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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Anti-obesity effect of Dunaliella salina: Study on the gastric inhibitory polypeptide, ROS, DNA damage and metabolic gene expression in rats Howaida Ibrahim Abd-Alla
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

This study aimed to identify the gene expression profiling of lipid related genes in animal model of obesity and the role of microalgal Dunaliella salina (alga) in modulating the expression of these genes during the initial period of obesity. The diet-induced obesity model was used using fifty male Wistar albino rats (weighing 150-160 g) that have obesity caused by being fed high-fat diet (HFD) for 12 weeks. These rats were randomly divided into 2 groups (10 rats each) and treated with D. salina extract and orlistat for 6 weeks. The anti-obesity effect of this halophilic unicellular green alga was compared to orlistat, a standard anti-obesity drug promoting weight loss as a gastric and  pancreatic lipase inhibitor. Treatment with the alga and orlistat showed significant effect in reducing gastric inhibitory polypeptide (GIP). Also, the treatment of obesity-induced rats with the alga increased significantly the mRNA expression levels of lipid catabolic genes (peroxisome proliferator-activated receptor PPAR-α and carnitine palmitoyltransferase CPT-1) and decreased significantly the expression levels of lipid anabolic gene (SCD-1) compared with obesity-induced rats. In addition, D. salina extract was able to decrease ROS generation and inhibit the rate of DNA damage in obese rats. The study was extended to evaluate the phytochemical composition of  microalgal extract. The fatty acid methyl esters were analyzed by GLC. The extract contained considerable level of omega-3 fatty acids. The presence of  palmitic (62.5%), linolenic (9%), oleic (8.6%) and linoleic (7.4%) was revealed. The percentage of saturated and unsaturated fatty acids were 67.7 and 32.1%, respectively. D. salina extract administration which is rich in omega-3 fatty acids, has anti-obesity properties. Results suggested that D. salina might be available as functional alga and bioactive diet supplement for the treatment of obesity.
Purify and Characterize the Xylanase from the Local Isolation of Trichoderma Longibrachiatum Shimal Younis Abdel-Hadi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Fungi are well known for their ability to produce extracellular enzymes into their surrounding environment. Xylanases are an important class of hydrolytic enzymes involved in degradation of xylene a backbone of hemicellulose, in this study; we have isolated three isolates of xylene analytic fungi taken from five samples of sand gathered from different sites in the University of Mosul. Depending on the halo's diameter of analysis and by using the Congo red indicator, one isolate has got a high activity in producing the exocellular xylanase enzyme related to Trichoderma longibrachiatum on the base of morphological, microscopic and internal area (ITS) features. The xylanase has been purified from the raw extracted enzyme of the selected isolate throughout four subsequent steps included: sedimentation by Ammonium Sulphate, dialysis, gel filtration in column (Sephadex-G 100) and the Ionic exchanger (DEAE Cellulose). After this step, the number of filtrations is (49.22) with enzymatic outcome reaching to (33.93%). Studying the description of the filtered enzyme, PH the optimal for the enzyme activity is 0.5 and the optimal range of PH for enzyme stability is (4-6). Moreover, the optimal temperature degree for enzyme activity is (50 °C), whereas the optimal temperature degree for enzyme stability is (50-60 °C).Keywords:  Mosul university, Xylanase, Trichoderma longibrachiatum.
Azotation and Coupling Reaction of Amino Oxadiazole Ligands with (Characterization, Chromatography, Solubility) Study Muhammed Abdel Hasan Shallal
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
Publisher : Journal of Global Pharma Technology

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Abstract

This  paper  involved   reaction  between   two moles of   semicarbazide   with  mole  of  diethyl malonate which   refluxed   for ( 17 hrs ) in absolute  ethanol   then  added ( 4 ml ) of  H2SO4 to produce amino  oxadiazole  , the  resulting  compound   used     in  azotation  then  coupling   reaction with  various   coupling  derivatives   of  phenol ( p-hydroxy benzaldehyde , p-hydroxy benzoic acid , p-hydroxy  nitrobenzene , p- hydroxyl toluene , p- hydroxyl phenol )to produce novel  oxadiazole   derivatives   as  a ligands .The above  ligands  were investigated    through   their spectral  methods  (UV- Vis , FTIR  ,1HNMR  , Mass ) , Chromatography  technique   and  studying  of  solubility  in  series   solvents.Keywords: Soluble, Series, Hydroxyl.
Exploring of Insertion/deletion Polymorphism in the Vascular Endothelial Growth Factor Gene Associated with Type 2 Diabetic Patients in Al-Diwaniyah City Mohanad Jawad Kadhim
Journal of Global Pharma Technology .
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Abstract

