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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Role of Sequencing Genetic for 708 T>A of Cholesterol 7α Hydroxylase (CYPA17) in Patient with Gallstone Disease Antesar Rheem Obead
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

AIM: To investigated the association of the CYP7A1 gene polymorphism and analyze the sequencing of CYP7A1 gene   with development of gallstone disease in Iraq population. Methods: The polymorphism were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two group match by age and sex: patient with gallstone (n=140) and stone-free control (n=140).Result: Novelty single nucleotide   polymorphism   in upstream of   CYP7A1 gene   was founded for   PCR amplification   708 T >A in patient with gallstone and conformed by sequencing data and allelic frequencies in patient and control for T of CYP7A1 gene  38.2% vs 54.6% were significant (p=0.0001).Conclusion: The result have been demonstrated that association between the polymorphism of 708 T> A for CYP7A1 gene and an effect on cholesterol 7 α hydroxylase serum level with high prevalent of gallstone disease.Keywords: CYP7A1, Gallstone, Polymorphism, Sequencing analyzing.
Antimicrobial Resistance among Escherichia Coli Causing UTIs in Women Hawraa Wahab Aziz; Israa Adnan Ibraheam; Hawraa Sabah Almusawi; Zeana AL Hindi; Tsahel H. Al-Dulaimi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Urinary tract infections (UTIs) are common bacterial infections, particularly in women. E. coli is  one of the most frequently isolated  bacteria in (UTIs), , it also caused of childhood diarrhea, severe anemia, ,kidney failure, pneumonia, sinusitis and endocarditis. The current study tried to detecting Antimicrobial Resistance Among Escherichia coli Causing UTIs in women. Of the total 48 isolates of Escherichia coli, very high rates of resistance was seen with Ticarcillin 48 (100%), Piperacillin48 (100%), Aztreonam 46 (95.8%), Cefepime and 44 (91.6%)  Ceftazidime 44 (91.6%) . High rates of sensitive was seen with Imipenem 48 (100%), Meropenem 48 (100%), Amikacin 46(95.8%) , Gentamicin 32 (66.6%) , Piperacillin\Tazobactam 32(66.6%), Tobramycin 28 (58.3%) and ciprofloxacin 26(54.1%) , while of Minocycline 8 (16.6 %) has intermediate susceptibility to antibiotics study .According to the last results  the most effective antibiotics were Meropenem , Imipenem and Amikacin so they are considered the best drugs used for treatment of UTIs which caused by Escherichia coli.  Keywords: Antibiotics, E. coli, Urinary Tract Infection, Vitek, Antimicrobial Susstebility.
Osteoporosis and Risk Factors among Postmenopausal Women in Integrated Health Post for Elderly Diana Lyrawati
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Abstract Objectives: The availability of prevalence data for osteoporosis in Indonesia is limited due to the constrained access to BMD measurements, especially in rural areas. Integrated Health Post for the Elderly (Posyandu Lansia) is one of the Indonesian government's programs to monitor and provide health care for the elderly, including postmenopausal women. This study aimed to determine the prevalence of osteoporosis and related risk factors in postmenopausal women. Methods: Respondents were 249 postmenopausal women from 440 people who attended the Posyandu Lansia from 9 villages in Sidoarjo. Quantitative ultrasound was used for calcaneal BMD measurement; other data were collected via questionnaires and enumerated by trained villagers. Results: Our study revealed that the prevalence of osteoporosis postmenopausal women was 73.5%. The osteoporosis risk factors of age, BMI, weight, and menopause duration were associated with T-scores both individually (p<0.05) or simultaneously (p< 0.001), while menopause age and exercise did not. Conclusions: Groups possessing high-risk factors associated with a high prevalence of osteoporosis are postmenopausal women age ≥ 65 years, BMI < 20 kg/m2, weight < 58 kg and duration of menopause > 6 years. Regardless of the groupings, the prevalence of osteoporosis was very high in postmenopausal women. Dietary and exercise adjustments as well as pharmacotherapy may be required to improve their bone health. 
Evaluate the Factors Associated with the Choice of Cesarean Section among Pregnant Women Rasool Gharaaghaji
Journal of Global Pharma Technology .
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Abstract

