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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Cardio Protective Effect of Neuregillin-1 against Cardio Toxicity Induced by Trastuzumab in Adult Mice Yousuf Qays Majeed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This work will be carried out to investigate the potential therapeutic effect of  Neuregulin-1 against cardio toxicity induced by trastuzumab in male mice Materials and Methods:  Forty five adult male and female mice (weighing 35-50 gm) were divided into 3 groups randomly, each group contains 15 animals, group A which received distilled water as control by using intraperitoneal injection (IP) route for 10 days group B, received Trastuzumab as 6 mg/kg/day by using intraperitoneal injection route for 10 days while group C, received Neuregulin-1 (2.5 mg/day/animal) just before the administration of Trastuzumab (6mg/kg/day) given by IP route for 10 days. The significance of difference was tested by using ANOVA followed by Tukey test. Statistical significance depends on the P<0.05. Results: Cardiac troponin I concentration was significantly elevated in the trastuzumab group when compared with the control group; while, concentration has been significantly lower in the group C when compared with the trastuzumab group. While, results of total antioxidant capacity had significantly higher in the group B and group C in compare with control group. Conclusion: Neuregulin-1 can be used as a cardio protective in cardiac complications of cancer treatment by its ability to attenuate the cardio toxic effect of trastuzumab by significantly lowering cardiac troponin I concentrations. Keywords: Neuregillin-1, Cardio toxicity, Trastuzumab, Cardiac troponins.
Dominating Energy in products of intuitionistic fuzzy graphs Shaik Sharief Basha; A kalimulla; R Vijayaragavan
Journal of Global Pharma Technology .
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Abstract

The concept of energy of an Intuitionistic Fuzzy Graph is extended to dominating Energy in various products in Intuitionistic Fuzzy Graph. In this paper, We have obtained the value of dominating Energy in different products such as ring Sum, Cartesian Product, Lexicographic Product, Tensor product  and Strong Product between two intuitionistic Fuzzy graphs. Also we study the relation between the dominating Energy in the various products in two Intuitionistic Fuzzy Graphs.
Emerging Developmental Genetic Model Platform in Holometabolous Insects Rehal Jehad Husain
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

The wide variety on grasshopper kind up to expectation is bent according to practical genetic studies is thriving rapidly then affords much instant research possibilities between developmental yet evolutionary biology. Nanotechnology is an interdisciplinary research field. The holometabolous bugs characterize a disproportionate percentage regarding brute diversity yet are for that reason well positioned after grant model species because of a large variety of developmental processes. Here we discuss emerging holometabolous fashions or review some recent breakthroughs. Nanoparticle-mediated cloth shipping according to flora then superior biosensors because of directness farming are viable only through nanoparticles yet Nano chips. Nano encapsulated conventional fertilizers, pesticides, and herbicides help within the gradual and sustained launch about nutrients yet agrochemicals ensuing of the precise degree to the plants. Nanotechnology-based drive into viral disease detection kits are also turning into popular and are useful of fast then promptly detection of viral diseases. In that article, the strong usage or benefits regarding nanotechnology between directness agriculture are discussed. The contemporary nanotechnology-based equipment yet techniques hold the potent in accordance with address the variety of problems regarding conventional agriculture then can revolutionize this sector.
Saccharomyces cerevisiae Immobilisation in Sodium Alginate for Red Dragon Fruit Winemaking N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Red dragon fruit is rich in sugar, organic acids and minerals and other nutrients. It has good processing properties; it is used in the production of fruit juice, jam, and preserved fruit. Its economic value in local market is quite low. Making wine is not only converting the fruit into wine, but also improves its economic value of dragon fruit. Objective of this study focused on the effect of encapsulation of Saccharomyces cerevisiae in sodium alginate complexed with calcium chloride in red dragon fruit wine fermentation. Different technical parameters such as sodium alginate concentration (2.0%, 4.0%, 6.0%, 8.0%, 10%), bead size (2mm, 4mm, 6mm, 8mm, 10mm), bead loading (5 g/100ml, 10 g/ 100ml, 15 g/100ml, 20 g/ 100ml, 25 g/ 100ml), initial total soluble solid (10, 12, 14, 16, 18oBrix), clarifying agent (gelatin, bentonite, wheat gluten, egg white, kieselsol and kaolin) in wine making. Results showed that the best wine quality based on ethanol content (19.38%v/v) and sensory score were recorded by encapsulation of Saccharomyces cerevisiae in 6% sodium alginate, bead size 6mm, bead loading 20 g/ 100ml, initial soluble solid 16%, gelatin as clarifying agent.Keywords: Dragon fruit, Sodium alginate, Calcium chloride, Saccharomyces cerevisiae, Encapsulation, gelatin, Wine.
