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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 65 Documents
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Search results for , issue "Volume 10 Issue 08: (2018) August 2018" : 65 Documents clear
Synthesis and Spectroscopic Studies of Some Metal Complexes of (4-Nitrobenzoyl) Carbarmothioyl) Histidine (NCH) Athraa Gazi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

(4-nitrobenzoyl) carbamothioyl) histidin (NCH) a new ligand was synthesized by reaction of Histidine with (4-Nitrobenzoyl isothiocyanate) by using acetone as a solvent. The prepared ligand (NCH) has been characterized by elemental analysis (CHNS), infrared (FT-IR), electronic spectral (Ultraviolet visible) and (1H, 13C-Nuclear Magnetic Resonance) spectra. Some Divalent metal ion complexes of (NCH) were prepared and spectroscopic studies by Fourier transform infrared (FTIR), electronic spectral (UV-Vis), molar conductance, magnetic susceptibility and atomic absorption.  The results measured showed the formula of six prepared complexes were [M (NCH) 2]    (M+2 =Manganese, Cobalt, Nickel, Zinc, Cadmium and Mercury), from the obtained data tetrahedral structure suggested for all complexes, except Copper complex has a square planer geometry.Keywords: Histidin, Metal Ion complexes, 4-Nitrobenzoyl isothiocyanate.
Technical Factors Affecting to Production of Dry-Salted Mudskipper (Pseudapocryptes Elongatus) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Mudskippers (Pseudapocryptes elongatus) are widely distributed in the brackish water, rivers, creeks and lagoons and are usually seen during low tide. Mudskipper (P. elongatus) is a potential species for coastal aquaculture and easy to farm in intensive or semi-intensive systems during rainy season in the Soc Trang province  (Vietnam). This species is considered as an alternative species to shrimp farming in rainy season. They are good sources of proteins, macro-nutrients, minerals and some vitamins. The mineral elemental levels and vitamins of this species is a function of the availability preferential accumulation. Aquaculture of P. elongatus in the Soc Trang province (Vietnam) has developed rapidly during the past decade due to relatively high demand and high market value. Drying stills continues to be the most widely used method for preservation of several foods including fish. Effectiveness of drying as a means of increasing the shelf life of fish is due to reducing growth of microorganism by reducing the availability of water.  Objective of this study focused on the effect of different aspects such as ethanol treatment to eliminate fishy ordor; addition of salt, sorbitol, as well as drying temperature that affected to to water activity, enterobacteriaceae load, and sensory score of dry-salted mudskipper. Shelf-life of the dried product was also evaluated during preservation. Results showed that 40% ethanol at ratio 25:75 for primary treatment; 2.5% of salt soaking; 1.25% of sorbitol addition; 48oC of drying were appropriate to maintain water activity (aw=0.65). By preserving under vacuum in PA bag, the dry-salted mudskipper still extended the product shelf-life for 12 months without any deterioration.Keywords: Mudskipper, Pseudapocryptes elongatus, Ethanol, Salt, Sorbitol, Drying, Enterobacteriaceae, Vacuum.
Long Term Consequences of Infliximab among a Sample of Spondyloarthropathic Patients Attending Baghdad Teaching Hospital Atta Ah mousa Al-Sarray
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Objective: To determine LFT, lipid profile and the increase in weight after one year of infliximab treatment among a sample of spondyloarthopathic patients attending ‘Baghdad teaching hospital’   Patients &Methods: prospective study was carried out for a period of one years  In Baghdad teaching hospital(biological unit) on 1st of January  2016 and ending on December 2017 .A total of 120 cases Anky losing  and psoriatic arthritis on biological agent(infliximab) had two reading of liver function test  , lipid profile  and body mass index first reading at( zero week)  and second reading at (one-year) after biological agents . Results: The mean age of study sample 36±10.3,mean age of onset 29±11.5and duration 11±8.5Significance abnormality of liver function test (ALT,AST and AP) at two reading (baseline and after one year of biological agent( p=0.0001).Regarding total Cholesterol , Triglycerides ,High Density Lipoprotein & Low density  Lipoprotein (TC,TG, HDL-c and LDL-c) Significance differences(p<0.0001) were seen  after biological  therapy in study sample. Significance differences were seen regarding body mass index and weight gain after one year of follow up of patients. Conclusion: Significance rise of LFT, abnormal lipid profile and weight increment in the study sample after one year of follow up after infliximab therapy in patients with spondyloarthopathy. Recommendation: Our findings suggest the need for more prospective studies regarding the relative contribution of infliximab treatment for abnormal Liver function test, Lipid profile and weight gain Keywords: Patients, Infliximab, Anti-TNF agents.
