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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Synthesis, Characterization and Biological Study of Mixed Ligand Complexes Derived from Dithiocarbamate and Azo Enaam I. Yousif
Journal of Global Pharma Technology .
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The formation, structural characterisation of mixed ligand complexes of Co II, Zn II and Cd II metal ions with dithiocarbamate, azo and 1, 10-phenanthroline are reported. Ligands and complexes were characterised by analytical and spectroscopic analyses including; FTIR, electronic and 1H, 13C-NMR spectroscopy, microanalysis, chloride content, thermal analysis, magnetic susceptibility and conductance. Physico-chemical techniques indicated complexes demonstrated six coordinate structures in the solid and solution state. Biological activity of the prepared ligands and their mixed metal complexes were screened for their antimicrobial activity against four bacterial species ((Bacillus stubtilis and Staphylococcus aureus (G+)), Escherichia coli and Enterobacter (G-)). Biological data showed that complexes become potentially more active against these tested bacteria compared with the free ligandsKeywords:  Mixed ligand complexes; Structural characterization; Thermal analysis; Biological activity.
The Vermicidal Effectivity of Wudani Leaf Extract (Quisqualis indica Linn) in Treating Infection caused by Gastrointestinal Worms in Cattle Ida Bagus Komang Ardana; Made Suma Anthara; Dan Anak Agung Gde Oka Dharmayudha; DK Harya Putra
Journal of Global Pharma Technology .
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The present study was aimed to study whether application of 100% extract of wudani leaf (Quisqualis indica Linn) was able to kill gastrointestinal worms Strongylus Sp. (vermicidal effect). In order to make comparation with commercial drug commonly used, one group was treated with Rheindazol (100 ml of Rheindazol contain 10 gram of albendazol) at a single dose of 10 mg/kg of body weight (BW). The other 3 groups were subjected to a single treatment with 100% wudani leaf extract at 10 mg, 15 mg, and 20 mg/kg of BW, respectively. Assessment on its vermicidal effect was carried out by conducting fecal egg count reduction (FECR). The results showed that the vermicidal property of 100% wudani leaf extract given at 10mg/kg BW was 100% and this was significantly (P < 0.01) higher than that of dose of 15 kg/kg BW (92.4%), 20 mg/kg BW (96%) and even compared to that of albendazol treatment (96%). Thus, from the present in vivo study, it can be concluded that 100% wudani leaf extract due to its vermicidal property can be effectively used to cure gastrointestinal worm infection and, therefore, can be subsequently applied to overcome worm infection in cattle. Keywords: Gastrointestinal worm, Wudani leaf extract, Vermicidal property.
Seroprevalance of Torch Infection in Pregnant Women in Basra City Southern of Iraq Ali. F. Hussein
Journal of Global Pharma Technology Volume 11 Issue 01.
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Background torch infection (toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus) the causative agent for congenital infections in infants and abortion in pregnant women. Objectives the goal of the study was to determine the rates of infection of the toxoplasmosis and viruses that cause abortion in pregnant women. Methods kit (torch) igm, elisa technique. Result: a total of 50 serological samples were collected from adult pregnant women from 2018 -10 to 2018-oct-12. The number of qurna samples was 25 positive infection counts 15 and the estimated infection was 15/25 which accounted for 60%.while the infection rate in abi al-khasib district of the total 25 samples of the number of infection 8 and estimated the proportion of infection 8/25, which constitutes 32% of the toxoplasmosis. the results of the current epidemiological study confirmed that the viruses that cause abortion in the qurnah& abe al-khasib district of rubella were 4of the 50 blood samples (serum) showing that the percentage of infection is4/50, which is 8% and the rate of infection of cytomegalovirus 8/50 which is 16% the results showed that herpes virus was more infected than the virus above 24/50 and that the percentage was estimated to be 48%. these results indicate that the most common percentage among pregnant women toxoplasmosis& herpes virus cytomegalovirus, rubella).)60%, 48%, 16%, and 8%, respectively. The results have been confirmed by using a technique elisa. Conclusion: we concluded from the study the two most common cause's abortion in pregnant women in basra city southern of Iraq t gondi 60%, herpes virus 48%  Keywords: TORCHT- Toxoplasmosis, R –Rubella C- Cytomegalovirus. H- Herpes simplex virus.
ART in Indonesia: A Current Review of Ethics cinta ayu abutari
Journal of Global Pharma Technology Volume 11 Issue 04.
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Currently, Assisted Reproductive Technology (ART) programs such as intrauterine insemination (IUI) and in vitro fertilization (IVF) are developed in Indonesia. As a religious country, the implementation of ART programs raises a variety of ethical issues and religion reactions such as sperm or oocyte donor was haram, sperm from the deceased husband, a sinful masturbation, surrogate mother was Zina, gender selection by human, man assumption as God to decide which embryo be transferred and to create life. Some specific religious organizations provide statements regarding this matter based on scriptural studies and the opinions of their respective religious leaders. Confucianism allows sex selection, while other religions refuse. Hindu and Buddhist allow all ART program, while Catholic declare rejection to all ART program. Islam allows ART programs, without sperm and oocyte donor or surrogate mother. This difference in views is mediated by government regulations that support ART programs but are still limited by legal marital status. The state provides government rules on the implementation of the ART program in Indonesia, although every spouse is allowed to follow their beliefs. In conclusion, ART programs were allowed by most of the religions in Indonesia, as long as not involve the third party as the donor.
