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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Microwave Vacuum Drying Variables Affecting to Processing of Dried Gomphrena globosa Floral Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Microwave vacuum drying is one of the most energy demanding processes. Water evaporation takes place at lower temperatures under vacuum, and hence the product processing temperature can be significantly lower, offering higher product quality. Gomphrena globosa is one of the traditional medicinal plants widely distributed in Vietnam. It’s considered as a valuable source for pharmaceuticals against various ailments. Gomphrena globosa L. flowers are a promising source of natural antioxidants. Objective of this study focused on the influence of processing parameters such as the microwave power (100, 150, 200, 250, 300 W), system pressure (20, 25, 30, 35, 40 kPa) and drying time (15, 20, 25, 30, 35 min) on shrinkage coefficient, rehydration ratio, color change, total phenolic, flavonoid, betacyanin of dried herbal during the microwave vacuum (MV) drying of Gomphrena globosa. At the end of drying process, we also monitored the stability of dried Gomphrena globosa flower during 12 months of preservation. Our results showed that the optimal drying process should be conducted at microwave power 250 W at 35 kPa within 30 min to get the best quality of dried Gomphrena globosa flower. From this approach, shelf-life of dried Gomphrena globosa flower could be last for 12 months without any deterioration. The low temperature and fast mass transfer conferred by vacuum combined with rapid energy transfer by microwave heating generates very rapid, low temperature drying and thus it has the potential to improve energy efficiency and product quality.Keywords: Gomphrena globosa, microwave vacuum drying, Shrinkage coefficient, Rehydration ratio, Color change, Total phenolic, Flavonoid, Betacyanin.
Antioxidant Potential, Total Phenolic and Flavonoids Content of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: The aim of this work was to estimate the total phenolic and flavonoids content, and to evaluate in-vitro antioxidant activity of ethanolic extract of Cordia obliqua.Methods: The ethanolic extract of Cordia obliqua was examined by Iron chelating activity, Total antioxidant activity, Total phenol and flavonoids with reference standard EDTA (Ethylenediaminetetraacetic acid), Ascorbate and catechol respectively through in vitro models.Results: The antioxidant activities of the extract were positively associated with the total phenolic and flavonoid contents of the ethanolic extract of cordia obliqua.Conclusion: Ethanolic extract of Cordia obliqua. showed strong scavenging activity. These in vitro assays indicate that this plant extract is a better source of natural antioxidants. The presence of antioxidants such as phenolics, flavonoids, tannins and proanthocyanidins in plants may provide protection against a number of diseases including cancer, neurodegeneration and inflammation. 
Self-care Maintenance of Heart Failure Patients in Babylon Teaching Hospitals Ameer Hassan
Journal of Global Pharma Technology .
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Abstract

Heart failure (HF) is currently one of the major public health problems in world, and its complex and gradual nature often results in reverse proceedings, such as high rate of  rehospitalization and mortality, which could be reduced if there were appropriate self-care, therefore, Self-care is one of the most significant aspects of the treatment of patients with heart failure  through  using special activities to reduce and relieve symptoms and maintain and promote health in patients. Quantitative research, descriptive design cross sectional study Non-probability purposive sample consisted of (100)  heart failure patients who admitted to the Babylon teaching hospitals were selected .The finding out of the study show most of the patient with heart failure have moderate self-care management  a high significant difference between the self-care ability  and their body mass index levels. a significant difference between this disease  and their chronic diseases, hypertension, diabetes mellitus  and duration of disease.Keywords: Self-care, Management, Heart failure patients, Babylon teaching Hospitals.
Photo Catalyst Degradation of Methylene Blue Dye by Synthesized TiO2/Graphene Oxides Composites Mayada Talib Al-Zubaedi
Journal of Global Pharma Technology .
