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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Selenium Linked to Increased Antioxidant Levels and Decreased Free Radicals in Lung Tissue of Wistar Rats Exposed to E-Cigarette Smoke Bambang Wirjatmadi
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Objective: This study aimed to find out whether selenium could increase levels of antioxidants and decrease free radicals in lung tissue of Wistar rats after exposure to e-cigarette smoke. Methods: This study used an experimental method with control group design. Male Wistar rats with criteria aged 2–3 months, weighing 200-250 grams were used as animal models in this study to assess cell damage through the expression of Superoxide Dismutase, Glutathione Peroxidase and Malondialdehyde in the lung tissue using immunohistochemical staining. E-cigarette smoke containing 6 mg of nicotine was given to each group of animal models with differences in the amount and duration of time. The adaptation process in experimental animals was carried out for approximately 5 days. Results and Conclusion: Selenium has been shown to increase the expression of antioxidant superoxide dismutase and glutathione peroxidase, and decrease the levels of malondialdehyde in cells following oral administration of selenium in Wistar rats (p <0.05). In addition, selenium also reduced the amount of free radical in the cells; when it was given before exposed to e-cigarette smoke. It can be concluded that oral selenium can increase antioxidants levels and decrease free radicals in lung tissue cells due to exposure to e-cigarette.
Investigating the Challenges of Developing Sports among the Elder Lies in Hamedan Province and Presenting Practical Solutions Rasul Monem
Journal of Global Pharma Technology .
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Abstract

The aim of this study was to determine the challenges of developing sports among the elderlies in Hamadan Province and their problems with exercising as well as providing practical solutions for developing recreational sports for this group of people in Hamadan Province. In order to investigate the research question, elder lies above 60 in 2014 were chosen as the statistical population. The sampling method was cluster-random and the data collection instrument was a researcher-made questionnaire which its face and content validity were tested and confirmed by a group of authorities. The reliability was calculated using cronbach-α (α=0.87).Data analysis indicated that there are significant relationships. between monthly income and engaging in sports activities, between elder lies` satisfaction from leisure time activities and the kind of activity, and  between quality of life and doing sports among the elderlies at α= 0.05. Findings of the present study indicated that lack of sufficient recreational and sports facilities, low level of education, low income, physical weakness, cultural factors, mental features, family , and proper education about advantages of sports and physical activity, and spending leisure time have prominent roles in proper use of sports and leisure time. Authorities in Hamadan province should take some serious steps including creating sports-recreational spaces and places in order to remove obstacles the elder lies face to increase elder lies` tendencies to sports.Keywords: Leisure Time, Sports Activity, The elderly.
The Relationship of Organizational Justice with Organizational Commitment, Organizational Trust, and Job Satisfaction of Employees of Sistan and Baluchestan Education Office Abdol Ali Keshtegar
Journal of Global Pharma Technology .
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Organizational justice refers to employee's feeling and understanding about fairness and equity in work behaviors and relationships. Various researches show that the increase of justice affects different aspects of organizational behavior. Based on this, current research tries to examine how the aspects of organizational justice and dimensions of its subset (including distributional, procedural, and relational justice) affect job satisfaction, organizational commitment, and organizational trust. Statistical population of current research is 120 employees of schools of Sistan and Baluchestan education organization. Standard questionnaires were distributed randomly among 40 statistical samples by using Cochrane formula. Niehoff and Moorman questionnaire was used for measuring aspects of organizational justice, Minnesota's questionnaire (MSQ) for job satisfaction was used for measuring job satisfaction of employee, Meyer, Allen, and Smith questionnaire was used for measuring organizational commitment, and Ellonen et al questionnaire (ot) was used for measuring organizational trust. Data analysis with SPSS software showed that the distribution of data is normal and therefore, Pearson correlation test was used for determining the relationship of variables. Results showed that all hypotheses of research are supported and there is a positive and significant relationship between organizational justice and job satisfaction, organizational commitment, and organizational trustKeywords: Organizational justice, Job satisfaction, Organizational commitment, Education organization, Sistan and Baluchestan. 
The Effect of Nutritional State on Immune Response for Adults Patients with Tuberculosis Mohammed A.K. Alsaadi
Journal of Global Pharma Technology .