α-Glucosidase Inhibitory Activity of Ethanol Extract Obtained from Dillenia suffruticosa and Pycnarrhena cauliflora Dzul Fadly
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The objective of the study was to find out the inhibitory of α-glucosidase activity and the antioxidant properties of an ethanol extract derived from leaves and stems of Dillenia suffruticosa and Pycnarrhena cauliflora. Dried powder of them was macerated with 96% ethanol solvents. α- Glucosidase inhibitory property was significantly demonstrated by the leaves and stems of D. suffruticosa. Antioxidant activity was found high in D. suffruticosa leaves and stems. The results indicate that D. suffruticosa stem may potential being antioxidant and antidiabetic compounds.Keywords: Dillenia suffruticosa, Pycnarrhena cauliflora, diabetes mellitus, α-glucosidase, ethanol extract.
ANALYSIS OF UKRAINIAN PHARMACEUTICAL MARKET RETAIL SEGMENT DEVELOPMENT Natalia Bogdan
Journal of Global Pharma Technology .
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The pharmaceutical market is an important part of the system of pharmaceutical provision of the country. In modern conditions, the pharmaceutical market performs many functions, among which the social function is one of the most important. The aim of our study was to analyze the dynamics of the development of the Ukrainian pharmaceutical market in the conditions of the socio-economic and financial crisis in the country. We conducted dynamics analysis of pharmacy sales development in retail sector of pharmaceutical market (2011-2017). We used historical, comparative, logical, graphical, and mathematical-statistical methods of scientific search. As a result of studies we have found that during 2011-2017 the retail segment of Ukrainian pharmaceutical market had zigzag-shaped development dynamics. We distinguished three main stages of its development. So, during the first stage (2011-2013), we observed positive growth dynamics of pharmacy sales expressed in hryvnia, U.S. dollar, and package pieces. What is more, increase of pharmacy sales' indicators, expressed in hryvnia and U.S. dollar, did not differ significantly. The second, the most difficult, period lasted for two years (2014-2015). This period was characterized with decrease of sales' volume, expressed in U.S. dollar and in natural indexes (package pieces). In 2015 the lowest indexes of pharmacy sales, expressed in U.S. dollar (22.75 million U.S. dollars), and in natural indexes (1507.1 million of package pieces), were observed. Increase (38.0%) of sales' volumes, expressed in hryvnia, which was observed in 2015, was due to devaluation of national currency. The third stage of market development started in 2016 and is continuing still. In the retail segment an increase in volume of pharmacy sales, expressed in hryvnia – by 22.0%, in U.S. dollar – by 4.0%, and in package pieces – by 6.0%, has been observed from2016. Inthe conditions of relative stabilization of U.S. dollar rate in 2017, growth of sales' volume in U.S. dollar was 17.0%, and in natural indexes – only 5.0%. Gradual slowdown of one sale weighted average cost growth, beginning in 2016, is an important positive characteristic of pharmacy sales market development. For example, in 2015 this index grew by 41.0%, in 2016 – by 16.0%, and in 2017 – only by 10.0%. Of special note is the fact of gradual increase of sales' volume per capita, expressed in U.S. dollar. For example, in 2015 this index was 36.04, in 2016 – 37.24, and in 2017 – 44.09 U.S. dollars.Retail segment of Ukrainian pharmaceutical market, in the conditions of political and social-economical crisis in the country, has shown the complex nature of its development. Devaluation of national currency in the conditions of high dependence of Ukrainian pharmaceutical market on import significantly influenced the dynamics of pharmacy sales. In these conditions Ukrainian consumers of pharmaceutical services should not be left alone with the problem of significant increase of prices of medical products. Implementation of systemic reforms in health protection, and development of consistent state policy of Ukrainian pharmaceutical market development and medicines' consumption regulation provide the real way out of this situation.
In Vitro Dissolution Enhancement of Curcumin by Melt Dispersion and Solvent Casting Technique Aided by Molecular Modelling Approach Anindya Jana; Subrata Kumar Biswal; Rudra Narayan Sahoo; Partha Niyogi; Subrata Mallick; Rajaram Mohapatra
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
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Purpose: The oral bioavailability of curcumin is low due to its lipophilic nature. The drug also tends to degrade in alkaline pH. This inherent character of curcumin limits its stability and oral bioavailability. Use of polymeric carriers to alter the physicochemical nature of the drug is one of the favoured techniques of drug formulation. Aim of this study was to improve the in-vitro dissolution and solubility of curcumin by using hydrophilic carriers such as polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) of different grades and to check the effect of the different excipients used in the formulation of curcumin by solid dispersion technique. Methods: Solid dispersions of curcumin have been prepared by the solvent evaporation and melting method by using carriers in suitable ratios. In this experiment, ethanol was used as an organic solvent for solvent evaporation. The presence of different release rate modifiers such as croscacamellose sodium, kollidon CL and sodium and lauryl sulphate (SLS) in the SD formulation were also studied. In-silico approach has been applied to quantify the curcumin and carrier interaction. Results: The solubility of the solid dispersion prepared by the solvent evaporation and the melting method was found to be 13.5 and 78.9 fold to that of the pure curcumin respectively. Physical characterization by FTIR and DSC studies advocated that the physical state of crystalline drug has been modified in solid dispersions due to its dispersion in the polymer matrix. Conclusion: Dissolution studies revealed that all the formulations were having better drug release profile compared to the physical mixture. The lowering of binding energy in in-silico ducking study indicated towards possible molecular drug carrier interaction. Keywords: Curcumin, Solubility, Dissolution, Solid dispersion.
