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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Antibacterial Effect of Freshwater Crab Powder against Pathogenic Bacteria Nebrass F. Chachain
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The objective of this study was to examine the antibacterial effect of crab powder on Klebsiella pneumonia, Pseudomonas fluorescens and Escherichia coli. Four concentration (250,300,400 and 500) mg /ml was used ,all bacteria giving the inhibition zone in all concentrations .Powder of freshwater Crab were  show the highest inhibition zone (18mm) in bacteria in  P. fluorescens at concentration 500 mg/ml and lowest inhibition zone  to same species of bacteria was  (11mm) at 250 mg/ml concentration .Keywords: Pathogenic Bacteria; Freshwater Crab Powder; Antibacterial Effect.
Synthesis, Characterization of Some Novel 1, 4- Benzoxazine- 3- One Derivatives Starting From O-Amino Phenol and Study Their Biological Activity Helen Abd Al Hassan Mahmood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this work: Benzoxazinone derivatives were used as a precursor to synthesize of many heterocyclic systems. The aim of current study was to use the easily available o-amino phenol for the synthesize of 1, 4-benzoxazine-3-one. The benzoxazinone compound of interest was  synthesized by reacting the  o-amino phenol with chloroacetyl chloride, The treatment of  o-chloro acetamidophenol (FH)  and anhydrous potassium carbonate in refluxing DMF afforded the corresponding 1,4-benzoxazine -3-one (1) in excellent yield. The treatment of ethyl chloroacetate with compound (1) gave compound (2), while compound (3) was produced by reacting of hydrazine hydrate with compound (2). Compound (3) was used as precursor to synthesize  (5a-d),(ST),(6),(7a,7b),(8,9)  by its reaction with different chemical reagents,  while on treatment of the compound (1) with 4-nitrobenzaldehyde in acetic anhydride: triethylamine (2:1) as a solvent gave chalcone (10). The structures the synthesized compounds have been confirmed by FT-IR, 1H-NMR, and Mass spectroscopy. The synthesized derivatives have been screened in vitro for antimicrobial properties. The results of this investigation revealed that the newly synthesized compounds are potent antimicrobial agents.Keywords:  2-Aminophenol, Benzoxazinone, Schiff’s base, 1, 2, 4-triazole, Antimicrobial.
Sequencing of Entamoeba Histolytic Cysteine Protease 5 (CP5) Isolated from Diarrheic Cases in Babylon Province Hayam K. Al- MasoudI
Journal of Global Pharma Technology .
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Abstract

The results of the current study revealed that the amplified DNA for cysteine proteinase (CP5) in 40 cases .The characterization of the cysteine proteinase  which is the most important virulence factors secreted by E. histolytica have led to a better understanding the pathogenic mechanisms of E. histolytica (pathogenic ) are distinct species from the nonpathogenic      or   a harmless commensal.
The Risk Factors That Affecting Carpal Tunnel Syndrome (CTS) Agusni Karma; Tri Riana Lestari; Ujang Abdul Muis; Rizki Rohimah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Nowadays, interaction between human and mechine is often happened, it can be with computer or laptop, using computer/laptop with mouse in long period without resting the wrist will lead to symptom of Carpal Tunnel Syndrome (CTS). CTS have a significant correlation with improper posture of the hand and the age. This research is to know the relation between age, improper hand position, and work period towards risk of CTS on staffs who work in front of computer/laptop >4 hours a day. Methods: For the method was give some questionnaires, direct observation and Phallen test to each respondent. Results: From 33 of respondents was found 26 staffs who had risk of CTS. In improper hand position and work period factor was found the p-value of 0.000. But in the age factor was found p-value of 0.277. Analysis: In improper hand position and work period factor it caused by wrong position of the hand and pressure median nerve. In the age factor it caused due to staffs often did wrist gymnastic on work hours which is one of the exercises that preventing CTS. Conclusion: There is correlation between improper hand position and work period with risk of CTS. Keywords: Carpal Tunnel Syndrome, Improper Hand Position, Work Period
Anxiety, Depression and Sexual Dysfunction in the Patients Undergoing Bone Marrow Transplantation Mohammadi Ali
Journal of Global Pharma Technology .
