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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 53 Documents
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Search results for , issue "Volume 11 Issue 01." : 53 Documents clear
Primitive Neuroectodermal Tumor (PNET) at the Level of Thoracic Spine: A Case Report Magetsari Rahadyan
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction Primitive neuroectodermal tumors (PNET) are malignant tumors thought to arise from the neural ectoderm and comprise of undifferentiated small round cells that affect soft tissue and bone. These tumors occur primarily in children and adolescents (thirteen to sixteen years old), with a tendency to recur quickly and metastasize especially to lungs, bone marrow, brain and lymph nodes. PNET are uncommon malignancies that are increasingly reported in the literature and located in the spine are extremely rare. In this study we present a case of 14 years old girl with PNET of the thoracic spine which recur after initial resection. Case Report a 14 years old girl presented with low back pain and progressive weakness of both of lower limbs of three months duration. On physical examination, motor and sensory function was lost, motoric strength in the lower limbs was grade 1/5 with hypoesthesia below L1 level. Magnetic resonance imaging (MRI) of the spine showed burst pathologic fracture of the 12th thoracic spine with suspicious malignant lesion in the 12th thoracic spine. Initially the condition was treated with laminectomy, decompression, stabilization and open biopsy. Histopathology and immunohistochemistry of the lesion revealed the diagnosis of PNET. During the early postoperative course, she had instance neurological recovery and was able to walk unassisted. But, 1 month later the neurologic deficit recurred and she was treated with extended laminectomy with tumor debulking. Then the patient received chemotherapy and planned for radiotherapy. Conclusion Primitive neuroectodermal tumors (PNET) are extremely rare and are aggressive with poor outcomes. Good modalities play a significant role in the identification of the feasibility of surgical excision of the tumors, detection of distant metastasis, and evaluation of the efficacy of therapeutic interventions.Keywords:  Primitive neuroectodermal tumor (PNET), Malignant Tumor, Rare Tumor, Spinal Tumor.
Effect of Different Solvent on Total Phenolic, Total Flavonoid, and Sun Protection Factor of Belimbing Wuluh (Averrhoa Bilimbi linn.) Fruits Fraction Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Ultraviolet (UV) radiation is related with a variety of damaging effects. Averrhoa bilimbi Linn (AB) known as Belimbing Wuluh in Indonesia, it contains phenolic compounds such as flavonoids, where the compound has the potential as a sunscreen. Objective: the study was to determine the Total Phenolic Content (TPC), Total Flavonoid Content (TFC) and investigate Sun Protection Factor (SPF) activity from different solvent for fractionation of AB among N Hexane (NH), Ethyl Acetate (EA), and Water. Methods: TPC, TFC, and Sun SPF were investigated using in vitro assay with spectrophotometric UV-Vis coupled chemometric using principal component analysis (PCA). In this study, TPC was determined using Folin-Ciocalteu reagent, the outcomes were expressed in (mg of gallic acid equivalent (GAE)/g sample), TFC content was determined by colorimetric using AlCl3 methods, the results were expressed in (mg of rutin equivalent (RE)/g sample), and SPF using Dutra calculation. Result:  EA showed the highest SPF (15, 38±1, 3).The similar fraction having the highest TPC (56, 87±1, 5212) mg (RE)/g of EA) and the highest TFC (24, 99±3, 2895) mg (GAE)/g of EA). When principal component analysis (PCA) was applied, high correlation among TFC and SPF activities was found. Conclusion: Hence, AB potential as sun screens.Keywords: Averrhoa bilimbi, Total Flavonoid Content, Total Phenolic Content, Sun Protection Factor, Chemometric.
