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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 64 Documents
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Search results for , issue "Volume 10 Issue 07: (2018) July 2018" : 64 Documents clear
Acceleration the Liver Regeneration by Hyperbaric Oxygen Therapy in Model Rabbit Zainab J. Malik
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

In this study, we were investigating the importance of therapy of the hyperbaric oxygenon the regeneration of liver. Sixteen mature rabbits of Iraqi breed were used. The animals divided equally into two groups (control and treated). The anesthetizing of animals was done byatropine sulphate (1mg /Kg B.W) intramuscularly; as premedication and 15 minutes later a mixture of xylazine hydrochloride (20mg /Kg B.W) and Ketamine hydrochloride (40 mg /Kg B.W) are giving intramuscularly. In control group the rabbits were anesthetized and preparation the site of operation was done in the upper part of abdomen.  Surgical incision made and exposure of fourth lobe of the live. The liver handling by thump forceps and the stitches was done on the lobe. Three knots were tied and we used dissecting scissors in order to cut the tied lobe just distal to the suture. After that the wall of abdomen was re approximated with a running 3-0 Polyglactinsuture, then the skin closed with a running 2-0 polyamide suture. While in treated group the same procedure that mentioned above with hyperbaric oxygen therapy was done. The clinical parameters included temperature, respiratory, and heart rates, were within acceptable limits post operatively in all animals in two groups. The intra-abdominal adhesions in different degrees of evaluations and occurred among liver, different organs and abdominal wall that more frequency in control group when compared with treated group. Histopathological Examinations was done by taken the liver biopsies on 15rd, and 30th, day postoperatively. The histopathological results of this study revealed that the liver regeneration more maturity in treated group than in control group.Keywords: Hyperbaric oxygen therapy, Liver, Rabbit, Regeneration.
The Utility of Homemade ELISA Based Outer Membrane Proteins (OMP) of Salmonella Typhi in Diagnosis of Chronic Typhoid Carrier Thanaa R. Abdulrahman
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Typhoid fever is an extreme multi-systemic infection, constitutional symptoms is a major findings with classic prolonged fever. The simplicity, sensitivity, specificity and cost effective of diagnostic test which will be used in diagnosis of typhoid fever in human carriers, would give a compelling apparatus in controlling and preventing typhoid. The aims of this investigation were to determine the proportion of typhoid carriers by using homemade ELISA test based on OMP extraction. This study included fifty febrile patients and thirty age and sex matched apparently healthy individual as control with no history of immunization in the recent past, they were 24 (48%) males and 26 (52%) females, the age was ranged between 18-40 year with mean (33.6) .Blood and stool samples were collected from each participant and these samples underwent culturing on special media, after OMPs extraction from Salmonella typhi. Sandwich homemade ELISA were developed for detection of anti typhoid IgG and IgM using crud OMPS as antigen .The results showed that 18 (36.0%) out of 50 patients were stool culture positive, while blood culture results confirmed typhoid fever in 7 (14.0%) patients. Out of 50 serum samples were tested by homemade ELISA kit, which prepared in this study for IgG /IgM detection, there were 35(70.0%) IgG positive and only 8 (16.0%) was IgM positive. For IgG and/or IgM, as tested by ELISA positive results in accordance with stool and blood culture assays .For stool positive culture, IgG ELISA (26%) 13/50, showed positive results, while IgM (6.0 %) 3/50.Keywords: Salmonella typhi, Outer membrane protein, Homemade ELISA, Anti-typhoid antibodies, Roc test.
Technical Factors Affecting to Durian (Durio Zibethinus Murr) Drink Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Durian (Durio Zibethinus  Murr) fruit possesses high nutritional value and has rich bioactive properties. The ripe durian fruit has unique taste and aroma. It is usually used for fresh consumption. During the durian havesting season, excessive supply of the fruit causes the price of durian decreasing dramatically. Therefore we have our tried to add value to the durian fruit. One method of adding value to fresh durian is processing it into drink. We carried out the investigation of extraction (ratio of water: durian, temperature and time of blanching); juicy mixture; preservation. Our result showed that the durian drink having the best quality when extracting with water: durian pulp ratio (70:30) at 85 oC in 3 minutes. The sample was then cooled to 37°C before the addition of pectinase enzyme at 0.06%. The juice was then incubated in a water bath at 37°C in 45 minutes. After the incubation process, the juice was heated in a water bath at 100°C for 2 minutes to inactivate all enzymes present. The hydrolyzed durian juice will be formulated with sugar 2%, citric acid 6%, gellan gum 0.03%. Durian drink shelf-life could be maintained for 12 months.Keywords: Durian, Durio zibethinus Murr, Drink, Gellan gum, Pectinase, Shelf-life.
