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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Effectiveness of Fining Agents for Wax Apple (Syzygium samarangense) Wine Clarification Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Waxe apple fruits are rich sources of nutrition with water, carbohydrate, protein, vitamins, and minerals, along with some medicinal properties. This fruit is highly perishable because of its thin skin and can be easily damaged. The processing of wax apple juice into wine could enhance the value of the fruit. However, turbidity in waxe apple wine is a major problem limiting its contribution to international commercialization. Wine clarification is a widely applicable procedure that involves an agent or a mixture being supplemented to clarify, stabilize or modify the sensory wine attributes. Objective of this study focused on the feasibility of different fining agents such as gluten, gelatin, maize zein, casein, bentonite for clarification of waxe apple wine. This research also examined if there was any synergistic effect while combining gluten with gelatin to improve their fining capability. Our results revealed that 5.0:3.0 g/hL (gluten: gelatin) was adequate to control the haze cloud or turbidity after 3rd week racking of waxe apple wine.Keywords: Waxe apple, Wine, Fining, Clarification, Turbidity, Gluten, Gelatin.
Frap Assay and Nitric Oxide Free Radical Scavenging Activity of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: Oxidative stress resulting from accumulation of reactive oxygen species has been associated with disease. Research study was undertaken to investigate and evaluate the in vitro antioxidant activities such as FRAP and Nitric oxide of ethanolic extract of cordia obliqua.Methods: The ethanolic extract of cordia obliqua was examined by Nitric oxide radical scavenging activity and Ferric Reducing Antioxidant Power Assay with reference standard ascorbate respectively through in vitro models.Results: Ethanolic extract of cordia obliqua showed significant free radical scavenging activity than that of standard.Conclusion: In vitro study indicates that these plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.
Effect of ZnO Nanoparticles on AST Activity in Gingival Cervicular Fluid of smokers and Nonsmokers Chronic Periodontitis Patients: in Vitro Study Zainab A. Salman
Journal of Global Pharma Technology .
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Abstract

Objectives: current studies to estimate the effects of cigarette smoking on oral periodontal health, and due to the lack of studies that simultaneously compared the periodontal condition smokers with periodontal disorders, and nonsmokers with periodontal disorders, we assessed the periodontal condition in these two groups.  The effect of ZnO NPs on aspartate aminotransferase (AST) activity in Gingival Cervicular Fluid (GCF) of smokers and nonsmokers patients with chronic periodontitis was studied as a part of assessment of tissue damage that has been occur due periodontal disease and smoking. Nanoparticles (NPs) have been studied in different areas to evaluate the effect of nanoparticles on the activity of enzyme as a part of more accurate diagnosis. Materials and Methods: GCF samples for 26 persons (aged 35-50 years) with chronic periodontitis were collected as patients group. Powder of ZnO NPs (< 80 nm) was used in this study. The activities of AST enzyme   in GCF were estimated in (smoker and nonsmoker) patients group with and without ZnO NPs as a pertinent biomarker of chronic periodontitis. The impact of ZnO NPs on AST activity in GCF of patients with chronic periodontitis was evaluated in terms of group with AST activity was assessed by colorimetric method. Results: results were showed that AST activity in smoker patients group with and without ZnO NPs was higher than its activity in nonsmoker patients.  Conclusion:  The impact of ZnO NPs on AST efficiency in GCF may be due to the vital role of ZnO NPs in durability against pathogens, in another hand, this impact may be reflects the changes on protein structure after interaction with ZnO NPs.Keywords: Gingival crevicular Fluid, aspartate aminotransferase , ZnO NPs , smoker and nonsmoker Chronic periodontitis .
The Investigation of Pharmacological Activity of Antihistaminic Gels with Dimebon Mayorova Alena Valentinovna
Journal of Global Pharma Technology .
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Abstract

The article covers the review of results of investigation for application safety of traditional gel with dimebon and gel with microcapsules dimebon of prolonged anti-allergic action. We have estimated the irritant action is situ and in vivo, studied acute toxicity by the survivability of mice considering calculated LD50. We have determined a signified antihistaminic (anti-oedemic) effect of gels with external application by the reduction of time and intensity of modelled limb swelling of rats. We have established regenerative action of gels by the reduction of burned skin area, augmentation of tissues epithelization and eschar rejection.Keywords: Dimebon, Gel, Anti-allergic action, Antihistaminic, Anti-inflammatory action. 
Serum Adiponectin Level as an Indicator for Incidence of Type -2 Diabetes Mellitus and Myocardial Infarction in Iraqi Population Shahlaa Kh. Chabuk
Journal of Global Pharma Technology .
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Abstract

