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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 52 Documents
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Search results for , issue "Volume 11 Issue 08 (2019) Aug. 2019" : 52 Documents clear
Using of Whey Proteins as Antioxidant in Some Food Products Nahla Tariq Khalid
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Oxidation of foodstuffs has become an issue concerning with food quality and consumer health, specifically in dairy products which contain a percentage of fat. The present study aimed to use whey proteins concentration (WPC) as additive to some samples of dairy products selected from local market. Adding WPC to these products with different concentration demonstrated a good activity of whey proteins concentration as antioxidant. Lipid oxidation measured on the basis of malondialdehyde by determining thiobarbaturic acid (TBA). Results obtained show differences in TBA value before and after adding WPC. Adding WPC reduced the TBA value about half in collected samples, and that led us that the period of lipid oxidation with adding WPC will be longer than these samples used without adding WPC. Using this method to protect food products from lipid oxidation by adding WPC has been proved the activity of whey proteins as antioxidant in this research.Keywords: Whey proteins, Antioxidant activity, Foods products. 
Efficacy of Edible Coating to Extend the Post-harvest Shelf-life of Shallot (Allium ascalonicum) Bulb N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Shallot or violet onion (Allium ascalonicum) bulbs are well known for their biological activity resulting from the presence of sulphur compounds. The health and nutritional benefits of shallot have led to their increased demand and hence production. Shallot harvest handling must be done immediately after harvest because these commodity are easily damaged. Plastic food packaging causes serious environmental problems. Edible coatings offer various physicochemical advantages for fruit and vegetable in preservation. Objective of this study focused on the effectiveness of different coating materials such as chitosan, CMC, xanthan gum, carrageenan, sodium alginate to the quality of shallot bulbs. Results showed that after 6 month storage by 3.0% chitosan at ambient temperature, shelf-life of shallot bulbs remained its stability. Edible coating could maitain shallot quality by controlling respiration rate as well as decay. It’s not only as an effective strategy for the product but also friendly environment.Keywords: Shallot bulb, Allium ascalonicum, Chitosan, Coating, Storage, Shelf-life.
Low Glutathione Peroxidase Plasma Levels Related to the Severity Degree of Vitiligo I Gusti Ayu Agung Praharsini
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Introduction: Vitiligo is a pigmentation disorder caused by damage to melanocytes which causes loss of pigment production on the skin and mucosal surfaces. The etiology of vitiligo is still unknown, but there are several theories regarding the occurrence of damage and death of melanocytes in vitiligo. One is a widely known theory is the theory of oxidative stress. The body has a defence mechanism against free radicals through the formation of antioxidants, one of which is glutathione peroxidase (GPx). Increased free radicals will result in decreased levels of glutathione peroxidase. This study aims to prove the correlation between plasma glutathione peroxidase and an increase in the severity of vitiligo. Method: The study design using an analytical study with a cross-sectional approach in vitiligo patients at Sanglah Hospital Denpasar. Sampling were done with consecutive sampling technique involving 40 vitiligo patients and 20 non-vitiligo controls that met the inclusion and exclusion criteria. Venous blood sampling was performed to measure GPx plasma levels and physical examination to measure the severity of vitiligo based on VASI scores. The collected data were analysed using SPSS version 23.0 with normality test, unpaired T test, correlation test and chi-square to get the prevalence ratio (PR).Result: The results showed a lower level of GPx plasma in vitiligo patients (72.3 ± 82.5 ng/mL) compared to non-vitiligo (160.63 ± 124.33 ng/mL) subjects (p<0.05), low GPx levels were a risk factor for vitiligo with a prevalence ratio (PR 1.57; CI 95% = 1.89-2.776; p<0.05) and plasma GPx levels have a strong negative correlation with the degree of vitiligo severity based on vitiligo area severity index (VASI) scores in vitiligo subjects (r=-0.60; p <0.05) Conclusions in this study there is a negative correlation between plasma GPx levels with vitiligo severity and low GPx levels are risk factors for vitiligo.Keywords: Glutathione peroxidase, Vitiligo, Vasi score.