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Abstract

Malnutrition is observed frequently in patients with pulmonary tuberculosis (TB), but their nutritional status, especially of micronutrients, is still poorly documented. The objective of this study was to investigate the nutritional status of patients with active TB compared with that of healthy controls in Babylon providence. In a case-control study, 50patients aged 18–75 y with untreated active pulmonary TB was compared with 40 healthy controls. Anthropometric and micronutrient status data were collected. Compared with the controls, TB patients had significantly lower body mass index and concentrations of serum albumin, andplasma zinc and vitamin C. And studying the factors that affecting the cell mediated immunity including phagocytic index, CD56  and IFN-γ for TB patients.Blood samples were collected from patients group and control group to estimate phagocytic index, interferon gamma (IFN-γ), CD56 and Vitamin C by ELISA (Enzyme linked immunosorbent assay) method and to estimate zinc and Albumin level were also estimated by using  spectrophotometer. The cell mediated parameters showing that there is a significantly decreased (p< 0.05) in phagocytosis activity of neutrophils in  TB  patients (6.04%)  compared  to  control group (11.70%)  and there is no significantly increased (p> 0.05) of IFN-γ level in the TB patients (0.159) IU/ml compared  to  control group (0.157) IU/ml .CD56 level in TB patient (78.043)IU/ml compared to control group (74.473) which was with no significantly increased (p > 0.05). The level of zinc in serum is significantly decreased (p<0.05) in the TB patients (51.18) g/dl compared with control (113.44) g/dl and albumin level in serum is a significantly increased (p<0.05) in the TB patients (38.973) g/dl compared with control (50.2) g/dl.Keywords:  TB. Tuberculosis. IFN-γ. Malnutrition
Identification of Some New Tetrazole and Thiazolidine Derivatives Synthesized From 4-Chlorobenzoic Acid and Evaluation Their Antibacterial Effect Maysoon Tariq Tawfiq
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The research  includes  the synthesis of some new derivatives of  tetrazole and thiazolidine  rings from the reactions of  2- (4-chlorophenyl)-5-hydrazinyl- 1,3,4-oxadiazole [4] with various substituted aromatic aldehydes  in absolute ethyl alcohol as  a  solvent and presence of glacial acetic acid as a catalyst to form Schiff's  bases [5-10]. The prepared new Schiff's bases [5 -10] reacted with sodium azide , and mercaptoacetic acid in THF to yield five membered rings  (tetrazole ring) [11-15], and (thiazolidine ring) [16-20]  in good products. The  spectral  methods  of  the   prepared  compounds  were  characterized  by FT.IR, and 1HNMR for compounds [9,13,14,and 19] , besides melting points were recorded , and the purity was checked through T.L.C. technique. Antibacterial activities for some of the synthesized compounds were examined.Keywords: Heterocyclic compounds, 4-Chlorobenzoic acid, Acid hydrazide, Oxadiazole, Schiff’s bases, Tetrazole, Thiazolidine, Biological activity.
Drug Use Evaluation in the Pediatrics Admitted with Severe Respiratory Tract Infections Vineela Chadalavada; Triveni P; Hameeda Begum Md; Pujitha S
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
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Abstract

The objective of the present study is to evaluate drug prescribing patterns in children admitted with respiratory tract infections into pediatric ward. This is a prospective cross-sectional study conducted for a period of one year at a tertiary hospital located in a city of Andhra Pradesh, South India. The study was done by using prescribing indicators from the World health organization (WHO) manual for the conduction of drug use evaluation studies. The prevalence of respiratory tract infections, particularly lower respiratory tract infection is high among children less than 5 years. 54.39% of drugs are prescribed with brand names, of which the majority of drugs are administered through parenteral route (58.26%). Antibiotics (34.7%) are highly prescribed in all the cases followed by other category drugs. A significant difference was found in the evaluation of prescribed daily dose and standard dose. The profile of drug use in the present study was similar to previous Indian studies. Most of the prescribing encounters are parental forms and band names that need exploration of the present treatment trends. The present baseline data can serve for the development of national Pediatric prescribing guidelines in the future.
Synthesis, Characterization of Some New Heterocyclic Derivatives Asstabraq Mohsin Yasir
Journal of Global Pharma Technology .
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The newly compounds containing a seven-member ring oxazepane and five-member ring tetrazole derivatives were prepared starting schiff bases. Synthesized by percyclic reactions of imine group with phthalic anhydride resulted the formation of 1,3-oxazepane-4,7dione derivatives (S1, O). The new tetrazole derivatives were obtained from treatment of each prepared schiff bases S and S1 with sodium azide to give derivatives (S2, T). Finally derivatives have been characterized by melting points, FT.IR and 1H-NMR spectroscopy.Keywords: Phathalic anhydride, Sodium azide, Tetrazole, Oxazepane-4,7dione.
Metastatic Breast Carcinoma on Diffuse Spine Metastatic Process Using Augmented Exoskeleton Cement: Proposing a New Technique Tjokorda Mahadewa GB
Journal of Global Pharma Technology .