Molecular Investigation of Curli Fimbriae Genes in Enterobacter cloacae Isolated from Various Clinical Sources in Baghdad, Iraq Tiba Ayad Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Thirteen isolates were collected from various clinical sources during the periodfrom 22/10/2017 to 22/12/2017. All the isolates were diagnosed based on the microscopic and biochemical propertiesby Vitek-2 Compact system. All isolates formed biofilm 100%, with 30% of isolatesbiofilm produced strongly and 70% on medium. The results of the present study have shown the presence of Curli fimbriae genes in E. cloacae bacteria from cases of urinary tract infections, infected patient with blood bacteremia and inflammation of wounds. Curli fimbriae is considered to be an important factor in the virulence of E.cloacae bacteria, which plays an important role in adhering and combining cells on solid surfaces to form the biofilmand helps in the adhesion of bacterial cells. As well as their involvement in the invasion of the host cells, and their interaction with the host proteins and activate it for the host's immune system.
Investigation of Dried Herbal Tea Production from Breadfruit (Artocarpus Altilis) Pulp Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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The fruits are great source of carbohydrate and it has low fat. Since the fruit can be steamed, fried, baked, roasted and fried, they can be eaten at all stages of growth. Drying was described as the reduction of material moisture to the required dryness values as a definite process and it is of major interest in food processing. To increase breadfruits popularity and expand their use in the food industry, it’s neccesary to explore the appropriate postharvest handling and storage. Therefore, objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to cinnamic acid (mg/100 gDW), antioxidant activity (mmol·Fe2+/kgDW), color (sensory score) of the dried breadfruit (Artocarpus altilis) tea. Results showed that breadfruit (Artocarpus altilis) should be blanched in hot water 95oC at 4 seconds in the present of CaCl2 2% and then beeing dried by heat pump dryer at 40oC until 6.5% moisture. The final herbal tea could be preserved under vacuum in PET/AL/PE bag at 4oC to maintain antioxidant activity for 12 months Keywords: Breadfruit, Artocarpus altilis, Herbal tea, Blanching, Drying, Antioxidant activity.
Physiological Study about the Hematological Effects of Rosuvastatin and Lovastatin as Compared with Sophoretin in Rats (Rattus Norvegicus) Madlen Qassm Abbas
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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To compare the possible hematological effects of the statins lovastatin and rosuvastatin with the flavon sophoretin, the present study was accomplished on rats. Thirty male rats allocated as five groups were used. The groups were: control, cholesterol, rosuvastatin, lovastatin and sophoretin groups. The animals of the control group were maintained on standard diet, while other groups were maintained on cholesterol diet 15mg/kg of diet and dosed orally and daily as follow: rosuvastatin 20 mg/kg body weight, lovastatin 4 mg, and sophoretin20 mg respectively. The study comprised some hematological parameters including red cells count, hemoglobin concentration, leukocytes count, hematocrit, differential leukocyte count, platelets count, red cells indices, and platelets indices. The results showed that cholesterol caused a significant increase in red cells count (RBC), hemoglobin (HGB), and hematocrit (HCT) with a significant decrease in total white cells count (WBC) and platelets count (PLT). Rosuvastatin caused a significant decrease in HGB, HCT and WBC while lovastatin caused a significant decrease in WBC, and PLT. For sophoretin, all the parameters were without significant differences as compared with control group at (P≤0.05). Considering other blood indices, they are more detailed in the results.Keywords: Sophoretin, Quercetin, Rosuvastatin, Lovastatin, Rats.
The Physiology of Motor Rhythm to the Arm of Performance and its Relationship with Accuracy of the Shooting in Handball Nabhan Hamid Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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The aim of the study was to study the relationship between the physiology of the motor rhythm and the accuracy of the shooting in the handball. This was done by studying some of the wave changes resulting from the work of the muscles involved in the movement of the arm related to the skill of the shooting in the handball, Electromyography (EMG), which includes (peak, time and space). The study included (15) young players. Electromyography)EMG) tests were carried out in a special form that was developed to classify the data and then processed statistically to reach the results of which were reached to reach the most important conclusions, which include: Through what was shown from the results we note that there is a strong correlation between the summit variable relationship of triceps brachial in the two parts lateral and medial with the shooting in the hand ball accuracy as this variable gives the fact contraction of muscle and the ability of the muscle to continue performance without fatigue, but for the This means that there is a delay in the speed of the response required to achieve the best accuracy shooting, and this requires a greater concentration in the reaction speed and response exercises because of the significant impact in increasing the precision accuracy variable to achieve advanced results.Keywords: Physiology, Motor rhythm and handball.