Disease conditions that are related to the effects of the vascular endothelial growth factor (VEGF) are common such as nephropathy and promoting of cancer growth and metastasis. The current study was launched to explore the presence of VEGF gene-based polymorphism of the insertion/deletion (I/D) in blood samples of 25 diabetic and 25 clinically healthy people in Al-Diwaniyah City, Iraq. Using polymerase chain reaction (PCR), the results have shown the presence of these genotypes in these samples with higher significant (p˂0.05) occurrence. The homozygous DD was significantly (p˂0.05) affected by the sex factor. This genotypic characteristic was shown significantly (p˂0.05) in females more than that in males. Moreover, this feature was significantly higher (p˂0.05) when compared to the other genotypes II and I/D for each of the females or males separately. For the DD genotype, ages between 40 to 49 years of old have shown significantly (p˂0.05) higher presence of this genotype than that in other ages. It has been also shown by these results that this genotype is present significantly (p˂0.05) higher than that in the other genotypes when compared together in each age category. These results suggest current relationship between the VEGF I/D polymorphism occurrence and diabetes with deeper correlation with sex and age factors.Keywords: VEGF I/D polymorphism, diabetes, sex, age.    
The Use of Diuretics on Hepatic Cirrhosis Patient with Ascites Didik Hasmono
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Hepatic cirrhosis with ascites complication increases the mortality up to 50% in a matter of years. Diuretics are a class of drugs that are often used as choices. The pattern of diuretics use of hepatic cirrhosis patient with ascites in the hospital needs to be studied further because if the use is not appropriate, it will potentially lead to drug related problems that affect patient management. Aim: to examine the pattern of diuretics use of hepatic cirrhosis patient with ascites which undergoing treatment in the hospital inpatient unit. Method: a descriptive and retrospective study using medical records. Criteria for inclusion of the sample were (1) Hepatic cirrhosis patient with ascites complication (2) Age> 20 years (3) Receive diuretic therapy (4) Complete medical record. The exclusion criteria were patient who was hospitalized for less than 3 days. Study samples were recorded on the data collection sheet. Sampling with time limited sampling method. Result: The total number of patients who met the inclusion criteria was 45 patients. The diuretics which most used was furosemide, both in single doses and in combination with Spironolactone. The hepatic cirrhosis patient with ascites in this study not only received diuretic therapy, but patient also received other drugs that used to prevent and overcome complication. In drug interaction, the potential use of Spironolactone with Potassium (KCl or KSR) preparation increases the risk of hyperkalemia. Conclusion: Most of the diuretic therapies obtained by hepatic cirrhosis patient with those who were hospitalized which have been in accordance with the available guidelines.Keywords: As cites, Drug Related Problems, Diuretics, Hepatic Cirrhosis.
Burnout Incidence during Online Lectures in Medical Students in Udayana University during the Covid-19 Pandemic Agung Wiwiek Indrayani
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease that caused by SARS-CoV-2 with new cases and mortality rates that are increasing recently. Due to inadequate of health facilities in Indonesia and the absence of a COVID-19 vaccine, some actions are required to reduce the spread of the virus, such as physical distancing. In educational aspect, conventional learning system are replaced by online learning system. This kind of system may cause burnout in medical students. The aim of the study was to describe the burnout incidence during online lectures in medical students in Udayana University during the Covid-19 pandemic. Materials and Methods: A cross sectional study with 175 medical students in Udayana Univerity class of 2018 and 2019 was conducted in this study. The data were collected via google form which includes informed consent and questionnaire which contains burnout scale. Univariate and bivariate analysis through chi-square test was conducted in this study. Results: According to univariate analysis, there was 75.4% students were experienced moderate burnout, 4.9% students were experienced high burnout, and 9.7% were experienced low burnout. Based on chi-square results (p
Fatty Liver and Liver Malondialdehyde Expression in Severe Malnourished Wistar Rats that given Virgin Coconut oil Compared to Corn Oil in World Health Organization Formula I Gusti Ayu Putu Eka Pratiwi; Soetjiningsih .; I N. Mantik Astawa; I Gusti Ayu Trisna Windiani; I Gede Ngurah Harry Wijaya Surya
