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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 81 Documents
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Search results for , issue "Volume 11 Issue 03" : 81 Documents clear
Cytotoxicity of Fumaria Officinalis on Leishmania Tropica, L20B Cell Lines and Bacteria In Vitro Ahmed Younus Abed
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Fumaria officinal is (Shahatraja in Arabic), one of the popular herbal medicines used in Iraq. There are more than 60 species of Fumaria around the world, and many useful properties recognized for this herb. The aim of this study is to investigate the effects of the extracted alkaloids, and crude alcoholic extract on Leishmania tropica (L tropica), and L20B cancer cell lines, in additional to study the toxic effect of these two extracts on many types of bacteria and comparing the results in both cases. Viability rate of treating L tropica cells by the alkaloids and crude extracts were increased significantly in all concentrations. All concentrations of alkaloids extract showed toxic effect on L20B cell lines, except (0.015 mg/ml). While for crude extracts, there was no effect on Viability rates of L20B cell lines at all concentration, except (0.125 mg/ml), shown some decrease in Viability rate. The antibacterial activities of the alkaloids increased comparing with crude extracts in four strains of bacteria, Staphylococcus aureus, Bacillus spp., Klebsiella spp., and Proteus spp. While for Salmonella spp., the inhibition zone was increased in crude extracts more than alkaloids. The results for three remaining bacteria (Streptococcus pyogenes, E. coli, and Enterobacter spp.) were equal in their inhibition activity. From results of present study, the alkaloids that extract from Fumaria officinalis, made the best effect as anticancer and antibacterial agent.Keywords: Cytotoxicity, Anticancer activity, alkaloids, Fumaria officinalis, L20B cell line, antibacterial agent.
Effect of Addition of Silver Nanoparticle on Optical Properties of Polymethylacrelate (PMMA) Films Adel H. Omran Alkhayatt
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of this work to a realization the effect of adding silver nanoparticles on the optical properties of Polymethylmethacrylate (PMMA) films were prepared by using casting technique At a temperature (50ᵒC) with thickness (8±1μm).The optical properties by measuring the spectra absorbability and transmission as a function of wavelength (200-800) nm. The results showed that the transmittance decreased with increasing doping because of increased impurity resulted holds attenuation in the intensity of incident light with a clear increase of absorption and a decrease in optical reflectivity.as well as calculated the optical constants (α,k, and εr) of the prepared films and the results showed an increase when increasing rate of doping .the real part of the Dielectric Constant conduct like the refractive index, while the imaginary part conduct like the extinction coefficient, as for optical conductivity its values increases with increasing the rate of the silver nanoparticles as well as identifying the types of electronic transitions and calculating energy gaps It was found there is diminution in energy gap for direct electron transmission reaching values (5.4 - 4.9) eV.Keywords: Polymethylacrelate, Optical Properties, Silver Nanoparticle, Optical Conductivity
Preparation of a Novel Cartridge of SPE Column using a new Surface of Hetrocyclic Azo Ligand with Modified Activated Carbon Faiq F. Karam
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Disposable cartridges have been created using low-cost activated carbon produced from waste as solid support via using a chemical activation method, and modified with the new tridentate [N.N.O] donor azo ligand to yield a solid-phase sorbent, the thiazole azo 2-[2ــ -( 5-nitro thiazolyl) azo]-4-methyl-5-nitro phenol ( 5-NTAMNP) derived from 2-amino-5-nitrothiazole and 3-methyl-4-nitrophenol by the diazotization operation and the adizonium chloride salt solution of 2-amino-5-nitrothiazole reacting with 3-methyl-4-nitrophenol as a coupling compound in alkaline alcoholic solution. The structure of ligand was identified and confirmed via resorting to various spectroscopic techniques which included, Proton nuclear magnetic resonance, Mass spectrum, UV–visible, Fourier-transform infrared (FTIR), X-Rays diffraction (XRD), the surface nature and morphology and size average and elemental composition of individual ligand particles were examined using a field emission scanning electron microscope (FE-SEM) coupled with an energy dispersive X-ray system (EDX), novel (5-NTAMNP)-modified activated carbon solid-phase sorbent were synthesized and characterized by chemical analysis by using, FT-IR, and XRD techniques and chelating sorbent were used as an adsorbent for the removal and for the determination of a hazardous heavy metallic ions Mn(II), Fe(III), Pb(II), Cu(II), in water under the optimum pH value for complexation with this azo ligand. The new (5-NTAMNP)-modified activated carbon showed highly effective solid phase extraction properties for these metallic ions.Keywords: Activated carbon, NNO donor azo ligand, Solid-phase extraction, Disposable cartridges, SPE.
