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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Salmonella enterica Serovar Enteritidis and Typhymurium: Phenotypic, Molecular Detection and Sequencing of Quorum Sensing Zainab Adil Ghani Chabuck
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Bacterial messaging and chatting, or Quorum sensing (QS) is a way that permitting the coordination behaviors of groups between many common bacterial pathogens. Objectives: Phenotypic detection of Quorum sensing production followed by Molecular Detection and Sequencing of its gene sdiA. Materials and Methods: A primers pair for PCR detection of sdiA gene of Salmonella enterica serovar enteritidis and typhymurium had been designed for its detection and followed by its sequencing for detection of mutation using automated sequencing. These were preceded by phenotypic detection of QS. Results: Quorum sensing produced by S. enterica was studied. Results revealed that homoserine lactone production causes the appearance of bacterial cells aggregation, which appears best after 4hours of incubation where it is representing a maximum concentration of homoserine lactone. In addition, sdiA gene is present in all isolates. Sequencing of sdiA gene from isolates of Salmonella enterica serovar enteritidis and typhymurium propose that there were 8 mutations in three isolates, also gave identity in a percentage of (98-99%) with standard strand according to NCBI web site. Keywords: Quorum sensing, Salmonella enterica, sdiA, sequencing.
The Efficacy of Hydraulic Pressure Sinus Lift VS osteotome Lift via Crestal Approach Utilizing Sinus Endoscopy (Randomized Clinical Study) Aseel Hamid Madab
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Rehabilitation of posterior maxilla is compromised by deficient residual bone height. Sinus lift procedure can be performed by either lateral or crestal approach. Crestal approach had many advantages in comparison with the lateral approach. Hydraulic pressure devices for sinus membrane elevation have demonstrated a low risk of sinus membrane perforation as well as ease of application. Endoscopic surgery has change the philosophy and practice of modern implant surgery in all aspects, it give rise to minimally invasive surgery procedures based on the ability to visualize sinus membrane perforation and to operate in an optimum manner. Assessing and evaluating the efficacy of osung sinus lift kit and the presence of maxillary sinus membrane perforation with the use of endoscopy, were the aim of this present study, thirty patients in rolled in this study with mean age of 46.86 years divided into 2 groups: group A (Osung) the hydraulic pressure technique and group B (osteotome) the conventional osteotome technique. For each patient, orthopantomography and cone beam computed tomography were recommended, an endoscope used intraoperatively in each case to assess the presence of shniedrian membrane perforation, 51.9% (27 cases) were managed by osung procedure for sinus lift, while 48.1% (25 cases) were managed by osteotome sinus lift, the perforation of sinus membrane occurred in (7.7%) in both groups. The use of endoscope is simple and quick for direct visualization of the Schneider membrane, maxillary sinus floor elevation using Osung water lift system kit is a predictable procedure with a low perforation rate. Keywords: Crestal approach, Endoscopy, Hydraulic pressure, Shniederian membrane perforation. Introduction
Study UV-Visible and FTIR Characterization of ZnPc Dye using Double Solvent Ban Mazin Alshabander
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The effects of dissolving zinc phthalocyanine (ZnPc) in two solvents, (N, N-dimethylformamide (DMF)/water, dimethylsulphoxide (DMSO)/water, tetrahydrofuran (THF)/water), on the absorption spectra and infrared spectra were studied using (UV–Vis) spectroscopy and FTIR spectrophotometer. Solvents affected on the photochemical and photophysical properties of ZnPc complexes. The noticed trend inside the difference of Q-band position with solvent was occasionally attributed to solvent parameters comprising aromaticity, arrange power, polarity, and refractive index. UV-V spectra analysis showed non-proof of aggregation in sol as a display throught great unperturbed phthelocyanine Q band. zinc phthalocyanine emerge absorption spectra with duo essential band electron the Q band with a generality (685, 675 and 680) nm separately as well as Soret B band with an extreme of (340, 340 and 350) nm separately. Farthest potential aggregation included method is such the H-aggregation because of rise shift energy of absorption spectrum as well as provided information via the potential electrostatic allocation onto molecule zinc phthalocyanine . FTIR results showed that elevate include peaks belongs to ZnPc with the alteration in the present of the two solvent furthermore little shift toward low energy existed. Keyword: Double solvent, Metal-Phthalocyanine dye, Energy bandgap.
