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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Epidemiological Study of Toxoplasmosis in Patients with Renal Failure form Kirkuk City /Iraq Sadia Shahab Hamad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The present study was aimed to estimate Toxoplasma gondii occurrence among immunocompromised patients Renal Failure (RF) patients in Kirkuk city / Iraq. A total of 71 sera were drown from renal failure patients attending to dialysis unit of Kirkuk general Hospital and 48 individuals having a normal immune system as healthy control. The serological were tested for toxoplasma antibodies using four types of test. Result of Latex Agglutination Test indicated that out of 71 sera examined 41(57.7%) were positive and 22(45.8%) for control group, without significant differences between them.                                                     The overall rate of Toxoplasmosis in (RF) patients using Modified Latex Agglutination Test (2-ME) was 25(35.21%), 12(25%) for patients & control group respectively, the differences between them was statistically significant. While Rapid test-Cassette showed 14(19.72%), 0(0%) for IgG, IgM for patients group comparing with control group 5(10.4%), 0(0%), for IgG, IgM respectively with significant differences. Using ELISA test (30.9%), (16.6%) of the sera were seropositive for anti- toxoplasma antibodies IgG while (2.82%), (6.25%)  for patients & control group sera were positive for anti- toxoplasma antibodies IgM moreover common infection was1(1.41%), 3(6.25%).Relationship between toxoplasma antibody distribution with patient age was significant  and the high rate was (75%), (25%) in the age group 71-81 year for IgG, IgM respectively .The infection rate in female was higher than those in male (40.63%), (23.08%),(3.1%),(2.56%) for female &male in  IgG, IgM respectively without significant.           Considered patients residency acute & chronic infection were higher recorder among patients from urban area and the rate was (36.3%),(26.3%) than rural area patients (6%),(0%) without significant, and the results of non-officer showed higher rate than officer by (33.8%),(3.08%)  for IgG, IgM with statistically significant differences.Keyword:    Toxoplasma Gondii, Renal Failure Patients,
Investigation of Tumor Necrosis Factor-Alpha (TNF A) Gene Polymorphism in Patients with Hypertension in Al-Diwaniyah City, Iraq Ghaidaa Raheem Lateef Al-Awsi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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A study was conducted on 100 in the outpatient whom consulted Al-Diwaniyah Teaching Hospital in Al-Diwaniyah City in the period between October 2017 to April 2018.One hundred blood samples (50 experimental and 50 controls) were collected under the supervision of the treating physician. TNF-α, which is an abbreviation of “tumor necrosis factor alpha”, is one of the key distinctive pro-inflammatory cytokines emerging evidence have confirmed the vital role of TNF-α in the progress of hypertension. The genotyping regarding (TNF a) were carried out through utilizing polymerase chain reaction, commonly denoted as (PCR), along with (RFLP), which is an abbreviation of “restriction fragment length polymorphism”. We aimed at determined vital variations within the genotype frequencies of (TNF a) among control and experimental sample groups.Keywords: Hypertension, RFLP, TNF A, SNPs. Polymorphisms, Diwaniyah, Iraq
Evaluation of Alpha-1-acid Glycoprotein and Alpha-antitrypsin in Bronchoalveolarlavage Fluid for Extra-bronchial Tumor and Intra-bronchial Tumor in Lung Cancer Hayder Hashim Alshalah
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Introduction: Lung cancer is one of the most common malignant tumors and the leading cause of cancer-related death worldwide. Aim of study: to evaluate of proteins (ALpha1 antitrypsin and alpha1 acid glycoprotein) in BALF in extra –bronchial Tumor and intra- bronchial Tumor of lung cancer. Material and method: this study was carried on 40 patients with lung cancer after they have bronchoscopy.  26 patients intra  -bronchial tumor in  BALF  (this is wash area of tumor when was be inside of bronchial)   14 patients extra –bronchial tumor in  BALF(this is wash area of tumor when was be outside of bronchial ) , detection (Alpha_1_antitrypsine,Alpha 1 acid glycoprotein )  in BALF were measure by Mispa Auto-analyzer Nephelometric immunoassay method).Result we found statistical significant between groups intra &extra - bronchial tumor  to each proteins .Our study also showed that at  a cut-off  to A1AT& ,A1AGthey  has a sensitivity, specificity, positive predictive value and negative predictive value of(100 ng/ml,100%,92 %,66.6%,100%respectively with an area under the ROC of A1AT .820) ,and (AGP, 70ng/ml, 100%93.3%,%50, 100%,)  respectively with an area under the ROC of AGP .745). Conclusion: A1AT & AGP are reliable markers to diagnosis extra &intra bronchia_ tumor in BALF for lung cancer.