Differential Profile of Cytokine TNF-Α, MDA and SOD Level in Sepsis Induced By Cecal Ligation and Puncture Compared with Induced By LPS Dian Samudra
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The aim of this study is to analyse the differential of TNF-α cytokine profile, MDA, and SOD levels between sepsis-induced in mice by cecal ligation and puncture (CLP) which were then compared with lipopolysaccharide (LPS) injection. Methods: This study made use of experimental animals, 28 mice divided into 4 groups: control (healthy mice), mice model of sepsis due to cecal ligation and puncture (CLP), a group of mice modeled sepsis due to LPS i.p injection of 103 (LPS1) and LPS 105 CFU i.p injection dose (LPS2). Afterward, TNF-α levels were examined using a sandwich enzyme immunoassay technique and calculation of MDA and SOD levels in blood, liver, and kidneys. Results: The results showed that the level of TNF-α cytokines in mice model of sepsis with LPS induction of 105 CFU (LPS2) increased significantly (p <0.05) compared to the sepsis model with CLP (LPS2: 1.11 ng/ml vs 0.34 ng/ml). MDA levels in serums, livers, and kidneys of the experimental animals were also found to increase after LPS induction of 103 and 105 CFU doses. In contrast, SOD levels experienced a significant decrease due to LPS injection of dose 105 CFU in comparison with the CLP sepsis model. Conclusion: This study found that the best sepsis model was the one with LPS induction of 105 CFU doses which was characterized by a high production of TNFα cytokines, excessive MDA levels, and low levels of SOD antioxidant enzymes. By finding the best sepsis model, it can be used for therapeutic needs by targeting the inhibition of TNF-α proinflammatory cytokines and oxidative stress indicators MDA and SOD. Keywords: cecal ligation and puncture (CLP), LPS, MDA, sepsis, SOD, TNF-α
Variables Factors in Wax Apple (Syzygium Samarangense) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Wax apple (S. samarangense) fruit is crispy, juicy and tasty with apple aroma. Fruit flesh contains spongy tissue. It represents potential benefits for human health because they are rich source of polyphenolic antioxidants. This fruit is also highly perishable. Its economic potentials have never been exploited. During its harvesting season, a considerable percentage of the fruits are not harvested due to lack of demand and inadequate storage facilities, therefore leading to wastage. The surplus could be used for fruit wine. Effect of primary fermentation duration (4, 6, 8, 10 days), sugar to pulp ratio (5, 10, 15, 20% w/w), Saccharomyces cerevisiae inoculation (2.0 x 106,4.0 x 106, 6.0 x 106, 8.0 x 106 cfu/g) on anthocyanin (mg/ 100 mL), total phenolic content (mg GAE/ 100 mL) and total flavonoid (mg CE/ 100 mL) content of fermented wax apple fruit drink were thoroughly investigated. The secondary fermentation (1, 2, 3, 4 weeks) was also examined to improve the turbidity (mJ/cm2) and sensory score of the final fermented drink. The optimal conditions for fermentation of wax apple juice should be conducted at 8 days of primary fermentation with 15% of sugar supplementation inoculated with 6.0 x 106 cfu/ml of Saccharomyces cerevisiae and 4 weeks of secondary fermentation (aging) to get pleasant physico-chemical characteristics of fermented wax apple drink. Fermented Syzygium samarangense drink was red-pink, clear and transparent. This present study revealed that horticulture farmers would get more added values from wax apple fruits not only by local commerce but also processing. It could be processed by fermentation and conversion into high valued wineKeywords: Wax apple, Wine, Fermentation, Sacchromyces cerevisiae, Anthocyanin, Phenolic, flavonoid
Investigation of Pineapple (Ananas Comosus) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Pineapple is a wonderful tropical fruit having exceptional juiciness, vibrant tropical flavor and immense health benefits. Pineapples are consumed as fresh, cooked, juiced, and fermented in a wide array of food stuffs. This fruit is highly perishable and seasonal.  Therefore we explored a wine fermentation from pineapple by focusing on the effect of different parameters such as Pectinex Ultra SP-L concentration and time of treatment for juice extraction, yeast inculate for wine fermentation, and secondary fermentation to wine quality. Our results proved that 0.4% Pectinex Ultra SP-L was used for juice extraction, 0.75% sacchromyces cerevisiae was used for the main fermentation at 11.5oC, and 3 weeks of sencondary fermentation in dark bottle at 9.5oC was applied to get a pleasant pineapple quality.Keywords: Pineapple, Wine, Fermentation, Sacchromyces cerevisiae, Pectinex Ultra SP-L.