Awareness of Chronic Kidney Disease among General Adult Population in Indonesia Susi Ari Kristina; Laksmy Anggun Larasati; Suci Hanifah
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Chronic kidney disease (CKD) is rapidly becoming a major problem for developing countries such as Indonesia in terms of complicated management such as hemodialysis, continuous ambulatory peritoneal dialysis (CAPD) or high-cost renal transplantation. In its initial stages, early diagnosis and management of CKD may help avoid or delay disease progression. This study aimed to assess CKD's awareness and knowledge in Indonesia's general population. Methods: Cross-sectional research design was performed among the general adult population in Yogyakarta province. Recruiting participants using a convenience sample. A pre-validated questionnaire consisted of two parts, demographic features and CKD information. A logistic bivariate regression was used to identify independent CKD predictors, and p-value
Synthesis and Characterization of Some Oxazepine Compounds from 2- Amino Thiazole Zainab Muhsin Bdaiwi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

A chains of new heterocyclic oxazepin compounds contain thiazole ring were Produced via two steps, the first step comprising condensation of 2- amino thiazol and various aldehydes, (3- hydroxy benzaldhyede, 4- nitro benzaldhyede, 4- chloro benzaldhyede and 4-dimethylamino benzaldhyede), and second step formation oxazepin as sevene membred ring compounds, by cycloreaction of these Schiff bases and (pathalic, malic anhydride) in tolune as solvent. These compounds were established via melting point, FTIR, HNMR, C13NMR spactra. Keywords: 2 amino thiazol, oxazepin heterocyclic, Schiff base.
Anredera Cordifolia Leaves Sub-fraction as Anti Hyperlipidemia R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This study aimed to evaluate the anti-hyperlipidemic properties of the sub-fraction of the Binahong (Madeira vine, Anredera cordifolia) extract in male Wistar rats. The rats were given high-fat food every day for 3 months and pure cholesterol on weeks 0, 3, 7, and 11. Furthermore, Ethyl acetate sub-fraction of binahong leaves with 0, 12 mg/kg BW, and 0, 24 mg/kg BW doses were given orally for 3 weeks and observed for lipid profile on day 21. The result showed that sub-fractions of Madeira vine leaves decreased in triglyceride, cholesterol, and low-density lipoprotein (LDL) levels and did not influence the high-density lipoprotein level (HDL). Meanwhile, statin decreased total triglyceride, cholesterol, and the LDL level, and increased the HDL level. It concluded that Madeira vine sub-fraction with 0, 24 mg/kg BW dose presented improved results in the lipoprotein profile. Keywords: Binahong, Madeira vine, Anredera cordifolia, hyperlipidemia, ethyl acetate fraction
The Characteristic of Congenital Fetal Anomalies at Sanglah Birth Defect Integrated Center (SIDIC), Sanglah General Hospital, Bali Indonesia Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction. Congenital anomalies are among the cause of neonatal morbidity and mortality. The aim of this study was to measure the occurrence of congenital fetal anomalies and explored the distribution of specific anomaly at SIDIC (Sanglah Birth Defect Integrated Center), Sanglah General Hospital Bali, Indonesia. Method. The study was a descriptive study of congenital anomalies who were screened at Maternal-Fetal Medicine Division outpatient clinic and who were delivered at Sanglah General Hospital Bali, Indonesia during the period January 2017-December 2018. Result. During two years study period, there were 109 pregnant women who gave birth to 118 babies with congenital anomalies. The system most involved were Gastrointestinal System 21.2% and Central Nervous System 21.2%. The majority of mother (70.6%) was at 20-35 years old. Regarding the gestational age, the majority accounting for 38.5% were at 28 - 34 weeks. Conclusion. In this descriptive study, the incidence of congenital anomalies most involving gastrointestinal system and Central Nervous system. Advanced in the knowledge of congenital anomalies could be important for better prevention. The preventive strategies such as preconception counselling, focused antenatal care, and care to optimized women’s health should be implemented. Keywords: Congenital anomalies, SIDIC, Fetal anomalies.
