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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 73 Documents
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Search results for , issue "Volume 10 Issue 06: (2018) June 2018" : 73 Documents clear
Cytotoxic Activity of 2- iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) Acetate from Sterculia Quadrifida R.Br Ethyl Acetate Fraction Rollando Rollando
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Faloak (Sterculia quadrifida R.Br) was used empirically as a traditional medicinal plant. The information of the active compounds contained in the faloak bark was not specifically published. This study aims to determine the active compounds contained in the fraction of ethyl acetate of faloak bark which has cytotoxic effect on breast cancer cell type T47D. Extraction method use maceration, isolation compound using gradient isolation method, structural elucidation using information from IR, H-NMR, C-NMR and LC-MS. Cytotoxic activity test on breast cancer cell line T47D using MTT method. The result show the isolate compound was 2-iminoethyl 2- (1-hydroxypentan-2-yl) phenyl) acetate with IC50 value on T47D breast cancer cell 7, 12 μg/mL and with selectivity index value was 47, 53.Keywords: Sterculia quadrifida R.Br, 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) acetate, T47D.
Survey about Shape Detection Ahmed Brisam
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The simplifying original shoreline of vector data into direction-line is the source of picture of baselines of the shape detection. Applying standard algorithms of vector data confining, such as the Douglas-Peucker algorithm, to analyze the real shoreline within direction-line, disregards the specific elements of a guarantee of general marine interests .To solve this problem, this research suggested an improved Douglas-Peucker algorithm. First, determine the curved vertices of the original shoreline as a choice set of points; later filter division points from curved vertices based on corner and length; ultimately, separate the data into different parts in order to complete the Douglas-Peucker algorithm, and compare the threshold of each part to efficiently select specialty points and protect shape detection. This research uses Python language to carry out the algorithm design, and openCV2. The results show that, compared with the Douglas-Peucker algorithm, the improved Douglas-Peucker algorithm improves how detect the contours, and shape detection, and the accuracy of curve simplification also fixed.
Synthesis of New γ-Lactam Derived from 3-Chlorobenzo [b] Thiophene and Evaluation of Anti Bacterial Activity Zainab B Hashim
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

New hetero cyclic, compounds derived from cinnamic acid was synthesized. 3-Chlorobenzo[b]thiophene-2-carbonyl (Z1) was synthesized from cinnamic acid and thionyl chloride . Carbohydrazide (Z2) was obtained by the reaction of 3-Chlorobenzo [b]thiophene-2-carbonyl chloride (Z1) with hydrazine hydrate. treatment of (Z1)with ethylene di amine to give  (Z3) .(Z2,Z3) undergo condensation reaction with different aromatic aldehyde in absolute ethanol gave the Schiff′s bases (Z4-Z19) new γ- lactams (Z20- Z35)  derivatives have been synthesized by reacting of succinic anhydride with Schiff’s bases These compounds were evaluated of the anti- bacterial activitiesKeyword: benzo[b]thiophene, γ- lactams, Schiff′s bases.
HOXB 13 Gene Single Nucleotides Polymorphisms as an Early Molecular Marker for Prostate Cancer Hasanain Ali Shubbar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

New single nucleotide polymorphisms in Hoxb13 gene has a related with prostate cancer and may be considered as early molecular marker and SNPs are located in gene promoters, exons, intronsas well as 5'- and 3'- un translated regions. The study investigation the association between single nucleotide polymorphisms and prostate patients Materials and Methods: 75 prostate cancer patients, 75 prostate benign and 81 healthy were included. A conventional PCR technique was used to defect variable region of HOXB13 gene by using specific primer pairs synthesized targeting certain region of exon one and two in the HOXB13. The DNA sequencing results for 134 samples were analyzed and aligned using NCBI nucleotide alignment tool, BLAST n (Basic Local Alignment Search Tool) in which DNA sequence obtained in this study were compared with human reference HOXB13 gene sequence. Results showed for HOXB13 gene deletion T located in 48728612 region complement (promoter region), substitution C >T Rs 8556 (exon 1 region), deletion A 48727109 region complement (intron region) and substitution G >A region complement.
