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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 63 Documents
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Search results for , issue "Volume 09 Issue 12" : 63 Documents clear
Tropaeolum Majus Leaves Extract as an Antifungal, Antiaflatoxigenic and Antiaflatoxin Agent Mohammad J. Al-Jassani
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Tropaeolum majus‎is widely cultivated both as an ornamental and as a medicinal plant. All parts of the plant are edible and highly nutritive and it was evaluated for its antifungal, anti-oxygenic and anti-aflatoxin activity. T. majus leaves were collected and let to dry in a shady place then grinded. Total of 100g of dry plant was extracted successively with 250 ml of Absolute ethanol. The plant extracts’ anti-fungal activity were tested against aflatoxigenic Aspergillus spp. isolates by disc diffusion method and the MIC, MFC was determined using microdilution method. The microplate fluorescence imaging procedure was used for antiaflatoxin activity test. The ethanoilic extract of T. majus showed high antifungal activity against most selected aflatoxigenic Aspergillus isolates at 100mg/ml of MIC and MFC. The ethanoilic extract of T. majus showed high influence on the inhibition and depression of AFs production genes at MIC of 50mg/ml and MDC at 25mg/ml. The concurrent addition of the ethanoilic extract of T. majus (2 to 0.25mg/ml) to the RBC suspension cased a significant reduction in AFB1-induced hemolysis in a concentration-dependent effect manner. The results showed that 1.5mg/ml of T. majus ethanoilic extract was the best concentration that prevented aflatoxin-induced hemolysis with 100% AFB1 elimination. As a first report, T. majus leaves extract is highly recommended as an additive to the food and feedstuffs as a nutritive, antifungal and antitoxin agent.Keywords: Tropaeolum majus, Antifungal, Antiaflatoxigenic, Antiaflatoxin.
Influence of Role Model for Professional Development in Medical Education Mainul Haque
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Influence of Role Model for Professional Development in Medical Education
Preparation, Diagnosis and Evaluation of the Bioavailability of New Heterogeneous Ring Compounds of Albendazole Hala Shkyiar Lihimes
Journal of Global Pharma Technology Volume 09 Issue 12
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The study includes the preparation of 12 new derivatives of heterogeneous cyclic derivatives of bendazole. The hydrazid (A1) derivatives of bendazole reaction with hydrazine in absolute ethanol were prepared, and from its reactor (A1) with 4-diethylamine benzaldehyde (A2). The ring closure was performed using succinic   anhydride to obtain the oxazepine ring (A3). Carboxylic acid derivative (A4) was prepared from hydrolysis of bendazole using concentrated hydrochloric acid, and its derived reactor (A4) with thainoid chloride obtained the acid chloride derivative (A5). After that the derivative (A6) was synthesized from its A5 derivative reacted amino acid glycine in NaOH (10%). ring closure was then performed using a number of different aromatic aldehyde   with acetic anhydride to obtain the oxazole ring (A7a, A7b). (A7a, A7b) were obtained and obtained derivatives (A8a, A8b), which were used in two different routes. First track obtained the pyrazole (A9a, A9b) by ring closure the reacted with hydrazine. The other path was to obtain hydrazide derivatives (A10a , A10b) by interacting with the aromatic aldehyde to obtain Schiff bases (A11a, A11b) and then conduct the ring closure of the derivatives above for derivatives (A12a, A12b). The compounds prepared by melting points, infrared spectra and H1NMR were diagnosed. Biochemical efficacy was also assessed.