Furnace Redesign to Reduce Levels of Dust in the Air, Fatigue, Workload, and Increasing Blacksmith Productivity in Batu Sangiang Village, Tabanan, Bali-Indonesia Ida Ayu Made Sri Arjani
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Introduction: Exposed to a hot environment for work is a situation that can potentially pose a danger to the safety and health of workers. Besides resulting in pain and injury, it can also cause occupational diseases. Blacksmithing was carried out with furnace and open flame, where the iron that will be heated with a sharp object repeatedly were sharpened again. The working process is quite heavy with exposure to heat radiation from the furnace and dust increasing fatigue and workload of a blacksmith. Therefore, to avoid the occurrence of health problems caused by exposure to high heat furnaces, a need for an ergonomic and good chimney that can provide comfort for its workforce. The purpose of this research is to reduce levels of dust in the air, fatigue, workload, and increasing blacksmith productivity in Batu Sangiang Village, Tabanan with furnace redesign. Methods this is an experimental research study. This research was conducted in the Batu Sangiang Village, Tabanan with a sample of 15 workers. Data collected include: levels of dust in the air, fatigue, workload, and work productivity. Before setting up a different test, the data normality was tested using Shapiro-Wilk test with a confidence level α = 0.05. In normal distributed data, Paired Sample t-test with α = 0.05 was used and abnormal distributed data were analysed using the Wilcoxon different test, α = 0.05, Results After working furnace was redesigned, decreased levels of dust in the air 89.20%, 24.03% reduction in fatigue, reduced workload of 14.48% and 83.26% increase in productivity. Results analysis using Paired Sample t-test, the amount of dust in the air, fatigue and workload in Period I and Period II, there is a significant difference (p <0.05), as well as analysis data using Wilcoxon test, labor productivity in Period I and period II, there is a significant difference (p <0.05). Conclusion: From this study we can conclude, after the furnace redesign was done, there was a significant decrease in the levels of dust in the air, fatigue and workload, and there was a significant increase in labour productivity. Suggested artisan blacksmith always applies and pay attention to the principle of ergonomics for improvements such as the redesign of the furnace shown to reduce levels of dust in the air, fatigue, and the workload and increase productivity.Keywords: Furnaces redesign, Levels of dust in the air, Fatigue, Workload and work productivity.
Effectiveness of Fining Agents for Wax Apple (Syzygium samarangense) Wine Clarification Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Waxe apple fruits are rich sources of nutrition with water, carbohydrate, protein, vitamins, and minerals, along with some medicinal properties. This fruit is highly perishable because of its thin skin and can be easily damaged. The processing of wax apple juice into wine could enhance the value of the fruit. However, turbidity in waxe apple wine is a major problem limiting its contribution to international commercialization. Wine clarification is a widely applicable procedure that involves an agent or a mixture being supplemented to clarify, stabilize or modify the sensory wine attributes. Objective of this study focused on the feasibility of different fining agents such as gluten, gelatin, maize zein, casein, bentonite for clarification of waxe apple wine. This research also examined if there was any synergistic effect while combining gluten with gelatin to improve their fining capability. Our results revealed that 5.0:3.0 g/hL (gluten: gelatin) was adequate to control the haze cloud or turbidity after 3rd week racking of waxe apple wine.Keywords: Waxe apple, Wine, Fining, Clarification, Turbidity, Gluten, Gelatin.
Frap Assay and Nitric Oxide Free Radical Scavenging Activity of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: Oxidative stress resulting from accumulation of reactive oxygen species has been associated with disease. Research study was undertaken to investigate and evaluate the in vitro antioxidant activities such as FRAP and Nitric oxide of ethanolic extract of cordia obliqua.Methods: The ethanolic extract of cordia obliqua was examined by Nitric oxide radical scavenging activity and Ferric Reducing Antioxidant Power Assay with reference standard ascorbate respectively through in vitro models.Results: Ethanolic extract of cordia obliqua showed significant free radical scavenging activity than that of standard.Conclusion: In vitro study indicates that these plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.