Genotoxicity of Ciprofloxacin in Bone Marrow Stem Cells of Mice Infected with Uropathogenic E. coli Muthana Ibrahim Maleek
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Background and Objectives: Ciprofloxacin is an antibiotic used for the treatment of uropathogenic Escherichia coli (UPEC) infections. It is intended in this study to investigate the genotoxic effects of ciprofloxacin on bone marrow stem cells of mice prior to and after infection with E. coli.  Method: Two groups of mice were injected intraperitoneally every 8 hours with 9.5 mg/kg Ciprofloxacin; the first was for 24 hours and the other was for 5 days. Similarly, two other groups of mice were injected with 0.5 ml (1.5×108 cfu/ml) E. coli and treated with ciprofloxacin for 5 days. Microscopic slides were prepared from bone marrow of treated mice and genotoxicity was assessed by counting the number of chromosomes aberrations (CAs), mitotic index (MI) and micronucleus (MN). Results and Interpretation: Significant increase in the number of CAs, a decrease in MI and insignificant change in number of MN were seen in mice infected with E. coli and treated for 5 days with ciprofloxacin. However, no change in the values of these aberrations was observed in mice treated for 24 hours. It is believed that the effects of Ciprofloxacin on DNA in combination with the accumulated effects of E. coli toxins were responsible for the observed DNA damages. Conclusion: The use of ciprofloxacin for the treatment of E. coli infection may increase genotoxicity in bone marrow stem cells, which produces significant DNA damage.  Keywords: Ciprofloxacin, E. coli, Stem cells, Mitotic index, Chromosomal aberrations, Micronuclei.
Effect of Two Species of Ticks and Lice on Some Blood and Biochemical Parameters and their Role in the Transmission of Toxoplasma Gondii to Turkey Meleagris Gallopavo during Spring and Summer Seasons in AL-Diwaniyah Province – Iraq Khalid Thamir Mattar AL-Shaibani
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

AL-Diwaniyah governorate was the research place, where the study was conducted in during spring and summer seasons from the start of March 2017 to the end of October 2018. 120 turkey birds were selected from some districts and areas of AL-Diwaniyah governorate such as AL-Diwaniyah, AL-Shamiya, AL-Daghara,AL- Sanniyah, AL-Hamza and Afak, With 20 birds per region (10 per season). Two species of ticks: Argus persicus and Dermacentor variabilis were diagnosed with 15% and 18.3% respectively, and two species of lice: Goniocotes gallinae and Menacanthus straminus with 37.5% and 27.5% sequentially. The results showed a significant increase in the Infection of ticks and lice in spring compared to summer, where the rate of infection of tick and lice was 51.66% and 85%, respectively, while infection rate in summer was 23.33% and 35%, respectively. Infection by lice was high during spring in the areas of AL-Dagara, AL- Saniyah,and AL- Hamza . It was observed that there increasing in the numbers of isolated lice species in these areas in comparison with the number of tick, whereas the lowest rates of infection by ticks and lice were in the province center.  The results revealed a significant decreasing ( P ˂ 0.05 )in the concentration of Hb, the volume of PCV and the total number of RBC of infected birds compared with non-infected, while a high significant increasing was observed in the total number of WBC of infected birds in comparison with non-infected ones. The results of biochemical parameters of serum showed a significant decrease P (0.05) in the values of total protein concentrations, cholesterol and glucose of the infected birds' serum. The lowest values were for infected birds with lice, followed by tick compared to control. Eye examination of the skin and feathers of infected birds illustrated the presence of important changes such as the fall; fracture and lack of feathers completely in some areas of skin as well as wounds, scratches, and bleeding were clearly observed.  The results of polymerase chain reaction (PCR) of tick A. persicus and lice M. stramineus tissues showed that diagnostic gene B1 (399bp) of T.gondii was present in 20 samples of the total number. This indicates the presence of this parasite in its tissues and ability to transmit it.Keywords: Turkey, Tick, Lice, PCR,
Anti-Diarrheal Activity of Aqueous Extract Datura Innoxia Leaves in Rat Farrah R. Jaafar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Two experiments were performed, to study the therapeutic effect DI leaf extract against chemically induced diarrhea as well as anti-enter pooling effect induced by castor oil in two gatherings (T1&T2) Treated orally with (Datura innoxia leaves aqueous) extract at doses of 100 and 200 mg/Kg B.W. and compared with atropine sulphate treated group as standard drug and control one, each group consist of 6 albino rat. Exp-The results show significant decrease (P<0.05) in charcoal Intestinal travelling percent (ITP)in both DI extract doses in dose dependent manner T2 when compared to of atropine sulphate (1mg/kg BW) show similar result. While Ex-2 Nearly same patter results as in exp-1in which both orally treated DI extract doses and atropine(3mg/Kg BW) caused significant reduction (P˂0.05) in(enter pooling impact) on intestinal substance weight and volume in examination with the control gathering. The possibly because the DI extract may have another impact component next ant muscarinic impact cause its tropane alkaloids content. Inclusion, DI leaves aqueous   seem to cause anti-diarrheal effect and intestinal anti-propulsion effect positive correlated with extract dose.Keywords:  Aqueous extract, datura innoxia leaves, Anti-diarrheal Activity, Enteropooling, Rat.