Pregnancy Course and Outcome in Relation to Maternal Age Suzan Yaseen Mahmood Alzubaidy
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Background: Pregnancy is considered as a special period during which woman needs special care and management of certain signs and symptoms. Advanced maternal age is defined as more than 35 years during pregnancy, while teen pregnancy is pregnancy during 15 – 18 years old. It is well established that advanced maternal age or teenage Pregnancy is associated with adverse effects that may affect the mother or the neonate like gestational hypertension or diabetes or preterm labor and others. Objective: The aim of this study is to observe the effect of maternal age during conception on the course and outcome of pregnancy Methods: The sample included 300 mothers chosen conveniently from four different PHCC in Baghdad during the period 1/2/2015 to 31/5/2015. The mothers were divided according to age groups. Data were collected by direct interview and answering the questionnaire, which provided demographic and health information about the mother and pregnancy. Results: Most mothers in the study were in the 18 – 35 years age group (61.7%). For the mothers aged less than 18 years, 64% of them had one child during the study period, 9%had abortions, 73%had term labor, 13%had preterm labor and 5%had post term labor. On the other hand, most women more than 35 years old had more than four children (64%), with abortion rates 15%, term labor 69%, preterm labor 10% and post term labor 5%. The study revealed that the rate of complications during pregnancy was 36% in the age group fewer than 18 years, 55% in the 18 – 35 years age group and 56% in the age group older than 35 years. Conclusion:  the number and rank of pregnancy are related to maternal age. 2. Term labor is the most frequent outcome of pregnancy in all age groups, with higher rates of preterm labor in young mothers and abortions in old mothers. 3. C.S is the most frequent mode of delivery in all age groups with higher rates in old aged mothers than young and preferable groups. Improved education level resulted in reduced complications during pregnancy in all age groups. Based on the findings we recommend regular visits by the mother to PHCC to reduce occurrence of complications during pregnancy, and advising families to delay the first pregnancy in teenage girls when early marriage happens.Keywords: Pregnancy course, Maternal age, Pregnancy complications. 
Effect of Physicochemical Factors on Cyanobacteria Biodiversity in Some Agricultural Soil of Al-Diwaniyah City during Spring Period Haider A. Alghanmi
Journal of Global Pharma Technology Volume 09 Issue 12
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The present study investigated the effect of some physicochemical factors on the biodiversity of Cyanobacteria In the agricultural soils of some areas in the city of Diwaniyah, where six areas are selected: Ghammas, Al-Shamiya, Al-Saniya, Afak, Al-Daghara, Al-sadeer with five farms per region during spring, Physical and chemical factors of the soil range between 21-23.5 °C and pH between 7.72-7.33, electrical conductivity between 233.8-3072  μs/cm, salinity between 0.268-1.730%, Nitrate between 7.46-20.0400 ppm, and phosphate between 1.340-5.260 ppm while the soil texture, the percentage of sand ranges between 12.08-15.68%, the Silt between 50.112-53.216%, and the clay between 34.208 -35.5%, the organic matter is between 3.350-6.202%, potassium 23-57ppm, calcium between 125.2-1320 ppm, magnesium between 51.46-557 ppm, and sodium between 1.3040-12.3580 ppm. Cyanobacteria species identified in this study are about 26 species. The dominant species of cyanobacteria represented by Oscillatoria sp. with percentage 50% followed by Phormidium sp.19.230%, then Chroococcus sp. and Spirulina sp. 7.692%, Finally, Gleocapsa sp., Microcoleus, sp. and Shizothrixsp. Reach to 3.864%. Some species of Cyanobacteria record in all soil areas like Oscillatoria acuta, O. Laetevirens, O. tenuis, Phormidium anomala, and P. pachydermiticum. The lowest number of Cyanobacteria is 2 in Afak and in Al-Sanyia and the highest number is 8 in Gammas. The Shannon Diversity index values of ranged between 2.350-2.685. While Simpson index Diversity values range between 0.935-0.960 in Afak and Ghamm as, respectively. The results of the statistical analysis showed significant differences and a positive, negative correlation between physicochemical factors and to the cyanobacteria numbers of some agricultural areas at p<0.05.Keywords: Cyanobacteria, Biodiversity, Soil, Physicochemical factors, Spring.
