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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Thiamine, Riboflavin and Magnesium Level Correction in Improving the Quality of Life of Patients with Chronic Heart Failure Fatima Dzalaeva
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Data are presented on the effectiveness of treating patients with chronic heart failure (CHF) with vitamins B1, B2 and magnesium (Mg) added to the standard complex therapy. The group of patients with cardiovascular diseases (CVDs) consisted of 143 patients with CHF I-III functional class according to NYHA (New York Heart Association Functional Classification), as a complication of coronary heart disease (CHD). To determine the preferred doses of vitamins B1 and B2, we studied the dynamics of the concentration of thiamine (B1) and riboflavin (B2) in blood plasma and their daily excretion with a single intake of vitamins by healthy volunteers at doses of 10, 20 and 30 mg. To determine the preferred magnesium-containing drug, Mg concentration dynamics in the blood plasma of healthy volunteers were studied when taken orally in an equal dose in the form of Mg oxide and in the form of Mg orotate. The study involved 80 healthy volunteers. In order to improve the quality of life for patients with CHF and increase tolerance to physical exertion, it is advisable to add Mg in combination with vitamin B1 and B2 in the standard complex therapy. When Mg salts are added to the standard complex treatment of CHF, it is preferable to use Mg orotate. When using vitamin B1 (thiamine), it is not advised to increase the daily dose of more than 10 mg/day, since this leads to a progressive increase in the excretion of this vitamin B1 and vitamin B2.Keywords: Chronic heart failure, Therapy, Mg salts, Thiamine (B1), Riboflavin (B2).
Forensic Systematic Fungal Infection Identification by PCR-DGGE in Human and Chicken Blood Samples Mohammad J. Al-Jassani
Journal of Global Pharma Technology .
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Abstract

PCR can act as a key clue in court after fungus infection is determined that give an indication of the source of infection in order to determine either a zoonotic infection and/or a possible bio-terror action in a disease outbreak or poisoning bio-crime. Total of 30 blood samples were collected in the EDTA tube that include (10 healthy (asymptomatic) human blood samples, 10 chicken blood samples and 10 human blood of poultry workers. The PCR-DGGE analysis showed multi-banding pattern for some ‎samples, which means that they are infected with more than one fungal ‎species. Some of these bands (OUT) are shared between human (asymptomatic), Chicken and poultry workers. Periodic fungal infections follow up, using PCR-DGGE technique, for fungal population variation and ‎detection of any new emerging strain, are highly recommended.Keywords: Forensic, Fungal infection, PCR-DGGE.
Antimicrobial Resistance Patterns and Metallobeta-lactamases Producing of Imipenem Resistant Pseudomonas aeruginosa Isolated from Clinical Samples of Iraqi Patients Marwa Lafta Jebur
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