Evaluation of Nucleated Red Blood Cell Morphology Flag Screening with ADVIA® 2120 R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The evaluation of nucleated red blood cell morphology flag screening with ADVIA® 2120 on behalf of blood smear has been investigated. The accurate and timely reporting of nucleated red blood cells (NRBC) is an important function of the clinical hematology laboratory because the presence of NRBC in human peripheral blood can show a special clinical status. It has been used 40 samples to evaluate an NRBC screening for the ADVIA® 2120 Hematology System with peripheral blood smears. The positive samples have a criteria % NRBC in range 0 – 15%. (in 100 leucocytes). The sensitivity and specificity for the presence of NRBC for all samples analyzed was 90 % and 63,33 %, respectively. There is a correlation on NRBC result screening between ADVIA® 2120 and peripheral blood smears with α 0,003 of spearman correlation. Keywords: Nucleated red blood cell (NRBC, flag, Clinical test, ADVIA® 2120.
The Comparison of Macular Thickness in Diabetic Patients without Proliferative Diabetic Retinopathy using Optical Coherence Tomography (OCT) at Prof. Dr. R D Kandou General Hospital, Manado, Indonesia Ade John Nursalim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Macular thickening that occurs in diabetic retinopathy has been known as one of the primary causes of vision loss functions in patients with diabetic retinopathy. In order to prevent further complications due to macular thickening, Optical Coherence Tomography (OCT) has been used as a diagnostic tool in diabetic retinopathy. This study aims to evaluate the importance of OCT in promoting early detection in retinal thickening as diagnostic tools and proper exams to diminish the chance of visual acuity related to diabetic retinopathy. Method: A case-control observational study was conducted among 22 subjects with Diabetes Mellitus Type-2 (DM-2) from the medical record of the Ophthalmology-Vitreoretinal Division at Prof. dr. R.D. Kandou State General Hospital, Manado from March-December 2018 period. They were divided into 11 patients with mild and moderate non–proliferative diabetic retinopathy (NPDR) and 11 non-diabetic patients’ group. OCT was used to evaluate the macular thickness in both groups. Data were analyzed using SPSS version 20 for Windows. Result: Most of subjects were female (59.1%), age 45-50 years (31.8%), ≥ 10 years duration of DM-2 (63.6%), refractive errors of 0.00-(-3.00) and 0.00-(+3.00) (33.3%), and HbA1c levels ≥6.5 % (54.5%). There was a statistically significant difference of the central macular thickness between NPDR (257.32±76.94 µm) and non-NPDR patients (213.14±19.23 µm) (p=0.006) by using OCT. Conclusion: Optical Coherence Tomography (OCT) could be used to compare the significant differences of macular thickness between diabetic patients without proliferative diabetic retinopathy at Prof. Dr. R D Kandou General Hospital, Manado, Indonesia. Keywords: Macular Thickness, Diabetic Retinopathy, Optical Coherence Tomography.
Chemical Quality Attributes of Refrigerated Mudskipper (Pseudapocryptes elongatus) under Vaccum and Modified Atmosphere Packaging Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Modified atmosphere and vacuum packaging were believed as emerging innovative technologies for food preservation. They changed food environment by withdrawing O2 or replacing the atmosphere inside the package by a mixture of gases. Mudskipper (Pseudapocryptes elongatus) has huge potential for coastal aquaculture development and is an alternative to shrimp farming in the Mekong Delta. Mudskipper fishes were refrigerated and stored at 4oC for 21 days under vacuum and modified atmosphere packaging. These samples were analyzed the changes of major chemical parameters such as total volatile base (TVB-N, mg TVB/g), trimethylamine (TMA, mg TMA/g), thiobarbituric acid-reactive substances (TBARS, mg malondialdehyde/kg) during preservation. Results revealed that vacuum packaging could maintain chemical quality attributes for 15 days; meanwhile modified atmosphere packaging could extend the chemical quality indicators for 20 days. It’s obviously presumed that modified atmosphere packaging should be an alternative technology for seafood storage. Keywords: Mudskipper, Vacuum, Modified atmosphere packaging, Total volatile base, Trimethylamine, thiobarbituric acid-reactive substances.

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