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Objective: There is a lack of antioxidant in severe malnutrition, and it may lead to increase oxidative stress. Fatty liver is one of severe malnutrition (SM) cardinal features. Virgin coconut oil (VCO) contains high antioxidant capacity and medium chain triglyceride. It is supposed to improve those problems. Methods: Posttest only control group design study was done to observe whether VCO could decrease fatty liver and liver malondialdehyde (MDA) expression in 38 male wistar rat with SM. The rats were divided into two group which were VCO Group (Group A) and Control Group (corn oil (Group B)). They were given feeding World Health Organization (WHO) Formula for SM (Formula 75 and Formula 100) that contained VCO or corn oil. After being SM, this formula was fed until 28 days. In the 29th day, they were sacrificed, and liver samples were obtained for fatty liver analysis and MDA expression. Results: Fatty liver was less in Group A (mean 13.74 cell in 5 view field (SD 1.32) than Group B (mean 20.74 cell in 5 view field (SD 2.01), and it was statistically significant (p=0.000). Cut off point for determining low and high liver MDA expression based on o ROC curve were <2.9% (low) and ≥2.9% (high). Low MDA expression (<2.9%) was higher in Group A than Group B (p <0.05). Conclusions: This study found less fatty liver and low liver MDA expression in severe malnourished rat given VCO than corn oil.  Keywords: Virgin coconut oil, Fatty liver, Malondialdehyde, Severe malnutrition.
The Effect of Papain Enzyme Against Collagen Density in Keloid Tissue Culture Herman Y. L. Wihastyoko
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: Papain enzyme in Papaya sap has the ability to increase collagen degradation, thus, it can be used for the treatment of keloid. Therefore, the aim of this study was to determine the effect of this enzyme on keloid tissue. Methods: Randomized Controlled Trial Post-Test Only Design using ten human keloid tissues was applied in this research. Each of the tissue was divided into four treatment groups. The histological preparation was conducted by Masson’s trichrome staining. All of the samples were observed using a microscope. The collagen density was determined through the use of Olyvia software. The hydroxyproline level was measured by total collagen kit assay using a spectrophotometer. All the results were analyzed using a one-way ANOVA test. Result and Discussion: The mean value of collagen density in group K = 193,273+4,099; P1 = 188,765±3,598; P2 = 187,217±2,839; and P3 = 185.143±2.871. The results of statistical tests (p <0.05) on collagen density mean value showed that there is a significant difference between groups K, P1, P2, and P3. The mean value of hydroxyproline levels in group K = 268.5±69.43; P1 = 389,1±43,58; P2 = 454.8±85.81; and P3 = 559.8±167.57. The results of statistical tests (p<0.05) on hydroxyproline groups also showed a significantly difference in the groups. Conclusion: The papain enzyme can decrease the collagen density in keloid tissue culture.Keywords: Collagen density, hydroxyproline, keloid, papain enzyme
Study of Lipids Profile Levels in Patients with Hypothyroidism in Al-Muthanna Province Duaa Hamad Hamza
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The objective of this study was to investigate the changes that occurred on lipids profile levels of patients with hypothyroidism in al-muthanna province. The current study is carried out in the ‘specialized center of endocrinology and diabetes’ in Al- Muthanna province. The study included 200 individuals (100 patients with hypothyroidism and 100 controls).The patients and control divided to three groups according to ages. The ages were between (20-49) years. The results show a significant increase at(P<0.05) in ( Total cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low density lipoproteins (VLDL) levels of patients comparing with control group in all age groups .In this study concluded that hyperlipidemia is associated with hypothyroidism. These enhance the risk for development of atherosclerosis and coronary artery disease.Keywords: Hypothyroidism, Total cholesterol, Triglyceride, High-density lipoprotein, Low-density lipoprotein, Very low density lipoproteins.
Effect of Physical Effort due to Increased Intensity in Biochemical Variables in Blood and Some Basic Skills of Volleyball Players Arif Abdul Jabbar Hussain
Journal of Global Pharma Technology .
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Abstract

AbstractThe object of research is to know effects of physical exercise on treadmill focused on enzymes, creatine, Phosphokinase, Cholesterol, Hemoglobin (H b), dehydrogenase (HDL) in blood and effect on performance of basic skills of volley ball.  Researcher presumed existence of significant differences between before and after examinations focused on Hemoglobin (H b), Cholesterol, and Enzymes like creatine, phosphokinase (CPK), lactate dehydrogenase (HDL) in performance of some basic skills of volley ball.  The tests proved differences. Total 18 persons physically suitable for the research were made to undergo in this trial.  The main experiment was applied which included biochemical values before the skill test and later physical exercise by running on treadmill for 12 minutes with change in its angle of elevation, then biochemical values recorded post skill test.  The result of research revealed positive effects for change in biochemical values related to this experiment and its enzymes like creatine, phosphokinase (HDL) (CPK) and at the performance of skill in volleyball like hitting ball within trial revealed said biochemical effect negative. It is also recommended in the research that biochemical tests bring traces of variation in blood within level related to each player at different level of their function.Keywords: Physical effort, Intensity, Biochemical, Blood and volleyball.

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