Effects of Binahong (Anredera Cordifolia) Leaf Ethanol Extracts on Blood Glucose Levels and Pancreas Histopathology in Hyperglycemic Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: The use of binahong leaf has been carried out for medical purposes for centuries. Severalstudies have shown that binahong contain alkaloids, saponins, tannins, glycosides, and terpenes,which can be known to have effects to reduce blood sugar levels. Objective: This study to determinethe effect of binahong leaf ethanol extract in reducing blood glucose and histopathological change inhyperglycemic rats. Method: This study was an experimental study using Wistar rats that weredivided into five groups. The normal group was given with distilled water (P0), the positive controlgroup received glibenclamide (P1), and intervention group was given orally binahong leaf extract ofethanol with a dose of 10mg/kg (P2), 15 mg/kg (P3) and 20 mg/kg (P4). Blood sugar level wasevaluated from the initial day of measurement to two weeks. Pancreas tissue was obtained toevaluate the histopathological change. Results: Mean blood sugar level in each group respectively94.28±6.19 mg/dL, 133.61±47.05 mg/dL, 117.56±26.73 mg/dL, 124.77±37.05 mg/dL, and 136.57±47.55mg/dL. The result of Kruskal-Wallis test was p=0.011. Multiple comparison test showed significantresult between P4 with P0 (p=0.011). Conclusion: Binahong leaf ethanol extract with a dose of 20mg/kg significantly reduce blood glucose level in the hyperglycemic rat.Keywords: Binahong, Anredera cordifolia, Blood glucose, Hyperglycemic rat.
The Implementation of Ergo-Learning 2.0 Strategy in Reducing Fatigue and Improving Speed, Thoroughness and Constancy of Vocational School Students in Semarapura City, Bali I Wayan Sudiarsa
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The ergo-learning strategy 2.0 is a combination between e-learning 2.0 and the principles of ergonomics, so that a humanistic learning process can be generated. This learning strategy was implemented in the form of improving the redesign of the classroom, lighting arrangements, learning media, active break, and stretching using Systemic-Holistic-Interdisciplinary-Participatory (SHIP Approach). This study was an experimental study, conducted using a Randomized Pre- and Post-test Control Group Design. Each group (control and treatment) consisted of 12 people. General fatigue data were collected using a 30 items of rating scale questionnaire with a Likert scale, while speed, thoroughness and constancy data were collected using the Bourdon Wiersma test. The results showed that the ergo-learning strategy 2.0 could reduce fatigue as seen from a decrease in general fatigue by 28.09%, an increase in student speed by 65.91%, an increase in student thoroughness by 50.88% and an increase in student constancy by 48.11%. It is recommended to teachers to implement the ergo-learning 2.0 strategy in learning and to policy makers in schools to consider applying the principles of ergonomics in the management of Education.Keywords: Ergo-Learning 2.0, fatigue, Speed, Thoroughness, Constancy, Ergonomics.
In-vitro Study of Layer Double Hydroxide Nanoparticles as Effective Carrier to Fight Breast Cancer Growth Mohammed S. K. Albermani
Journal of Global Pharma Technology .