Differentiated Approach to Surgical Treatment of Cholelithiasis Complicated by Choleducholithiasis and Obstructive Jaundice Aliya M. Aitbayeva
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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This study contributes to solving problems of steady increase in cholelithiasis incidence with high percentage of associated complications, high mortality rate and unsatisfactory outcomes. This study rises from universally recorded increase in the incidence of gallstones, from the prevalence of complicated disease forms, from high mortality rate and unsatisfactory treatment outcomes. This study aims to improve the outcomes of surgical treatment in patients with complicated cholelithiasis who underwent a differentiated surgical intervention. This study analyses treatment outcomes in 140 patients who undergone surgery for cholelithiasis complicated by choledocholithiasis and obstructive jaundice. Patients underwent surgical interventions in a clinical unit under the West Kazakhstan Marat Ospanov State Medical University in 2014/2018. The findings show that a surgical approach towards the treatment of patients via minimally invasive surgery should depend on the severity of obstructive jaundice. Postoperative complications were found in 7.8% of patients in the main group, and the death rate was 1.1%. By contrast, in the control group, 32% had postoperative complications and the death rate was 4%. If differentiated, minimally invasive surgical treatment of cholelithiasis complicated by choledocholithiasis and obstructive jaundice allows avoiding serious complications when correcting abnormalities in the biliary system via traditional laparotomy with a wide incision. These findings suggest that a differentiated approach can significantly improve treatment outcomes in patients with cholelithiasis complicated by choleducholithiasis and obstructive jaundice.Keywords: Cholelithiasis, Choledocholithiasis, Obstructive jaundice, Endoscopic interventions.
The Result of Taking Mare’s Milk for Nonalcoholic Steatohepatitis Bakytzhan Bimbetov
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) and is linked to overweight, obesity and metabolic syndrome. The main role in treating NAFLD is attributed to leading a healthy lifestyle, keeping a healthy low-calorie diet and high physical activity. In dealing with issues of healthy diets of patients with NASH, mare’s milk can be considered a pathogenically based, highly effective and affordable natural therapeutic dietary agent. The value of the product is defined by its similarity to the chemical components of women’s breast milk. This article reports a case of a successful treatment of NASH with the help of monotherapy using sublimated mare’s milk within a relatively short period of time, devoid of laborious dieting, physical activity or any side effects.Keywords: Non-alcoholic fatty liver diseases, Non-alcoholic steatohepatitis, Mare's milk, Sublimated mare's milk, Medical and dietary properties of mare's milk.
Various Parameters Affecting to Production of Dried Jasminum sambac Flower Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Jasminum sambac is one of the most cultivated species in Vietnam. The plant is much valued for its exquisitely fragrant flowers. Flowers of Jasminum sambac have been utilized as traditional medicines to treat many diseases. Objective of this study focused on on the effectiveness of different parameters of freeze-drying such as pressure (0.06, 0.08, 0.10, 0.12 mbar), primary drying temperature (-3oC, -5oC, -7oC, -9oC) and secondary temperature (26oC, 28oC, 30oC, 32oC) to the total phenolic (mg GAE/100 g) and total flavonoid (mg QE/100 g) of dried Jasminum sambac flower. At the end of drying process, we also monitored the stability of dried Jasminum sambac flower during 6 months of preservation. Our results showed that the optimal drying process should be conducted at 0.08 mbar, primary drying temperature -7oC, secondary temperature 28oC to achieve the best dried Jasminum sambac flower. From this production, shelf-life of dried Jasminum sambac flower could be last for 6 months without any deterioration.Keywords: Jasminum sambac, Dried flower, Freeze-drying, Total phenolic, Total flavonoid, Shelf-life, preservation.
Synthesis, Characterization and Biological Activity of New Derivatives of Hetrocyclic Compound Athraa B. Mohamad
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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This study included the preparation and characterization of a series of new derivatives of  pyrazoline, isoxazoline by two steps the first step involved the preparation of chalcones by reaction between aldehyde and acetophenone the second step involved the react of chalcones two stepe react chalcones with hydrazine to form pyrazoline also chalcones was reacted with hydroxylamine hydrochloride in present a basic medium for the preparation of the derivative isoxazoline The derivatives has shown moderate to good activity against gram-positive bacteria (Staphylococcus aureus), gram-negative bacteria (Escherichia coli)  when compared with standard antibiotic gentamycin .all prepared compounds were diagnosed by spectra of H1-NMR, mass.Keywords: Isoxazolin, Pyrazoline, Chalcones, Synthesis, Biological activities. ­­­­­­

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