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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Young Papaya Seeds Ethanol Extract (Carica Papaya Seed) Inhibit Testosterone Hormone and Leydig Cells of Male Mice (Mus Musculus) Bagus Komang Satriyasa
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Currently, the effort to invent ideal natural male contraceptives still faces many obstacles, especially due to the fact that ideal contraceptives should meet certain requirements such as: be able to cause total azoospermia; easily used; cause no untoward or toxic effects; not disturbing libido or sexual behavior; and be reversible. As male contraceptives are very limited in types, efforts to develop ideal male contraceptive drugs is crucial; particularly the effort to find alternative effective substances derived from natural resources. The purpose of this study is to investigate whether of young papaya seeds extract has a to inhibit the testosterone. The study used 30 male mice strain Balb-C which were allocated by simple random sampling into two groups: Control Group (P0) consisted of 17 male mice and Treatment Group 1 (P1) consisted of 17 male mice. After 36 days of treatment, control group and treatment group were taken for their blood. The blood was taken for testosterone hormone test using Radioimmunoassay (RIA) technique and the scrotum was taken for obtaining the Leydig cells. The result of t-test analysis showed that the level of testosterone in control group was 104,27 ± 25,79 ng/dl and Leydig cells 129,41±30,92, in treatment group 91,76 ± 30,45 ng/dl and Leydig cells 122,94±20,85.  The difference between control group and treatment group was the decrease of testosterone and Leydig cells. Young papaya seeds extract reduces testosterone and Leydig cells insignificantly.Keywords: Papaya seeds extract, Testosterone hormone, Leydig cel, Male Mice balb/C
The Activity Test of Ethanol Extract in Hibiscus Leaves (Hibiscus Tiliaceus L.) as the α-Glucosidase Enzyme Inhibitor by Using ELISA (Enzyme Linked Immunosorbent Assay) Reader Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Hibiscus leaves (Hibiscus tiliaceus L.) was a plant from the family of Malvaceae, which contained triterpenoid, saponins, flavonoids, and polyphenols compounds that functioned as antidiabetic mellitus. The purpose of this study was to determine the activity of α-glucosidase enzyme inhibitor from the ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.). The test was carried out through in vitro by using α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida (PNPG) substrate, and measured by ELISA reader. The simplicia was macerated with alcohol 96%. The reaction of α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida substrate produced yellow p-nitrofenol. The reaction product was measured at a wavelength of 405 nm. The results showed that ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.) had activity as an inhibitor of α-glucosidase enzyme with Inhibitor Consentration IC50 37.98 µg / mL and could be categorized as active.Keywords: Hibiscus tiliaceus L., Hibiscus leaves, Α-glucosidase enzyme inhibitor.
Asthma Exercise Enhanced IL-10 Secretion but Had No Effect on IFN-ɣ in Patients with Persistent Atopic Asthma Rahmaya Nova Handayani
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Asthma is a chronic respiratory disease which is considered as a frequent non-communicable disease that could affect the quality of life. It is widely known that Th1 and Th2 imbalance is one of the underlying pathogenesis of asthma and many approaches had been devised to interfere this process. One of the well-known non-pharmacological approaches in asthma is asthma exercise. Therefore, this study aimed to investigate the role of asthma exercises on the balance of Th1 (IFN gamma) and T-regulator (IL-10). Methods: A pre-post-test group quantitative study was conducted using 39 subjects with persistent atopic asthma. All subjects participated on asthma exercise program that was conducted twice a day, 60 min per session. Atopic status was determined by skin prick test while IFN-Ɣ and IL-10 was determined by ELISA. Results: Median level of IL-10 was increased from 1.6 pg/ml before intervention to 2.2 pg/ml after intervention (p=0.000). However, the exercise program failed to produce any effect on IFN-Ɣ level which only showed a slight median increase from 9.374 pg/ml before intervention to 10.238 pg/ml in the post-test analysis (p=0.07). Conclusion: Asthma exercises significantly increased IL-10 level, but not significantly affect serum IFN-Ɣ in patients with persistent atopic asthma.Keywords: Asthma exercise, IL-10, IFN-Ɣ, T-h1/T-h2 balance.