Evaluation of CD4 and CD8 in Patients Infected with Genital Wart Caused by Human Papilloma Virus in Babylon Province/Iraq Nisreen Kaddim Radi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Genital warts it’s a skin projection due to human papilloma virus infection (HPV) .Thirty skin lesion and sera were collected from patient (females) infected with genital warts that visit dermatological department of medical Moran city. Twenty sera was collected from healthy person used as control group.  The diagnosis of viral infectionwas achieved by dermatologist (specialist) and by using IgG anti HPV ELISA kit to detect papilloma virus in human serum, and ELISA testwas used to evaluate the level of CD4 and CD8 at patient with genital warts. The result demonstrates that:- 99% of samples dedicate positive for IgG anti HPV. Immunological study revealed that  :- decrease the ratio of CD4/CD8 at patient with genital wart( ratioCD4/CD8:-0.1), decrease in CD4 level at patient infected with genital warts compared with control group .CD8 increased at patient with genital warts compared with control group. There is significant differences between patient and control group, p value ≤ 0 .05.Keywords: HPV, Genital wart, CD4, CD8, Koliocyte.
A Comparative Study between the Blood Pictures of Iraqi Camels Infected with Trypanosomiasis and the Blood Picture of the Healthy Iraqi Camels Zahra M. Al-Hakak
Journal of Global Pharma Technology Volume 09 Issue 12
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This study was conducted to compare the blood picture of healthy Iraqi camels with the blood picture of camels infected with trypanosomiasis. Collected (100) blood samples randomly for a period from 1/10/2015 to 30/9/2016.    The blood samples collected from camels which are brought to the veterinary clinic in Najaf and Karbala, from camels that bring to slaughter in the Najaf, Karbala and Qadissiya massacres. These camels some of them healthy and others were observed with illness fatigue, wasting, high Temperature, patches of fall of lint,paleness of mucous membranes and accumulation of edema in different areas of the animal's body. The age of these camels ranged between (8 - 15 years) for camels and she camels. The study included the collection of blood samples and the examination the number of red and white blood cells, count the different type of white blood cells, measure the proportion of hemoglobin and measure pact cell volume of red blood cells .Then make blood smear to see the normal shape of red blood cells and the form of all types of white blood cells to do counting differential type of white blood cells.. We also conduct blood swabs of trypanosomiasis to watch the parasite and make a differential count of white cells and changes in erythrocytes.  The results obtained from a sample size (100) camels and she camels, (92) non-infected aninals and (8) animals with trypanosomiasis, the number of healthy camels (60) and (32) animals she camels. The number of infected camels (5) and (3)infected she camels .In healthy camels the number of red blood cells are( 8.6 - 9.9 × 106 / ul),the number of white blood cells are (8.8 - 10.9 × 103 / ul), the percentage of hemoglobin recorded were ( 11.7 - 12.5 g / dl) and the pact cell volume are  (48.8 - 48.9%), number of neutrophile( 41.8 -48.9 %) , lymphocytes (35.7 - 42.9%),monocyte (5.7 - 8.4%), eosinophile (3.2 - 4.5%). In all samples we saw one basophile cell in age (8 years - 11 years).   In infected animals the number of red blood cells (3.15 - 4.75 × 106 / ul) , white blood cells are (8.9 - 17.5 × 103 / ul), the percentage of hemoglobin recorded in infected animals with trypanosomiasis is (6.5 - 8.5 g / dl)and pact cell volume ( 19 – 24.3 %) .The account of differential type of white blood cells are  (36.3 - 50%) neutrophile, lymphocyte (33 - 47.6%), monocyte cells (5-10%), and number of eosinophile (6 - 14)% of the rods did not see any cell.Keywords: Camels, Infected, Iraqi, Comparison, Blood test.