Correlation of Serum Dynorphin /KOR System with Serum IL-6 and IL-10 in Major Depressive Disorder Hussein Kadhem Al-Hakeim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A case-control study was applied to improve if there is a relation between endogenous opioid dynorhpin (Dyn) and its receptor KOR with serum interleukin-6 (IL-6) and interleukin-10 (IL-10) among MDD patients versus a group of apparently healthy subjects.  The study included 60 depressed pretreatment male patients and 30 (age and gender matched) controls. The serum Dyn, KOR, IL-6 and IL-10 levels were measured and the relation between these factors was obtained in addition to comparison of these factors between MDD patients and control group. Each parameter was determined by using ELISA technique. The comparison between both groups indicated a significance increase (p<0.05) in Dyn, IL-6 and IL-10 in MDD group comparing with controls. Whereas KOR didn’t show any significant difference. The correlation results indicated that there was no correlation between the two systems (endogenous opioid and immune systems). The conclusion of the study is that there was no relation between Dyn/KOR with inflammatory marker IL-6 and IL-10. This finding indicates that there is no effect of endogenous dyn on the immune function.
Age Gender and Site Effect on Immunohistochemical Expression of TGF-β1 and IFN-γ in Hereditary Gingival Fibromatosis Ali Omran Mousa
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Back ground: Gingiva as other part of oral cavity has been effected with hereditary diseases. When navigate in the jungle of gingival disease hereditary gingival fibromatosis will appeared as vague hereditary condition and the pathogeneses of disease is not clearly understood.  Clinically it’s characterized by massively increasing in gingival tissue mass, which appeared more fibrous.  Transforming growth factor beta 1 (TGF-β1) is growth factor which had critical role in pathogeneses of (HGF) together with interferon gama (IFN-γ) which inflammatory cytokines the level of these cytokines may be changed according to gender, age or site distribution (generalized, localized). Aim:  To evaluate the level of TGF-β1and IFN-γ immunohistochemically in hereditary gingival fibromatosis according gender, age and site distribution. Methods: Immunohistochemistry for detection of TFG-β1 and IFN-γ in paraffin embedded tissue sections for 17 blocks of hereditary gingival fibromatosis. Result: Non-significant difference of TGF-β1 according to gender, age and site in .Also Non- significant difference of INF -γ according to gender and site. On other hand significant difference of INF-γ according to age. Conclusion: Age, gender and site have no effect on expression of TGF-β1 in hereditary gingival fibromatosis; same findings were for IFN-γ except the age which has an obvious effect on IFN-γ expression.Keywords: Hereditary Gingival Fibromatosis.
Synthesis and Characterization of Some New Derivatives Starting from (4, 4'-diaminophenoxy) Ethane Containing Diazonium Groups Iftikhar Ahmed Hussein
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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The diazonium salts are highly reactive compounds. They are used as intermediate in different reactions. The diazonium salt [C2] was synthesized and reacted upon with (Acetyl acetone, ethyl acetoacetate, salicyladehyde) to produce [C3-C5].Then reacted [C3, C4] with hydrazine hydrate 80% due to [C6,C7]  . Then reacted [C5] with (Methyldopa and Atenolol) as drugs obtained [C8, C9].The prepared derivatives were identified by infrared spectra, 1HNMR, and physical properties.Keywords: Azo compounds, Heterocyclic rings, Schiff bases.
Study of Some Biochemical and Blood Parameters as Screening Markers for Breast Cancer Patients before Adjuvant Therapy in Thi Qar Government-Southern Iraq Jamal Harbi Hussein Alsaadi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Breast cancer is the most common malignancy disease in women. The study includes Eighty-three  cases were divided according age into women (patients and healthy ) average age more than forty five( Age > 45 year)   Fifty - five confirmed  subject of breast cancer patients (n = 42), healthy as control group (n=18) and women (patients and healthy) average age less than forty five Age (< 45 year) twenty three distributed to(2) groups too  .The first  group  confirmed (n=13)cases of breast cancer patients  and  second group (n=10)as control group. They were evaluated for blood parameters and some biochemical parameters that are associated with breast cancer occurring in Thi-Qar Government .Iraq. study has revealed that  significant decreasing (p<0.001) observed in  HB , PCV, RBC  and  WBC   levels  and a significant increasing  (P < 0.05) Platelets   , ESR   and  Monocyte retrospectively  in cancer patients comparison to normal control subjects and significant correlation (P< 0.05) between Neutrophil and Lymphocyte  , rates of NLR and PLR were significantly higher in breast cancer patients compared to control group   at  Age  > 45 year .While  the results showed for women   mean Age (< 45 year). The mean haemoglobin (Hb) , packed cell volume( PCV)  and  Red blood cells  (RBC) levels in the patient group were a significantly and lower than the control group at (p>0.05). There was high significant differences in WBCs   neutrophils, lymphocytes, monocytes also significant difference ESR (p>0.01) compared with healthy female .The values of NLR and PLR were showed significantly but no high   in the patients compare   with   healthy group. In this study  biochemical Parameters(lipid profile ) ,were showed  a significant decreasing at (p>0.01) for ;lipid profile parameters (Cholesterol, T.G, HDL and LDL) compared with  biochemical Parameters measurement  values of  female control mean  Age  > 45 year , while results showed  that significant increasing at (p>0.05)in  some lipid profiles in breast cancer patients compared with healthy control group  in women Age (<45 year).Keywords: Breast cancer, Lipid profile, Blood Parameters.
