cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Abd. Kakhar Umar
Contact Email
abdulkaharumar@gmail.com
Phone
+6282216335184
Journal Mail Official
sciphar@etflin.com
Editorial Address
Sungai Manonda Street, Syukur Aisle No. 2, RT 004/ RW 001, Duyu Village, Tatanga District
Location
Kota palu,
Sulawesi tengah
INDONESIA
Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : https://doi.org/10.58920/sciphar
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 12 Documents
 1   2 
Search results for , issue "Volume 5 Issue 1" : 12 Documents clear
Efficacy and Safety of Tenofovir in Preventing Perinatal Hepatitis B in Jakarta Muzakar, Cholid; Sandhiutami, Ni Made Dwi; Ramadaniati, Hesty Utami; Sriyono, Bimantoko Hadi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vertical transmission of hepatitis B virus (HBV) remains a major public health challenge in Indonesia, particularly among pregnant women with high viral loads. Tenofovir disoproxil fumarate (TDF) has been recommended to prevent perinatal transmission; however, local data regarding its efficacy and safety remain limited. This study aimed to evaluate Analyzing the effectiveness and safety of TDF in HBsAg-reactive pregnant women and its relationship with the infant's HBsAg status is necessary. An observational cohort study was conducted on 103 HBsAg-reactive pregnant women at five referral health facilities in Jakarta. Maternal effectiveness was measured by changes in SGPT and SGOT levels before and after therapy using the Wilcoxon test. Safety was assessed based on adverse events, pregnancy complications, and renal function using the chi-square test. Infant effectiveness was analyzed based on HBsAg status and tested using multivariate logistic regression. TDF significantly reduced SGPT and SGOT levels (p < 0.001). No significant association was found between TDF duration and adverse events, complications, or renal impairment (p > 0.05). Ninety-one-three percent of infants were HBsAg non-reactive, and 93.2% received complete hepatitis B vaccination. Complete vaccination (OR = 414.52; p < 0.001) and the absence of pregnancy complications (OR = 0.048; p = 0.021) were the main protective factors. TDF is safe and effective in preventing vertical transmission of HBV. Successful prophylaxis is highly dependent on infant vaccination and maternal health. These results support the integration of TDF into the national hepatitis B elimination program. 
Nanochemistry in Vaccine Delivery: Lipid Nanoparticles, Polymers, and Hybrid Systems Chandipwisa, Courage; Shimilimo, Agness; Zenda, Tendai Pride; Banda, Harrison
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Conventional vaccines face challenges in antigen stability, delivery efficiency, and scalability, particularly in low- and middle-income countries. Nanochemistry offers innovative approaches through lipid nanoparticles, polymeric carriers, and hybrid systems. This review evaluates these platforms using criteria such as physicochemical properties, immunological outcomes, translational feasibility, and One Health relevance. A narrative literature review was conducted across major databases between 2015 and 2025. Studies were screened by title and abstract, excluded if not directly relevant to vaccine delivery, and weighted according to design, with clinical trials prioritized over in vitro or modeling studies. Reference lists of key papers were also examined to ensure comprehensive coverage. Lipid nanoparticles supported mRNA delivery in licensed COVID-19 vaccines, achieving strong immune responses but with variability across populations and reported adverse events including myocarditis and anaphylaxis. Polymeric nanoparticles such as PLGA and chitosan enabled controlled antigen release, though cost-effectiveness remains constrained by manufacturing and scalability challenges. Hybrid lipid-polymer systems demonstrated enhanced stability and multi-antigen presentation, with current evidence largely limited to preclinical studies. One Health implications are defined as the potential of nanochemistry to contribute to zoonotic disease prevention, food safety, and cross-species vaccine design, requiring clearer frameworks for integration. In conclusion, nanochemistry-based vaccine platforms show promise for advancing immunization strategies, but unresolved issues in safety evaluation, regulatory harmonization, and equitable access highlight the need for cautious interpretation and further interdisciplinary collaboration.
Management of Iodine Contrast Media Related Anaphylactic Shock following Renal Arteriography: A Rare Case Report Kino, Kino; Karmia, Rofila Dita; Harun, Harnavi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501429