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Metastatic breast cancer (MBC) to the cervicothoracic area of the spine is very rare cases. In this case report, we describe a case for this rare lesion. Case: a thirty-nine-year-old female with a history of weakness of the legs and pain in the upper back spine came to the hospital with history of breast biopsy with result of adenocarcinoma and positive long tract signs. On whole-spine MRI, it is shown the bone metastatic process on C5-7, T3, T5-7, T9-10 with bony destructions and extradural mass around T5-7 and T9-10. Two stages of surgery were planned for this patient. The first operation was addressed to cervical metastatic process through the posterior approach, in the form of a cervical fusion with laminectomy biopsy. The second step was via posterior approach for thoracic decompression and fusion. Since the Karnovsky score was 60 and single step surgery was chosen, led to cervicothoracic decompression fusion at single stage using augmented exoskeleton cement technique. During follow-up, the patient was neurologically improved on the both legs function significantly, though gait was still tolerable and recovery program was still ongoing in outpatient department. MBC treatment for long spine involved lesions can also be handled via a single posterior approach with good results especially for case with cervicothoracic metastatic process.Keywords: Metastatic breast cancer, Posterior approach, Cervicothoracic fusion, Exoskeleton.
Flagellin Immunization against Urinary Tract Infection Caused by p. Mirabilis Astabraq A. Al-Sodanii
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective Proteus mirabilis is dimorphic a (gram negative bacteria that alternates between a rod –shaped swimmer stage and multinucleate, highly elongated swarming stage. Methods  Urine Samples collected from three hospitals in Baghdad city from adult and child patients Suffering from urinary tract infections for 6 months .The samples get reached 1152 distributed among the patients old between few days to 80 years most patients living in hospital with urinary tract catheter , 56 samples of Proteus mirabilis were identified after isolation and diagnosis of bacterial species in different methods because there different complications in UTIs Patients specially Stone formation ,  catheter obstruction , and renal damage. Results these bacteria were diagnosis in api 20 E and vitek2 system and one isolate of Proteus mirabilis was selected for the study according to distance movement by measurement (swarming motility). Flagellin which is the flagella protein was extracted and predicated, followed by SDS-polyacrylamide gel electrophoresis for protein molecular weight estimation and  concentration of protein counted by Bradford method ,then immunization protocol were tested in Albino rabbits in different concentrations 10,20,40 microgram from flagella protein then immunoglobulin antibody IgG ,IgM in serum were tested by single radial immunoglobulin diffusion plate , positive results  showed raised the concentrations of these antibodies with high significant differences .Immunized  females rabbits was tested to ascending urinary tract infection challenge by inoculation 145×107">  cfu from P.mirabilis and tested in 1 , 3 , 7 , 14 days , any  females rabbits didn’t show urinary tract infection by P.mirabilis  when urine culture tested and, the concentration of IgG , IgM  antibody in balance also showing white blood cells in normal range .While rabbits females that inoculated by 145×107">  cfu in positive control group showed urinary tract infection by P. mirabilis  after 7 days post inoculation the tested urine culture showed raised in IgG , IgM and white blood cells concentration. Conclusions In the present study, flagellin protein immunization in rabbit showed that there are rising in IgM and IgG titers. After challenging by ascending urinary tract infection, we showed neutralization of IgG and IgM and white blood cells.Keywords: Flagellin, P. Mirabilis, UTI, Vaccine.
Study the Ascorbic Acid Levels, Lipoprotein Ratio and Hypocholesterolemia Action of Dry Okra Extract on Experimental Model of Locally Male Rabbits Hamzah H. Kzar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Okra (Abelmoschus esculentus) is a flowering plant in the mallow family. Okra is important for its edible green and dry seed pods. The plant is cultivated in tropical, subtropical and warm temperate regions around the world. The geographical source of okra now is very available in Iraq. The rabbit rapidly develops severe hypercholesterolemia and decrease in levels of ascorbic acid and increase in ratio of bad cholesterol to good cholesterol in response to dietary manipulation. The results of this study showed that, there was a significant decrease in serum total cholesterol  and lipoprotein ratio for groups of rabbits that administrated with dry okra aqueous extract with its seeds (0.5g/kg) (DOE+ cholesterol oil-fed) as compared to control group( not administrated) at the end of six week of experiment (398±4.0) vs. (175± 5) (P < 0.05). On the other hand, a significant difference in the level of serum total cholesterol (P<0.05) starts in control group treated with cholesterol-oil fed at the end of six week of experiment as compared to cholesterol+ DOE group  (398±4) vs. (543±4). The aqueous extract of dry okra may be enhancing the conversion of cholesterol to bile acids in the liver by activation of an enzyme α-hydroxylase. DOE may be having inhibition action on HMG-COA synthase that responsible on endogenous synthesis of cholesterol in liver. Keywords: Dry okra extract, Induce cholesterol. Lipoprotein ratio, Ascorbic acid.

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