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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Use of Various Polymers with Solid Dispersion Application of Hot Melt Extrusion (HME) Preparing New Delivery Drug System Sofi Nurmay Stiani
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Hot Melt Extrusion (HME) at the beginning appeared widely used in the plastic industry and food industry, but in the last few decades, many researchers have succeeded in applying the HME method as a drug delivery system and determining various dosage forms in the pharmaceutical industry. The challenges that arise in the pharmaceutical are related to the solubility, dissolution rate, and bioavailability of drugs, especially for drugs that have low solubility in water. The low solubility and bioavailability will reduce the pharmacological effect of a drug. Solid dispersion using HME method succeeded in answering this challenge by distributing the drug evenly in the hydrophilic polymer during the extrusion process and changing the crystalline form to the amorphous form while maintaining drug stability. This review will examine the polymers are suitable for the HME method, Mechanism for solid dispersion using HME method, Steps must be taken to prepare solid dispersions using HME and characterization of solid dispersion resulting from HME and determinants of success of solid dispersions Keywords: Polymer, Solid Dispersion, hot-melt extrusion, Mechanism of solid dispersion, Step HME.
The Biological Activity of Extraction of Protein Compound From Metapenaeus on Giardia Lamblia Shatha Khudhaier Abbas
Journal of Global Pharma Technology .
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Abstract

The study includes the extraction of whole bodies of local shrimp from Shatt Al-Arab during Jun 2012 on Giardia lambia which collected  sample from Ibn Al-Balady hospital in Baghdad from patients clinic. The result of study the extract caused all effect was killed of parasite on sixth day followed by  shrimp extract and then  shrimp extract and cyst continue to decline until it reached  in seventh day and (WBC) in  extractwas  and  in  extract compare with control group  and Flagel group , and the result found MLC in  killed the parasite in seventh day.Keywords: Giardia lamblia, Metapenaeus, Red blood cells, White blood cells, Hemoglobin, Packed cell volume.
Analytical Method Development for Simultaneous Estimation of Cobicistat and Darunavir by RP-HPLC Method A. Sindhuja
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

A new method was established for simultaneous estimation of Cobicistat and Darunavir by RP-HPLC method.  The chromatographic conditions were successfully developed for the separation of Cobicistat and Darunavir by using Xterra C18 5µm (4.6*250mm) column, flow rate was 1ml/min, mobile phase ratio was Phosphate buffer (0.05M) pH 4.6: ACN   (30:70%v/v)   (pH was adjusted with orthophosphoric acid), detection wave length was 255nm. Five trails have been done with various composition of mobile phase. Among them the mobile phase composition Acetonitrile and phosphate buffer in the ratio of 70:30 (trail no 5), using C18 column as stationary phase and detection at 255nm has produced a well resoluted peak. The no of theoretical plates was 5105, 3788 with a tailing factor of 1.3, 1.4. The peak retention time was 2.399, 3.907 with a peak area of 946124, 11541. The results shown that developed method is rapid, specific for the simultaneous estimation of cobicistat and darunavir in combined dosage form.Keywords: Cobicistat,Darunavir, RP-HPLC, Phosphate buffer, ACN
Application of Agar/ Glycerol as Biodegradable Coating on Storage of Star Apple (Chrysophyllum Cainito) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Star apple (Chrysophyllum cainito) is a non climacteric fruit, with high antioxidant capacity and high nutritional and health benefit. The flesh of star apple is very sweet with glucose as the main sugar. The fruit is very susceptible to water loss so they are easily shrinkage and fruit softening during storage, resulting in the decrease of their commodity value. The major postharvest losses of star apples are due to fungal infection, physiological disorders, and physical injuries. The prevalent method of preservation of postharvest star apples is the use of moderately low temperatures and high humidity. However, low temperatures induce chilling injury. Edible film is environmentally friendly and safe for human health since it is made from natural ingredients. One of the marine polysaccharide used as base material for edible film preparation is agar. Glycerol is also the most widely used plasticizer in edible film making. An investigation on coating of star apples by using agar/glycerol was investigated. Star apples which were coated with 2.75% agar and 6.8% glycerol still maintained good quality until 30 days of preservation. Application of edible coating on star apple is able to reduce quality changes and slow down moisture loss by controlling and modifying the internal atmosphere of the individual fruits. The great benefit conferred by edible coatings is that these are natural biodegradable products.Keywords: Star apple, Agar, Glycerol, Biodegradable, Coating, Storage, Shelf-life.
Synthesis, Electro Conductivity, Thermal Stability and Antibacterial Activity of New Bis 1, 3, 4-Oxadiazole Copolymers Munged Jabbar Mohsin
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