Abstract

Background, anaphylactic shock (AS) caused by iodinated contrast media (ICM) is a rare but potentially life-threatening immediate hypersensitivity reaction. Despite widespread use of ICM in diagnostic imaging, data on ICM-related AS are limited, particularly in Indonesia. Early recognition and timely intervention are crucial to reduce morbidity and mortality. Case presentation, a 28-year-old female underwent renal arteriography with iodixanol. Within 5 minutes of contrast administration, she developed a generalized pruritic rash, dyspnea, vomiting, hypotension, and unstable cardiac parameters. Clinical presentation confirmed iodixanol-induced anaphylactic shock. Management, initial management included intramuscular epinephrine, rapid intravenous fluids, intravenous antihistamines and corticosteroids, and norepinephrine infusion. The patient’s hemodynamic status stabilized, and she was monitored in the CVCU for 48 hours. Outcome and conclusion, the patient recovered fully without complications. This case emphasizes the importance of rapid recognition and prompt pharmacologic intervention in ICM-induced anaphylaxis, while highlighting the value of thorough allergy documentation and preventive counseling.
Animal Models of Acute Exacerbations COPD: Mechanistic Insights and Translational Challenges Dewi, Rika Sari; Wuyung, Puspita Eka; Louisa, Melva; Sandhiutami, Ni Made Dwi; Pratomo, Irandi Putra
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501482

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent critical events in disease progression, yet their complex pathophysiology remains incompletely understood. Understanding the mechanisms underlying these exacerbations is essential for developing effective therapeutic strategies and improving patient outcomes. This literature review aims to synthesize current knowledge on the cellular and molecular mechanisms driving acute exacerbations of COPD, highlighting the importance of utilizing appropriate animal models for future research. This review identified rodent models, particularly mice (C57BL/6 strain) and rats (Sprague-Dawley) are predominantly employed due to their genetic tractability and physiological relevance, with occasional use of guinea pigs for airway hyperresponsiveness studies. Combined approaches using cigarette smoke exposure followed by inflammatory triggers (LPS, viral infections) showed the highest translational relevance. Key pathophysiological mechanisms studied include neutrophilic inflammation, oxidative stress, airway remodelling, and mucus hypersecretion. Current animal models provide valuable insight into AECOPD pathophysiology but face limitations in fully recapitulating human disease complexity. Future directions should focus on incorporating comorbidities, aging, and standardized outcome measures.
The Relationship Between Medication-Related Burden and Therapy Compliance of Hypertension Patients Supadmi, Woro; Afifa, Shafira Diestra; Izzah, Fiya Nailil; Gustinanda, Rizky
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501420

Abstract

Hypertension prevalence in the Special Region of Yogyakarta (31.8%) is higher than the national average (30.8%), and long-term medication use may create a burden that negatively affects adherence. This study aimed to evaluate the relationship between medication-related burden and adherence among hypertensive outpatients at Panembahan Senopati Bantul Regional Hospital and Yogyakarta City Regional Hospital. Using a cross-sectional design, 161 patients were recruited between January and February 2025. Medication-related burden was assessed with the Living with Medicines Questionnaire version 3 (LMQ-3), while adherence was measured using the Medication Adherence Rating Scale-5 (MARS-5). Most patients experienced a low burden (76.4%), followed by no burden (15.5%) and moderate burden (8.1%). Regarding adherence, 83.2% showed moderate adherence and 16.8% high adherence. Spearman’s correlation analysis revealed a significant negative relationship between medication-related burden and adherence (p=0.000; Rho = -0.461). These findings suggest that a higher treatment burden reduces adherence to antihypertensive therapy, highlighting the need for strategies to minimize patient burden and improve treatment outcomes.
Effect of Tween 80 and Span 80 Surfactants Systems on the Malus domestica Emulsions for Anti-Cutibacterium acnes Handoyo, Theodorus Rexa; Resmi, Juniar Kalpika; Hutabarat, Rahmi; Guanse, Yovi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Red apple (Malus domestica) extract, rich in hydrophobic quercetin, was formulated into oil-in-water (O/W) emulsion using a 22 factorial design to evaluate Tween 80 (8-10 g) and Span 80 (2-4 g) concentrations, targeting pH (4.5-6.0), transmittance (90-100%), and viscosity (10-2000 cPs). Design-Expert® 13 analysis identified formulations F1, FA, and FAB within acceptable physical property ranges, with all red apple emulsions exhibiting O/W type, skin-compatible pH (5.20-5.48), high transmittance, and suitable viscosity. Freeze-thaw cycling (3 cycles, -15/25°C) and centrifugation showed physical stability with non-significant changes for F1 (p > 0.05). The agar well diffusion assay was performed on F1 (n = 3), which exhibited optimal physical parameters and met stability criteria, revealing Cutibacterium acnes inhibition zones up to 22.7 ± 0.577 mm. Thus, F1 emerges as a promising nanoemulsion candidate demonstrating antibacterial activity against acne-causing bacteria.
Inappropriate Use of Parenteral Analgesics for Mild Pain and Uncomplicated Fever in the Emergency Department: Findings from an Internal Audit Dewi, Rissa Maharani; Rosyid, Abdur; Timur, Willi Wahyu; Nastiti, Nindita Sari; Ningrum, Dwi Monika; Widiyanto, Dimas
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501519