In this study, a total of 160 clinical samples (72 burned skin, 25 wound, 18 sputum, 24 urine and 21 ear samples) were collected from five hospitals in Baghdad during the period December 2017 - April 2018. The samples were cultured on MacConkey agar and blood agar plates to isolate Pseudomonas aeruginosa in order to estimate its prevalence rate, which was 65% (104/160) of the total clinical samples. It was found that 37.5% (39/104) of P. aeruginosa isolates were resistant to imipenem (IRPA). A phenotypic detection of beta-lactamases showed that all IRPA isolates did not produce extended spectrum beta-lactamases, while 89.7% (35/39) of these isolates produced metallo-betalactamases (MBLs). Antibiotic susceptibility test against 11 antibiotics using the disk diffusion method showed that all metallo-betalactamases producing IRPA isolates were sensitive to polymyxin B, while resistance rates were 100% to both cefotaxime and ceftazidime, 94.3% to both netilmicin and amikacin, 91.4% to each of meropenem, gentamicin and tobramycin, 88.6% to cefepime, 82.9% to aztreonam and 77.1% to piperacillin/tazobactam. The resistance of metallo-betalactamase producing IRPA isolates for antibiotics according to MIC values was 100% to both tigecycline and cefazolin, 91.4% to meropenem, 85.7% to tobramycin, 80% to both cefepime and gentamicin, 71.4% to each ceftazidime, amikacin and levofloxacin, and 51.4% to ciprofloxacin.Keywords: Pseudomonas aeruginosa; Metallobeta-lactamases; and Antimicrobial Resistance.
Choledocholithias Ascending Cholangitis and Gallstones Pancreatitis Diyar Ali Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Gallstone ailment is certain over the most frequent yet near high-priced digestive illnesses to that amount require hospitalization within the United States together with an estimated anniversary advise worth of $5.8 billion. Gallstone sickness is newly diagnosed of greater than 1 million people yearly, or cholecystectomy is executed of 700,000 cases. The incidence of gallstones has ethnical variability, with occurrence prices about 10% in accordance with 15% within the United States yet Europe. The medical spectrum concerning cholelithiasis degrees from an asymptomatic state in accordance with fatal complications .Patients any bear asymptomatic gallstones lift an annual hazard about approximately 1% because of biliary colic, over 0.3% for exquisite cholecystitis, concerning 0.2% because of symptomatic choledocholithiasis, then of 0.04% in conformity with 1.5% because of gallstone pancreatitis (GSP). These small percentages, however, signify a considerable quantity about patients, attached the common incidence about gallstones.
The Effect of Special Exercises for the Development of Performance Endurance Ability and Correlation it with Accuracy Scoring from Jumping in Basketball Dhaher Ghanawi Mohammed
Journal of Global Pharma Technology .
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Abstract

The objective of the research was to identify the effect of the special exercises in the research in developing the ability to withstand the performance of the basketball as well as to identify the relationship between the performance and accuracy of the scoring of jumping basketball. The researcher used the experimental method for his research problem. The research sample was chosen in a deliberate way. They are (22) players who are divided into two equal groups (10) players for the experimental group and (10) players for the control group and a percentage of (90%) from the original search community where players were excluded for the purpose of the exploratory experiment. After the main experiment and tests were completed, the (SPSS) program was used for statistical data processors to reach the results, after which the results were presented and discussed. The results of the study showed that there were statistically significant differences between the post tests of the two groups in the basketball endurance test and for the benefit of the group. The results showed that there is a correlation between the ability to withstand performance and the accuracy of the scoring of basketball jump as the increase in working periods affect the concentration and thus reduce accuracy. The researcher recommended the use of special exercises according to the skill requirements to be developed in order to reach the required level. He also recommended the need to develop the ability to withstand the performance of the players because they are closely related to the accuracy of the scoring. And recording when the basketball.Keywords: Special exercises, Performance endurance, Ability, Accuracy and jumping.
Sublay and Onlay Mesh Application Compared with Tension Free Suture as Treatment Techniques for Ventral Hernia in Sheep Ahmed Kadhim Munahi
Journal of Global Pharma Technology .
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Abstract

The present study was assigned to find the optimal surgical repair for reconstruction of experimentally induced ventral hernia in sheep. A ventral hernia (5×5) cm had been made in the right flank of 9 ewes and left for a month. After that those ewes were randomly divided into 3 treatment groups; the first group of ewes was applied with polypropylene mesh repair by onlay technique. Whereas the second group was applied with polypropylene mesh repair using sublay technique. While in the third group the hernia was repaired with tension free sewing technique using catgut. The postoperative complications were monitored for a month following the previous applications. Macroscopic results showed that recurrence of hernia was experienced in the first and the third groups accompanied by wound infection and fever.  On the other hand, the second group did not face life threatening problems but experienced mild seroma and fever. There was no recorded mortality case until the end of the experiment in all treatment groups. Histologically, the onlay group demonstrated reaction of granulomatous foreign body response with process of fibrosis. In contrast, the sublay group revealed a separate granulomatous foreign body reaction and minimal response of inflammation and fibrosis. Whereas, the third group showed hyperemic blood vessels, abundance of fibrous connective tissue and deposition of collagen as well as inflammation around the suture materials. These results revealed the success of the sublay technique over the onlay and the catgut suture for herniorrhaphy.Keywords: Onlay, Sublay, Tension free suture, Ventral hernia, Sheep.
Antibacterial Activity of Bis (2-Ethylhexyl) Phthalate Leaves Fraction of Colocacia esculenta L against Enteric Gram Negative Bacteria Herwin Herwin; Siska Nuryanti; Muzakkir Baits; Sjafaraenan Sjafaraenan
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