Introduction Caesarean section is usually limited to factors that vaginal delivery is not possible or associated with the serious risks to the fetus and mother. So, it is expected a few specific indications forces are an delivery, and the rates do not exceed certain limits. But in our country today, the cesarean rate is reported to be more than acceptable. The aim of this study was to evaluate the social, cultural and demographic factors associated with the choice of delivery method. Methods the population of pregnant women was in cities and villages around Uremia city and the intended sample sizewas299 for pregnant women of which171wereurbanand 128 were rural. Sampling was in classification. Using question naire, data was collected and data was analyzed by SPSS software and logistic regression and Pearson Chi-Square. Results Inferential multi variate statistics and findings indica tea significant association between maternal education and the mother's age and father's occupation and child birth with choosing cesarean, but there was no significant relationship between the place of residence (urbanorrural), father's education, mother's occupation, father's occupation, father's age, wanted and unwanted babies and sex with choosing cesarean. The variables, maternal education, maternal age and rating childbirth were entered. According to the importance of place of residence variable its correlation with mode of delivery was confirmed using the Chi-square test. Conclusion Maternal education, maternal age, parental occupation, rating childbirth andplace of residence (urbanorrural) variables was the most important factors in choosing cesarean section. So, it is necessary to organize training workshops form others with high education and young age that are experiencing their first pregnancy, to reduce cesarean section cost.Keywords: Pregnant women, Cesarean section, vaginal delivery.
The Comparison of the Strength of the Arm Muscle between the Conventional Basket Ball Training and the Training Using the Medicine Ball Ida Ayu Kade Arisanthi Dewi
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The training for athletes in the basketball sports must have the excellent biomotor skills, especially in the components of the strength of the arm muscle to be able to do the passing and shooting with the maximum movement. The basketball game uses three main elements namely passing and catching, dribling, and shooting. Until now, the training technique in order to maximize the function of the arm muscle is carried out by loading sand in the body weighing 0.5 kg. This training technique is felt to be uncomfortable when moving, thus another technique is needed to perfect it, namely the training with the medicine ball. This research is a quasi-experimental study using the randomized pre and posttest control group design. The results show that the comparison of athlete's arm muscle strength levels using the conventional training technique with the medicine ball in a row, with the result of 21.45 : 42.3, i.e., there is an increase in the strength of the arm muscle by 49.29% in the medicine ball training. The training by using the medicine ball is an exercise plan using a 1.7-kg medicine ball which can improve the conventional training method.
The Effects of Varieties Sources of Omega- 3 Fatty Acids on Diabetic Male Rats Eman A. Al-Rekabi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The aim of the present study was to investigate the effects of varieties sources of omega-3 on blood parameters, lipid profile and liver enzymes in diabetic male rats. Fish oil and flaxseed oil were used and the animals were maintained with (0.5ml/animal/day). The results indicated that the treatment of diabetic male rats with fish oil and flaxseed oil caused a significant increase (P<0.05) in Hb and PCV and caused a significant decrease (P<0.05) in WBC in compared with diabetic male rats. The results showed a significant decrease in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and liver enzymes, whereas it explained a significant increase in high density lipoprotein (HDL) of  diabetic male rats treated with fish oil and flaxseed oil when compared with diabetic male rats. The study suggested that fish oil and flaxseed oil especially may be as antidiabetic.Keywords: Diabetic male rats; Omega-3; Fish Oil; Flaxseed Oil; Blood parameters; Lipid profile; Liver enzyme.
Antimicrobial and Bacteriological Study for Men Patients with Respiratory Disorder Diseases Hasanain Khaleel Shareef
Journal of Global Pharma Technology .
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Abstract

The current study aimed to designation and investigation for bacteria in the respiratory secretions 40 sputum samples form men patients which found after laboratory examination 40 samples infected with pathogenic bacteria in respiratory disorder diseases patients infected with lung cancer and pneumonia , the results included of Gram Positive Bacteria isolated  were: Staphylococcus epidermidis  had the most presence with 24 (60%) , followed by Streptococcus pyogenes with 5 (12. 5%) , followed by 3(7. 5%) for Staphylococcus aureus ,and about Streptococcus pneumonia represented the lowest percentage 2(2.5%) ,while the Gram Negative Bacteria isolated from sputum were : Klebsiella spp.  and Escherichia coli have the same percentage had the equal presence with2(5% ),while Mycobacterium tuberculosis with 2(5% ),also the study had been included the determination of the antibiotic effected of ( Key: AMC=Augmenting/Amoxicillin, E=Erythromycin, CIP=Ciprofloxacin, AZM= Azithromycin ,CN=Gentamycin, CRO=Ceftriaxone, AM=Ampicillin , P=Penicillin ) on bacterial pathogen isolates from respiratory disorder diseases, they were found: resistance to Azithromycin, Augmenting/Amoxicillin, Ciprofloxacin, Ampicillin and Penicillin were showed by most for bacteria, while most isolated have been found to be sensitive to Gentamycin with Ceftriaxone. Mycobacterium tuberculosis and Streptococcus pneumoniae species showed resistance to most of antibiotics, Kellbesilla spp.  showed resistance to most of antibiotic agents except Ceftriaxone while Streptococcus pyogenes which isolates displayed sensitive for most antibiotics except for Augmenting/Amoxicillin, Ampicillin and Penicillin. Generality of the isolates were Escherichia coli showed best sensitivity to Gentamycin just but resistance for all antibiotics in the study, Staphylococcus epidermidis had to be sensitive for Augmenting/Amoxicillin, Gentamycin and Ceftriaxone which Staphylococcus aureus had to be sensitive for antibiotics agents Gentamycin and ceftriaxone. Conclusions: The respiratory disorder diseases are a serious problem and healthy issue in any community that might refer to elevation diseases of males than females. Also the most common bacteria accompanying in (Lung cancer, pneumonia) are Staphylococcus epidermidis, Streptococcus pyogenes and Staphylococcus aureus respectively from patients in Babylon province. Although the proper antibiotics had been used were the Gentamycin and Ceftriaxone which give high sensitivity for studied bacterial species.Keywords: Respiratory; Disorder; Diseases; Lung; Cancer; Pneumonia; Respiratory; Allergic; Antibiotic.
Genetic Polymorphism of IL-4 Gene as Risk Factors for Patients Suffering from House Dust and Storage Mites Allergy Suaad Almas. Brakhas
Journal of Global Pharma Technology .
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Abstract