Objective lower level of "adiponectin" were observed to be related with obesity, type 2" diabetes" and "CAD" because of the significance of it in this field this consideration was assigned to the role of  "adiponectin" on rate ofT2DM crosswise over classes of BMI, , baseline  glucose and insulin. We likewise proposed to contemplate the relationship of "adiponectin" with rate of incidence of myocardial infarction (MI) regardless the BMI and other traditional risk factors. Subjects and methods: This case-control think about was completed in patients took care of Marjan teaching hospital in Babylon province in Iraq from September 2016 until January 2017. The contemporary investigation was incorporated 54 patients, among of them. 27patients experiencing T2DM and 27 patients experiencing MI contrasted with 25 healthy volunteers of a similar age and sex. Blood sample was taken for evaluation of "adiponectin", and insulin resistance by Elisa technique. Totally the patients experienced a therapeutic checkup and estimated their BMI.Results: the primary consequences of contemporary examination were revealed a critical reduction in the sera level of "adiponectin" in patients with T2DM paralleled with those of control group(P<0.05) . What’s more, a very noteworthy increment in the sera level of HOMA-IR in patients with T2DM contrasted and those of control group (P<0.01). Additionally present outcomes demonstrated reduction "adiponectin" level significantly (P<0•04) contrast with control group• notwithstanding that present result did not demonstrate any significant correlation between "adiponectin" and BMI in MI patients. Conclusions Present examinations suggested that, "adiponectin" consider as predictor for occurrence of T2DM based on the increase BMI that lead to development of insulin resistance, also contemporary study showed that "adiponectin" was linked with MI incidence with no association presented with BMI, sex, age and other CAD risk factors.
Peripheral Neutrophil-to-Lymphocyte Ratio (NLR) and Breast Cancer Distant Metastasis: Analysis of a Simple Diagnostic Biomarker Ni Putu Yenny Kendarini
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Introduction: Neutrophils and lymphocytes serve as easily accessible indicators representing the immune landscape in breast cancer. Combination of such variables in the form of neutrophil-to-lymphocyte ratio (NLR) allowed for extensive analysis and better interpretation. The heterogeneity in predictive role of NLR to prognosticate breast cancer sruvivalcould be attributed to metastatic spread. Methods: Data from breast cancer patients attending Oncology clinic in Sanglah Hospital, Bali was collected retrospectively. Samples were selected by simple random sampling technique from a sampling frame of patients with available preoperative complete blood count in the registry. Bivariate and multivariate analysis was performed with NLR value stratification using optimal NLR cut-off value derived from receiver operating characteristic (ROC) curve analysis. Results: A total of 51 patients diagnosed within the period of January 2016 through November 2017 were investigated. The cut-off point of NLR value in this study was 3.1 (Area under ROC curve [AUC]: 0.826). A significant association between NLR value and distant metastasis was found consistentlyin bivariate (PR 5.4, 95%CI 2.5-11.8, p=0.001) and multivariate analysis (Adjusted PR 4.9, 95%CI1.53-16.1, p 0.01). The association was not affected bybreast cancer subtype, histological grading, lymphovascular invasion, and tumor-infiltrating lymphocytes level. Conclusions: The NLRvalue was found to be an independent factor for distant metastasis in breast cancer. Its added value on diverse NLR clinical prognostication utility warrants further prospective investigation. Keywords: Neutrophil to lymphocyte ratio, Neoplasm metastasis, Breast neoplasms, Biomarkers.
Molecular Detection of Per-1 Type Extended Spectrum Β-Lactamase among Clinical Isolates of Klebsiella Pneumoniae in Baghdad Hospitals Buthainah Mohammed Taha
Journal of Global Pharma Technology .
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Abstract