This study is aimed at testing the antibacterial activity of the compound Bis (2-Ethylhexyl) phthalate leaves fraction of Colocacia esculenta L against enteric gram negative bacteria. The search for bioactive compounds employs the vacuum liquid chromatography method used for fractionation and purification, spectroscopic analysis (infrared, proton and carbon core magnetic resonance, chromatography-mass spectroscopy) gas, Minimal Inhibitory Concentration (MIC), Minimal Bactericidal Concentration (MBC), Agar diffusion and TLC-Bioautography for activity testing against Enteric Gram Negative Bacteria. The results of the fractionation shows that based on agar diffusion, the B fraction obtains the MIC value is 0.1%, and MBC value is 1%. Spectroscopic analysis of the secondary metabolites of the leaves fraction of Colocacia esculenta L obtains the chemical structure of Bis (2-Ethylhexyl) phthalate with the molecular formula C24H38O4 and molecular weight 390.5. The test on the compound Bis (2-Ethylhexyl) phthalate from the leaves fraction of Colocacia esculenta L L by TLC-Bio autography obtains an active Rf value of 0.7 against bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella thypi, Streptococcus mutans, and Vibrio cholerae, by diffusion Agar method, the largest inhibition zone in Salmonella thypi bacteria. Based on the results, the identification of secondary metabolites from the leaves fraction of Colocacia esculenta L obtains the chemical compound Bis (2-Ethylhexyl) phthalate and based on the results of the antibacterial activity test of the chemical compound Bis (2-Ethylhexyl) phthalate leaves of Colocacia Esculenta L is potential for the treatment of enteric gram negative bacteria infections. Keywords: Colocacia esculenta L, Bis (2-Ethylhexyl) phthalate, Antibacterial
Behavioral Factors Affecting Patient's Compliance in Consuming Anti-diabetic Oral Drugs Liza Pristianty
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Treatment compliance is a major problem in overcoming diabetes mellitus. This case inhibits the achievement of optimal levels of health for people with diabetes mellitus. However, various types of factors that enable patients to be disobedient to treatment have not been widely studied in terms of pharmacy. Objective: This study aimed to identify behavioral factors that influence diabetes mellitus patient compliance in taking oral antidiabetic drugs. Methods: This study was observational analysis using cross-sectional design. Sampling was obtained by accidental sampling method. The independent variables in this study were the knowledge and attitudes of patients; availability of health care facilities, and behavior of pharmaceutical officers. Whereas, the dependent variable was the compliance of the patients with diabetes mellitus taking antidiabetic drugs. Data were collected using valid questionnaires then analyzed using correlational analysis. Results: The results of this study indicated that the support of pharmacists had significant effect on patient compliance (p = 0.006). Whereas, knowledge, behavior, and availability of health service facilities had no significant effect on patient compliance in taking oral antidiabetic drugs (results in sequence: p = 0.642; p = 0.379; p = 0498). Conclusion: The role of pharmacist is very important in efforts to provide information and motivation for the treatment of diabetes mellitus, especially the consumption of oral antidiabetic drugs. This research is expected to improve pharmacy services related to the accuracy of providing information to patients. It will also have an impact on improving the quality of life of patients and providing quality services.Keywords: Behavioral factors, Diabetes mellitus, Patient compliance.
Effectiveness of Gac Aril Extract to Stickiness, Retrogradation and Staling of Glutinous Rice Cake Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Gac fruit (Momordica cochinchinensis Spreng) is a popular fruit in rural area of Vietnam. Its aril contain high amount of β-carotene, lycopene, α-tocopherol and fatty acid. Its bright red color attracts consumers besides phytochemical constituents. It is very important to utilize these valuable constituents in Gac aril for multiple food processing applications. Glutinous rice cake is a kind of folk cake, very rustic, was present very early in the cuisine of Vietnam, also the specialty cakes of the local countryside, quite familiar and impressed in the hearts of people, products with aromatic fatty flavor, tasty, sweet flowing with delicate. Nowadays consumers require glutinous rice cake with superior appearance, texture, taste and flavor while stabilizing its nutritional value. Therefore in this present research, we examined the supplementation of Gac aril extract in different concentrations (2.0, 3.0, 4.0, 5.0%, 6.0%) to the physico-chemical, sensory and shelf-life of the glutinous rice cake. Our results showed that 5.0% Gac aril extract was adequate to supplement into glutinous rice cake making to extend its shelf-life for 5 days. Consumers have more chance to enjoy glutinous rice cake in good appearance and high functional properties.Keywords: Gac aril extract, Glutinous rice cake, Supplementation, Physico-chemical, sensory, Shelf-life.
Technology of Cognitive and its Effect on the Level of the Enzyme (Acetyl cholinesterase) and (Lactic Acid) and the Performance of most Important Offensive Skills in Fencing for Female Students Hayder Naji Habash Alshawi
Journal of Global Pharma Technology .
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Abstract

