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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Usage of Paracetamol and Ibuprofen in Children with Persistent Ductus Arteriosus . Yulistiani
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

Backgrounds: Persistent Ductus Arteriosus (PDA) is the structure of the ductus arteriosus that failed to close after the birth of the baby. One of the therapies which are used to overcome the closure of PDA is pharmacological therapy using prostaglandin inhibitors. Aim: to determine usage profiles, including dosage, frequency, route, and duration of paracetamol administration and ibuprofen for DAP. In addition, it also assesses the actual outcomes and side effects of using paracetamol and ibuprofen in children with PDAs. Method: this research was a quantitative research with a retrospective method. The sampling method used random sampling. The total sample was 32 children who were hospitalized with diagnosis of PDA with or without complications. Data was collected by conducting an assessment of the patient's medical record to the documentation sheet.  Results: Based on research in 32 patients, 78% of patients received paracetamol therapy, 16% of patients received ibuprofen, and 6% of patients received replacement therapy for paracetamol to ibuprofen. From 25 patients who received paracetamol therapy, 12 patients (48%) gave the outcome of PDA closure and eliminated patient tachypnea and cyanosis. The average dose of paracetamol used for PDA is 7.5-15 mg / kg every 6 hours for 3-7 days by oral route (9%) and intravenously (63%).While the average dose of ibuprofen for PDAs is 10 mg / kg / day for the first day and 5 mg / kg / day for the second and third days by oral route (100%). Conclusion: the use of paracetamol and ibuprofen for PDAs was in accordance with existing literature relating to the dose, route, frequency, and duration of administration for PDAs. However, there were some patients with special conditions that require adjustment of the second dose of the drug. The use of paracetamol and ibuprofen for PDAs did not cause actual side effects. The use of paracetamol for PDAs needs to be further investigated regarding the effectiveness and drug related problems and the need to consider the use of ibuprofen for PDAs related to potential side effects that can be caused.Keywords: Patent ductus arteriosus, Paracetamol, Ibuprofen, Pediatrics.
Green and Health Constitution of Green Open Space and Its Implementation in Surakarta Absori Absori
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Purpose: to find the essence from 1945 Constitution of the Republic of Indonesia Article 28H Paragraph (1) confirms that the right to obtain a good and healthy environment and good health services is part of human rights. Methods: this reaserch is a normative juridical methods and his research aimed at describing the Green Constitution in government policy regarding green open space and its implementation in Surakarta as an attempt to carry out the development and planning of the city that is environmentally friendly. This research was legal research conducted using a qualitative non-doctrinal approach. The results: showed that the Green Constitution that is friendly and perspective of the environment contained regulations and protections for environmental perspective. Based on data from the Regional Spatial Planning Coordinating Team (called TKPRD) Surakarta has 10% open space and the latest research conducted by the Geographic Information System (2015) of Surakarta has 9.17% green open space. Conclussion: The Municipal Government of Surakarta should provide green open space about what is mandated in Law by 30%.
The Effect of Eight Weeks of Hydrotherapy on Quality Of Life of Elderly Women Residing in Jahrom, Iran: A Quasi-Experimental Study Ehsan Rahmanian
Journal of Global Pharma Technology .
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Abstract

Introduction: Exercise is generally believed to be an effective method in preventing elderly disorders which delays elderly. Exercise programs and regular and continuous physical activities can increase the Quality Of Life (QOL) of elderly people, cause greater independence in daily tasks, and help a more favourable ageing process. Therefore, this research aimed to study the effect of 8 weeks of hydrotherapy on Quality Of Life of elderly women aged over 50 residing in Jerome, Iran. Method this is a quasi-experimental study by pretest-posttest design. A sample of 29 elderly women aged over 50 was selected using convenience sampling. Hydrotherapy was performed for 8 weeks (24 sessions). Quality Of Life was assessed at two stages (before and after hydrotherapy) by SF-36. Descriptive and inferential tests, paired t-test, and Kolmogorov- Smirnov Test were employed to analyze the data. Findings: The mean age of women was 51.04±9.63. No significant difference was found on the QOL before and after the intervention (P-Value>0.05). Paired t-test results showed that a significant difference was found on Role-Playing Limitation due to Emotional Reasons before and after the intervention (P-Value<0.05). A significant difference was also found on Physical Pain before and after the intervention (P-Value<0.05). No significant difference was found on QOL components (general health, physical functioning, role-playing limitations due to physical functioning, social functioning, vitality and mental health) before and after the intervention (P-Value>0.05). Conclusion: Although QOL declined after the intervention, the result was not statistically significant. Therefore, hydrotherapy was not effective in elderly women QOL. Keywords: Exercise, Hydrotherapy, Quality of Life, Elderly Women.
Detection of Some Virulence Factors Genes in S. Aureus Isolated From Different Clinical Cases Rawaa M. Mohammed
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

