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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Effects Mixture Powder of Black Rice, Red Beans and Moringa Leaves on Blood Glucose in Hyperglycemic Rats Lalu Juntra Utama
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: The increase in blood sugar or hyperglycemia is a metabolic disorder known as diabetes mellitus and is associated with the rise of oxidative stress and complications in the vascular system. Further, it will cause alteration in carbohydrate and fat metabolism leads to a reduction of the antioxidant defense system. Black rice, red beans and moringa leaves contain oleic acid, butyric amino acid, antioxidants, phytic acid and arginine which can improve insulin sensitivity and blood glucose homeostatis. This study aims to identify the effect of mixture powder (black rice, red beans, and moringa leaves) based feeding against the blood glucose level in rats. Methods: The study was an experimental research with pre and post control group design. A total of 20 Sprague Dawley female rats were divided into four groups, namely standard feed (PS), 80% mixture powder feeding (PB8), 50% mixture powder feeding (PB5) and 20% mixture powder feeding (PB2). The mixture powder intervention was executed about 5% of body weight for 28 days. Fasting blood glucose was measured using the GOD-PAP method. The data obtained was conducted the statistical analysis using the Analysis of Variance (ANOVA) at a 95% confidence level. If it showed a significant effect on the response variable, then Duncan's Multiple Range Test would be conducted. Results: There were significant differences in fasting blood glucose among groups after the mixture powder intervention. The results revealed that after 28 days, mixture powder might lower the serum glucose concentration from 122.69 mg/dL to 97.70 mg/dL (20.37%) in the PB8 group and from 123.91 mg/dL to 113.28 mg/dL (8.58%) in the PB5 group, but vice versa, the blood glucose in the PS group, intervened by standard-based feeding increased by 5.73%. According to these results, mixture powder can be considered to reduce blood glucose in people with obesity and metabolic syndrome. Conclusion: The intervention of a mixture of black rice, red beans, and Moringa leaves may significantly influence the fasting blood glucose in rats. Keywords: Black rice, red beans, moringa leaves, fasting blood glucose
Antimicrobial Effect of the Crude Phenolic, Alkaloid and Terpenoid Compounds Extracts of Myrtus Communis L. against Human Gram-Negative Pathogenic Bacteria Ali Hussein Al-Marzoqi
Journal of Global Pharma Technology .
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Objective: To reveal the effect of the crude phenol, alkaloid and torpedoed compounds extracts of Mitres Communes L. on some Human gram-negative Pathogenic Bacteria. Methods Antibacterial activities of the crude Phenol, Alkaloid and Torpedoed of medicinal plant were determined in vitro by agar well diffusion-method against some human pathogenic bacteria. Results obtained results showed that active compounds of Mitres Communes L. had wide spectrum antibacterial activity against gram- gram-negative bacteria Conclusion This study demonstrates that we can conclude that the effect of active compounds in same plant has different effect on different pathogenic organisms in different concentrations.Keywords: Antimicrobial, Myrtus Communis, L Pathogenic Bacteria, Gram-negative Bacteria.
Investigating the Genetic Change in BRAF Gene Causing Manifestation of Prostate Cancer in a Sample of Iraqi Patients Jaleel I. Asaad
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study included 100 patients suffering prostate cancer, 15 persons with family history of cancer served as positive control, and 30 healthy men served as negative control.  Prostate cancer tissues were collected from surgical room and subjected to DNA extraction for further processing.  Four primers were designed to investigate lethal changes at BRAF location related to this disease. Six pathogenic mutations were found among patients included in this study. These were rs1131692058, rs180177042, rs397507484, rs121913364, rs121913377, rs113488022, and rs1131692058. These represented ingle nucleotide polymorphism except for rs1131692058 which was found a deletion mutation. More data showed that positive control were less specific to associate with BRAF primer suggesting they bear variations susceptible for lethal change that may developed to cancer.