Doppler Study and Cell Free DNA Biomarkers by using PCR in Hypertensive and Diabetic Pregnant Iraqi Wom Dhelal Qasim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Doppler ultrasonography has been used to assess both the fetal and placental circulation, to facilitate the diagnosis and monitoring of important conditions. Circulating cell-free (cf-DNA) in plasma is considered a novel biomarker with promising clinical applications. This biomarker was reported in prenatal diagnosis and in adverse pregnancy outcomes. Hypertensive disorders of pregnancy and both type 1 diabetes and type 2 diabetes in pregnancy represent a significant cause of maternal and perinatal morbidity and mortality. The aim of the study is to relate the Doppler study of the umbilical cord and uterine artery to the presence of different primers in hypertensive and diabetic pregnant women. Ninety women had been enrolled in this study. Thirty (33%) of them with diabetes mellitus and the other 60 (67%) women were with hypertension. The mean age of study sample was (29.7 ±6.33 years (. Careful history was taken from all women. Uterine blood flow for women below 28 weak gestational age, and umbilical artery blood flow for 28 weak pregnancies and more was done by Doppler Ultrasound. Blood samples were taken from all women and cf-DNA was measured using PCR technique. There is significant association (P ≤ 0.05) between Autism primers 3 with the Doppler study in hypertensive pregnant women. Also there is significant association between Sirti primers 3, 4 with the Doppler study in diabetic pregnant women, and there is significant association between Trisomy primers 3 with the Doppler study in hypertensive pregnant women. There is no difference between the negative and positive results in relation to Doppler study regarding hypertensive and diabetic pregnant women except for the above primers.  Keywords: Doppler study, Cf-DNA biomarkers, PCR, Hypertension, Diabetes.
Removal of Malachite Green from Aqueous Solution by PMUC: Equilibrium and Thermodynamic Studies Muneer A. Al-Daamy
Journal of Global Pharma Technology .
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Abstract

Removal of Malachite green dye has been carried out by using (Porcelanite- Melamine –Urea) (PMUC) as an adsorbent. The characterization of (PMUC) was done by using FTIR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and Atomic force microscopy (AFM) . Different experimental data such as contact time, pH, adsorbent dosage and ionic strength were studied. The equilibrium experimental data were analyzed by Langmuir, Freundlich and Temkin isotherm models. Thermodynamic parameters such as change in free energy (ΔG°), enthalpy (ΔH°), and entropy (ΔS°) were also determined.Keywords: Adsorption, Porcelanite rocks, Malachite green, Isotherms, Langmuir, Freundlich, Temkin.
Pulmonary Arterial Hypertension and Risks of Progression Evgeniya Malashenko
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Pulmonary arterial hypertension is an increase in blood pressure above 140 and/or 90 mmHg, caused by irreversible changes in arterioles, either by an unknown reason (essential), or as a secondary condition.  691 people under the age of 7 to 14 years (343 males and 348 females) were examined. They divided into two groups: 1st-with high blood pressure; 2nd-control group with normal blood pressure. The study results show that 19.5% of the total number of patients had high blood pressure, where 46.7%-7-10 years old children and 53.3%-11-14 years old. Almost equal ratio of boys and girls was noted in both age subgroups. Thus, there were 24.4% of boys and 22.2% of girls among children with high blood pressure aged 7-10 years and 24.4% of boys 28.9% of girls aged 11-14 years. The gender differences were found in blood pressure, heart rate and pulmonary arterial hypertension, accordingly. The systolic blood pressure (SBP) and heart rate (HR) of 7–10 years girls were significantly lower than that of male peers (96.8 and 93.2%, respectively). The most of physical development indicators of males with hypertension significantly exceeded peers with normal blood pressure. The average body weight of males with PAR significantly exceeded the control groups of the corresponding age by 16 and 25.2%, respectively, in the studied age periods. The thoracic region of the younger subgroup boys with PAH was significantly greater than that of boys with normal blood pressure by 6.5%; in the middle age subgroup - by 11.3%. The hypertension in childhood and adolescence is associated with an increase in height, weight, BMI, BFM, MM, and LBM. Hypertension occurred much more often because of overweight and obesity than with normal body weight and protein-energy malnutrition.Keywords: Pulmonary arterial hypertension (PAH), Absolute muscle mass (MM), Body mass index (BMI), lean body mass (LBM), Body fat mass (BFM).
Development of Behavior Models of Pregnant Women towards High Risk Pregnancy Conditions Based on Social and Culture Capital Evi Pratami; Sukesi Sukesi; Ervi Husni
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: A person behavior in acting is influenced by social and cultural aspects. Someone has a wide stretch throughout the activities carried out namely: walking, working, thinking and another. Aim: To analyze the effect of social capital and culture capital on behavior, prove the model of social capital and culture capital on improving the behavior of high-risk pregnant women. Methods: The study was conducted in 2 stages: First, using a cross sectional design, the population of pregnant women in the Surabaya City Health Service area. Sample size was calculated by the ROT formula, a number of 314 respondents. The sampling technique used non probability sampling. The data were analyzed using PLS. Second stage, tests the model obtained. Results: Social capital affects behavior in the regularity of antenatal care, the accuracy of taking drugs or vitamins, diet, monitoring of fetal movements (T> 1.97), but in the pattern of activity (T
The Effect of Fluctuations in Climate Parameters on Wheat Market Mahmoud Daneshvar Kakhki
Journal of Global Pharma Technology .
