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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Investigating the Relationship between Organizational Memory and Management of Organizational Conflicts in Chaharmahal and Bakhtiari Social Security Staff Meisam Jamalzadeh
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Human resources, the most important and valuable factor, are from different sources of organization and conflict is a phenomenon that has positive and negative effects on the performance of individuals and organizations. The ability to deal with the conflict and its management is of a great importance to the success of the managers of the organizations. Therefore, the purpose of this study is to investigate the relationship between organizational memory and management of organizational conflicts among Chaharmahal and Bakhtiari social security staff. The research method is descriptive and survey method. The statistical population of this research includes all employees of Chaharmahal and Bakhtiari social security and the sample is 150 with Cochran formula. For measuring the variables, a researcher-made organizational memory questionnaire and Stefan Robbins organizational conflict management questionnaire were used. The reliability of the questionnaires was calculated using Cronbach's alpha method and validity of the questionnaire is confirmed by content method. Pearson correlation coefficient was used to analyze the data using SPSS 19 software. The results showed that there is a significant positive correlation between 5 components of organizational memory (personal skills, mental models, organization structure, data retrieval and information recording) and management of organizational conflicts among Chaharmahal and Bakhtiari social security staffs.Keywords: Organizational memory, Management of organizational conflicts, Social security organization.
The Role of In-service Training Courses to Improve the Effectiveness of Human Resources in Anticipation of Zabol University of Medical Sciences Mohammad Ghasemi
Journal of Global Pharma Technology .
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Abstract

Nowadays, increasing the efficiency of organizations depends upon the enhancement of efficiency of human resources. Eenhancing the efficiency of human resources in order to do things successfully, also depends on training, expansion of knowledge and skill as well as developing desirable behaviors. This study aimed at investigating the impact of training programs of development plan and promotion on the improvement of employees’ effectiveness. Participant s of the study includes 550 of the personnel of Zabol University of Medical Sciences. A researcher-made questionnaire was used as the research instrument which was designed based on Likert model. It is to be mentioned that the validity of the questionnaire was confirmed by expert supervisors and reliability was examined and approved through applying Cronbach alfa. Data analysis was done through applying SPSS, Kolmogorov-Smirnov, Pearson simple and multiple regression along with descriptive methods to test research variables. The results of the study indicated that training programs of development plan and promotion have significant impact on the improvement of employees’ effectiveness and its components such as job identifying, responsibility, management ability, and improvement of mutual relations.Keywords:  Effectiveness, Job identifying, Employees’ responsibility, Management ability, Improvement of mutual relations.
The Effect of Special Exercises in the Development of Some Physical and Motor Characteristics to Performance Arm for Handball Players Nabhan Hamid Ahmed
Journal of Global Pharma Technology .
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Abstract