Combined Effect of Nanoparticles and Leuconostoc mesentroides ssp. cremoris Bacteriocin against Listeria monocytogenes Isolated from Locally Soft Cheese Nibras Nazar Mahmood
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Listeria monocytogenes has been as important opportunistic bacteria for human since 1929 and as food borne pathogenic bacteria since 1981.  Out of Twenty samples of locally soft cheese, only two isolates of Listeria monocytogenes were isolated and identified using microscopically, cultural and biochemical methods. The isolates were multi drug resistant to ceftriaxone ,trimethoprime amoxicillin ,aztreoname, ciprofloxacin and penicillin. While, these isolates were sensitive to Ampicilin, imipenem, and azithromycin. The antilisterial activity of 400 µg/ml of both silver and zinc Nanoparticles and bacteriocin of L. mesentroides ssp. cremoris in soft cheese for 24 h. was evaluated. The results showed that bacteriocin, silver nanoparticles and zinc nanoparticles reduced the growth of L.monocytogenes in cheese with inhibition percent (49.48, 19 .38, 38.14) % respectively .The combination between bacteriocin with nanoparticles (1:1) showed increased in the reduction of L.monocytogenes growth with (58.76 and 67.01) % for bacteriocin with silver nanoparticles and bacteriocin with zinc nanoparticles respectively. These results indicate that the combination of bacteriocin with nanoparticles has a protective effect against   Listeria monocytogenes in locally soft cheese Keywords: Leuconostoc mesentroides; Cheese; Listeria monocytogenes; Nanoparticles.
The Adsorptive Removal of Rhodamine 6G Dye from Aqueous Solution by Using Poly (Fumaric Acid-Co-Acrylic Acid) Hydrogels Wissam L. Benyan
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The removal of rhodamine 6G from aqueous solutions was achieved by adsorption using poly (fumaric acid-co-acrylic acid) as adsorbent surface. Several variables that affect the adsorption were studied including adsorbent dosage, contact time, pH, temperature and ionic strength. The results indicate that hydrogel has a strong capability of removing rhodamine 6G dye directly from aqueous solutions. The equilibrium adsorption data is analyzed using three common adsorption models: Langmuir, Freundlich and Temkin. The Thermodynamic parameters ΔH, ΔG and ΔS are calculated for the adsorption rhodamine 6G onto hydrogel.Keywords: Hydrogels, Rhodamine6G, Adsorption, Isotherms, Thermodynamic.
Study for Murine Mammary Adenocarcinoma Implanted in Female Albino Mice for Evaluation of Antitumor Activity of Trigonella foenum graecum (Fenugreek) Seed Alkaloid Extract against Breast Cancer Alaauldeen SM Al-Sallami
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The current study was designed to prepare the alkaloid extract of the Trigonella foenum graecum and studying the therapeutic potential of cancer in laboratory mice with a study of the physiological effect of the alkaloid extract, 48mice were used for studying, in the following groups (8 mice in each group) : The first group infused  normal group injection with normal saline for 2 weeks and was considered a negative control group. The second group was its untreated tumor-bearing mice group for two weeks and was considered a positive control group. The third group was tumor-bearing mice treated using the 80 g / kg for 2 weeks. The fourth group was treated using alkaloids extract and 120 g / kg for 2 weeks. The fifth group was not infected with the tumor and was injected with the 80 g / kg alkaloids extract for 2 weeks. The sixth group was not infected with the tumor and was injected with the 120 g / kg alkaloids extract for 2 weeks.  The results of the study showed that the tumor inhibition rate in the group rats treated with the plant extract 80 g / kg for two weeks was higher by significant difference (P <0.05) than the group treated with 120 g/kg alkaloids. The results of the CEA study and TP53 production showed a significant difference (P <0.0001) between the control groups and the treated and untreated tumor groups (positive control). No significant difference was found between positive control groups and tumor groups. The results of the physiological effect on the study groups showed higher levels of AST and ALT in tumor aggregates compared with control group but did not show significant differences between the groups injected with alkaloid extract only compared to the control group.Keywords:  Fenugreek; Seed alkaloid extract; Trigonella foenum graecum; and female Albino mice.