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Abstract

Vinblastine is well known alkaloid chemotherapy to treat various types of cancer including breast cancer, merging the field of nanotechnology and therapeutic drugs have brought a great interest. However nanodrugs delivery system has been given great attention in this field especially cancer-drug delivery system due to its significant properties which can be increased drug loading, reduced side effect of the drug and suppress cancer proliferation. Layers of magnesium and aluminum layered double hydroxide nanoparticles (LDH) have been synthesized by co-precipitation method with 25 to 50 nm size as SEM has revealed. Vinblastines have been intercalated in to LDH by ion exchange. Breast cancer cell line  MCF-7 have been  used to determine the cytotoxicity of Vin-NPs via MTT survival assay at different time interval 24 hrs, 48 hrs and 72 hrs. Cell viability of MCF-7 through MTT assay suggests drug intercalated LDHs has better drug delivery vehicle for cancer cell line against poor bioavailability of the pure Vinblastine. These observations clearly demonstrate that Vinblastine intercalated LDH NPs is a potential drug delivery vehicle for anticancer drugs which can increase drug efficiency , reduce the side effects and reduce the cost of the drug as well.Keywords:  LDH nanoparticles, Vinblastine sulfate, MCF-7 cell line and MTT assay.
Various Parameters Affecting To the Dried Salted Snakehead Fish Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Fish is highly perishable, and is spoiled rapidly if improperly handled. Salted dried, one of the techniques for preserving fish has been practiced for long period and it is an alternative to lowering the water activity of flesh fish. Snakehead fish (Channa striata) is a potential freshwater fish species and has become an important commodity in health food industry due to its abundant albumin content. The snakehead fish has commercial value due to its health benefit. It is a good source of medicinal food because it contains high level of amino acids and fatty acids. Therefore we conducted several experiments to identify the effect of salt soaking time, salt soaking concentration, dry temperature and stability of the dried snakehead fish filler by prerservation time. Our results showed that the best quality of the dried snakehead fish fillet could be obtained if the dried snakehead fish fillet treated with 1.0% salt in 1.5 hours and drying at 60oC to 20% moisture content. This application could preserve the dried snakehead fish fillet for 12 months in PA bag without any deterioration. Through this investigation, the added value of snakehead fish could be improved in domestic consumption.Keywords: Snakehead fish, Fillet, Salinity, Drying, Soaking, Preservation
Comparative Analysis of the Level of Hygienic Dental Knowledge of Hard of Hearing and Hearing Disabled People in the City of Penza and the Penza Region Marina Suvorova; Anna Belousova; Galina Emelina; Anna Teplova
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Modern health care has a set of problems. Our native medicine is in great need in the socially oriented help to different groups of the population of the country. One of socially unprotected groups is hard of hearing persons. The special social status does this contingent of the population especially vulnerable in the questions of stomatologic education. It involves the low level of hygienic stomatologic knowledge, and also insufficient motivation to preservation and promotion of an oral cavity health. In Russia there aren't enough researches devoted to the appreciation of the preventive stomatologic help level and to the specified contingent’s needs in it. Creation of the program of prevention of stomatologic diseases of hard of hearing persons is one of the important problems of stomatology. It is available for their specific world’s perception. Relevance is caused by the high level of distribution of stomatologic pathologies among hard of hearing persons of Penza region. Keywords: Hard of hearing persons, Stomatologic education, Hygiene of an oral cavity, Prevention of stomatologic diseases.
Different Parameters Affecting to Rhodomyrtus tomentosa Wine Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Fermentation is a relatively efficient, low energy preservation process which increases the shelf life, and decreases the need for refrigeration or other forms of food preservation technology. It is, therefore, a highly appropriate technique for use in developing countries and remote areas where access to sophisticated equipment is limited. Rhodomyrtus tomentosa plays an important holistic role in the daily lives of several ancient cultures, providing medicinal benefits. There is limited study mentioning to processing of this nutritional fruit. Therefore we explored a wine fermentation from Rhodomyrtus tomentosa by focusing on the effect of different parameters such as pectinase concentration and time of treatment for juice extraction, yeast inculate for wine fermentation, fermentation temperature and secondary fermentation to wine quality. Our results proved that 2.5% pectinase was used for juice extraction in 40 minutes, 2.5% sacchromyces cerevisiae was used for the main fermentation at 29.5oC in 15 days, and 6 weeks of aging in dark bottle at 10.5oC was enough to get a pleasant Rhodomyrtus tomentosa quality. Using Rhodomyrtus tomentosa having medicinal and nutritional value as a substrate for wine production, the health benefits of them can be improved widely.Keywords: Rhodomyrtus tomentosa, Wine, Pectinase, Fermentation, Sacchromyces cerevisiae, Aging.

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