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Abstract

The great dependency of agricultural sector on climate conditions and high attribution of this sector to the economy of developing countries shows the importance of agricultural sector and its impressions from climate change phenomenon. One of the important questions that occur in mind is the effect of fluctuations in climate parameters on market of agriculture sector products. Since production in agriculture sector is important because of food provision of society members, studies in this field are so important for policy making and planning aspects. This issue is more important in countries and regions in more vulnerability of climate changes. Therefore, dry and semi-dry climates of Iran and Khorasan Razavi province were mentioned to study the production and demand for strategic product, wheat, by consideration of climate changes condition. To reach this goal, first an index to study climate parameters fluctuations was designed and calculated. Then, wheat economic model was made by aim of reaching balanced price by making supply and demand sides. The demand and supply functions were estimated as panel data for 30 provinces of country in 2005-2015 in Stata software. Then, optimization model was made in GAMS software to reach product equilibrium in the studied region. Results of calculations displayed that permanent risks have a negative and significant effect on product and wheat balanced price in Khorasan Razavi province whose price was obtained 12863 Rial in 2015. It is suggested to policy makers and planners to use simulation of various parts of the model and the obtained results from scenario for prediction in order to select the adapted policies with climate changes or reduce negative effects of this phenomenon in regions such as studied region.Keywords: Price, Permanent risk, Recurrent risk, Partial equilibrium.
Efficacy of Edible Coatings on Enhancing the Shelf-Life of Fresh and Frozen Tilapia (Oreochromis niloticus) Fish N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Tilapia (Oreochromis niloticus) is generally processed to fresh and frozen fillets for domestic consumption. Deterioration of fish quality in refrigerator storage has great impact on the nutritious value of fish and the health of consumers. Freezing and cold storage is an efficient method which preserves taste and nutritional value. Glazing is a process used to reduce undesirable drying or dehydration of fish during frozen or cold storage. Objective of the current research studied the feasibility of edible coating in maintaing and preserving the chemical, microbial and sensory attributes of fresh and frozen tilapia fillet. The fresh and frozen tilapia fillets were treated with different formulas (N0: control; N1: 1.5% w/w chitosan and peracetic acid; N2: 1.5% w/w chitosan and gelatin; N3: 1.5% w/w whey protein isolate and ethanol; N4: 1.5% w/w xanthan gum). The chemical quality was based on the analyzed results of ammonia (µNH3/g) and pH; biogenic amines such as putrescine (mg/kg), cadaverine (mg/kg), histamine (mg/kg), spermine (mg/kg), spermidine (mg/kg); lipid oxidation or malondialdehyde value (mg/kg); microorganism such as Total plate count (cfu/g), Enterobacteriaceae (cfu/g), Coliform (cfu/g), E. coli (cfu/g), Staphylococus (cfu/g), Listeria (cfu/g), Salmonella (cfu/g), Vibrio (cfu/g); sensory score. All treated fresh tilapia fillets were tested after 21 days of cool storage (4oC). All treated frozen tilapia fillets were tested after 12 months of cold storage (-18oC). Results revealed that the incorporation of 1.5% w/w chitosan and peracetic acid could inhibit microbial spoilage and lipid oxidation and therefore maintain the freshness of tilapia fillet for 21 days at 4oC and 12 months at -18oC storage. The study indicated that the combination treatment with edible coating could be commercially utilized to maintain the freshness and prolong the shelf‐life of fresh and frozen tilapia fillet effectively.Keywords: Frozen, Tilapia fillet, Chitosan, Peractic acid, Gelatin, Whey protein isolate, Ethanol, Xanthan gum.
Domperidone Maleate Orodispersible Tablet Formulation Using Primojel® Superdisintegrant with the Wet Granulation Method D. Gozali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Orodispersible tablets are a solution for people who have problems swallowing drugs because they will break down instantly in the mouth without having to be swallowed. Objective: The aim of this research was to formulate orodispersible tablets using Primojel® as a superdisintegrant and domperidone male ate as an active compound to achieve the best disintegration time in the oral cavity by a wet granulation method had been carried out. Method: The tablet of 180 mg in weight was made with variation of concentration as followed 7, 2 mg (F1); 9 mg (F2); 10,8 mg (F3); 12,6 mg (F4); 14,4 mg (F5). F1, F3, F4, and F5 were qualified based on uniformity of weighing. Results: All of the formulas (F1, F2, F3, F4, and F5) were qualified based on the disintegrating time of orodispersible tablets (below three minutes). F2 has a quickest disintegration time and F1 has the longest disintegration time. Statistical analysis at α = 0, 05 showed that the concentration variation of Primojel® affected the disintegration time of the tablet. Hedonic test with five parameters included likeness, flavor, taste after taste showed that F5 was the most favorite formula. Conclusion: All formulas met the requirements of the Indonesian Pharmacopoeia IV crush time that was no more than 3 minutes. The results of the statistical analysis stated that F5 was the most preferred formula of domperidone maleate orodispersible tablets.Keyword: Orodispersible tablets, Primojel®, Wet granulation, Domperidone maleate, Tablet formulation.

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