Effect of Regular Sports Activity in the Salivary Glands in Short and Long Distance Sprinters for Track and Field Games Hayder Flayyih Hasan
Journal of Global Pharma Technology Volume 09 Issue 12
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Saliva is produced in salivary gland and the human saliva consists of 99.5% water but contains many important substances such as electrolytes. Mucus antibodies to bacteria and various organisms. This study was studied by enzymes which are biological catalysts of different chemical structures. And affect the speed of some reactions without consumption. The importance of this research lies in the role of these enzymes, which are studied in the health of teeth and mouth “isosomiee, hactoferin, Bromine, globin alga” and the percentage of the concentration of these enzymes. Which are of the quantity and quality of saliva produced from the salivary glands? The latter is an acquired by adapting the activity of the sports activity with the training intensity. Such as long - term diseases of the field work of these glands in secretion is very important in the durability of motor performance such as sports activities. By moisturizing the mouth and facilitating the process of breathing and swallow saliva especially that such sports activities rely on the energy … so the study assumes that the long-distance runners have a quality and the amount of salivary secretion useful more than short- distance runners during periods of rest or practice of normal daily life because the saliva of the mouth decreases during the exercise of violent physical exercise this necessarily means that long - distance sprinters enjoy the health of teeth and mouth over short runners to contain their saliva on an enzymatic con centration.Keywords: Regular sports, salivary glands, short and long distance and sprinters. 
The Effect of Some Chemical Materials against Virulence Factors of Candida Ssp Isolated from UTI Patients Fatima Abdul Hussein Mejbel
Journal of Global Pharma Technology Volume 09 Issue 12
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During the period from September 2016 to December 2017, a total of 135 urine samples were collected from urinary tract infection patients attending to AL-Zahraa Hospital in AL-Najaf Governorate. The present study was conducted to isolate and identify Candida spp. isolated from urinary tract infection patients by different methods including direct examination , laboratory culture ,  biochemical test and by modern techniques (Api Candida kit) and determine the virulence factors phenotypic to Candida spp which involved (bio film formation, phospholipase and germ tube).The percentage of females to males was as following , female (84) 62.2 % (21) infected and male (51) 37.8% (1) infected with all age categories. The results in this study are explain that is some Candida spp. such as C. albicans, have high susceptible to eugenole follow by phenol and umbellulone. The efficiency of some chemical substances such as (eugenole, umbellulone, and phenol) was evaluated to inhibit the growth of Candida ssp as well as some virulence factors such as bio film formation, germ tube and phospholipase which were studied in this research. Statistically analysis results have been significance difference between the results of the substance concentrations and the concentrations of the different other substances.
A Novel Anti-bacterial, Histopathological and Immunomodulatory Effect of Lactobacillus Reuteri and Exopolysaccharide in Pneumonia Model Likaa Mahdi
Journal of Global Pharma Technology Volume 09 Issue 12
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Objective: The current study aimed to evaluate the antibacterial activity of exopolysaccharide (EPS) against multidrug resistant Klebsiella pneumoniae isolated from blood cultures in vitro and evaluate the potential antibacterial, histopathological and immunomodulatory efficacy of Lactobacillus reuteri and EPS against K.pneumoniae in-vivo. Materials and methods: purification and characterization of EPS produced from L.reuteri.BALB mice were injected with   K. pneumoniae, and treated with either L. reuteri or EPS, bacteriological, histopathological and cytokine production were determined. Results: Antibacterial activity of purified EPS was higher than crude P<0.05. In-vivo L. reuteri and EPS  demonstrate a significant decreasing in the number of bacteria in liver and spleen, while complete clearance of K. pneumoniae  in lung comparing with control P<0.05  and accelerated recovery of the defense mechanisms against K. pneumoniae by inducing two types of  cytokines. These cytokines would be involved in the improvement of the immune response and limiting the injury caused by infection. Succeeded to eradicate K. pneumoniae infection improves histological patterns of the lung, spleen and hepatic tissues. Conclucion: L. reuteri and EPS, they could be novel therapeutic agents for prevention and treatment of pneumonia infection and   introduced as potential novel candidates that have to be subjected for more in vivo and application studies for treatment and control of resistant K. pneumoniae.                                                                                  Keywords: L. reuteri, Exopolysaccharide, Immunomodulatory, Antibacterial, K. pneumoniae.

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