Abstract

Inappropriate prescribing of parenteral analgesics in patients with mild pain or uncomplicated fever remains a relevant concern in emergency care. This study reports findings from a retrospective internal audit conducted in the emergency department of a private hospital in Banjarbaru, Indonesia, to evaluate the appropriateness of non-steroidal anti-inflammatory drug (NSAID) use. Medical records of 384 emergency department visits were reviewed, including data on pain intensity using the Numeric Rating Scale (NRS), clinical indications, route of administration, and immediate adverse reactions. Inappropriate use was defined as administration of parenteral NSAIDs in patients with mild pain (NRS 1–3) or uncomplicated fever when oral therapy was feasible, based on Royal College of Emergency Medicine (RCEM) guidelines. The audit identified inappropriate parenteral NSAID use in 7 patients (3.6%). These cases were associated with mild, immediate adverse effects such as nausea and dizziness. Although the proportion was small, the findings indicate potentially avoidable use of injectable analgesics and highlight the need for improved adherence to guideline-based analgesic selection. Reinforcement of routine pain assessment, clinician re-education, and periodic prescribing audits are recommended to support rational and patient-centered analgesic use in emergency settings.
Ethanolic Extract of Curcuma zedoaria Enhances Burn Wound Healing in Male White Rats Yuliawati, Yuliawati; Kasmadi, Fathnur Sani; Elisma, Elisma; Dewi, Hasna; Afryandes, Amelya; Puteri, Vanya Gita
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501488

Abstract

In addition to its widespread use as a culinary spice, white turmeric rhizome (Curcuma zedoaria (Christm.) Roscoe) exhibits important pharmacological activities, including anti-inflammatory, anticancer, and antioxidant effects. The rhizome contains secondary metabolites such as flavonoids, alkaloids, saponins, phenols, tannins, and terpenoids, which are believed to contribute to its potential efficacy in treating burns. This study used a fully randomized post-test-only control group design consisting of five treatment groups: P1 (5% ethanol extract of white turmeric rhizome), P2 (10%), P3 (15%), K⁺ (positive control: Bioplacenton), and K⁻ (negative control: Vaseline flavum). Parameters observed included reduction in burn wound diameter and collagen density, which were assessed through histological analysis. The results showed significant differences between treatment groups (p < 0.05). The 10% concentration showed the highest wound healing activity, reaching a healing rate of 54.72% and producing denser collagen compared to the other treatments. However, its effect did not exceed the positive control (Bioplacenton). The 5% concentration showed moderate healing activity (43.84%) with intermediate collagen density, while the 15% concentration produced the lowest effect. Overall, the findings indicate that the ethanol extract of white turmeric rhizome, particularly at a concentration of 10%, enhances burn wound healing and increases collagen formation, supporting its potential as a natural therapeutic agent for the treatment of burns.
Health-Related Quality of Life in Patients with COVID-19 in Indonesia: A Cross-Sectional Study Fajriansyah, Fajriansyah; Lestari, Keri; Zulfahmidah, Zulfahmidah
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501487

