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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Effect of Infection with Toxoplasma and Cytomegalovirus on (IgG and IgM) Levels in Women with Primary Infertility from Wasit Province-Iraq Hind A. Hanoon
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The purpose of this study is to clarify the respective roles of the parasite Toxoplasma and cytomegalovirus in primary infertility women in Wasit governorate, the samples were collected from each of infertility center at Al-Kut Hospital and Al-Zahra Teaching Hospital during the period from of 20may to 20 Oct. /2016. and was compared with the control groups Pregnant  and healthy women , it was the reconstruction of aggregates rate between 17- 45 years, and have been working with ELISA .this study showed  a significant decrease (P <0.05)  in IgM in  first and second  groups when compared with healthy women and no significant when compared with pregnant women at toxoplasmosis .In Cytomegalovirus, significant increase (P <0.05) for all categories compared with healthy in IgM  and significant increase (P <0.05) in first and third categories in IgG when compared with pregnant women and significant decrease (P <0.05) in second group in IgM when compared with pregnant women.Keywords: Toxoplasma gondii, Cytomegalovirus, Infertility women, Pregnant women, ELISA.
Synthesis, Characterization & Evaluation of Biological Efficiency of Some Transition Metal Complexes with Schiff Base E-3-(Phenylhydrazono) indolen-2-one Israa A. Al-H. Hamdan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work involved synthesis of Schiff base derivative from the condensation reaction of the phenylhydrazine with 1H-Indole-2, 3-dione (isatin). Metal complexes of the Schiff base ligand with Cu (II), Zn (II), Fe (III), Ni (II), and Mn (II) ions were prepared by reacting ligand with the metal salts in ethanol. The chemical structures of the ligand as well as the stereo-chemical structures and geometries of the studied metal complexes were suggested depending on the results obtained from CHN analysis, H-NMR, FT-IR spectrophotometer, Uv-vis electronic spectra, conductivity measurements, and magnetic measurements. The mole ratio of the ligand to the metal ion was 1:2 with bi-dentate bonding behaviors of the coordinating ligand with the metal ions. The Metal complexes of the Schiff base ligand that prepared show variety of bioactivity against three types of bacteria. Keywords: Isatin, Schiff Bases, Metal Complexes, Antibacterial activity, Data spectra.
Testing the Efficiency of Zinc Oxide Nanoparticles, Honey, Honey Supported by Zinc Oxide Nanoparticles and Phylex in Degradation of Aflatoxin B1 in stored Sea Maize Seeds Dema A Yousif
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This study was conducted at the Mycotoxins Laboratory/ Department of Plant Protection /College of Agriculture/ University of Baghdad to test the efficacy of zinc oxide nanoparticles (ZnO (NP)), honey, honey supported by zinc oxide nanoparticles and Phylex in inhibition of Aspergillus flavus and degradation the toxin that produced by the fungus. The efficacy of ZnO(NP) was tested with concentration 2% and honey with concentration 20% and honey supported by ZnO(NP) with 20% concentration and the Phylex 0.2% under storage conditions. The results indicated that all treatment resulted a significant decline in the reduction rate and concentration of Aflatoxin B1 (AFB1) in stored Sea maize seeds with a significant difference from control treatment, which was 0.0 and 1.13 μg/kg by using high performance liquid chromatography (HPLC). As for choosing best concentration for each of the materials used to inhibit fungus growth, the results showed the used of ZnO(NP) and the Phylex have the highest reduction rate. This rate in Aflatoxin B1 was 93.80% with a concentration of 0.07 μ/kg and 91.15% with a concentration of 0.10 μg/kg respectively. The results of using honey showed the reduction rate of Aflatoxin B1 79.64% with a concentration of 0.23 μ/kg. Then was followed by the use of honey supported by ZnO(NP) with a reduction rate of Aflatoxin B1 82.30% and concentration 0.20 μg/kg. The results showed the efficacy of ZnO (NP), honey and honey supported by ZnO(NP) and Phylex in degradation A. flavus and prevent producing of Aflatoxin B1 in Sea  maize seeds in compression of control treatment that was 1.12 μg/kg using HPLC device. It was found when using ZnO(NP) reduction rate of Aflatoxin B1 was 96.42% with concentration of 0.04 μg/kg, while the rate of Aflatoxin B1 reduction was 72.32% at a concentration of 0.31 μg/kg when using honey. The results of the use of honey supported by ZnO(NP) indicated a rate of reduction Aflatoxin B1 was 83.92% B1 with a concentration of 0.18 μg/kg, the results of the use of the Phylex showed the reduction rate of Aflatoxin B1 was 94.64% with a concentration of 0.06 μg/kg.Keywords: Aflatoxin B1, ZnO(NP), Phylex, honey, Inhibition, Aspergillus flavus.