Different Parameters in Coconut (Cocos Nucifera) Wine Fermentation Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Coconut (Cocos Nucifera) juice is an ancient tropical beverage whose popularity on the international market has been continuously increasing in recent years. The coconut (Cocos nucifera L.) is an important fruit tree in the tropical regions and the fruit can be made into a variety of foods and beverages. Coconut water is the clear liquid inside young coconuts. Coconut water (coconut liquid endosperm) is one of the world’s most versatile natural products. This refreshing beverage is consumed worldwide as it is nutritious and beneficial for health. An attempt explored a wine fermentation from coconut juice by examining the effect of different parameters such as soluble solid content (14.0oBrix, 14.5oBrix, 15.0 oBrix, 15.5 oBrix), fermentation temperature (28.5oC, 29oC, 29.5oC, 30.0oC), yeast Sacchromyces cerevisiae ratio (1.0%, 1.5%, 2.0%, 2.5%) to coconut wine quality. Our results proved that 15.0oBrix of coconut juice; fermentation temperature 29.5oC with 2.0% Sacchromyces cerevisiae was adequate for coconut juice wine fermentation. Using coconut juice having medicinal and nutritional value as a substrate for wine production, its health benefits can be improved effectively.Keywords: Coconut juice, Wine, Fermentation, Sacchromyces cerevisiae.
Implementation of Integrated Nursing Model towards the Quality of Services and Patients’ Satisfaction Deli .
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Introduction: The lack of nursing quality indirectly can be seen in patients dissatisfactory. Today society demands service that focuses on patients need, and the correct approach will be determined by the selection of the nursing model. To increase the quality of service in nursing, require a redesigned model through implementing integrated healthcare services. Methods: This is a quasi experimental study to implement an integrated nursing model using an intervention group and a control model. A total of 154 samples were chosen using consecutive sampling technique and equally distributed to each group. T-test were used to analyze the patients satisfaction level of the nursing service. Results: The result shows in the intervention group, there were 60 people (78%) that are satisfied, while in the control group, there is only four-person (5%). The increase might be caused by the nursing that is more consistent, cooperative, and responsive. The nurse understand problem identification and actively collabore in search of solution in the integrated model. Constructive integrated structure model about responsible is essential in increasing professional nurse performance. Conclusion: In conclusion, there are significant differences; higher patient satisfaction level on the model implementing integrated model than without implementing integrated model.Keywords: Integrated model, Service Focus on Patients.
The Use Two Methods of Presentation Clarity and Individual Competition to Develop of Mental Energy Mobilization and Learn Some Basic Skills for Students in Football Khalil Hamid Mohammed Ali
Journal of Global Pharma Technology .
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Through the follow-up of field researchers to teach football in the lesson of physical education, he noted that many of the learners have difficulty in learning the basic skills as a result of their teaching methods, and that teaching requires other methods that lead to the best possible learning in accordance with the development of the game This is reflected in the upgrading of this game. The researchers' interest in this problem began in an attempt to reveal the use of methods to develop psychic energy and to learn the basic skills of football for students better. The objective of the research is to:Preparation of an educational program using the method of clarity of presentation in the development of mental energy mobilization and learn some basic skills for students of footballPreparation of an educational program using the method of individual competition in the development of mental energy mobilization and learn some basic skills for students of football.Identify which method (s) used best in the development of mental energy mobilization and learn some basic skills for football students.The Main Conclusions WereA clear improvement in the development of (experimental groups in the measure of mental energy mobilization and learn some of the basic skills of football.The first experimental group (individual competition mode) is superior to the second experimental group (the method of presentation clarity) in the development of the mental energy mobilization scale.The second experimental group (the clarity of presentation) has learned to teach the first experimental group (the style of individual competition) in the basic skills of football.Keywords: Two methods clarity of presentation and individual competition and the mobilization of psychological energy.
Nephrotoxicity: protection of silica nanoparticles loaded sodium salicylate and ginger in experimental rats Eman Refraat Youness
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Ultrasound-assisted sol−gel method was used to prepare hollow structured porous silica nanoemulsion loaded with sodium salicylate as a model drug. Objective: This work was extended to achieve the target of the current work via investigating the protective role this nanoemulsion model as anti-inflammatory drug or ginger for its antioxidant effect against cisplatin-induced nephrotoxicity in male albino rats. Results: The results clarify that the nanoemulsion model was synthesized using ultrasonic assisted with small size and well stabilization as proved by TEM and DLS analysis.  Additionally, blood urea and serum creatinine were increased after cisplatin injection with disorders in oxidative stress and rising of homocysteine levels. Also, histopathological changes of the kidney tissue were observed.  These changes back to normal via treatment with silica nanoparticles loaded sodium salicylate (Si-Sc-NPs), ginger or both. Oil /water nanoemulsion of (Si-Sc NPs) and ginger showed a protective and promising preventive strategy against nephrotoxicity due to their antioxidant and anti-inflammatory effects.
