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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 19 Documents
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Search results for , issue "Volume 09 Issue 05" : 19 Documents clear
Simultaneous Analytical Method Of 6-Mercaptopurine and 6-Methylmercaptopurine In-vitro Study With Bio-Sampling Venipuncture and Dried Blood Spot Yahdiana Harahap
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Objective: 6-Mercaptopurine (6-MP) is a cancer chemotherapeutic agent. Metabolic pathway by thiopurine S-methyltransferase (TPMT) to become 6-methylmercaptopurine (6-MMP).Bio-sampling is required to obtainbiological sample, using two technique; invasive (venipuncture) and minimum invasive(dried blood spot). This study aims to obtain an optimization and validation analysis 6-MP and 6-MMP in vitro study with bio-sampling venipuncture and dried blood spot (DBS). Method: Plasma from venipuncture method extraction was done using dichloromethane. Separation was performed using Waters HPLC, C18 SunfireTM column (5μm, 250 x 4.6 mm), with gradient elution, flow rate 1 mL/min and detected at UV-PDA wavelength of 303 nm. Bio-sampling dried blood spot with DBS CAMAG® paper diameter of 8 mm and extracted with acetonitrile-methanol (1:3). Separation was performed with Waters LC-MS/MS UPLC C18 column (1.7 μm, 2.1 x 100 mm) with gradient elution, flow rate 0.2 mL/min. 5-fluorouracil (5-FU) was used as internal standard.Result: The method venipuncture was linear at concentration range of 2-200 ng/mL for 6-MP and 20-2000 ng/mL for 6-MMP. The method dried blood spot using Waters Xevo TQD for mass detection with positive electrospray ionization (ESI) for 6-MP, 6-MMP and negative ESI for 5-FU in Multiple Reaction Monitoring mode. Linear with the range 26-1000 ng/mL for 6-MP and 13-500 ng/mL for 6-MMP.Conclusion: The developed method is valid for 6-MP and 6-MMP simultaneously in vitro from venipuncture using HPLC and from dried blood spot using LC-MS/MS and showed good selectivity, linearity, accuracy and precision, matrix effect and stability.Keywords: 6-mercaptopurine, 6-methylmercaptopurine, Venipuncture, Dried blood spot.
A Review on Role of miRNA in Kidney Diseases Priyadarshini .
Journal of Global Pharma Technology Volume 09 Issue 05
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micro RNA or miRNA are short non-coding RNAs species that inhibit target gene expression by blockingprotein translation or by mRNA degradation. Several studies have shown that miRNAs regulatethousands of gene expressions throughout the genomic machinery and play important roles in thephysiological and pathological events. In addition, miRNA play important role in pathogenesis of variousrenal diseases, including diabetic nephropathy, renal carcinoma, polycystic kidney diseases, allograftrejection etc. miRNA as a biomarker has been an area of intensive researches, as it has been discoveredto be potential therapeutic tools to manage several diseases. Therapeutic potential of miRNA-basedtreatment though promising but various challenges such as target specificity is still to be explored.Identification of miRNA and their target can provide a novel therapeutic candidate for curing variouskidney diseases. In this review, we have stated the role of various miRNAs in the development of variousrenaldiseases.
Structure of Groups with At Most Six Character Degrees Mohammad Hosein Salmani Yengejeh
Journal of Global Pharma Technology Volume 09 Issue 05
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Let a, b, c and d be relatively prime integers greater than 1 and cd(G) be the set of all irreducible complex character degrees of a finite group G. Mark Lewis in [4] proved that every group G with  cd(G) = {1,  p, q, r, pq, pr},where p, q and r are distinct primes, is the direct product of two groups H and K with cd(H)={1, p, q} ; cd(K)={1, p, r} and so is solvable. We try to use classification of finite groups and drop the primness hypothesis and show that the same result holds in a special case. In fact we show that if a, b, c and d be relatively prime integers greater than 1 and cd(G) 14⊆"> {1, a, bd, cd, abd, acd}, then G is solvable. Also as an interesting application of this theorem we prove that there is no group G with cd(G) = {1, a,  bd,  cd}, where a, b, c and d be relatively prime integers greater than 1.Keywords: Character degree, Solvable group, Irreducible character degree set, Degree graph. 2010 AMS Mathematics Subject Classification: 20C15; 20D05.