Antimicrobial Resistance Patterns and Extended Spectrum Beta-Lactamases Producing MRSA Isolated From Wounds and Burns of Iraqi Patients Issraa Hamza Yassin
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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A total of 160 samples included 61 wounds samples and 99 burns samples were collected from Baghdad province hospitals. All samples were cultured on blood agar and mannitol salt agar plates to isolate     S. aureus bacteria. Results showed that rate of S. aureus isolates was 59% of wounds samples and 82.8% of burns samples. MRSA rate of S.aureus wounds and burns isolates was 58.3% and 93.9% respectively. Antibiotic susceptibility test showed that there was no resistance (0%) in ciprofloxacin, vancomycin and imipenem for all isolates, low levels of resistance were recorded for several antibiotics: trimethoprim 5%, rifampin 7.5%, chloramphenicol 7.5%, gentamicin 7.5%, levofloxacin 10% and cefotaxime 17.5%. High and moderate levels of resistance were recorded against cefepime with 82.5%, cefoxitin with 61%, piperacillin with 42.5%, ceftazidime with 27.5%, azithromycin with 25% and amoxicillin/clavilonicacid with 2.5%. 29 different patterns of resistance to 15 different antibiotics were observed as resistance profiles. High rate of 58% of total MRSA isolates was ESBLs producing isolates.
Using Rapid and ELISA Test for Detection Hepatitis C Virus and Human Immunodeficiency Virus among Healthy and Renal Failure Population Huda J.B. Al-Khilkhali
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Human immunodeficiency virus (HIV)-infected, hepatitis c virus (hcv)-uninfected sufferers are at risk for incident hcv infection, however little is understood approximately screening practices for incident hcv among HIVinfected individuals in HIV primary care clinics. The current study aimed at detecting the prevalence of HCV and human immunodeficiency virus (HIV) infection among haemodialysis patients that suffering from chronic kidney disease and healthy people using the Rapid Immunochromatographic Test (ICT) and enzyme linked immunosorbent assay (ELISA) In In the detection of these viruses .This study was carried out during the period from the November (2017) to January (2018), , a total of (28) patient on HD was collected from Specialized Center for Diseases and Kidney Transplant in AL-Sadder Medical City in AL- Najaf Governorate, and(30) samples Represented healthy people collected from the University of Kufa Faculty of Science.All samples ranged in age (20- 45) years. There were 35 male and 23 female. Viral detection revealed that there were 11(19%) was positive and 47(81%) was negative in Rapid (ICT). We further tested samples with ELISA for confirmed results Similarly 58 samples were tested for HCV out of which 16(28%) were ELISA positive and 42(72%) were negative for anti- HCV antibody but the age group(20- 28)year revealed high significant(p<0.05) in the ratio of infection with hepatitis C virus 71% (5:7)  than other age groups. the results of this study showed  high sensitivity and specificity for rapid (ICT) in present study represent good result for depend rapid test for detection of hcv antibodies and  first-line tests in screening and prognosis of hcv infection..in all groups of patient's seropositive anti-HCV antibodies and seronegative anti-HCV tested for anti-HIV Ab typ1 and typ2 by Rapid (ICT) were negative (0.00%) in all age groups in both sexes. The current study showed that males are more affected with HCV (56%) than females (44%) and the prevalence of hcv contamination amongst kidney failure patients in this study was 57%. Results of the current study showed that the healthy groups were negative anti-HCV Ab by both methods.Keywords: Hepatitis C virus, Chronic kidney disease, Hemodialysis patients, ELISA, Rapid (ICT).
New Mixed Ligand Complexes; Synthesis, Spectral Analysis and Biological Activity Enaam Ismail Yousif
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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The formation, structural characterization of mixed ligand complexes of Co II, Zn II, Cd II and Hg II metal ions with the Schiff base ligand (Z)-3,4,5-trihydroxy-N'-(4-hydroxybenzylidene) benzohydrazide and 8-hydroxyquinolineare reported. Ligand and complexes were characterized by analytical and spectroscopic analyses including; FTIR, electronic and 1H, 13C-NMR spectroscopy, microanalysis, chloride content, thermal analysis, magnetic susceptibility and conductance. Physico-chemical techniques indicated the formation of complexes with four-coordinated arrangement in the solid and solution state. Biological activity of the prepared ligand and their mixed complexes were screened for their antimicrobial activity against four bacterial species (Staphylococcus aureus and Bacillus subtitles (G+)), Enterobacter and Escherichia coli (G-)). Biological data showed that complexes become potentially more active against these tested bacteria compared with the free ligandsKeywords: Mixed ligand complexes, Structural characterization, Spectral analysis, Biological activity.

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