Studying the Pattern of Phenotypic Resistance to some Antibiotics for Local Isolates of Enterobacter Cloacae and its Evolutionary Relationship with Global Isolates Safaa M. Salman
Journal of Global Pharma Technology .
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26 isolates of Enterobacter cloacae from 264 specimens from different clinical sources and from inpatients for ages ranged from one Week to 73 years from 15/12/2016 to 18/7/2017collected from two hospitols of AL-Diwaniyah city. The isolation and diagnosis process was based on the results of phenotypic and biochemical tests and the Vitek system .The sensitivity of the isolates for antibiotics were tested against 15 antibiotic using disk diffusion  method , The results showed an absolute resistance (100%) for Amoxicillin, Cephalothine and Doxycycline, while their sensitivity to Amikacin , Gentamicin, Tetracycline, Nitrofurantoin and Nalidixic acid were various, they resisted it at percentage of 11.53 %, 34.61% , 73.07% , 34.61% and 23.07% respectively . For the rest of the Cephalosporin group (Cefoxitin, Cefotaxim and Ceftriaxone) , the isolates were resisted  them with percentage 65.38%, 57.69% and 34.61%, respectively , While   all isolates (100%) were sensitive to Chloramphenicol, Ciprofloxacin, Impenem and Meropenem . Twenty-four isolates (92.30%) were able to produce β-lactamase. PCR was used to amplify HSP60 gene which used to determine the sequence of nucleotides and draw the phylogenic tree and find the relationship between the current isolates of this study with global isolates.Keywords: Enterobacter cloacae, HSP60 gene, PCR, evolutionary relationship.
Influence of Li Doping in NiO Thin Films Prepared by Simple Chemical Method Ahmed N. Abd
Journal of Global Pharma Technology Volume 11 Issue 05.
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This study deals with the study of the structural and visual properties of NiO and Li Doped NiO films in different percentages (0.02, 0.04, 0.06, 0.08% mol).Thin films of NiO were deposited on glass substrates at 300 ° C and 150 nm using droplet casting technique. X-ray diffraction (XRD) showed that multi-crystalline films had a cube structure with a preferred orientation along the length of (111). The tonic stimulator did not change between 0.02, 0.04, 0.06 and 0.08% Grammy% of the preferred trend. The average grain sizes of crystals classified from XRD data were found in the range of 15.62 - 37.52 nm. Atomic Force Microscope (AFM) data shows that the film surface is extremely smooth. The photovoltaic permeability of pure NiO membranes is 72% in the visual and x-ray regions (NIR), which is important for their applications as window layers in solar cells.Keywords: Nickel oxide, XRD, AFM, grain sizes, thin film.
Detection of Anti- Ovarian Antibodies and Anti-sperm Antibodies in Sera of Sub Fertile Women in Baghdad Farhan A Risan
Journal of Global Pharma Technology .
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The study was  carried out through  the period  March/2017 to  October/2017,for   estimate the ant ovarian antibodies and anti sperm antibodies in  sera (fifty  nine) sub fertile women  compared with( twenty seven ) healthy women as control  group.  Their mean aged 28 years. The diagnosis of  anti ovarian antibodies concentration   were  a done  by enzyme linkage immunosorbent  assay(ELISA)  A high  significant in cement (p≤ 0.001 ) was observed  in the  sera of sub fertile women( 819 uL) compared  with  control  group( 476uL),while   the anti-sperm antibodies concentration  show high significant in cement (p≤ 0.0l) in the sera of sub fertile women(211 uL) compared with control group(42  UL).Keywords:  Anti-ovarian antibodies, Anti-sperm antibodies, Sub fertile women.

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