COMPARISON THE ANTIHYPERTENSIVE AND ANTIOXIDANT POTENTIAL BETWEEN YOUNG MAHOGANY SEEDS EXTRACT WITH MATURE MAHOGANY SEEDS EXTRACT IN RATS WITH HYPERTENSION I Wayan Putu Sutirta Yasa; Putu Astawa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
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Mahogany seeds have been used in the community as an antihypertensive and antioxidant. Antihypertensive and antioxidant efficacy of mature mahogany seeds has been proven in hypertensive rats. The purpose of this study was to compare the antihypertensive and antioxidant effect of mature mahogany seeds extract with young mahogany seeds extract. This study is a laboratory experimental design with pre-test and post-test design control groups, with Wistar rats as samples. Thirty rats were divided into 5 groups, each group consist of 6 rats. The control group was given saline every day as a rat model of hypertension. 1-4 treatment groups were each given NaCl and water extract of young mahogany seeds for treatment 1, the ethanol extract of young mahogany seeds as treatment 2, water extract of mature mahogany seeds as treatment 3 and ethanol extract of mature mahogany seeds as treatments 4. Dosages of extract mahogany seeds is 100 mg / head / day for 4 weeks. Before treatment, evaluation of rat blood pressure with special sphygmomanometer was held, and examination of blood MDA as a pre-test data. Further evaluation of MDA and SOD blood pressure are at the end of the study. The data were tested by ANOVA to see the difference between the groups. The results showed a decrease in blood pressure and levels of MDA were significant in all treatments (p <0.05) compared with control as well as an increase in SOD were significantly (p <0.05). The ethanol extract of mature mahogany seeds showed the most excellent antihypertensive and antioxidant properties (p <0.05). From these results, it can be concluded that the ethanol extract of mature mahogany seeds is better than young mahogany seeds extract as an antihypertensive and antioxidant in hypertensive rats.Keywords – antioxidants, hypertensive rats, mature and young mahogany seeds
Vitamin C (L-Ascorbic Acid) Degradation Kinetics during Simultaneous Infrared Dry-Blanching and Dehydration of Apple Slices with Intermittent Heating Method Hassan Sabbaghi
Journal of Global Pharma Technology Volume 09 Issue 05
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Vitamin C (L-Ascorbic Acid) is the most important vitamin in nutritional terms. The polyphenols existing in apple exhibit the highest antioxidant rates hence the preservation of apples’ nutritional quality during the heating process is of a great importance. Simultaneous infrared dry blanching and dehydration (SIRDBD) based on intermittent heating method is a novel process during which the temperature is kept constant. The present study investigated the effect of irradiation temperature and the product’s thickness on polyphenol oxidase (the enzymatic browning agent) and Vitamin C degradation. For this purpose, apple slices, in different thicknesses, namely 5mm, 9mm and 13 mm, and diameter of 20 mm were prepared. Irradiation was carried out in three surface temperatures, i.e. 70, 75 and 80°C. The temperature of product center was recorded during processing. The enzymatic activity of polyphenol oxidase (PPO) and ascorbic acid content were assessed in various 2 min and 30 min intervals, respectively. Vitamin C degradation kinetics was studied. The results indicated that the enzyme degradation time was significantly lower in 80°C (P<0.05). At the time of blanching sufficiency, the center temperatures for apple slices with thicknesses of 5mm, 9mm and 13mm were 64.4, 61.7 and 60.8°C, respectively. The vitamin’s degradation kinetic constant (k) was found significantly increased with the increase in temperature or thickness (P<0.05). With the increase in thickness, the vitamin degradation was more dependent on temperature elevation (higher activation energies or Ea). Vitamin C contents were very close at the beginning of the process in different temperatures. Therefore, the high-temperature short-time approach (HTST) can, meanwhile accelerating the enzymatic inactivation, preserve the nutritional quality of the products.Keywords: Vitamin C, Blanching, Infrared, Polyphenol oxidase.