Assessment of Pregnancy Complications among Internally Displaced Women in Karbala Governorate Ridha M. lefta
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Background Pregnant women face increased risks of complications as they exposure to displaced conflict zones with damaged and destroyed health facilities in out conflict zones. Objectives: To determine the pregnancy complications among displaced women, and to find out the relationship between dietary habits for displaced pregnancy and complication of pregnancy. Methodology: A descriptive analytic study has been conducted on non-probability purposive sample of (200) displaced pregnant women select AL-Hussein Teaching Hospital in Karbala governorate. This study has been conducted during the period of 1st December until (30)th December 2017. A questionnaire is used as a tool of data collection to fulfil the study. A content validity, which is carried out through 13 panels of experts .Validity is determined by a panel of experts while the reliability utilization its split half. A descriptive and inferential statistics are used to analyze the data. Results: This table shows that the study result for demographic data the majority of the study samples 21-25 years old are 32% and the most the sample related level of education  have secondary school 38% and housewife are 93% and resident in urban. The study results indicate that the economic status sufficient to some extend and living at camp are 53%. This table depict that the complication among pregnancy displaced that indicate majority of pregnancy suffer from anemia is 49%.This table depict that the there is a non- significant between complication among pregnancy displace women and diatery habit domain at p. value more than 0.05. While there is a significant between complication pregnancy displaced and (dental problems and prenatal vitamin) at p. value less than 0.05, also the correlation between foreign food and complication pregnancy displaced women is high significant at p. value less than 0.01. Conclusion: Anemia is the major pregnancy complication among IDPs women. Recommendations: A special education programs focused on improvement the women knowledge and practices about the prevention and management of pregnancy complications.Keywords: Internally displacement, Pregnancy complications, Anemia, Prenatal vitamins, Dental problems.
External Morphological Study of Aporiacrataegi (Linnaeus, 1758), (Lepidoptera: Pieridae). Northern Iraq Mouhannad M. Aljaf
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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This work was included external morphological study of male Black veined white butterfly Aporiacrataegi L. 1758. The study involved morphological characters of many body regions, in addition the male genitalia. This morphological characters study supported by illustrations, it should be noted the work specimens were collected from northern Iraq.Keywords: Butter fly, Lepidoptera, Pieridae, Aporia, Description.
Production of Curcumin- Dry- Salted Spot-Fin Spiny Eel (Macrognathus Siamenis) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Macrognathus siamensis is a tropical fish founding in the rivers of Southeast Asia. Coming from the natural resource, it flesh has valuable nutrients. Objective of this research focused on the processing of spot fin spiny eel into the curcumin-dry-salted product by salting and drying method. Different technical experiments were investigated such as the effect of salt, curcumin ratio during soaking, temperature of drying, and packaging storage to chemical, microbial and sensory characteristics of the finished product. Results revealed that dry salting was better than wet salting. With addition of 0.75% of curcumin, drying at 50oC in 4 hours, the curcumin-dry-salted spotfin spiny eel products had the good physicochemical, microbiological and sensory characteristics. By preserving under vacuum at 4oC, the curcumin-dry-salted spotfin spiny eel could be maintained shelf-life for 12 months without any deterioration.Keywords: Spot-fin spiny eel, Macrognathus siamenis, Curcumin, Salting, Drying, Vacuum, Shelf-life.
Association of ABO Blood Groups with Diabetes Mellitus Mohammed. L.A. Al-Baaj Al-Baaj
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The aim of this study is to highlight the potential relationship between blood groups and diabetes for the local population of the city of SuqAl-Shuyukh in Thi-Qar, Iraq. The study included the identification of blood groups to 276 diabetes patients for the period from December 2018 to March 2018. ABO blood groups of all subjects were determined by slide agglutination method. Chi- square statistical analysis among different blood groups between non-diabetic (n= 100) and diabetic population (n= 276) revealed no significant relationship of any blood group with diabetes mellitus (p ˃ 0.05). But relative risk (RR) were calculated in reference to blood group O, it has been observed that slight increase of risk of developing diabetes mellitus among AB (RR 1.111), a (1.045) and B (1.025).Keywords: Diabetes Mellitus (DM), ABO Blood Groups, A, B, AB, O.
Identification of Echinococcus Granulosus Genotype in Iraqi's Sheep by Using Nd1 Gene MJ Muhaidi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Hydatid Cysts were obtained from 15 sheep from hepatic, pulmonary, spleen, heart, and peritoneal cavity, between December 2014 and October 2015. Hydatid cysts (protoscoleces) were used for DNA extraction by using mechanical grinder. The purification of mt DNA was done by (promega kit, USA). The mitochondrial NADH dehydrogenase subunit 1 (ND1) genes was applied as aim for amplification by using polymerase chain reaction (PCR), all of 15 hydatid cysts yielded amplification products.PCR product for NADH1 800 bp. The PCR products had been purified and fractional sequences were produced. The sequences obtained were found to align with corresponding region for ND1 gene in the Gene Bank nucleotide database confirming to genotype of sheep strain (G1) in Iraq, Phylogenetic dissection of fractional sequence datum from ND1 gene for obtained Phylogenetic tree. G1 genotype was the majority widespread taxon and the genuine provenance of infection for Iraqi’s sheep. All of 15 specimens were G1 strain (sheep strain) according to the fractional sequences of NADH dehydrogenase 1 (ND1).Keywords: G1 strain, Hydatid cyst, ND1 gene, sheep, Sequences.