A total of 60 specimens (urine, burn swabs, and wound swabs) from different clinical cases were collected from patients (in different age groups) who admitted to several health centers in Al-Dewaniya General Teaching Hospital, during a period extending from October 2016 to January 2017. Some virulence factors was investigated for 30 isolates only of MRSA using Single and Multiplex PCR For detection virulence factor genes which both coa gene encoding  production of coagulase, clfA gene encoding for clumping factor, spa gene encoding for protein A, fnbA gene encoding for fibronectin binding proteins, luks gene encoding production of Panton Valentine Leukocidin (PVL), Results showed that all 30 isolates (100%) were possescoa, clfA, spaand fnbA genes, 13 (43.3%) were possesluks gene. Nanoparticle represented by gold and silver were tested in this study to defect their effect on viability of S.aureus. The results indicated that? Particle were more effective to inhibit the grow that of this bacterium (data are not showing in this paper).Keywords: virulence factors, MRSA, PVL, S.aureus, Nanoparticles.
Prevalence of Toxoplasmosis among Aborted Women and Immunohistochemical Evaluation of their Placenta Kawther A. M. Al-Mussawi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Toxoplasmosis is one of the zoonotic diseases caused by the obligate intracellular protozoan Toxoplasma gondii, which is associated with spontaneous abortion in infected pregnant women. In the present study, the sera of 228 first-trimester aborted women were screened for anti-Toxoplasma IgG and IgM antibodies, and the infection was further assessed in the blood and placenta of positive and negative cases by molecular methods. The results revealed that 47.4% of aborted women were sero-positive for toxoplasmosis (AT) by the latex agglutination test, while 52.6% were negative (NT). It was also found that 74.1% of AT cases were positive for IgG, while 25.9% were positive for IgM. In addition, the examined AT cases showed the amplified DNA fragment of the parasite, while it was not observed in NT samples. The placenta of molecularly diagnosed AT and NT cases were subjected for immunohistochemical expression evaluation for T-bet, GATA-3, FOXP3, IL-17, CD8, CD68 and perforin. A significant increased expression of T-bet, IL-17, CD8, CD68 and perforin was observed in AT cases compared to NT cases. In contrast, FOXP3 showed a significant decreased expression in AT cases, while no significant difference was observed for GATA-3. In conclusion, toxoplasmosis is an important risk factor for spontaneous abortion, which was associated with abnormal expression of some immunological markers in placenta.Keywords: Toxoplasmosis, Abortion, Prevalence, Immunohistochemical expression.  
Effect of Season on Arabian Camel (Camel us Dromedarius) Semen Parameters Hayder A.N. AL-Zamely
Journal of Global Pharma Technology .
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Abstract