The importance of research to the study of cognitive technology and its effect with the formulation of acetylcholinesterase and lactic acid for female students in the fencing, the problem of research was that the game of fencing of games of relatively small space requires the player to have positive qualities, so the researchers studied the effect of the enzyme acetylcholinesterase in technology of cognitive plus and lactic acid to achieve the best results, the objectives of the research were to identify the level of cognitive technology (Cogni Plus), acetylcholinesterase, lactate acid level, and the level of some physiological variables for female students in fencing, to identify the correlative relationship between the (Cogni Plus) level and the acetylcholinesterase and lactic acid in the fencing for female students, the researchers used the descriptive method in a survey and correlative method to suit the nature of the problem. The sample of the research included the players of the Middle and South Euphrates clubs in the youth fencing participating in the premier league for the 2016-2017 sports season, the nine clubs (Basra, Maysan, Muthanna, Wasit, Dhiqar, Rafidain, Solidarity, Babil and Karbala). The sample was selected in a simple random way, (20) players (10) for Al-Tadamon Sports Club and (10) for Al-Rafidain Sports Club. The researchers used the following tests: First: Cognitive Level of Cognitive Plus, Biochemical Variables, Lactic Acid concentration, and acetylcholinesterase concentration. The researchers concluded that cognitive cognition technology increased in players due to psychological effect they have. Decreased action of the enzyme acetylholinesterase due to the concentration of lactic acid in the muscle, which leads to slow work and send instructions, Increase the proportion of lactic acid in the muscles as a result of the high level cognitive technology (Cogni Plus) and recommended the adoption of the results of research and use by the trainers of the fencing to see the psychological effects of physiological fencing players. Attention to the psychological preparation of the players during the training process along with the physical, skill and plan numbers because of its importance in the reflection on the physical and physiological aspects of the performance. To establish a department of sports medicine in the faculties of physical education and sports sciences and provide all specialized devices in order to facilitate the task of carrying out research and studies. Conducting research and similar studies by researchers to standardize and define standard levels of cognitive technology scale (Cogni Plus) on individual and group games.Keywords: Cognitive technology, Acetyl cholinesterase, Lactic acid and fencing.

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