Red Piper Crocatum Leaves Extract Ethanol Lowering Malondialdehyde (MDA) and Blood Glucose Level In Hyperglycemic Wistar Rat Sri Wahjuni; I Made Sukadana; dan Luh Putu Arisanti
Journal of Global Pharma Technology Volume 09 Issue 05
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Changes in fast-food behavior became one cause of diabetes. Potential of the red betel leaf (Piper crocatum) can lower blood sugar levels allegedly because it contains antioxidant-potent compounds inductively induce certain organs to produce insulin hormones that play a role in lowering glucose levels in the blood.The aim of the study is to determine the effectiveness of Piper crocatum leaf ethanol extract in fixing the pancreas β-cell damage rate in alloxan induced hyperglycemic Wistar Rat. Methods: This study used randomized pre-and posttest control group design. Twenty-four (24) male Wistar rats divided into 6 groups namely P0 positive control (P0), P1 as a negative control (allowance 125 mg Kg -1BW), P2 (alloxan and extract dose 50 mgKg-1 BW), P3 (alloxan and extract dose 100 mg Kg -1 BW), P4 (alloxan and extract dose 150 mg Kg - 1 BW), P5 (alloxan and glibenclamide 0.18 mg/day 200g -1BW). Blood glucose measurement was taken through a vein tail performed by the glucose test method. Measurement of MDA levels, blood was taken from the jugular vein and analyzed by the TBARS method. The yield of Piper crocatum extraction with ethanol solvent was 13,1%.  The most significant results were shown by dosing of 150 mg Kg -1BW and extract of 50 mg Kg -1 BW gave a comparable effect to glibenclamide as a blood sugar-lowering drug. The results of phytochemical tests showed that Piper crocatum contains phenolic, alkaloid, and steroid. The results of GC-MS analysis of extracts active Piper crocatum were suspected to contain 29 compounds of 13 compounds known as phytol, neophytadiene, β-bisabolene, germacrene-D, α-humulene, sulfamethoxazole, caryophyllene, nandrolone phenylpropionate, thiamin, linalool, β-ocimene, Anthocyanin, and β-myrcene.Keyword: Red Piper crocatum leaf, Blood glucose, MDA (Malondialdehyde).
MOLECULAR ANALYSIS OF LACTIC ACID BACTERIA ISOLATE SR2 FROM BALI CATTLE RUMEN I Dewa Made Sukrama; Komang Januartha Putra Pinatih; I Wayan Suardana
Journal of Global Pharma Technology Volume 09 Issue 05
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Bali cattle with its distinctively genetic characteristics, namely simple life or easy to adapt on unfavorable environmental condition was known as cattle pioneer. These characteristics were due to specific type of lactic acid bacteria (LAB). These facts indicate that the LAB identification with specific advantages was absolutely necessary for further research in order to prevent incorrect interpretation. Generally, molecular approach is the accurate method of identifying microorganism, and in this case, we used the analysis of the 16S rRNA gene. Research activities began with cultivation of SR2 isolates on specific media deMann Rogosa Sharpe (MRS) followed by Gram stain, catalase test, and formation of CO2 gas. Molecular analysis was performed by PCR of the 16S rRNA gene using primers 27F and 1492R. The PCR products were sequenced and nucleotides data were analyzed by Mega 5.2 Software tool. The results showed that phenotypical isolates of SR2 showed characteristics as LAB isolates, and the results of the 16S rRNA gene analysis showed that isolates SR2 included into Lactococcus lactis strain with a bootstrap value of 100.Keywords - Bali cattle, lactic acid bacteria, molecular analysis, rumen, SR2 isolate
Gap Analysis between the Current and Desired states of Talent Management Programs and Determination of Improvement Priorities by using Importance-Performance Analysis (IPA) Abdolali Keshtegar
Journal of Global Pharma Technology Volume 09 Issue 05
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Today, talent management is one of the main areas of human resources management for gaining competitive advantage and it is essential for organizations to examine systematically the status of their talents and take steps in order to enhance the situation. Given the importance of this subject, the present study aims to conduct a gap analysis between the current and desired states of talent management and also determine the improvement priorities using the Importance-Performance analysis (IPA). This study is a descriptive survey and the statistical population consists of all staff of the department of education in the city of Birjand in Iran. A sample size including 86 people was determined. In this study, two researcher-made questionnaires were used in order to achieve the research goals. After the confirmation of validity and reliability, these two questionnaires were distributed among the respondents and finally, 76 questionnaires were collected and studied. The gathered data were analyzed by means of SPSS statistical analysis software and based on the IPA model. The results of this study showed that there was a significant gap between the current and optimal states of talent management, and this gap was present in all four main dimensions of the research and all factors. According to the IPA model, the eight following factors were determined as improvement proprieties: Adjustment of salaries of employees with their activities, planning to prepare right people for filling key roles, harmony between the post and people who are selected for it, the existence of the sense of success and progress in the organization, continuous evaluation of staff performance and identifying their weakness and strengths, modifying undesirable behaviors, actively creating equal development opportunities for employees, coaching and educating prominent and professional people. According to the existing gap and given that the improvement priorities are of all four dimensions of talent management, it is thus recommended to focus on all four aspects for improving the situation and in case of restrictions, it is recommended to put the aforementioned determined improvement priorities at the top of improvement programs in the short term.Key Words: Gap analysis, Talent Management, Determination of Improvement Priorities.