This study was conducted on forty (40) of one- hamped Arabin camels to evaluate the effect of season on semen parameters, therefore the semen was collected from these animals in four seasons which are Winter, Autumn, Spring and Summer, the parameters which are studied include: semen concentration, semen motility, semen volume, the percentage of life sperms and the percentage of abnormal sperms. The results were revealed that, there is significant increase in sperms concentration, semen volume and semen motility during cold seasons (Winter and Autumn) as compared with other seasons also there is increase in percentage of life sperms and decrease in percentage of abnormal sperms in cold seasons (Winter and Autumn) as compared with other seasonsKeywords: Arabian camel, semen, season.
Chemoprofiling of Active n-Hexane Fraction as Alpha-Glucosidase Inhibitors from Kanunang (Cordia myxa L.) Leaves from Enrekang South Sulawesi Ahmad Najib
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Kanunang (Cordia myxa L.) is a native plant from tropical Asia. This study aims to determine the profile of chemical compounds contained in leaves of Kanunang (Cordia myxa) which can inhibit alpha-glucosidase enzyme. Extraction of Kanunang leaves was done by maceration method using ethanol 96% solvent for 3 days then filtered and thickened with rotary vacuum evaporator. Resulting extract with yield value of 5%. The extract was fractionated using conventional column method with n-hexane: ethyl acetate (10: 0) eluent. The n-hexane fraction was tested using the GC-MS instrument with the following condition; injector temperature 250°C, initial oven temperature 70°C, up to 325°C increasing 10°C/minute. The results obtained was 24 compounds which have alpha-glucosidase enzyme inhibitors activity with maximum abundance at RT 12:43, as 9,12,15-Octadecatrienoic Acid, methyl ester (C19H32O2) compound.Keywords: Cordia myxa L.; Chemical profile; GC-MS; Alpha-glucosidase.
Association between Obesity and Markers of Inflammation, Oxidative Stress and Neuronal Injury in Women with Non-alcoholic Fatty Liver Moushira Zaki
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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The present study aimed to investigate the association of Nuclear Factor (NF)-κB, oxidized –low density lipoprotein (o-LDL), total antioxidant capacity (TAC), neuron-specific enolase (NSE) and CD4 in obese women with non-alcoholic fatty liver (NAFLD). A total of 36 NAFLD obese women were enrolled in this study and 36 female control healthy women (aged 30-39) without cognitive impairment were examined. NAFLD patients were diagnosed by magnetic resonance elastography. Anthropometric parameters including body height, weight, waist circumference (WC) and body fat % were measured. Serum NF-Κb, TAC, CD4, o- LDL and NSE   were measured by ELISA.  Also, liver function tests, lipid profile were done. The present results showed marked elevation in serum NF-κB and o-LDL, while significant reduction in TAC and CD4 in obese NFALD than normal control subjects. In conclusion results provide evidence of association between obesity, high levels of oxidative stress, inflammatory markers and brain biomarker in women with NAFLD.
Evaluation and Investigation of the Prevalence of Superficial Mycosis among Primary Schools Pupils in Al-Dewaniyah Governorate, Iraq Sara K. Al-Zubaidi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: The Superficial mycosis infections are the widespread types of mycosis among children primary schools. Objective: To detection and evaluation the extent and prevalence of superficial mycosis infection among primary school pupils in Al-Dewaniyah province. Subjects and methods: The survey included the selection of the pupils were randomly selected based on those with tinea (ringworm) lesions sample of 103 pupils (males 81, females 22) respectively from ten primary schools (six male and four female schools), they clinically diagnosis dermatophytoses, in the Diwaniyah Teaching Hospital, Dermatology unit, during a period from the beginning of December 2018 till the final February 2019. The specimens were collected in sterile plastic Petri dishes or sterile plastic envelopes and consisted of skin scales, hairs, or clippings from fingernails and toenails. The samples of fingernails and toenails were cut or to get mycelial elements. Results: The results of identity and incidence of the dermatophytes and non-dermatophytes isolated were revealed that dermatophytic isolation " Tinea" was 36/103(34%) among patients and this percentage was distributed to various clinical cases of ringworm ''tinea'', Mean age of patients enrolled in the present study was 20.11+10.99 years with a range of 7 to 13 years, According to gender patients were classified into 25 male s (69%) and 11 females (31 %). dermatophytes infections Is a problem in the health system of many developing countries and influences all ages chiefly primary pupils.  Conclusion: The current study prevalence of superficial mycosis among pupils of primary school was significant risk factors assessed such as poor personal hygiene, overcrowding. Consequently, proper health education, personal and environmental sanitation, provision of infrastructure, primary health care and regular clinical studies are recommended for these primary school pupils.Keywords: Dermatophytes, Primary school pupils, Mycelia, Superficial mycosis.
Preparation and Characterization of Bacterial Cellulose and its Composites with Nano Silver Particles of Bioactive Elements Alaa Abdulnabi Ahmed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Bacterial cellulose has unique physical and mechanical structural properties. Which qualifies it for use in many industrial, medical and other applications? It is more effective in putting out wounds or burns as it used as a catch to take advantage of one of its advantages, which is its ability to retain fluids for longer due to its low degree of crystallization. Where a study carried out for the preparation of Nano silver cellulose compound of two methods, namely thermal reduction and Electrical mothed. An FT-IR spectrum analysis was s and to know the interconnection between silver Nano particles with bacterial cellulose. The size of the particles was estimated silver nanoparticles of (34.6-35.0) nm respectively for both methods with the AFM technique and to ensure the occurrence of actual adsorption with UV-Vis, SEM and EDX technology, while the x-ray technology showed the shape of silver Nano particles cube and at a volume rate of (4.49, 10.06) nm respectively for both methods and was studied  Biological efficacy towards the bacteria of wounds and burns where the results of both methods showed a strong effect to inhibit and stop these bacteria, Finally, compare it to both methods in terms of advantages and disadvantages in terms of the purity of the output was the best but the rate of molecular size and biological effectiveness and time of thermal reduction is the best.Keywords: Bacterial cellulose; Silver nanoparticles; Composites; Antibacterial activity.

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