatitis B vaccination. Complete vaccination (OR = 414.52; p < 0.001) and the absence of pregnancy complications (OR = 0.048; p = 0.021) were the main protective factors. TDF is safe and effective in preventing vertical transmission of HBV. Successful prophylaxis is highly dependent on infant vaccination and maternal health. These results support the integration of TDF into the national hepatitis B elimination program. 
Nanochemistry in Vaccine Delivery: Lipid Nanoparticles, Polymers, and Hybrid Systems Chandipwisa, Courage; Shimilimo, Agness; Zenda, Tendai Pride; Banda, Harrison
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

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Abstract

Conventional vaccines face challenges in antigen stability, delivery efficiency, and scalability, particularly in low- and middle-income countries. Nanochemistry offers innovative approaches through lipid nanoparticles, polymeric carriers, and hybrid systems. This review evaluates these platforms using criteria such as physicochemical properties, immunological outcomes, translational feasibility, and One Health relevance. A narrative literature review was conducted across major databases between 2015 and 2025. Studies were screened by title and abstract, excluded if not directly relevant to vaccine delivery, and weighted according to design, with clinical trials prioritized over in vitro or modeling studies. Reference lists of key papers were also examined to ensure comprehensive coverage. Lipid nanoparticles supported mRNA delivery in licensed COVID-19 vaccines, achieving strong immune responses but with variability across populations and reported adverse events including myocarditis and anaphylaxis. Polymeric nanoparticles such as PLGA and chitosan enabled controlled antigen release, though cost-effectiveness remains constrained by manufacturing and scalability challenges. Hybrid lipid-polymer systems demonstrated enhanced stability and multi-antigen presentation, with current evidence largely limited to preclinical studies. One Health implications are defined as the potential of nanochemistry to contribute to zoonotic disease prevention, food safety, and cross-species vaccine design, requiring clearer frameworks for integration. In conclusion, nanochemistry-based vaccine platforms show promise for advancing immunization strategies, but unresolved issues in safety evaluation, regulatory harmonization, and equitable access highlight the need for cautious interpretation and further interdisciplinary collaboration.
Management of Iodine Contrast Media Related Anaphylactic Shock following Renal Arteriography: A Rare Case Report Kino, Kino; Karmia, Rofila Dita; Harun, Harnavi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501429

Abstract

Background, anaphylactic shock (AS) caused by iodinated contrast media (ICM) is a rare but potentially life-threatening immediate hypersensitivity reaction. Despite widespread use of ICM in diagnostic imaging, data on ICM-related AS are limited, particularly in Indonesia. Early recognition and timely intervention are crucial to reduce morbidity and mortality. Case presentation, a 28-year-old female underwent renal arteriography with iodixanol. Within 5 minutes of contrast administration, she developed a generalized pruritic rash, dyspnea, vomiting, hypotension, and unstable cardiac parameters. Clinical presentation confirmed iodixanol-induced anaphylactic shock. Management, initial management included intramuscular epinephrine, rapid intravenous fluids, intravenous antihistamines and corticosteroids, and norepinephrine infusion. The patient’s hemodynamic status stabilized, and she was monitored in the CVCU for 48 hours. Outcome and conclusion, the patient recovered fully without complications. This case emphasizes the importance of rapid recognition and prompt pharmacologic intervention in ICM-induced anaphylaxis, while highlighting the value of thorough allergy documentation and preventive counseling.
Animal Models of Acute Exacerbations COPD: Mechanistic Insights and Translational Challenges Dewi, Rika Sari; Wuyung, Puspita Eka; Louisa, Melva; Sandhiutami, Ni Made Dwi; Pratomo, Irandi Putra
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501482

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent critical events in disease progression, yet their complex pathophysiology remains incompletely understood. Understanding the mechanisms underlying these exacerbations is essential for developing effective therapeutic strategies and improving patient outcomes. This literature review aims to synthesize current knowledge on the cellular and molecular mechanisms driving acute exacerbations of COPD, highlighting the importance of utilizing appropriate animal models for future research. This review identified rodent models, particularly mice (C57BL/6 strain) and rats (Sprague-Dawley) are predominantly employed due to their genetic tractability and physiological relevance, with occasional use of guinea pigs for airway hyperresponsiveness studies. Combined approaches using cigarette smoke exposure followed by inflammatory triggers (LPS, viral infections) showed the highest translational relevance. Key pathophysiological mechanisms studied include neutrophilic inflammation, oxidative stress, airway remodelling, and mucus hypersecretion. Current animal models provide valuable insight into AECOPD pathophysiology but face limitations in fully recapitulating human disease complexity. Future directions should focus on incorporating comorbidities, aging, and standardized outcome measures.
The Relationship Between Medication-Related Burden and Therapy Compliance of Hypertension Patients Supadmi, Woro; Afifa, Shafira Diestra; Izzah, Fiya Nailil; Gustinanda, Rizky
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501420

Abstract

Hypertension prevalence in the Special Region of Yogyakarta (31.8%) is higher than the national average (30.8%), and long-term medication use may create a burden that negatively affects adherence. This study aimed to evaluate the relationship between medication-related burden and adherence among hypertensive outpatients at Panembahan Senopati Bantul Regional Hospital and Yogyakarta City Regional Hospital. Using a cross-sectional design, 161 patients were recruited between January and February 2025. Medication-related burden was assessed with the Living with Medicines Questionnaire version 3 (LMQ-3), while adherence was measured using the Medication Adherence Rating Scale-5 (MARS-5). Most patients experienced a low burden (76.4%), followed by no burden (15.5%) and moderate burden (8.1%). Regarding adherence, 83.2% showed moderate adherence and 16.8% high adherence. Spearman’s correlation analysis revealed a significant negative relationship between medication-related burden and adherence (p=0.000; Rho = -0.461). These findings suggest that a higher treatment burden reduces adherence to antihypertensive therapy, highlighting the need for strategies to minimize patient burden and improve treatment outcomes.

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