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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 19 Documents
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Search results for , issue "Volume 09 Issue 05" : 19 Documents clear
The Role of Government Health and Education Expenditure on Economic Growth in OPEC oil Exporting Countries Ebrahim Anvari
Journal of Global Pharma Technology Volume 09 Issue 05
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Economic growth is one of the goals of development in economic plans of every country. Achieving self- development in OPEC member Oil - exporting countries takes precise awareness of the amount of economic variables. Among these variables, oil revenues, total government expenditure, government expenditure for education and  government expenditure for health could be mentioned.In this research using panel data studies of relationship between health expenditure and education expenditure and economic growth in OPEC oil-exporting countries for 2004 to 2014. Hence, panel data method has been applied in order to estimate  models and panel var method has been applied in order to examine the causality relationships between variables. The results shows a positive meaningful relationship between oil revenues, total government expenditure, government expenditure for education, government expenditure in health, and economic growth of OPEC oil-exporting countries in the studied period. Furthermere, the result of Granger Causality test suggest that there was one –side relationship of economic growth with government expenditure for health in OPEC member countries in the studied period.Keywords: Economic growth, Government expenditure, Oil revenue JEL: H51, H40, C13.
COMPARISON OF OSTEOGENIC AND CHONDROGENIC DIFFERENTIATION POTENTIAL BETWEEN WHARTON’S JELLY AND ADIPOSE TISSUE MESENCHYMAL STEM CELLS AS THE ALTERNATIVES OF BONE MARROW MESENCHYMAL STEM CELLS: A SYSTEMATIC REVIEW Petrus Aprianto
Journal of Global Pharma Technology Volume 09 Issue 05
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Introduction. Currently, Bone Marrow is the most common source of Mesenchymal Stem Cell (MSC). The limitation of the source and pain post harvesting procedure make the next alternative of BM-MSC is needed. Wharton Jelly, offer a low cost and pain free collection method. Adipose tissue provide abundant amount stem cell and has a interestingly compatible osteogenic and chondrogenic activity. The objective of this study is to search alternative Bone Tissue Engineering (BTE) source other than BM-MSC.Materials and Method. Literature search was conducted using several search engines. This review used all In vitro experimental comparison of Adipose Tissue Mesenchymal Stem Cells (AT-MSC) and wharton’s jelly stem cell (WJ-MSC). We compared osteogenic and chondrogenic differentiation potential between these MSCs. The group of comparison is divided into two sub groups, animal MSCs and human MSCs.Result and Discussion. The first study that compared osteogenic and chondrogenic differentiation from animal AT-MSC and WJ-MSC consists of 7 trials. Most of the result shows that AT-MSC has greater osteogenic differentiation potential compared to WJ-MSC and controversial result for chondrogenic differentiation between them. The second study consist of 3 trials. In these studies, the results were more homogenous and concluded that AT-MSC has higher osteogenic differentiation potential than WJ-MSC but the chondrogenic differentiation were not significantly different.Conclusion. AT-MSC may be more appropriate than WJ-MSC for osteogenesis and bone repair usage.Keyword: Osteogenic differentiation, Chondrogenic differentiation, Wharton’s jelly Mesenchymal Stem Cells, Adipose Tissue Mesenchymal Stem Cells
WATER EXCTRACT OF PURPLE SWEET POTATO INCREASE SUPEROXIDE DISMUTASE, CATALASE GENES AND DECREASE MDA LEVEL IN MULTIPLE ORGANS OF DIABETIC WISTAR RATS Bagus Komang Satriyasa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
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Objective: The purpose of this study was to prove the water extract of purple sweet potatoes can increase superoxide dismutase (SOD) gene expression and catalase (CAT) and decrease malondialdehyde (MDA) in vital organs of diabetic rats. Method: This study was randomized experimental design with posttest only control group design. Sample divided into 2 groups: control and treatment groups, respectively 18 diabetic Wistar rats. The control group will be given streptozotocin. The treatment group was given streptozotocin and water extract of purple sweet potato 4 cc/day. This treatment is carried out for 2 months. Result: Water extract of purple sweet potato was proven significantly increased mRNA expression of aorta and kidney SOD but decreased SOD mRNA expression in the liver (p <0.05). This water extract also increases SOD mRNA expression in cardiac but not statistically significant (p> 0.05). Water extract of purple sweet potatoes also found significantly increased renal and cardiac expression of CAT mRNA (P <0.05), but not statistically significant (p> 0.05). Conclusion: Purple sweet potatoes extract to decrease the expression of liver CAT mRNA non-significantly, and decrease MDA in liver and kidney of diabetic Wistar rats significantly (P <0.05).