Synthesis, Characterization and Evaluation the Biological activity for New Mesogenic 1, 3-oxazepine-4, 7-dione Derived from Trimesic Acid Nasreen R. Jber
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

In this work new liquid crystalline oxazepine compounds derived from trimestic acid were prepared. In the first step, 1, 3, 5-tris-[3-thiol-4-amino-1, 2, 4 triazole-5-yl] benzene [E] was synthesized through the preparation of 1, 3, 5-benzenetricarboxylic acid hydrazide [C]. The second step was the condensation reaction between different aldehydes: 4-hexyloxybenzaldehyde, 4-heptyloxybenzaldehyde and 4-octyloxybenzldehyde to yield new Schiff bases compounds [F1-F3] respectively. In the final step, oxazepine compounds [G1-G3] were prepared from reaction imines compounds [F1-F3] with succinic anhydride in dry benzene. All these derivatives were characterized via FTIR spectroscopy, elemental analysis and 1H-NMR spectroscopy. Polarizing optical microscope and DSC were used to assessment the mesomorphic properties of the synthesized compounds. The synthesized compounds [G1-G3] were examined for antibacterial activity against Staphylococcus aureous, Staphylococcus saprophyticus (Gram-positive) and Kelebsiella pneumonia, Escherichia Coli (Gram-negative).Keywords: 1, 3-oxazepine-4, 7-dione, 3-mercapto-4-amino- 1, 2, 4- triazole, Liquid cystal, Antibacterial activity.
Determination of Hydrogen Peroxide (H2O2) by New Design of Continues Flow Injection Unit Dakhil Nassir Taha
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

This study includes the design of continues injection system to determine the hydrogen peroxide (H2O2) containing valve is designed locally and this method is quick, cheap and characterized by high accuracy. The method is based on the fast reduction of the complex compound K3[Fe(CN)6] by H2O2 in basic medium with maximum wavelength at 420 nm. Various parameters (physical and chemical) affecting on the determination have been investigated such as flow rate, volume of the loop, concentration of the complex compound and concentration of the base. The calibration curve was prepared and the dispersion coefficient, reproducibility and application were studied. The linear range was (0.06 - 0.8) % at sampling rate of 60 sample per hour, (R2=0.9923) and the detection limit at S/N=3 was 0.02%. Dispersion coefficient was also measured for the method.Keywords: Continues Injection, Determination Hydrogen peroxide H2O2.
Formulation and In-Vitro Evaluation of Dabigatran Etexilate Loaded Nanostructured Lipid Carriers Haithem Najmuldeen Abed
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The nanostructured lipid carriers (NLCs) is an interesting delivery system that can protect the encapsulated drugs and improve their dissolution, permeability and over all bioavailability. The aim of the present study was to prepare dabigatran etexilate (DAE)-encapsulated NLCs (DAE-NLCs) using glyceryl monostearate (GMS) and oleic acid (OA) as solid and liquid lipid matrix respectively, together with different surfactant types and ratios; DAE-NLCs were prepared using the hot emulsification-ultrasonication technique and the prepared formulations were characterized in terms of their particle size distribution, encapsulation efficiency (EE%), zeta potential, surface morphology and physical state characteristics. The prepared lipid nanoparticles shows a spherical shape with a particle size (62.4±5.75nm), poly dispersity index (PDI) of (0.286±0.001), zeta potential (-33.81±0.001 mV) the EE% was (92.42±2.31) and the drug loading capacity (LC %) was found to be (7.69±0.17). the in-vitro drug release study shows a bi-phasic drug release pattern with initial burst followed by a prolonged drug releasing phase with a 92% of the loaded drug was released in 24hr the release kinetics was fitted to Korsmyere-Peppas model with anomalous release mechanism. The solid state characterization depict an amorphous state of entrapped drug within the lipid matrix of the optimized DAE-NLCs. Short term stability study shows no significant change in nanoparticle characterization at refrigerator compared to room temperature. DAE-NLCs could be a potential delivery device for improved drug loading with controlled release properties that will improves oral bioavailability of the drug.Keywords: Dabigatran Etexilate, Hot emulsification/ultrasonication, Nanostructured lipid carriers, Cremophor-EL.
Isolation of active compounds from aerial parts of Albizia Procera S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The purpose of the study is to isolate active compounds from herbal plants that have various effects on living systems. The plants are indispensable sources for both preventive and curative medicinal preparations of various traditional medicine systems practiced worldwide. Albizia species is used to treat anxiety, cancer, depression, insomnia, sore throat and to reduce swelling associated with trauma. Isolation of active constituents and pharmacological screening can assist us to find new therapeutically active drugs. The compound (1) 2,2- dimethylvinyl methyl ketone and  compound (2) 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexene (C30H50) are isolated from hexane and ethyl acetate fraction of albizia procera belonging to the family mimosoideae. The above isolated Compound (1) is an intermediate to synthesis a number of different types of organic compounds and Compound (2) showed potential hepatoprotective effect against drug induced hepatotoxicity. The structure of compound have been established [1] by IR, 1H NMR, 13C NMR and MASS spectrophotometry.

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