The study aimed at preparing special exercises for the development of some physical and motor characteristics of the performance arm of handball players. The study was subjected to poor performance of the correction arm, which led the researchers to prepare special exercises to develop the speed related ability of the arm concerned with the correction. A player from the university team of Anbar province, they were divided into two experimental and control groups, and each group (8) players. The program of exercises was applied to the experimental group, after which the tests were carried out and the collection of data and unloaded in special forms and processed statistically to reach the most important conclusions:There were significant differences between the results of the Pre and posttests of the experimental and control groups.There were significant differences in the results of the post tests to test the speed-related ability. There were no significant differences between the other variables in the research.The exercises used by the researchers worked on developing some of the variables used in the research.Keywords: Special exercises, Physical, Motor characteristics and performance.
Arterial Hypertension and Diabetes Mellitus: Therapy with Telmisartan, Interrelation Modeling, Approaches to Diagnosis and Complex Therapy Evgeniya Malashenko
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Diabetes mellitus (DM) is an illness for an increasing number of people. Among the consequences that DM leads in the first place can be called degradation changes in the body, ultimately leading to limited physical capabilities. In DM, one of the related phenomena is a high risk of cardiovascular diseases (CVDs). This is due to the following factors: a) already the presence of risk factors before the DM development; b) the presence of obesity; c) arterial hypertension (AH). AH is present in 75-80% of patients with DM type 2, with half of them die. Due to the fact that AH and DM have a pathogenetic relationship, this fact naturally increases the risk of death. On the basis of data from Polyclinic No. 3 in St. Petersburg (Russia), a group of 200 patients with DM (female, age range 45-65) with concomitant AH were selected. The control group consisted of 100 females of the same age. Therapy was carried out with Telmisartan, with a dosage of 85 mg for a period of 8 weeks. As a result of the therapy, telmisartan has shown a positive effect on such parameters as carbohydrate metabolism and insulin resistance, as well as lipid metabolism. For patients with metabolic syndrome, during the period of therapy, telmisartan was noted to significantly (p≤0.05) reduce the rates associated with lipid metabolism. First of all it affected the cholesterine rate in the blood .Also obtained reliable data on the triglycerides reduction (TG), from 1.67 mmol/l 2.0 times more than half of the patients (41% of 75% who had elevated TG levels) undergoing telmisartan therapy. In addition, a decrease in the load on the AH time index, as well as a decrease in microalbuminuria rate was noted in patients. This indicates the organ-protective effect of telmisartan therapy. Permanent control of blood pressure is of primary importance for CVD prevention in patients with DM. When prescribing an antihypertensive agent, it is necessary to take into account RAAS-blocking drugs (renin-angiotensin-aldosterone system). Telmisartan has shown a positive effect on carbohydrate metabolism, reduced the elevated lipids levels (in particular, TG), and also affected insulin resistance.Keywords: DM (diabetes mellitus), AH (arterial hypertension), CVD (cardiovascular disease), telmisartan.
Cefazolin as a Prophylactic Antibiotic in Laparoscopic Cholecystectomy: A Systematic Review Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 12 Issue 12 (2020) Dec. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Cefazolin is a first-generation cephalosporin prophylactic antibiotic which recommended for open cholecystectomy. Laparoscopic cholecystectomy is a clean contaminated surgery that does not require prophylactic antibiotics. Some surgeons still have the habit of giving prophylactic antibiotics for laparoscopic cholecystectomy. This systematic review aimed to examine evidence from randomized controlled trials comparing the incidence of surgical wound infection with cefazoline use. Methods: We collected randomized controlled trials (RCTs) throughout the years 2010-2020 from the Cochrane Library and PubMed in English language, which examined the incidence of surgical wound infection between the cefazolin prophylactic antibiotic groups versus placebo on laparoscopic cholecystectomy. Results: Six RCTs were included in the final analysis for a qualitative assessment using the Jadad scale, with four articles in the high category and the other two in the good category. The incidence of surgical wound infection in the cefazolin group was 1.09-4.8% (mean 2.63%) and did not differ significantly from the placebo group. Old age (> 60 years), obesity, timing of antibiotics, as well as tissue trauma and billiard spill during laparoscopic cholecystectomy were not significant factors. Conclusion: The prophylactic antibiotic cefazolin was not significant in reducing the incidence of surgical wound infection in lapaoscopic cholecystectomy. It is necessary to review the guidelines for prophylactic antibiotics in each health service place. Keywords: Cefazolin, Prophylactic antibiotics, Laparoscopic cholecystectomy, Surgical wound infection.
Feasibility of Composite Edible Coating Derived from Chitosan and Carboxymethyl Cellulose on Star Apple Quality during Post-harvest Preservation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Star apple (Chrysophyllum cainito) is well known as non climacteric fruit with high antioxidant capacity, high nutritional and health benefit. Its pulp is very sweet with glucose as the main sugar. This fruit has a short shelf life due to its perishable nature. Edible coatings have been extensively applied in the fruit preservation as an alternative method to preserve foodstuffs, improve shelf life and control loss of firmness and moisture in fresh fruits. Hence, purpose of this research penetrated on the efficiency of composited edible coating film prepared from chitosan and carboxymetyl cellulose (CMC) in different formulas to preserve star apple fruit. Weight loss (%), firmness (N), total soluble solid (oBrix), and vitamin C were the key indicators used to monitor during 15 days of preservation. After chitosan-CMC coating, the weight loss rate was restrained, and higher firmness, total soluble solid, and vitamin C were reserved. Our finding revealed that chitosan 2.0% combined with CMC 1.0% was appropriate for extending self-life of this valuable fruit. There has been a great demand of emerging fruit packaging from chitosan-CMC composited coating as antibacterial and barrier film. Composited chitosan-CMC coating would have wide prospect in the preservation of other post-harvest fruits and vegetables.Keywords: Chrysophyllum cainito, Chitosan, CMC, Coating, Weight loss, Firmness, Soluble solid, Vitamin C.
Phytochemical screening and assessing the bioactive constituents of Lepisanthes tetraphylla (vahl) radlk through GC-MS analysis Sudha Kesavarthini P; Rani S; Vishwanath B A
Journal of Global Pharma Technology Volume 11 Issue 02 (2019) Feb. 2019
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Abstract