The Role of Meta-Cognitive, Dysfunctional Cognition and Early Maladaptive Schemas on Obsessive Compulsive Disorder Fatemeh Rezaei
Journal of Global Pharma Technology Volume 09 Issue 05
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This study aimed to examine the mediating role of meta-cognitive and dysfunctional cognition in the relationship between early maladaptive schemas and obsessive-compulsive disorder (OCD). The study participants consisted of 600 staff of Khuzestan Steel Company (KSC). They filled out the following questionnaires: Obsessive-Compulsive Inventory-Revised (OCI-R, Obsessive Beliefs Questionnaire-44 (OBQ-44), Dysfunctional Attitude Scale (DAS), Young's 90-item Early Maladaptive Schemas Questionnaire, Meta-Cognitive Belief Inventory and Negative Automatic Thoughts Questionnaire (NATQ). The results indicated that the proposed model has an acceptable fit (RMSEA=0.078). According to this model, early maladaptive schemas directly and indirectly predicted the OCD (β=0.93, P<0.0001) through metacognitive beliefs (CI= 0.18-0.09) and dysfunctional cognition (CI= 0.31-0.14). It was also revealed that dysfunctional cognition is mediating between early maladaptive schemas and the OCD (CI= 1.14-0.13). This study illustrated that the early maladaptive schemas restrain the surface cognitive processing. Therefore, it is recommended that the early maladaptive schemas, metacognition, and dysfunctional cognition are attended to treat the OCD.Keywords: Early Maladaptive Schemas, Meta-cognitive, Dysfunctional Cognition, Obsessive-Compulsive Disorder.
QUALITY OF LIFE IMPROVEMENT OF CHRONIC HEART FAILURE PATIENTS AFTER THE EFFECT ENHANCED EXTERNAL COUNTERPULSATION (EECP) THERAPY Starry Homenta Rampengan; Anita Dundu; Joedo Prihartono; Suzanna Immanuel; Minarma Siagian
Journal of Global Pharma Technology Volume 09 Issue 05
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Objective: This study aimed to evaluate the risk factor of depression level before and after EECP therapy in chronic heart failure (CHF) patients. Methods: We performed a double-blind random clinical trial between January 2014 and June 2015 in 99 patients with CHF who had received EECP therapy at Jade Cardiovascular Clinic, Manado, North Sulawesi, Indonesia. The CHF patients were categorized into 2 groups, i.e. 49 patients had sham EECP therapy and 50 patients had EECP therapy. The patients filled WHO-5 questionnaire before and after receiving EECP therapy. Statistical analysis was performed for all output, either for primary, secondary or safety output. Results: The baseline characteristics of both groups have no significant difference. We found no significant difference of WHO-5 questionnaire result in sham before and after EECP therapy, but in EECP group showed statistically significant difference (p<0.05). WHO-5 questionnaire attributes result were found significantly improvement of felt cheerful and good spirit (p=0.03) and woke up feeling fresh (p=0.030) in EECP group compared with sham group. Conclusion: EECP therapy was effective to reduce depression so that improve quality of life in CHF patients.Keywords - chronic heart failure, enhanced external counterpulsation therapy, quality of life, world health organization
Characterization of Biofilm production and quorum sensing phenomenon among antibiotic resistant Acinetobacter baumannii isolated from wound infections in Iraq Rawa Abdul Redha Aziz; Sawsan Sajid Al-Jubori
Journal of Global Pharma Technology Volume 09 Issue 05
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Objective(s): Acinetobacter baumannii has emerged as a significant hospital pathogen, quickly becoming resistant to wide range of antimicrobials. It has gained notoriety as a cause of debilitating soft tissue infections in soldiers returning from Iraq and Afghanistan.This study focused on the characterization of biofilm production in Iraqi A. baumannii and its regulation by quorum sensing. Material and Methods: twenty four isolates were collected from Baghdad and Al-Najaf hospitals and re-diagnosed by compact Vitek 2 and genetically using housekeeping gene (recA). Phenotypic detection of biofilm formation was screened by microtiter dish assay, twitching motility assay, and SEM. Quorum sensing phenomenon (QS) was detected using conventional PCR. Results: 100% of isolates formed either strong or weak biofilm by microtiter dish assay. Twitching motility test revealed that 79.2% of isolates were motile. SEM analysis showed 79.2% of isolates made different stages of biofilm started with adhesion step and ending with a mushroom like architecture as highly magnification images showed on glass cover slips. PCR analysis of QS showed that 91.7% of A. baumannii harbored AHL gene encoding N-acyl homoserine lactone hydrolase at amplified size 498bp, while 83.3% of A. baumannii isolates could harbor abaI gene encoding N-acyl homoserine lactone synthase at amplified size 382bp. Conclusion: it could be concluded that A. baumannii isolates were capable to produce biofilm and control it using quorum sensing genes expression. This would raise the concern of dissemination of chronic infections among hospitalized patients in two cities: Baghdad and Al-Najaf.