DNA METHYLATION IN THYROID-STIMULATING HORMONE GENE: PREDICTOR OF GRAVE’S DISEASE RECURRENCE IN INDONESIA Luluk yunaini; Dwi Anita Suryandari; Trisia Lusiana Amir; Dwi Yanti; Fatimah Eliana
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Thyroid-stimulating hormone receptor (TSHR) has a critical role in Graves’ disease (GD). GD is an autoimmune disease which is multifactorial. Environmental factors can affect the epigenetic, a changes in gene expression without any changes in base sequence of the DNA. One of the epigenetic types is methylation. This study aims to determine the status of DNA methylation in TSHR gene in patients with GD to be one of the predictors of recurrence. This study used a case control design with 58 samples of GD patients divided into 29 groups of recurrence and 29 groups of non-recurrence. DNA methylation examination used methylation-specific PCR (MSP) method. Our result found that DNA methylation profile of GD in Indonesia were 5% with complete DNA methylation, 17% complete DNA unmethylation and 78 partial DNA methylation. Statistical analysis showed no significant different between recurrence and non-recurrence group (p>0.05). Nevertheless, our result showed no patient with complete status DNA methylation was found in recurrence group. This shows that in recurrence occur a reduction of DNA methylation resulting in increasing of TSHR production. Thus, DNA methylation in TSHR gene might be has a role in the risk of recurrence GD.
The Effect of Complex Exercises in Different Shapes and Spaces to Develop Some Special Physical Abilities and the Velocity of the Skillful Performance of Football Players Hussein Habib Mosleh
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The problem of research is the amount of weakness in the level of some physical abilities, which has a negative impact on the low level of skill performance and shows through random play and slow movement within the stadium and the large number of cases cut in performance. Objectives There are statistically significant differences between the results of the post and remote tests of the two research groups in the search variables and in favor of the post tests. There are also significant differences between the control and experimental research groups in the remote tests and in favor of the experimental group. The experimental method was used for the nature of the research problem. The sample consisted of (48) players distributed to 22 control groups (22) for the experimental group and they represent the Soran Club. The experimental method of the experimental group in the experimental curriculum has developed in some special physical abilities and the velocity of the skillful performance of the research sample. The most important recommendations are to adopt the training method in specific areas and in different forms in the training curricula in the preparation and special stages.Keywords: Complex exercises, Physical abilities, Velocity and skillful performance.
Study of Some Histological and Biochemical Changes in Patients with Celiac Disease Ilham Abd Allah Ali Al-Saleem
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Introduction: Celiac disease (CD), a common heritable chronic inflammatory condition in the small intestine caused by permanent intolerance to gluten/gliadin. Aim of object: to investigate the disorders associated CD. Materials and methods: The present study carried out on the 30 patient’s and25 individuals as control group had been clinically diagnosed as celiac who underwent endoscopic examinations due to gastrointestinal symptoms. Blood samples were collected from the groups for determination of serum transaminase enzyme. The patients underwent upper gastrointestinal endoscopy. Three biopsies were taken from the second portion of the duodenum, fixed in 10% formalin embedded in paraffin. Marsh scores used for the histological evaluation of the intestinal mucosa damage that have been suggested .Results: This study demonstrated that 25(45.5%) in the total of 30(54.5%) of patients with celiac disease at the age under than 12 years old associated with Glutamic- pyruvic transaminase higher level. This study also demonstrated that 22(40.0%) from a total 27 of patients with celiac disease are associated with Glutamic- Oxaloacetic Transaminase higher level are under 12 years. From our results we found that 8(14.5%)of a type 3a and18(32.7%) of a type 3b,when we retain to the marsh classification .In the sections of duodenal mucosa in study group. we show increase intra epithelial lymphocytes and also the sections revealed crypt hyperplasia, focal partial villous atrophy and subtotal villous atrophy .Conclusions: this study demonstrated that there is a positive relationship between CD and hypertansaminase and the majority of them are of type3 of marsh classification.  Key words:  Biopsy-celiac disease scores- crypt hyperplasia- hypertransaminase- intraepithelial lymphocyte- mucosa damage- villous atrophy.

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