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Abstract

A ternary nanocomposites of TiO2-Fe2O3/graphene oxide (GO) and TiO2-Fe2O3/reduced graphene oxide (RGO) were prepared from TiO2-Fe2O3 successfully and by precipitation method and graphene oxide (GO) has been prepare from graphite by Hummers method. The ternary nanocomposite possessed enhanced charge separation efficiency. The comparison studied between the three catalysts resulted in the presence of different decomposition data that were affected differently; pH, H2O2, concentration, pollutant concentration, temperature, irradiation time, also the morphology of the ternary nanocomposite and the average diameter which was studied by Atomic Force Microscopy (AFM). The photocatalytic degradation efficiency for methylene blue on the nanocomposites were scanned and the efficiency of photocatalytic degradation of ternary composite was best than that of pure TiO2. Show the result that the photocatalytic efficiency of ternary nanocomposite was obtained and reach 90.8% in 30 min. It is suggested that the ternary composite of TiO2/Fe2O3/RGO can be an efficient multifunctional.Keywords: Photo degradation, TiO2/Fe2O3, composite, Methylene Blue, Fenton's reaction.
Human sperm DNA integrity : A difference of storage temperature and period of freeze-drying process silvia werdhy lestari; ahmad silalahi; hamdani lunardi; agustinus agustinus
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The cryopreserve technique using liquid nitrogen is used to preserve human sperm. Nevertheless, this technique has several disadvantages, such as bacterial/viral contamination and its expensive cost. Freeze-drying process offers more simple and cheaper of sperm storage technique. This study aimed to investigate the effect of storage temperature and period of freeze-dried human sperm on DNA integrity. Human sperm samples of 15 donors were prepared with simple washing techniques. Post-washing samples (T0) were divided into 4 groups with the same volume. The four group of samples carried on the freeze-drying process and stored based on different temperature and period: 4°C for 1 week (T1), room temperature (24-25ºC) for 1 week (T2), 4°C for 3 months (T3), and room temperature for 3 months (T4). Sperm DNA integrity was analyzed before and after the storage period of each group. There was a statistically significant difference of sperm DNA integrity of freezes - dried at 4°C in 1 week versus 3 months (T1 vs T3), at room temperature in 1 week versus 3 months (T2 vs T4) (p
Removal of Celestine Blue Dye From Textile Wastewater by Adsorption over the Mixed Oxide NiO –MgO Huda Salam Ghani
Journal of Global Pharma Technology .
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Abstract

This study was carried out for the purpose of estimating the adsorption kinetics and removal of Celestine Blue Dye from textile wastewater by adsorption over mixed oxides NiO–MgO that prepared in our laboratory. The optimum conditions for removal  were studied which includes the appropriate concentration of dye as well as weight of adsorbent, temperature ,pH effect, speed of shaking  and optimum time for the removal  where the best concentration of the adsorption process is ( 100 ppm), the best economic weight is( 0.025 gm)at( 45 min) shaking time at the acidity of the dye which is( pH = 5) and shaking speed of( 175 cycle per minute) at the temperature of the laboratory (25oC ).Keywords: Adsorption, Mixed oxides, Celestine blue B dye.