The Diagnostic Value of Hba1c Turbidimetry Immunoassay in Sanglah General Hospital Denpasar, Bali, Indonesia Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Introduction: Diabetes mellitus (DM) is a common health problem in Indonesia. Currently, Hemoglobin A1c (HbA1c) is the gold standard to diagnose and monitor DM patient. HbA1c could be assessed using turbidimetry immunoassay and High-Performance Liquid Chromatography (HPLC). However, the comparison between the two devices is never conducted. Thus, this study aimed to determine the sensitivity, specificity, and correlation of HbA1c measurements using turbidimetry immunoassay method compared to HPLC as the gold standard. Methods: A cross sectional study was conducted from May to June 2017to measure the diagnostic values and correlation test between turbidimetry immunoassay method and HPLC. Diagnostic values were measured as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Blood samples were collected in EDTA tubes and measured with turbidimetry immunoassay and HPLC, with a cut-off value of 6.5 mg/dL. Results: Fifty samples were collected during the study. HbA1c ≥6.5mg/dL were obtained from 27 samples, and normal results were obtained from 23 samples. Sensitivity, specificity, PPV, and NPV from turbidimetry immunoassay were 92.86%, 100%, 100%, and 91.67% respectively. Pearson correlation test of HbA1c result from turbidimetry immunoassay and HPLC revealed a strong positive correlation with r = 0,988. The ROC curve analysis yield AUC value of 0.926 with P=0.000 which indicate a strong diagnostic value.Conclusion: Turbidimetry immunoassay method had high sensitivity and specificity and had strong diagnostic value according to ROC analysis. There was also a strong positive correlation between turbidimetry immunoassay and HPLC HbA1c reading.Keywords: HbA1c, HPLC, Turbidimetry immunoassay.
Single Nucleotide Polymorphisms of Transcription Factor 7-LIKE 2 Gene Expressed Different MRNA Isoforms in the Peripheral Blood Made Ratna Saraswati; I Gusti Ngurah Kade Mahardika; Ketut Suastika; Sukma Oktavianthi; Herawati Sudoyo; Safarina G. Malik
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Background: Single Nucleotide Polymorphisms (SNPs) of the Transcription Factor 7-Like 2 (TCF7L2) diabetes susceptibility gene were located in the noncoding region. Intronic SNP may play a role in mRNA splicing. This study aimed to elucidate whether SNPs of the TCF7L2 gene expressed different mRNA isoforms in the peripheral blood. Methods: Across sectional study was conducted in Legian Bali. A total of 56 subjects were grouped into carrier of TCF7L2SNPs (28 Balinese age 30-74 years,eitherheterozygote or mutant of the rs12255372 SNP [GT or TT], rs7903146 [CT or TT], and rs10885406 [AG or GG])and wild-type of TCF7L2 (28 matched in age and sex Balinese,rs12255372 [GG], rs7903146 [CC], and rs10885406 [AA])which has been identified in the previous study.In this study, the mRNA isolation was done using LS Trizol reagent (Nitrogen®) and variants of the mRNA isoform in the TCF7L2 gene was identified by reverse transcriptase-polymerase chain reaction (RT-PCR) method, using two pairs of overlapping primer.The first primer PCR products were grouped into Group-A, Group-B, Group-C and Group-D. The second primer PCR products were grouped into Group-a, Group-b, Group-c and Group-d. Oral glucose tolerant test (OGTT) was done to both groups.Blood samples were taken during fasting, at 1 hour and 2 hours after the oralglucose load, for blood glucose, and insulin level measurement. Results: There were seven pairs of the group combination including group A-a, A-c, A-d, C-a, C-c, C-dand D-c, and group C-c was the most commonly found among all subjects in this study (42.3%). Subjects with diabetes risk allele were 2.66 times more likely to express group C-ccompared to subjects without diabetes risk allele of SNPs in the TCF7L2 gene (95%CI 1.24–5.72 p=0.011). Mean response of insulin increment after oral glucose load among group C-c was higher compared with the non-group C-c, 84.63±41.01 vs. 62.02±38.09ng/ml (mean difference 22.61 95%CI 0.41–44.80 p=0.046). However, blood glucose level, fasting insulin, HOMA %B and HOMA IR were similar between the two groups. Conclusion: Variants of TCF7L2 gene expressed different mRNA isoformsin the peripheral blood.Compared to subjects without diabetes risk allele of SNPs in the TCF7L2 gene, subject with diabetes risk allele expressed dominant variant isoform mRNA 2.66 timeshigher.The higherresponse of insulin increment after oral glucosewas observedin the dominant variant which may reflectthe early condition of insulin resistant.Keywords: Diabetes, SNP TCF7L2, isoforms mRNA.

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