The Protective Effect of Sesame Oil on the Male Reproductive System in Male Rabbits Exposed to the Experimental Hyperlipidemia Omar A. Kanosh
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The current study aimed to investigate the protective effect of sesame oil on the male reproductive system in male rabbits exposed with experimental hyperlipidemia. The study was conducted at the Animal House of the College of Education for Pure Sciences / University of Tikrit and included 15 rabbits of New Zealand rabbits and distributed to 3 groups and each group consisting of 5 animals. First group) Control group (: Treated with standard mixture of food and regular drinking water. Second group: were treated with standard mixture of food and added cholesterol (1% g / kg) .Third group: treated with a standard mixture of food and added cholesterol at a concentration of (1% g / kg) and sesame oil (1 ml / kg). The experiment lasted for 21 days. The results showed a significant decrease in concentrations of Cholesterol, HDL, LDL, VLDL and MDA in cholesterol and sesame oil groups and significant increase in GSH concentration compared with the cholesterol group. The results showed that hypercholesterolemia resulted in a significant decrease in the level of sperm and natural and live sperm and a significant increase in the level of deformed and dead sperm, while treatment with sesame seed oil showed a significant increase in the ratio of natural and live sperm and vitality and a significant decrease in the proportion of dead and deformed sperm. From that we conclude that sesame seed oil has excellent role on the prevention of the negative effects of hypercholesterolemia on the properties and vitality of the sperms.Keywords: Hypercholesterolemia, Sesame oil. Lipid profile, Glutathione, Malondialdehyde.
Molecular Identification of Extended-spectrum β-lactamase Resistant Genes in E coli Recovered from Individuals Suffered Urinary Tract-based Infection Sara K. Al-Zubaidi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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The intended purpose of the current identifying study was to know the recent occurrence of E. coli-related extended-spectrum resistant-genes of blaCTX-M, blaSHV, blaTEM and blaAMPC that are responsible for community-based acquired urinary tract infection (CAUTI) and nosocomial infections (NCI). The study also was intended to reveal the genetic-based links between recovered strains. To answer these questions, non-similar 50 isolates of E. coli were recovered from UTI samples handed by 3 hospitals in Babylon City, Iraq. These samples were subjected to cultivation processes and a polymerase chain reaction technique (PCR). The resistant genes, according to PCR, were detected in 10 positive-ESBL phenotypes of the isolates. Using PCR, The blaCTX-M and blaAMPC genes were 100%-frequently identified in those 10-positive samples. However, the other genes were detected in low rates in those samples. The results, here, identify the important role of the horizontal gene transfer (HGT) in obtaining resistance by the E. coli isolates against β-lactamase-related antibiotics in Iraq.      Keywords: E. coli, Extended, β-lactamase resistant genes, Spectrum.
Study of Some Immunological and Biochemical Parameters Related with Vitiligo Patients Alaa Jawad Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The current study aimed to determine the relationship between certain immunological and biochemical parameters with Vitiligo patients.  The results revealed that a significant decrease (P<0.05) in the concentration of  CD8 (ng/ml) and a significant decrease (P<0.01)  in concentration of hormone T4 (ng/dl) in patients compared to healthy group , whereas there was non- significant differences in the levels of  CXCL-10(pg/ml) and TSH(µIU/ml), but there were a significant difference (P<0.01) in  the concentrations of  T3 (ng/ml) and reactive oxygen species(ROS) (ng/ml). According to the gender the males of patients has shown a significant decrease (P <0.05) in the concentration of CD8 in comparison with males control group and a significant decrease (P <0.01) in the concentrations of T4 and TSH hormones, while the data noticed a significant increase (P <0.05) in the concentration of (CXCL-10) as well as a significant increase (P<0.01) in the concentrations of ROS and T3. The comparison between females of patients with control showed a significant decrease in the concentrations of CD8, CXCL-10, T4, and TSH, but there was a significant increase in concentrations of ROS and T3.Keywords: Vitiligo, Immunological parameters, Hormones.