Abstract

Evidence on health-related quality of life (HRQoL) among hospitalized COVID-19 patients in Indonesia remains limited, particularly during the acute phase of infection. This study aimed to describe HRQoL and its associated sociodemographic and clinical factors among hospitalized COVID-19 patients in Indonesia. A cross-sectional study was conducted among adult patients with polymerase chain reaction confirmed COVID-19 who were hospitalized at Rumah Sakit Darurat COVID-19 (RSDC) Wisma Atlet, Jakarta, between October - December 2021. HRQoL was assessed using the validated Bahasa Indonesia version of the EQ-5D-5L questionnaire, including the utility index derived from the Indonesian value set and the EQ visual analogue scale (EQ-VAS). Descriptive statistics were used to summarize HRQoL distributions, and group differences were analyzed using the Mann–Whitney U test and Kruskal–Wallis test. A total of 154 patients were included in the analysis. The mean EQ-5D-5L utility index was 0.762 (SD 0.23; 95% CI: 0.726–0.798), and the mean EQ-VAS score was 75.00 (SD 15.81; 95% CI: 72.48–77.52). Utility index values ranged from 0.311 to 1.000, with 31.17% of participants reporting full health. Among the EQ-5D-5L dimensions, anxiety/depression was the most frequently reported problem (68.83%). Statistically significant differences in utility index scores were observed across sex, age groups, and occupational status (p < 0.05). In conclusion, hospitalized COVID-19 patients in Indonesia reported moderately high overall HRQoL, while psychological problems particularly anxiety and depression were highly prevalent. These findings highlight the importance of integrating mental health support into inpatient care and recovery services. 
GC-MS Analysis and In Vivo Antimalarial Activities of Seed Extract and Solvent Fractions of Telfairia occidentalis in Plasmodium berghei-infected Mice Sunday, Nsikakabasi Enefiok; Osigwe, Chinyelu Clementina; Enin, Godwin Ndarake; Uwaeme, Ugonma Florence; Essien, Grace Emmanuel; Okokon, Jude Efiom
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Telfairia occidentalis Hooke. F. (Cucurbitaceae family), a vegetable whose parts are used for both nutritional and medicinal purposes was investigated for anti-malarial activity in mice. The dried seed powder was separately cold extracted in 50% ethanol and gradient solvents (n-hexane, dichloromethane, ethyl acetate and methanol) along polarity gradient to obtained crude ethanol extract and solvents fractions of T. occidentalis seed. Based on previously established median lethal dose, the seed extract (138-553 mg/kg) and solvents fractions (276 mg/kg) were investigated for in vivo activity against Plasmodium berghei infection in mice using suppressive, prophylactic and curative standard models. Gas chromatography-mass spectroscopy (GC-MS) analysis of the active fraction was also done to identify its chemical constituents. The seed extract and fractions (138-553 mg/kg, p.o.) exerted significant (p < 0.05–0.001) chemosuppressive activity against P. berghei infection in suppressive (65.67%; 18.33 ± 3.71 days), prophylactic (55.39%; 17.66 ± 2.18 days) and curative (77.48%; 18.00 ± 1.15 days) tests with methanol fraction having the highest activity. GC-MS analysis of the active methanol fraction revealed the presence of polyunsaturated fatty acids and monoterpenes which have been implicated previously in antimalarial activity of plants. These results revealed the strong antimalarial potentials of the methanol seed fraction and its phytochemical constituents which can be exploited in the development of antimalarial remedies.

Page 1 of 2 | Total Record : 12

 1   2 

Filter by Year

2026 2026


Reset
Filter By Issues
All Issue Volume 5 Issue 1 Volume 4 Issue 4 Volume 4 Issue 3 Volume 4 Issue 2 Volume 4 Issue 1 Volume 3 Issue 4 Volume 3 Issue 3 Volume 3 Issue 2 Volume 3 Issue 1 Volume 2 Issue 4 Volume 2 Issue 3 Volume 2 Issue 2 Volume 2 Issue 1 Volume 1 More Issue