Perioperative outcome between open renal stone-removal surgery and PCNL in patients with staghorn stones Gede Wirya Kusuma Duarsa
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Percutaneous nephrolithotomy (PCNL) has become the treatment of choice for staghorn stones, replacing open stone surgery. However, in a developing country, open stone surgery is still the treatment of choice due to its nature for not requiring endourology devices, it can be performed by a general surgeon, and it is financially acceptable.Objective: This study aims to compare the cost-related outcome between PCNL and open renal stone surgery in patients with staghorn stones.Method: Data were collected retrospectively, taken from patients’ medical records who underwent PCNL and open stone surgery in three hospitals from 2016-2017. Seventy-eight patients were divided equally into PCNL group and open surgery group. Data of the hospital length of stay, the volume of blood loss during surgery, stone-free rate, and post-operative additional procedures were recorded.Outcome Measurements and Statistical Analysis: The data were analyzed using SPSS version 23.0 for Windows.Results: The hospital length of stay was shorter in PCNL compared to open stone surgery (3 vs. 4 days, p<0.001). The post-operative stone-free rate was lower in PCNL compared to open stone surgery (48.7 vs. 92.3%, p<0.001). More post-operative additional procedures were found in PCNL compared to open stone surgery (p<0.001). There was no significant difference in the amount of blood loss during surgery in both groups (p=0.102).Conclusions: PCNL is a minimally invasive procedure that is effective and safe for treating staghorn stones. Nevertheless, in places where PCNL is unavailable, open stone surgery can still be a choice for treatment. 
Encrusted Double-J Stents: Risk Factors Analysis Besut Daryanto
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction Since its introduction by Finney and Hepperlen in 1978, the double-J (DJ) stent has become a common armament that every urologist uses every day. The use of the DJ stent cannot be separated from the morbidity or complications that might occur, including discomfort arising from the insertion of stents, forgotten to remove, urinary tract infections, biofilm formation, and even encrustation of the stent. This research aims to determine the correlation between the risk factors in the formation of encrustation in patients with urinary tract stones. Materials & Methods This is a cohort study using the chi-square analysis and odds ratio calculation. We evaluated urine metabolite, urine culture, time of removal of the DJ stent, and encrustation formation in the DJ stent. Sixty patients with urinary tract stone and 60 without urinary tract stone participated in this research. Results The presence of urine bacteria and neglected DJ stent in the stone group and abnormal urine levels of magnesium in the non-stone group had significant correlation with encrustation formation of the DJ stent (P < 0.05). Conclusions various factors lead to encrustation formation in the DJ stent, and patients with a history of stones have more risk factors for encrustation formation.Keywords DJ Stent, Bacteria, Urine Metabolite, Neglected, Encrustation.