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Abstract

Introduction nowadays, following improvement in bone marrow transplantation (BMT) techniques, and increase in life expectancy in patients whom undergoing this procedure, researchers have paid attention toward improvement in quality of life of these patients. Some of the most important problems of these patients include anxiety, depression and sexual dysfunction. Considering that there are few studies regarding the prevalence of these disorders and its related factors and because of controversy in their results, and lack of any study in this topic in Iran, this study was performed. Material and Method: This study was a cross sectional study and the sampling method was simple sampling method. The studied community was 60 patients who were received BMT and referred to oncology clinic of Taleghani hospital in Tehran. The inclusion criteria were receiving BMT from 3 months to 3 years, and having consent for participation in the study. The exclusion criteria were not having consent for participation in the study, and the age under 18 years. The study tools were three questionnaires: Persian version of hospital anxiety and depression scale (HADS) and Arizona Sexual Experience Scale (ASEX) both were standardized previously; and a questionnaire regarding demographic data of participants and other needed data such as history of anxiety, depression and sexual dysfunction prior to BMT, type of primary disease, and type of performed BMT that were extracted from the patient’s records. After data gathering, the data was analyzed using SPSS software version 22 and using general indexes of descriptive statistics, qui-square and t-test. Results 25 participants were female and 35 men. The rate of anxiety, depression and sexual dysfunction prior to BMT were 21(35%), 10(16.7%) and 16(26.7%) respectively and after BMT were 7(11.7%), 6(10%) and 38(63.3%) respectively. The increase in sexual dysfunction after BMT was statistically significant. (p=0.024) Conclusion the rate of sexual dysfunction may increase after BMT.Keywords: Bone marrow transplantation, Anxiety, Depression, Sexual dysfunction.
Spectrophotometric Method for Determination Folic Acid via Diazotization and Coupling with 4-Aminoantipyrine Resala A. Saleh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Uncommon coupling reagent is used for the simple and sensitive spectrophotometric determination of folic acid in pure form and in its pharmaceutical preparations. The method is based on the diazotization of the p-aminobenzoyl glutamic acid formed after reductive cleavage of folic acid, followed by coupling 4-amino antipyrine to give an orange product with λmax of 469nm. The results follow ‘Beer’s law in the concentration range of 2-100 µg.mL-1 with molar absorptive of 3266.36 L.mol-1.cm-1. The limit of detection was found to be 0.1482 µg.mL-1 and the Sandell’s sensitivity value was 0.1351 µg.cm-2. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods. The proposed method was successfully applied to the determination of folic acid in pharmaceutical preparations.Keywords: Folic Acid; Spectrophotometry; 4-Aminoantipyrine
The Impact of Training Program to Develop the Most of Functional and Skill Abilities for the Players in the Volleyball Maysaloun Zuhair Hussein
Journal of Global Pharma Technology .
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Abstract

The preparation stage in the quality of the year and the private is the basis on which the team is built and which depends on access to high levels of sports, both in terms of functional or technical and the requirements of training in volleyball is many and multiple, the training process has become complex, and requires planning based on the sound scientific foundations through which possible to achieve the best possible results in light of the capabilities of the player and its potential, so that training these capabilities is the cornerstone on which the training is based on the type of the game as the player cannot reach the high performance without the availability of such Capacity and sustain training and improve their level, and the importance of this study in building the basic rule of volleyball and the need to develop a training curriculum interested in how to train the early stages of the year, which prompted the researcher to engage in this research attempt to apply the scientific foundations in the training of volleyball with appropriate ages and important in sports training.The research objectives to:Preparation of a training curriculum to develop some of the skills and skills of the players of the volleyball.Knowledge of the impact of the curriculum in developing some of the functional and skill capabilities of the players of the volleyball.The researchers used the experimental method (designing two groups) to suit the problem of research. The research community determined the club members in front of Al-Mutaqin and Al-Husseiniya club in the youth category. The number of players was 32 and a simple random sample of 24 players was selected and divided into two groups (Experimental and control).From the results obtained, the researchers reached the following conclusions:The training curriculum has a positive effect on the development of functional abilities (lactic non-oxygen ability, lactic oxygenation, oxygen capacity), and skill capabilities (Service, defense of service, preparation (passing), spike and block).The evolution of experimental group members was better with the functional and skillful abilities of all tests compared to control group members.The highest significant value of the experimental group in the non-lactic capacity tests for the functional abilities and the overwhelming impact on the skill capacity.Keywords: Training program, Functional and skill abilities.