IN VITRO COMPARISON OF OSTEOGENIC DIFFERENTIATION POTENTIAL BETWEEN BONE MARROW STEM CELLS AND ADIPOSE TISSUE MESENCHYMAL STEM CELLS : A SYSTEMATIC REVIEW Prima Rizky Oktari
Journal of Global Pharma Technology Volume 09 Issue 05
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AbstractIntroduction. Bone tissue engineering (BTE) becomes a promising issue to improve bone defect repair. Stem cells are the first choice in BTE due to the ability of  selfrenewal and multi-lineage differentiation. Adipose tissue (AT) is another alternative source that can be obtained by a less invasive method and in larger quantities than bone marrow. Materials and Method. Literature search was conducted using several search engines, such as Cochrane, Scopus, PubMed, EBSCO, and Google Scholar. Studies were screened for inclusion and exclusion criteria.. This review used all In vitro experimental comparison of Mesenchymal Stem Cells (MSCs) derived from adipose tissue and bone marrow. We compared osteogenic differentiation potential between these MSCs. The group of comparison is divided into two sub groups, first group is the comparison among the animal MSCs, and the second group is the comparison among the human MSCsResult and Discussion. From three invitro study and one animal study that compares osteogenic activity of MSC from adipose and MSC from bone marrow, Most of the study shows the osteoblastic differentiation of ATMSCs as demonstrated by AP staining was less than that of the BMMSCs. The amount of matrix mineralization shown by Von Kossa staining also showed statistical differences between the two MSCs.Conclusion. ATMSC have differentiation potential similar to that of BMMSC, ATMSC may be a better source for tissue repair in the respect of their abundance and accessibility.Keyword: Osteogenic differentiation, Mesenchymal Stem Cells, Adipose Tissue Mesenchymal Stem Cells.
IMPLEMENTATION OF MARKER PROTEINS USING STANDARDISED EFFECT Shruti Jain
Journal of Global Pharma Technology Volume 09 Issue 05
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In this paper we have discussed the null hypothesized mean,  standardized effect, true population mean, group sample size,  population S.D., type I error rate (Alpha),  critical value ,and power of different marker proteins (AkT, EGFR, ERK, JNK, MK2, IRS and FKHR) theoretically and validate it with Minitab and Statistica Software. Different plots have been plotted between power and sample size, power and standardized effect, power and type 1 error rate. Later we have plotted a correlation graph for different marker proteins which shows mean, SD, max, min, histogram plot, and scatter plot for each marker protein.
The Role of Career Path Management in Nurses’ Succession Planning Abdolali Keshtegar
Journal of Global Pharma Technology Volume 09 Issue 05
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Background and purpose: Nurses are ones of service organizations’ forces who are in direct contact with clients. So, they must have special mastery in their work. Therefore, nurses’ career path and process of their succession is very important. This research aimed to study the relationship between career path management and succession of nurses. Study method: The present research was descriptive-correlation. The present research’s statistical population included 280 nurses working in Iranshahr hospitals selected by census method as statistical sample and the questionnaires including succession Rothwell (2006) and career path management Delong (1982) were distributed among them. Formal validity was used to determine questionnaires validity and Cronbach’s alpha was used to determine reliability which was 0.84 for succession questionnaire and it was 0.85 for career path. Data was analyzed by Pearson correlation inferential test and simple regression in SPSS21software.  Findings: The variables of career path management and succession were in a good position. At 99% significant level, correlation coefficient of career path management and succession and its dimensions including succession planning assessment, filing the educational vacancy, personal performance assessment, current work requirements and making a commitment to systematic succession planning) were 0.65, 0.784, 0.72, 0.682, 0.570, 0.178, -0.352 and -0.203, respectively. According to regression results, 42.3 percent of succession changes can be explained based on career path management. Conclusions: Career path management appropriately explains succession system. A more worthy succession system will be established through career path management. So, we will enjoy the existence of qualified nurses in positions by a special consideration to career path management.Keywords: Nurse, Succession, Career path management.

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