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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 5 Documents
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Search results for , issue "Volume 11 Issue 03 (2019) March. 2019" : 5 Documents clear
Isolation of active compounds from aerial parts of Albizia Procera S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The purpose of the study is to isolate active compounds from herbal plants that have various effects on living systems. The plants are indispensable sources for both preventive and curative medicinal preparations of various traditional medicine systems practiced worldwide. Albizia species is used to treat anxiety, cancer, depression, insomnia, sore throat and to reduce swelling associated with trauma. Isolation of active constituents and pharmacological screening can assist us to find new therapeutically active drugs. The compound (1) 2,2- dimethylvinyl methyl ketone and  compound (2) 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexene (C30H50) are isolated from hexane and ethyl acetate fraction of albizia procera belonging to the family mimosoideae. The above isolated Compound (1) is an intermediate to synthesis a number of different types of organic compounds and Compound (2) showed potential hepatoprotective effect against drug induced hepatotoxicity. The structure of compound have been established [1] by IR, 1H NMR, 13C NMR and MASS spectrophotometry.
Knowledge, Awareness and Practices Regarding Dengue Fever among the Rural and Urban Populations of Salem District Mohamed Yasir Arafath
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The objectives of the study were to assess how many people have knowledge and level of awareness on dengue, to know about most prevalent preventive measure, to ascertain the source of information regarding dengue and to enquire about the diagnostic measures and treatment strategies used by affected individuals.Methods: A cross-sectional observational study was conducted on 1000 respondents in Rural and Urban areas of Salem district, Tamilnadu to evaluate the knowledge, awareness and practices regarding dengue fever.Results: The results showed that only 52% of the rural respondents and 96% of urban respondents were aware about dengue fever.53% of the rural respondents and 97% urban respondents identified the vector as mosquito. The overall knowledge of dengue specific symptoms was much lower, in rural as compared to urban areas. The knowledge about the preventive measures was inadequate among the rural respondents when compared to that of urban respondents. Majority of the rural respondents (30%) had no source of information about dengue fever. While among the urban respondents, 29% had information about dengue fever from T.V/radio.Conclusion: The overall knowledge, awareness and practices regarding dengue fever were found to be inadequate among the rural populations when compared to urban populations. There is a need to make rural people aware of different preventive practices and reduce this knowledge application gap.Keywords: Dengue Fever; Knowledge; Awareness; Practices; Rural; Urban
Quantitative Estimation of Gallic Acid in Triphala Churna by HPTLC Gouri Kumar Dash
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A simple, reliable and rapid HPTLC method was developed for qquantitative estimation of gallic acid in the methanol extract of Triphala churna. The method was validated as per ICH guidelines for linearity, accuracy, precision, and specificity. Silica gel 60 F254 pre-coated aluminium plates were used as the stationary phase. Toluene: Ethyl acetate: Formic acid: Methanol (12: 9: 4: 0.5) constituted the mobile phase.  Percentage of gallic acid was estimated through densitometry scanning using a TLC Scanner III (Camag, Switzerland) with winCATS software. The amount of gallic acid present in the sample was found to be 0.41 ± 0.08 % w/w with respect to dried plant material. Thus, the developed method can be applied in quantifying the amounts of gallic acid in Triphala churna and results of this work will support in the standardization process of Triphala churna using gallic acid as the biomarker.Keywords: Triphala churna, Methanol extract, HPTLC, Gallic acid.
Herbal Drugs, Diet and Lifestyle Changes for Liver Diseases- A Review S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The liver is an important part of human digestive system. The organ’s function include food metabolism, energy storage, waste removal, detoxicification, immune system support and production of chemicals. There are several things damage the liver such as toxic substances, viruses, medications, genetic diseases and alcohol. Some of the herbal drugs and its extracts showed a good potentials for use in liver diseases.  Therefore, the present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity. In addition diet and lifestyle changes can help to improve the conditions of hepatotoxicity. 
Incidence and Sensitivity Pattern of Klebsiella Pneumoniae, Escherichia Coli and Pseudomonas Aeruginosa in a Tertiary Care Hospital Rahul Radhakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Antimicrobial resistance is a serious problem worldwide and differs from region to region. This study was carried out to determine the incidence and sensitivity pattern of gram negative bacteria mainly Klebsiella pneumoniae (K. pneumoniae), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) in our region and discuss the general issues related to antimicrobial resistance. Methods: Retrospective study was carried out in 6 months. Samples of urine, blood, pus, CSF and miscellaneous samples (fluids, swabs, sputum and stool) were collected from indoor and outdoor patients for isolation and antimicrobial susceptibility of K. pneumoniae, E. coli and P. aeruginosa were carried out in the Department of Microbiology in a Tertiary care Hospital.Results: Out of the 800 samples analyzed 618 showed growth,where 427 samples were isolated and it constitutes E.coli (43.32%), K. pneumoniae (33.02%) and P. aeruginosa (23.65%). Both E.coli and K. pneumoniae showed highest sensitivity for doxycycline (73%; 65% resp.) and second highest for levofloxacin (68%; 62% resp.), whereas, P. aeruginosa showed highest 55% sensitivity for amikacin followed by 46% for levofloxacin. β-lactam antibiotics and aminoglycosides showed high mean resistance (K.pneumoniae-81%, E.coli-77%, P. aeruginosa-84.4%) and (K. pneumoniae-73%, E. coli-59%, P. aeruginosa-68%) respectively.Conclusion: The data indicates high resistance among the gram-negative bacteria for β-lactam and aminoglycoside antibiotics. This study concludes that a proper awareness about antibiotics is essential as well as proper measures is to be implemented to control irrational use of antibiotics in this region. Keywords: Antibiotics;  Antimicrobial sensitivity; Gram-negative bacteria; Resistance

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