Potential Of Biological Activities From Chemical Compounds Of Nigella Sativa As Anti-Osteoporosis, An Insilico Study Mohammad Kuntadi Syamsul Hidayat
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: The objective of the study was to investigate the potential of biological activities from chemical compounds of Nigella sativa (NS) as anti-osteoporosis using the computational chemistry insilico study. Methods: Database search from KnapSack was conducted to find out NS active compounds. Next, explore using the PASS Server database to find out compounds that have anti-osteoporosis potential. Exploration with STITCH to analyze the interaction of NS active compounds with cell proteins related to anti-osteoporosis, then docking using PyRx to determine the bond affinity that occurs between NS active compounds and cell proteins. Result: There were 36 active NS compounds, 28 of which had anti-osteoporosis potential. One active compound that has a probability to be active value (Pa)> 0.7 and 21 active compounds that have Pa: 0.3 - 0.7. Found 6 active compounds that have interactions and play a major role in the anti-osteoporosis process. With the docking process, binding affinity longifolene is obtained with estrogen receptors: -8.2 kcal / mol, compared to Bazedoxifene -9.6 kcal / mol Conclusion: From the study of insilico, Nigella sativa has the potential as an anti-osteoporosis Keywords : Osteoporosis, Nigella sativa, insilico, anti-osteoporosis
Efficacy of Chitosan as Clarifying Agent to Physico-chemical and Organoleptic Attributes of Pineapple Juice during Clarification Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Turbidity is a major obstacle in preservation of fruit juice and concentrate. This phenomenon is also not acceptable in handling and distribution of commercial beverage. Fruit juice is a complex of soluble and insoluble multi components in suspension. Clarification is a crucial step to remove pectin, carbohydrate, metal ion as well as solid particles existing in fruit juice to achieve a clear and stable status. As a natural abundant polymer, chitosan has been proven as an alternative approach for juice clarification with diversified manipulations in appropriate cost. Our study focused on the feasibility of chitosan as clarifying agent to physico-chemical and organoleptic properties of pineapple juice during clarification. Different concentrations of chitosan (0.05, 0.075, 0.1, 0.125, 0.15%) and agitation speeds (40, 60, 80, 100, 120 rpm) have been investigated fruit juice to evaluate turbidity (NTU), viscosity (cP), total soluble solid (oBrix), total phenolic (mg GAE/g), flavonoid (mg GE/g) and sensory score after clarification. Our results revealed that 0.125% chitosan; agitation speed 80 rpm were adequate and efficient for juice clarification. As being nontoxic and biodegaradable, chitosan could be effectively utilized as an alternative agent for refining of fruit juice.Keywords: Pineapple juice, Clarification, Chitosan, Turbidity, Viscosity, Total soluble solid, Total phenolic, Flavonoid, Sensory score.
A Centralized Automated System of Monitoring Adverse Events of Medications- “Medreminder” Serikzhan Berdakhovich Sydykov
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Research ObjectiveTo develop and test the methodology of the centralized automated system of monitoring adverse events of medications in the Republic of Kazakhstan.Research TasksThe analysis of the existing practice of monitoring adverse events of medication in the Republic of Kazakhstan, the identification of problems and the directions to improve the situation.Testing the models of an automated system collecting information about adverse events of medications and the evaluation of effectiveness of the developed system collecting information about adverse events of medications, identifying patients/consumers’ roles of Kazakhstan medical products in the system of pharmacovigilance.Keywords: pharmacovigilance, monitoring the safety of medications, patients, consumers, monitoring adverse events, “yellow card”, consumer reporting.
The Role of Lipopolysaccharide and Tight Junction Protein-1 (Zo-1) Levels and Symbiosis of Black Rice Extract in Obese Patients Armanto Makmun
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Excessive fat accumulation, which is commonly known as obesity, causes health problems for the community, such as metabolic disorders. Recent studies have shown that the gut micro biota is involved in the occurrence of metabolic disorders in obesity. The gut micro biota can regulate body weight by influencing metabolic processes, regulating the expression of host genes, increasing the ability to extract and store energy. Intestinal micro biota imbalance and increased plasma lipopolysaccharide (LPS) contribute to inflammation in obesity. The latest safe approach in cases of obesity is to use active ingredients from local foods. In South Sulawesi, Indonesia and also in other Asian countries found black rice as the local product that is very good for health because the high level of bioactive compounds that are important for health such as anthocyanin, proteins, amino acids, and phenolic acids. The ingredients in black rice play a role in modulating the composition of the intestinal micro biota as indicated by the increasing composition of Bifid bacterium and Lactobacillus. The increase in the composition of Bifid bacterium causes improvement in the expression of tight junction proteins in the intestinal epithelium, thereby contributing to prevent the translocation of LPS into the circulation. Apart from its role in modulating the composition of bacteria, it can also function to influence intracellular signaling.

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