A series of bis oxadiazole copolymer were synthesized. The first series was synthesized by the reaction the resorcinol with ethylbromacetate to obtain diethyl 2,2'-[benzene-1,3-diylbis(oxy)]diacetate (1). Compound 1 was converted to their corresponding di hydrazide (2). This compound was reacted with oxalyl chloride in pyridine and N-Methyl-2-pyrrolidone (NMP) to obtained P1. This polymer was converted to P2 by cyclized it in the presence of polypesporic acid (PPA) as dehydrating agent to obtain P2 as bis oxadiazole copolymer. P3-P7 was synthesized by the reaction of compound 2 with five various di carboxylic acid in PPA as depicted in Scheme 1. These copolymers were characterized by IR and 1H-NMR. The electro conductivity of synthesized copolymer were tested at 20, 20000 Hz at 25, 35, 45, 55, 65, 75, 85 and 95 ̊C. Various positive and negative conductivity were recorded in most copolymers at different temperature. Thermal stability was studied for all copolymers. Copolymers 6 and 7 exhibited significant stability at 450 C. The antibacterial activity for these copolymers was tested against gram negative and gram positive bacteria. Copolymer P1, P2, P5, P6 and P7 showed antibacterial activity against all bacteria under test and P5 exhibited highest inhibition zone (23 mm) against Shigella dysentery, while P7 showed same inhibition against Bacillus subtilis. Furthermore, P7 exhibited inhibition zone equal 19 mm against Esherichia Coli.Keyword: Copolymer, Bis oxadiazole, Electro conductivity thermal.
Phytonanotechnology Synthesis and Characterization of Silver Nanoparticles using Methanolic Extract of L. Inermis: A Study of the Effect of Temperature, Ph on the Rate of Synthesis and Biochemical Properties Hiba Adnan
Journal of Global Pharma Technology .
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Abstract

Phytonanotechnology synthesis methods are environmentally friendly, readily available, safe and nontoxic. In this study, methanolic extract of Lawsonia inermis has been used for the synthesis of silver nanoparticles. To improve the biological composition of natural nanoparticles, many parameters were investigated, and these were concentration of the extract, pH and temperature of the reaction. The characterization process was performed using techniques of UV-visible spectroscopy, Energy Dispersive X-Ray (EDX) and scanning Electron Microscopy (SEM).  The results illustrated that silver nanoparticles had a size of (150-600) nm and a spherical shape, showed SPR sharp peak between 390- 451 nm and EDX attested that Ag, W, Ru, Cl and C elements exhibited weight percentages of 69 %, 17%, 7.5%, 5.3% and 1.2 % respectively. The antibacterial activity was examined against two Gram positive bacteria (S. aureus and S. pneumoniae) and two Gram negative bacteria (E.coli and P. aeruginosa) by using the agar disk diffusion method , showed that silver nanoparticles had a strong effect against Gram positive bacteria and it is more than Gram negative bacteria. Antioxidant activity was also tested by DPPH test. The % inhibition values were found to be 82.66, 75.43, 71.57 and 62.67μg/ml for Ag NPs, ascorbic acid, L. inermis and BHA respectively at100 μg/ml.Key words: Silver nanoparticles, Law Sonia inermis, Antibacterial and Antioxidant activity.
Pervasiveness, Related Hazard Factors and Antimicrobial Defenselessness Example of Campylobacter Species among Dogs Hayder Hamzah Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Campylobacteris the most widely recognized bacterial cause for enteric sickness for the both humans and animals around the world. Over 90% of human Campylobacteriosisin industrialized nation’s results from utilization of debased chicken items, just as beef and milk. Drinking water and swimming water may likewise be a source of disease. To a lesser degree, contact with other nourishment animal species, wild birds, and pet dogs and cats has been related with human Campylobacteriosis. Ingestion of as few as 500 living beings can prompt contamination. At the point when center signs happens, early signs create after a brooding time of 1 to 7 days and incorporate fever, defame, spewing and migraine, which by and large last 1 to 3 days, trailed by as long as multi week of watery to ridiculous loose bowels and stomach torments. Zoonoses may be contracted from dogs and cats through introduction to their feces, parturient fluids, salivation, respiratory outflows, scratches, skin, conceal, pee, or outside parasites. Pollutions may be parasitic, bacterial, infectious or viral. Campybacteriosis has a higher rate in AIDs quiet than all in all populace causing extreme, frequently bleeding, looseness of the bowels and cramping, queasiness and fever. Most Campylobacter infections in canines and man are brought about by C. jejuni. Proof shows that contact with infected dogs, particularly diarrhoeic dogs can increase hazard of obtaining C jejuni..
Managing Consumer Loyalty in the Pharmaceutical Market of a Metropolis Olga Pashanova
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The article presents the results of a study of a complex of factors that determine consumer behavior in a pharmacy for visitors of an older age group (elderly people over 65). The main problems in providing pharmaceutical care to elderly consumers in the local pharmaceutical market of a large metropolis (for example, Moscow) are identified. Positive and negative factors of consumer loyalty of elderly customers of Moscow pharmacies are indicated. The purpose of the study was to formulate a comprehensive socio-psychological portrait of an elderly consumer receiving pharmaceutical assistance in pharmacies in Moscow. In order to achieve this goal, a study of the behavior of visitors to pharmacies over 65 years of age, their sociological surveys, as well as a survey of pharmacy managers and employees to identify positive and negative factors that affect the consumer behavior of the studied focus group of customers, were conducted. A sociological survey of visitors to Moscow pharmacies and a survey of managers and employees of pharmacies revealed the positive and negative factors of consumer behavior of elderly consumers and identified the main problems encountered in pharmacies in the provision of pharmaceutical care for this category of patients. A comparative analysis of Russian and world experience in serving elderly visitors in pharmacies was carried out. The necessity of studying the behavior of consumers of older adult focus groups is proved in order to improve the quality of pharmaceutical and psychological care. Elderly clients (over 65) account for 40-65% of visitors to Moscow pharmacies. The consumer behavior of the studied category of patients is characterized by pronounced polypharmacy, the need for advisory services and psychological assistance, the need for communication, a significant lack of information about the assortment, the interaction of drugs, their correct use, and storage. The psychological and medical problems in most elderly patients complicate the process of providing them with timely and high-quality medical care; require the use of a special psychotherapeutic approach in the work of pharmacy employees, and the introduction of a specific “client-oriented pharmaceutical advising”.Keywords: Elderly patients; Elderly consumers; Older adults; Polypharmacy; Pharmaceutical assistance; Pharmacy organizations; Socio-psychological portrait; Client-oriented pharmaceutical advising.
Expression of DAZL and BOULE in Spermatogenic Failure of Infertile Men: A Study Silvia Werdhy Lestari
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