Modest Simultaneous Determination of Acetylsalicylic Acid and Salicylic Acid in Plasma by High Performance Liquid Chromatography UV Detection Yahdiana Harahap
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: Acetylsalicylic acid (ASA) is one of the drugs used in antiplatelet therapy. ASA is rapidly hydrolyzed to salicylic acid (SA) and has low levels in plasma. Analysis of ASA and SA in plasma has been done using LC-MS/MS, UHPLC, and HPLC with hydrolysis and fluorescence detector. Compared to those methods, HPLC equipped with UV detector is less expensive. The method using HPLC with UV detector also has been done but not sensitive enough according to the LLOQ. Therefore a sensitive and selective analysis method needs to be developed. This study aims to develop an analytical method of ASA and SA in human plasma using HPLC with UV detector.Method: The method used in this study is Reversed Phase - High Performance Liquid Chromatography using C18 column (Waters, Reliant™ 5 μm; 250 x 4.6 mm) with UV-Vis detector and was detected at wavelength of 230 nm. This method was developed using furosemide as internal standard (IS). Human plasma containing ASA and SA was extracted after protein precipitaion method using 15% perchloric acid with a liquid-liquid extraction method using ethyl acetate.Result: The method obtained was linear (r ≥ 0.99) at concentration range of 0.05 – 1.5 μg/mL for ASA and concentration range of 0.2 – 5.0 μg/mL for SA. The validation result of ASA and SA analytical method fulfilled the validation requirement of EMEA Bioanalytical Guideline in the year 2011. Therefore the method provides modest, sensitive, and selective measurements of ASA and SA concentrations.
Synthesis and Characterization of New4, 5-dihydrooxazole and 1H-imidazole-5(4H)-one Derivative and Study its Effects on some Antibacterial Fadhel Omran Essa
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

New1H-imidazole-5(4H)-one derivatives have been prepared to start from the reaction of 2-phenyl-4H-1, 3-benzoxazine-4-one with tyrosine. The reaction of compound 1 with thionyl chloride produced 3-(4-hydroxyphenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanoyl chloride2. Condensation of compound 2 with glycine afforded 2-(3-(4-hydroxyphenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl)propanamido)acetic acid3.The reaction of compound 3with acetic acid, acetic anhydride, and benzaldehyde derivatives yielded 3-(1-(4-benzylidene-4,5-dihydrooxazol-2-yl)-2-(4-hydroxyphenyl)ethyl)-2-phenyl-quinazolin-4(3H)-one derivatives 4a-e.Treatment of compound 4a-d with hydrazine hydrategave3-(1-(1-amino-4-benzylidene-4,5-dihydro-1H-imidazol-2-yl)-2-(4-hydroxyphenyl)-ethyl)-2-phenylquinazolin-4 (3H)- one derivatives 5a-d. The reaction of compound 5a-d with benzaldehyde derivatives resulted in the formation of 3-(1-(-4-benzylidene-1-(benzylidene amino)-4, 5-dihydro-1H-imidazol-2-yl)-2-(4 hydroxyphenyl) ethyl)-2-phenyl-quinazolin-4(3H)-one6a-6b.The structure of novel synthesized compounds were assured from IR, 1HNMR, and13CNMR spectra.Keywords: Phenylquinazolines, Imidazole, Benzylideneamino, Dihydrooxazole.
Effectiveness of Edible Coating to Preservation of Passion Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Passion fruit (Passiflora edulis) is considered an exotic species with attractive flavor and aroma. This is a rich source of bioactive compounds, as polyphenols. The interest in P. edulis has been increased because of its antioxidant compounds. Passion fruit is generally considered to have a short storage life, because it is a very delicate, perishable fruit. The main problem of postharvest losses associated with passion fruits is rapid loss of firmness. The objective of the present study was to identify the effect of different carrageenan concentrations (1.0%, 1.5%, 2.0%, 2.5%, 3.0%) and storage temperature (8 oC, 12 oC, 16 oC, 20 oC) to the weight loss, firmness, total soluble sugar and ascorbic acid in passion fruit (Passiflora edulis) fruits during preservation. Moreover, shelf life (0 day, 7 days, 14 days, 21 days and 28 days) of passion fruit (Passiflora edulis) fruit in storage also clarified. Results demonstrated that carrageenan 2.5% and storage temperature 8 oC could maintain passion fruit (Passiflora edulis) fruit quality for 28 days without any deterioration. This is an opportunity to develop value‐added products reducing the postharvest losses, improving nutritional value and generating additional revenue for passion fruit growers.Keywords: Passion fruit, Carrageen an, coating, Firmness, Shelf life, Preservation.

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