The present study was carried for the preliminary phytochemical analysis of the ethanolic extract of the plant Lepisanthes tetraphylla (vahl) radlk belongs to the family Sapindaceae. Bioactive constituents in the ethanolic extract of Lepisanthes tetraphylla was analysed by GC-MS analysis. Phytochemical screening revealed the presence of carbohydrates, proteins and amino acids, saponins, tannins, flavonoids, gums. In GC-MS analysis, around one hundred and seventeen compounds were present, in which many compounds where not reported for their biological properties. The presence of various bioactive compounds confirms the application of Lepisanthes tetraphylla for various diseases by traditional use.
Malondialdehyde and Antioxidant Vitamins in Breast Cancer Iraqi Patients Firas A. Hassan
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present research was proceeded to explore the situation of plasma anti-oxidative vitamins (E andC) and lipid peroxidation on sixty no patronize breast cancer patients and 30 salutary women. Alteration in the standard for “total antioxidant capacity”, malondialdehyide (MDA), Nitreic oxide (NO) were temperate in specimen patients influenced through breast tumor. The effect detected that plasma vitamin E and vitamin E regulated for the aggregated of cholesterol and triglycerides diminished significantly in patients group (p 0.01). The grade of (MDA) increment significantly in patients as contract to the control. considerable variation were also spotted amidst patients together (non-metastatic and metastatic) breast cancer according  respects specimen(NO) that were minimize in metastatic by contrast together non-metastatic breast tumor.Keywords: Vitamin C, Lipid peroxide, Total Antioxidant capacity, Nitric oxide.
Molecular Diagnostic of Treponema pallidum in Blood Specimens of Donors Using Simple PCR and Real-Time PCR in Thi-qar Province, Iraq Kamil M. Al-Jobori
Journal of Global Pharma Technology .
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Abstract

Syphilis is a   perplexing infection; it is a complex multistage disease responsible for a range of severe clinical manifestations when untreated or as a result of treatment failure in its sole human host.  The objective of current study was    to diagnostic of Treponema pallidum in blood specimens of donors using molecular methods. A total of 150 samples (25 serums, 25 plasma and 100 whole blood) were used for this purpose. Samples were analyzed using   simple PCR and RT-PCR by amplifying 16Sr and polA genes).During the study period, out of 150 samples of serum, plasma and whole blood collected from males and females, whole blood samples of 14 male and 1 female gave positive result for DNA extract , and and only 15 samples were positive for simple PCR  and RT-PCR for the 16Sr gene . But polA gene   not succeeded to amplify by simple PCR, however, succeeded to amplified 15 samples using RT-PCR. In conclusion, Blood samples, regardless of the compartment (serum, plasma or whole blood) used for testing, appear to be unsuitable for PCR analysis. However, from blood compartment whole blood was the best sample for spirochete detection of syphilis infection   than from serum and plasma samples.Keywords: Blood donors, Syphilis, Treponema pallidum, 16Sr gene, polA gene, Simple PCR, RT-PCR.
Removal of Hexavalent Chromium from Aqueous Solutions Using Azolla Plant Leaf Mojtaba Afsharnia
Journal of Global Pharma Technology .
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Abstract

Soluble hexavalent chromium Cr is one of the most important and most dangerous toxic and carcinogenic heavy metals. This metal in accordance with health organizations has been classified as one of six probably carcinogenic agents through ingestion. This study was conducted to evaluate the level of removal of hexavalent chromium from aqueous solutions using Azolla plant leaf. In this experimental study, the effect of influencing variables was analyzed, including pH (2, 3, 5, 7, 8, 10 and 12), contact time (5 to 120 minutes), adsorbent dosage (0.1, 0.3, 0.5, 0.7, 0.9, 1 and 1.5 g/l) and initial phenol concentration (10-200 mg). Adsorption isotherms were studied using Langmuir, Freundlich and Temkin isotherms. The results showed that acid- heat- modified Azolla plant leaf had greater potential for absorption of chromium in comparison with washed with distilled water or unmodified conditions, so that the absorption rate was about 53% in pH 2 with an hour contact time. Also according to the results, the absorption rate in pH 2 was greater than in pH 4. Therefore, Azolla plant leaf compared with some adsorbents investigated so far is considered as an effective, suitable and inexpensive adsorbent for removal of Cr from aqueous solutions.Keywords: Hexavalent Chromium, Adsorption, Azolla, Aqueous Solutions, Adsorbent

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