Preparation of a New Acrylonitrile Co-Polymer and Studying the Flammability and Mechanical Properties of Its Composites Mohammad N AL-Baiati
Journal of Global Pharma Technology Volume 09 Issue 05
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Acrylonitrile co-polymer was prepared, by four steps, the first was prepared the hetro-cyclic monomer,the second include prepared linear polymer, the third step includes prepared partially cross-linkedpolymer and the fourth step includes added four different moles (0.5, 1.0, 1.5 and 2.0 mole) ofacrylonitrile monomer. The effect of four types of inorganic phosphors salts in four different weightpercentage (0.2, 0.4, 0.6 and 0.8%), on flammability and mechanical properties (Flexural and Tensile)strength of co- polymer, has been studied. Four standard test methods used to measure the flameretardation and mechanical properties, which are: ASTM: D–2863, ASTM: D–635,ASTM: D – 790 andASTM:D-638.Results obtained from these tests indicated that, the co-polymer which prepared has highvalue of flame retardant and mechanical properties comparing with any thermosetting polymer, on theother hand, additive IV has high efficiency as a flame retardant and high effect on the values ofmechanical properties, but additive I show low effect on retard composition and low effect on the valuesof mechanical properties. This ability to flame retardency increased with the increasing in the number ofmonomers of acrylonitrile.Keywords: Polymer, Modified co-polymer, Acrylonitrile co-polymer, Condensation Polymerization, Fireretardant, Flammability, Additives.
Studying the Effect of Organizational Justice on Manpower Maintenance in Birjand University of Medical Sciences Abdolali Keshtegar
Journal of Global Pharma Technology Volume 09 Issue 05
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Manpower is considered as one of the basic and important resources of organizations. In order to reach their goals, organizations need specialized and committed human force to achieve their goals. Therefore, one of the most important duties of organizations regarding the management of human resources is manpower maintenance. To this end, the present study has aimed to investigate the effect of organizational justice and its dimensions on manpower maintenance in Birjand University of Medical Sciences. The present study is an applied research in terms of its objective and it is a descriptive survey in terms of its data collection method. The statistical population of this research has been composed of the employees of Birjand University of Medical Sciences. 150 of these employees were selected as the research sample using the judgmental sampling method. In order to test the hypotheses, the Pearson correlation coefficient and the multivariate regression analysis were used. The results obtained from the Pearson correlation coefficient showed that there is a positive and significant relationship between organizational justice and manpower maintenance (r=79.3). Also, the results of multivariate regression analysis have shown that interactive justice, procedural justice and distributive justice variables have been able to separately explain 50.3, 30.5 and 20.6 percent of the scores of the maintenance system, respectively. In other words, among the components of organizational justice, interactive justice has had the most substantial impact on manpower maintenance and distributive justice had the least substantial effect on it in the population under study.Keywords: Organizational justice, Procedural justice, Distributive justice, Interactive justice, Man power management.

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