The study was design to show and shed light on the Association between IL-4 Gene polymorphism with allergic Rhinitis and Asthma in patient suffering from House Dust and Storage Mite allergy that diagnosed by Skin Prick test forHouse Dust Mites (HDM) Dermatophagoidespteronys sinus, (D.p), Dermatophagoides farina (D.f) and Intradermal skin test for Storage mites Glycyphagusdomesticus   with detected of IL-4 level in serum by ELISA, IL-4 Gene polymorphism (RFLP-PCR), and Total IgE level. A highly significant difference in IL-4 level and totaling E level between allergic asthma, allergic rhinitis and control. In HDM allergy The C allele showed a significant increased polymorphism in Asthma patients (43.33%) and rhinitis patients (40.00%) compared to controls (33.33%). CC genotype was observed to have a significant increased frequency in patients compared to controls while CTand TT genotype frequencies were significantly decreasedin patients compared to controls, increased risk of asthma might be associated with CC genotype, while the genotypes CT and TT are thought to havea protective effect from asthma. Season of mites allergy have major role for disease, the positive Skin Prick test for Dermatophagoidespteronys sinus, (D. p) (46.67%), Dermatophagoides farina (D.f) (70.00%) increased in winter (55.00%) while Glycyphagusdomesticus positive Intradermal skin test (47.67%) increased in autumn. Genetic polymorphism and environmental factors play major role for House dust and Storage Mite mite’s allergy.Keywords: House Dust Mites (HDM), Storage Mites, Serum IL-4, Serum Total IgE, Gene polymorphism IL-4, Allergic Rhinitis and Asthma.
Effect of Different Temperature in DNA State of Teeth Samples Mona N. Al-Terehi
Journal of Global Pharma Technology .
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Abstract

There are many forensic  techniques used today that benefit to identify human remains from mass grave, explosion, fire, disasters, first step of DNA analysis was DAN extraction from biological evidence ,DNA retraction must be free from contamination as possible. The source of DNA is varying numerous as blood, saliva, nail, hair, bone, skin, urine and teeth. All source of DNA can be isolated from any living or dead organism even from ancient specimens. The aims of this study was evaluated DNA  states in teeth samples which exposure to heat at different time, Teeth sample were collected from 30 female from Q adisiyah province \ Iraq. Extraction of DNA were made by Gene MATREX UROX Bone DNA purification kit ,27teeth were burn at 100°C,500°C,1000°C  for(10,30,60) minutes,3 sample of teeth were extraction without exposure to heat as control. The results show that genomic DNA was obtained only in samples exposure to 100°Cand 500°C, no DNA was obtained from samples at 1000°C. The amplification of Exon -7 of gene CYP1A1 by PCR show that 20% of samples was amplified in the 100 C and 500 C grope and no amplification appeared in 1000 C samples. We concluded that DNA was more stable in teeth sample under different temperature, furthermore sample under 1000 C need more investigation like RT-PCR to detect DNA state in low concentrations and purity.Keywords: DNA states, Forensic evidence, Teeth samples PCR.
Implementing Lifestyle Management Using Health Promotion Model Approach Khamida Khamida
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: There are problem-related to student’s health behavior in Islamic boarding schools, they do not washing their hand before they have their meals, hanging wet clothes in their room,  and they do not really care about toilet hygiene.  The aim of this research was to know the effect of peer group support to student's lifestyle management using health promotion model approach. Method: The design was quasi-experimental, pre-post-test control group the population were students who stayed in Islamic boarding school in Surabaya and Sidoarjo, and the total sample was 100 students, 50 in control group, 50 in the intervention group, the sample taken by simple random sampling.  In the intervention group, they’ve got health education and peer group support while the control only got health education by giving a student lifestyle management module. The independent variable was peer group support and the dependent variable Student's lifestyle management. The data were taken by the questionnaire and were analyzed by the Mann Whitney test. Result: The result showed that after the treatment, students in the intervention group have Mean 23.28 SD 4.83 meanwhile the control group has SD 4.27 and Mean 4.38. Conclusion: It means that peer group support could change lifestyle management based on the health promotion model. The leaders or caretakers of Islamic boarding schools are expected to continue to monitor the behavior of students in implementing the management of the student's lifestyle and activate the boarding school health center.Keywords Student, Lifestyle management, Islamic Boarding School Peer Support Group.

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