Synthesis and Curing of New Phenolic Resins Linking to Pyromellitdiimides Abeer Khaleel
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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In this work a series of new phenol-formaldehyde resins linking to pyromellitdiimide were synthesized via three steps in the first one a series of four N, N- bis ( hydroxy phenyl) pyromellitdiamic acids were synthesized by reaction of pyromelliticdianhydride with amino phenols. In the second step, the prepared diamic acids were dehydrated by fusion producing the corresponding pyromellitdiimides and these in turn were introduced in poly condensation reaction with formaldehyde producing the new target phenolic resins. Treatment of the prepared resins with benzoyl chloride afforded the corresponding modified resins. The newly synthesized and modified resins exhibit new properties that may serve many applications.Keywords: Pyromellitdiamic acids, Pyromellitdiimide, Phenolic resins, Amino phenols.
Determination of lactic acid bacteria isolated from the gastrointestinal tract of Bali cattle with potential probiotic role Dewa Made Sukrama; I Wayan Suardana
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Bali cattle is known as pioneer’ cattle resulted by their high ability to adapt in poor quality of feed so that was assumed for finding the specific species of lactic acid bacteria.  The study aimed to investigate the potency of lactic acid bacteria isolated from the gastrointestinal tract of Bali’ cattle as a candidate for new probiotic. Fifteen isolates of lactic acid bacteria isolated from 15 intestinal tracts of Bali cattle were grown on the specific medium deMan Rogosa Sharpe (MRS) broth followed by Gram staining, catalase test, the formation of CO2 gas, and antimicrobial activities against Bacillus cereus. The result of this study confirmed 15 isolates were Gram-positive bacteria, and 14 out of 15 isolates were categorized as homofermentative. Probiotic potency test showed 11 out of 15 isolates were tolerant against lower pH (pH 2, 4 and 6), and also resistant to bile acid with NaDC concentration 0.2, 0.4, and 0.6 mM.  Identification of isolate using API 50CH test kit found 4 out of 5 isolates as Lactobacillus sp. and the remainder as Lactococcus sp. The study concluded isolates of lactic acid bacteria isolated from the gastrointestinal tract of Bali cattle showed potential as a probiotic candidate.
Role of Estrogen in the Oxidation Process in Postmenopausal Osteoporosis Elaf Mahmood Shihab
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Introduction: Bone exerts important functions in the body, such as locomotion, support and protection of soft tissues, calcium and phosphate storage, and harboring of bone marrow. Osteoporosis is a common metabolic bone disease characterized by reduced bone mass, micro architectural deterioration of bone tissue, and an increased risk of fragility fracture. After menopause, the period of time after a woman has experienced 12 consecutive months without menstruation called postmenopausal period. Estrogen showed to be the most important sex steroid in preventing osteoporosis in women, so estrogens modulate bone growth and turnover in vivo. Total antioxidant capacity (TAC) is the measure of the amount of free radicals scavenged by a test solution, being used to evaluate the antioxidant capacity of biological samples. Estrogens are steroid hormones that have been shown to affect numerous tissues, including reproductive tissues (such as the breast, endometrium, and vagina) and the skeletal, cardiovascular, and central nervous systems(11).The aim of the study was to evaluate the effect of estrogen therapy on the level of total antioxidant capacity  in serum of postmenopausal osteoporotic women. Materials and Methods: Randomized, single blind clinical trial carried out at the Rheumatology outpatients department of Baghdad Teaching Hospital / Medical City Complex in Baghdad, Iraq from the 10th of Jan to the 12th of June 2016.The study was carried out on 24 postmenopausal women, with  amenorrhea for  more than 12 consecutive months. Venous blood samples (10 ml) were drawn from each patient by venipuncture .Blood samples were taken from participants at day zero of treatment as baseline and after 90 days of treatment to obtain serum for measurement of total antioxidant capacity .Total Antioxidant Capacity (TAC) Bio Assay TM Elisa Kit manufactured by US Biological. The manufacturer instructions were strictly adhered during the laboratory procedure. Results: A total of 24 osteoporosis woman patients were enrolled in this study and they consisted of two studied groups: Group A:12 postmenopausal osteoporotic women were treated by conjugated equine  estrogens tablet  0.625mg (PREMARIN ®) once daily for 90 days.  Group B:12 postmenopausal osteoporotic women were treated by placebo one capsule (filled with starch) daily for 90 days and served as a control group. The mean age of the patients was 56.3 ± 6.14 (range:47 – 65). The mean Body Mass Index (BMI) of the participants was 26.86 ± 2.1 (range: 22.3 – 29.4) kg/m2. On the other hand, the comparison of mean age and BMI across the two studied groups revealed no statistically significant differences, (P>0.05) .Statistics had shown that there was no significant changes between pre and post treatment in Group A or B with baseline increase from (476.35 ± 112.79) to (484.11 ± 117.67) and (471.87 ± 165.59) to (472.78 ± 184.12) respectively ( P value > 0.05).Conclusion: daily dose of 0.625 mg of estrogen therapy for 90 days duration was not proven to be effective in lowering the oxidation level following menopause in osteoporotic women.Keywords: Estrogen, Postmenopausal osteoporosis, Antioxidant.

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