Antifungal Activity of Alkaloid and Flavonoid Extracted from Curcuma longa Zeena G. Faisal
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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The present study investigates the use of agar well diffusion method and the inhibitory effect of Alkloids and flavonoids againist some pathogenic fungi. The statistical analysis of the results  showed of the inhibitory effect of Alkaloids extracted from  Curcuma longa on the growth of fusarium and penicillium, there are significant differences below the level of probability (P<0.05) between the inhibitory effectiveness of Alkaloids extracted from  Curcuma longa of the studied  species, compared with the standard antifungal (Itraconazole), Alkaloids extract of the Curcuma longa gave higher inhibition  impact compared with the inhibitory effect of antifungal (Itraconazole) at the concentration 98% .The inhibitory percentage showed the  effect of Flavonoids extract of Curcuma longa in growth of fusarium and penicillium, that there are significant differences below the level of probability (P<0.05) between  the inhibitory effectiveness of the extract Flavonoids and the fungal genera compared with the standard antifungal (Itraconazole),. Showed Flavonoids is less inhibitory effect of inhibitory effect of Itraconazole antifungal at all concentrations of Flavonoids extracts. The inhibitory effect of Flavonoids extract of Curcuma longa at concentration 99% (22, 25,) mm to fungal species (fusarium and penicillium) respectively.
Synthesis Five and Seven Heterocyclic Compounds: from Starting Materials Furoic -2-Carboxylic Acid (Pyromucic Acid) Amal Abd Al-Rada
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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This work involves synthesis of different five and seven member heterocyclic ring starting from furoic-2-carboxylic acid(pyromucic acid) This part involved  synthesis of ethyl-2- chlorobenzoate  via reaction of 2-chlorobenzoic acid with sulfuric acid in ethanol absolute and the product reacts  with hydrazine hydrate in ethanol to get 2-chlorobenzohydrazide then reaction of different acide (aromatic)Keywords: Oxadiazoles, POCl3, 2- chlorobenzaoic acid, Furoic acid, Biological.
Template Synthesis of Hybrid Schiff Base Complexes of Zn2+, Cd2+, and Hg2+ Ions Abdul-Razak H. Al-Sudani
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Five Schiff base complexes of d10 metals were prepared via Template synthesis procedure. This procedure included the synthesis and isolation of intermediate diamine complexes derived from N,N-Diethylethylenediamine; (Et2ne), and appropriate metal salt; MCl2; (M= Zn2+, Cd2+, and Hg2+), followed by the condensation of either of Ortho-phathaldehyde (OPA) or Benzaldehyde with different intermediate diamine complexes of aforementioned metal ions. Moreover, the condensation reaction of the intermediate diamine complexes of the formula [HgCl2 (Et2ne) 2] with OPA failed to produce either the corresponding Schiff base – Mercury- or Organo - Mercury Complex. The identification of the reported Schiff base Metal complexes were  based on Elemental Analyses, Atomic Absorption; FT-IR, Vis-UV; and Molar Conductance. In addition to those techniques, 1H NMR and Mass Spec. were recorded for a couple of the reported complexes.Keywords: Template synthesis, Hybride Schiff Base, Schiff base-d10 metal complexes, Reduction of mercury diamine complex, N,N-Diethylethylenediamine,  Benzaldehyde, o- Phathaldehyde.
Assessment of NT-ProBNP and Troponin T in Sera of Iraqi Patients with Renal Failure Nour Saeed Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Background: Patients with renal failure have high risk of cardiovascular disease which is a leading cause of morbidity and mortality among these patients. This study aimed to evaluate the effect of renal failure on the cardiac system by measuring the following markers (NT-ProBNP and Troponin T) and compared with healthy subjects. Method: This study consists of a total (90) subjects, among them (60) patients with end stage renal failure and (30) healthy persons that served as control group. This study has been carried out in AL-Yarmok Teaching Hospital and AL-Karama Teaching Hospital in Baghdad for the period from February 2017 till May 2017. Serum (NT-ProBNP and Troponin T) were done by enzyme-linked immunosorbent assay (ELISA). Results: this study showed an increasing significant in the levels of NT-Pro BNP and Troponin T for patients with renal failure compared with control group.  Conclusion: Renal failure was affected on cardiac system as the cardiac markers (NT-ProBNP &troponin T) levels were increased significant. Keywords: NT-ProBNP, Troponin T, Renal failure.

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