DAZ-like (DAZL) on chromosome 3 and BOULE on chromosome 2 are genes included in the DAZ gene family. These genes have a role as regulator of specific cell cycle in germ cells. Mutations on DAZ gene family cause meiotic arrest and infertility. DAZL and BOULE are known to have interaction with CDC25 in regulating meiosis in the cell cycle. The examination of infertility on azoospermia cases, which are caused by spermatogenesis arrest, has so far been limited by histological examination from testicular biopsy. Therefore, molecular research is needed to determine the candidate genes that could be used as a marker in improving the quality of testicular biopsy examination. This research is a cross-sectional study which used 40 biopsy testes samples based on Johnsen scores 2 to 8. The mRNA expression analysis of DAZL and BOULE used qRT-PCR. The DAZL gene began to be expressed in scoring 5-8, where there was an increase from scoring 5-7 then a decrease in scoring 8. The BOULE gene began to be expressed in scoring 2 – 8, but there was an increase from scoring 4 – 7 and then a decrease in scoring 6 and 8. The correlation between the mRNA expressions of DAZL and BOULE showed a significant positive correlation (r = 0.415, p<0.05). These results indicated that both DAZL and Boule contribute in the failure of spermatogenesis.Keywords: Male infertility, Spermatogenic failure, Johnson score, DAZL, BOULE
Effectiveness of Drugs Therapy of Hypertensive Patients in Undata General Hospital Palu Ingrid Faustine
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Increased blood pressure above normal will result in increased morbidity and mortality by improving risk factor for other diseases. Data obtained from Undata General Hospital Palu, showed the number of hypertensive patients died in 2016 as many as 513 patients, this number increased in 2017 as many as 637 patients. This study aims to determine the accuracy of the selection of antihypertension therapy and dose as well as determine the effect of antihypertension drugs to decrease blood pressure in hypertensive patients in hozpitalized Undata Generala Hospital Palu in 2016-2017. This study uses a quantitative method with retrospective approach. The results showed that the most significant decrease in blood pressure based on length of stay occurred in patients with 4-7 days of stay ie 42.64/21.17 mmHg and the most significant reduction in blood pressure based on the treatment regimen occurred in three combination antihypertension 57.14/28.57 mmHg with a significance value of<0.05. So we concluded the accuracy of therapy and dose in hypertensive patients based on the guidelines JNCVII showed a patient diagnosed with mild, moderate, and severe hypertension overall proper drug selection and dose received by all patients with hypertension better use of antihypertension drugs singly or in combination in accordance with the standards of the JNCVII, and paired t-test for hypertensive patients with a single drug decreased blood pressure 37.80/16.19 mmHg (p=<0.05), hypertensive patients with two combinations of drugs decreased blood pressure 29.26/18.94 mmHg (p=<0.05) and hypertensive patients with three combinations of drugs decreased blood pressure 57.14/28.5 mmHg (p=<0.05).Keywords: Effectivenes, Drugs Therapy, Undata General Hospital, Hypertension.

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