The Correlation between Metacognitive Knowledge with Mathematics Anxiety in the First Grade High School Female Students Farhad Karimi
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The aim of this study was to investigate the relationship between control source and role-personality conflict the purpose of this study is to investigate the correlation between met cognitive knowledge and math anxiety. The population of the study consists of 1950 female students in the first grade of high school in Tehran 8th district. 323 female students were selected using cluster sampling. The instrument consisted of two standardized questionnaires designed by Swanson to assess problem-solving met cognitive knowledge and Math Anxiety Scale constructed by Chiu and Henry. Using factor analysis and Cranach’s alpha, both validity and reliability of the questionnaires were attained. Analyzing the data in the descriptive statistics area was conducted by frequency and percentage and in inferential statistics with the Pearson correlation showed that the relationship between met cognitive knowledge and problem solving with math anxiety is negatively significant at 99%confidence level (r=-0/454).The relationship between the components of met cognitive knowledge (person, task and strategy) with math anxiety is significantly negative. In other words, the more the learner informed and aware of the cognitive system, task, and strategy, the less he/she will feel math anxiety. The index of knowledge of strategies demonstrates the most significant negative relationship with students' math anxiety while the two other indexes, knowledge of self and task, are in the next levels respectively. The results generally indicate that more students are aware of problem-solving met cognitive knowledge, less they suffer from math anxiety.Keywords: Math Anxiety, Met cognitive knowledge, The first grade high school.
Technical Factors Influencing to Instant Powder from Strawberry (Fragaria) Juice N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Strawberry (Fragaria), a rich source of phytochemicals (ellagic acid, anthocyanins, quercetin, and catechin) and vitamins (ascorbic acid and folic acid), has been highly ranked among dietary sources of polyphenols and antioxidant capacity. Bioactive compounds in strawberry revealed high abundance of anthocyanins, flavonols, flavanols, and cinnamic acid.  To increase strawberrys popularity and expand their use in the food industry, it’s neccesary to explore the appropriate postharvest handling and storage.The aim of this work was to study the feasibility of spray drying of strawberry juice juice. Various characteristics of spray-dried fruit juice powders are well affected by spray-drying conditions including inlet air temperature, out let air temperature, feed flow rate, drying carrier agent. Results revealed that inlet/ outlet spray drying temperature (155oC: 85oC), speed flow rate (12 ml/ min), γ‐cyclodextrin: maltodextrin (4: 6 % w/v) were appropriated for spray drying of dried strawberry powder from its juice. The spray-dried product of γ‐cyclodextrin-maltoxetrin-strawberry juice was considered to be the good technique to dry strawberry juice on the result of phytochemical determination, physical and chemical properties and antioxidant activity. Value addition of strawberry juice has been created by changing in the physical form of the agricultural produce which leads to its greater acceptability, extended availability, enhanced market viability and increased cost to benefit ratio for the grower of the strawberry produce.Keywords: Strawberry juice, Spray drying, Dried powder, Inlet air, Out let air, Speed flow rate, γ‐cyclodextrin, maltodextrin.
Post Reconstitution Stability of Co-Amoxiclav Injection for Multiple Usages in Developing Countries Mazlina M Said
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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OBJECTIVE: Co-amoxiclav injections are stored after reconstitution by healthcare givers for multiple usage contrary to manufacturer’s instructions in pediatric patients to reduce the cost of treatment in developing countries. The purpose of this study is to determine the percentage content of amoxicillin and clavulanic acid in co-amoxiclav injections at the point of administering of second dose after reconstitution.METHODS: Samples were reconstituted according to manufacturers’ instructions and stored in a refrigerator (2-5°C) and at tropical temperature (30°C and 75% RH). The samples were assayed immediately and then 8 hours after reconstitution. The assay was carried out using HPLC according to the USP monograph for amoxicillin-clavulanic acid suspension and the percentage content during the administration of the second dose was calculated in reference to a freshly prepared samples.RESULTS: The percentage content of amoxicillin and clavulanic acid in refrigerated samples was <70% and <35% of the freshly prepared samples respectively, While at simulated tropical room temperature, it was <45% and <15% of the freshly prepared samples respectively.CONCLUSION: The study showed that storage of reconstituted co-amoxiclav injection will lead to administering of lower dose at the point of admistration of the second dose; this will lead to treatment and antibiotic resistance.

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