This study was aimed to determine the presence of PER-1 type Extended-Spectrum β-Lactamases (ESBLs) in clinical isolates of Klebsiella pneumonia in Baghdad. During a period extended for three months ((July- September, 2014), 26 clinical K. pneumoniae isolates were collected from two hospitals in Baghdad (Fattima-AL-Zahra hospital for pediatric and obstetric and Baghdad Teaching Hospital). Out of these 26 isolates, 11 isolates from blood, 7 from urine, 6 from sputum and 2 from wound. All isolates had 100% resistance to ampicillin and cefazolin while the most effective antibiotics were imipenem and meropenem with high sensitivity rate (92.31%). Out of 26 K. pneumoniae isolates, 17(65.38%) isolates were positive ESBL producing isolates phenotypes and 9(34.62%) isolates were negative ESBL producing isolates (non ESBLs) .Genotypic Detection of blaPER-1 gene by polymerase chain reaction showed that out of all seventeen ESBL-producing K.  Pneumoniae isolates by phenotypic detection, 6 isolates (13.8%) were contained blaPER-1 gene (925bp).Keywords: Klebsiella pneumonia, Blaper-1 gene, Extended-spectrum β -lactamases (ESBLs).
Pregnane-X-Receptor Genotype and Hepatotoxic Incidence on Tuberculosis Patients Receiving Antituberculosis in Bali i gusti ayu artini
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Drug-induced liver injury might lead to serious illness. One of the drugs that potentially toxic to the liver is antituberculosis. Many factors could influence antituberculosis-induced liver injury, including genetic variation. One of such genetic variation is polymorphism of pregnane-x-receptor (PXR) gene. PXR plays a crucial role in the regulation of many drug metabolizing enzymes and drug transporters. The association between PXR polymorphism and hepatotoxic incidence in several studies showed the inconsistent result. Therefore, it’s very important to study the PXR genotype pattern and its relation with hepatotoxic incidence among tuberculosis patients who received antituberculosis treatment. This study aimed to investigate the incidence of hepatotoxic according to PXR genotype pattern among tuberculosis patients who received antituberculosis treatment in Bali. Methods: This study was a cross-sectional study. About 65 subjects were enrolled in this study, selected from tuberculosis patients who attended the pulmonary outpatient clinic of Sanglah Hospital, Bali Indonesia and received the antituberculosis drug. Identification of PXR genotype was performed using PCR/RFLP technique with MboI restriction enzyme. Results: The proportion of wild type and mutant genotype of PXR were 72.3% and 27.7%, respectively. There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR. Conclusion: There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR on tuberculosis patients who received antituberculosis in Bali.
Antiseptic White Honey Liquid Soap Formulation and its Effectiveness against Nosocomial Infections Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa Multiresisten (PaMR) are the main bacteria that cause nosocomial infections. Prevention of MRSA and PaMR transmission can be done by maintaining a clean body through the use of antiseptic bath soap that is sensitive to this bacterium. This study aimed to carry out a white honey antiseptic liquid soap formula that could be useful for killing MRSA and PaMR bacteria. This research was based on laboratory research on white honey as an antiseptic derived from natural ingredients. Organoleptic examination, pH, viscosity, consistency, antibacterial effectiveness for 56 days of storage, then from the evaluation results of the formula was best done a hedonic test. Statistical calculations with fixed random block complete design models were applied for a conclusion of evaluation tests. The results of the test activity of the liquid shower soap showed that all three formulations had activity against the MRSA and PaMR bacteria. Growth Inhibitory Concentration Minimum preparation of antiseptic liquid bath soap was 12.5% w/v. Antiseptic liquid soap with a concentration of 12.5% had a phenol coefficient of 0.4167 for MRSA bacteria and 0.9 for PaMR bacteria. The comparative test results showed that the best formula (F2) activity was 0.859: 1 against MRSA and 0.7167: 1 against PaMR compared to liquid bath soap in the market. The test results showed that the best liquid bath soap formula based on stability and the lowest GICM value was white honey antiseptic liquid soap with a concentration of 12.5% w/v.Keywords: Antiseptic bath soap, Nosocomial infections, White Honey, Methicillin-Resistant Staphylococcus aureus (MRSA), Multiresistent Pseudomonas aeruginosa (PaMR).
Extraction Flavonoid Compound from Foeniculum Vulgare and Study its Anti-Bacterial Activity Mohanad Jawad Kadhim
Journal of Global Pharma Technology .
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This investigation incorporated the extraction of the flavonoid compound in the fennel plant and the investigation of the natural viability of this compound by secluding it and playing out a few synthetic breaks down, to be specific the utilization of IR spectra, Uv spectroscopy, TLC, Using the shading information of the concentrate. Two distinct kinds of Staphylococcus aureus were watched. We watched the impact of flavonoids on the bacterial separates of positive and negative cumin individually (Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922). The adequacy of flavonoid extricate was observed to have the capacity to repress positive or negative bacteria. The zone of microbes’ hindrance19mm, 20mm.Keywords: Flavonoid, Antibacterial movement, Fennel plant, Foeniculum vulgare, phenolic compound, antimicrobial.

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