Teaching Curriculum Using the Effect Competitive Learning Style According To the Training Network Exercises Learn Some Offensive Skills of Basketball Emad Toma Radi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Research objectives of preparing an educational platform for educational units using the teaching and learning style of individual and collective competition according to exercises training network to learn some offensive skills of basketball.The researcher pilot curriculum sample that consisted of the first grade students of faculty of Physical Education in the  Mustansiriyah  University, whose number reaches 57 students divided into three experimental groups used tools and means of information collection and tests the skill and experience of the scientific Choose foundations of exploratory pretest curriculum dimensional tests and statistical means. And then present, analyze and discuss the results of the three aggregates, and then the researcher arrived to conclusions as follow:That the teaching curriculum using competitive learning network, according to the training exercises had a positive impact on learning performance level skilled in the handling of the Invite long over your shoulder shots jumping among students in the sample.Keywords: Teaching curriculum, Competitive learning, Training network exercises and offensive skills.
Exotoxins A, T and S among Pseudomonas Aeruginosa Isolates from Clinical and Hospital Environment Samples Ahmed Jamal Hussein; Frial Gemeel Abd
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Pseudomonas aeruginosa is one of the most widely recognized Gram-negative   opportunistic pathogens related with nosocomial infections. The presence of several virulence factors, for example, exotoxins of the bacteria making a genuine risk to the patient. This study was intended to detect Exotoxin A, T and S genes in P. aeruginsoa isolates utilizing PCR system. It includes (30) isolates of bacteria diagnosed by traditional techniques and confirmed by the API 20Eand Vitek 2 Systems  , DNA isolated and subjected to amplify using specific primers for bacteria. The consequences of PCR amplification for the genes encoding for exotoxin A, T and S demonstrated that all P. aeruginosa isolates showed the presence of the genes encoding for exotoxin A and exotoxin T corresponding to 100 % of the isolates while twenty two (22) isolates comparing to 73.33 % of the total thirty (30) isolates were recorded to be positive for exotoxin S gene . It can be concluded that exotoxins are a conspicuous virulence factors for P. aeruginosa and responsible for a genuine threat to patients.Keywords: Exotoxin, Pseudomonas aeruginosa ,Toxin ,Environmental Isolate. 
Genetic Variation of At-Hook Transcription Factor (Akna) Rs3748178 is Associated with the Relapse of Graves’ Disease Dwi Anita Suryandari
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: As many as 30-60% of patients with Graves' disease (GD) have relapsed after antithyroid withdrawal, which may be caused by genetic variation of susceptibility factors. This study aimed to analyze the genetic variation of AT-hook transcription factor AKNA rs3748178 and its association with relapse in Graves' disease patients.Methods: This research was a case-control study examining 60 DNA samples of GD patients, who were equally allocated into relapse and remission groups. Genetic variation was analyzed with PCR-RFLP. Fisher's exact test was used for statistical analysis and a p-value less than 0.05 was considered significant.Results: The proportion of patients who experienced a relapse with homozygote wild type (n= 27, 90%) was significantly higher (p= 0.015) compared to the heterozygote and homozygote mutant (n=3, 10%). Graves’ disease patients with GG genotype were more likely to have a relapse (OR 6.00, 95% CI 1.48–24.3, p= 0.015). The proportion of patients who experienced a relapse with G allotype (95%) was significantly higher (p= 0.004) compared to A allotype (5%). Graves’ disease patients with G allotype were more likely to have a relapse (OR 6.33, 95% CI 1.73–23.2, p= 0.004).Conclusions: Genetic variation of AT-hook transcription factor AKNA rs3748178 is associated with relapse in GD patients.Keywords: Graves’ disease, recurrence, genetic variation

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