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Ahmed Abdillah
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Journal of Advances in Medicine and Pharmaceutical Sciences
Published by Lamintang Education & Training Centre
ISSN : 2964268X     EISSN : 29634253     DOI : https://doi.org/10.36079/lamintang.jamaps-xxxx.xxx
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health
Journal of Advances in Medicine and Pharmaceutical Sciences (JAMAPS) scope are including but not limited to: ☛ Drug ☛ Chemistry ☛ Herbal Medicine ☛ Pharmaceutical Science ☛ General and Internal Medicine ☛ Pathology and Forensic Medicine ☛ Pharmacology, Toxicology and Pharmaceutics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 3 No 2: November 2024" : 5 Documents clear
Evaluating the Effectiveness of Thai Basil Extract in Managing Type 2 Diabetes Charoensup, Nathirat; Ruksiriwanich, Loryuenyong; Juruwan, Maneeton
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.584

Abstract

This study investigated the potential of Ocimum basilicum var. thyrsiflora (Thai basil) extract as a natural adjunct therapy for the management of type 2 diabetes. The increasing prevalence of diabetes globally and the limitations of conventional therapies require alternative approaches, especially in regions where Thai basil is culturally accepted. The objective was to evaluate the effects of Thai basil on blood glucose levels and glycemic control in patients with type 2 diabetes. A randomized controlled trial was conducted in 2024 with 200 participants, aged 30–65 years, diagnosed with type 2 diabetes. Participants were assigned to either the Thai basil extract group (500 mg daily) or the placebo group, with clinical data collected at baseline, mid-intervention, and post-intervention. Findings showed that the intervention group experienced significant reductions in fasting blood glucose and HbA1c levels, indicating improved long-term glycemic control. In addition, lipid profiles, including cholesterol and triglyceride levels, were positively affected. However, no significant weight loss was observed. This review highlights the therapeutic potential of Thai basil bioactive compounds, including flavonoids and essential oils, which have antioxidant, anti-inflammatory, and antidiabetic properties. Limitations such as sample size and study duration are noted, indicating the need for further studies with larger, more diverse populations and longer duration. Future studies should explore the optimal dosage, formulation, and long-term effects of Thai basil. This study supports the inclusion of Thai basil in diabetes care, especially in regions where basil is widely available and culturally accepted.
Activity Test of Matoa Leaves on Angiotensin II as an Increasing SOD and GPx Oentari, Octaviana Dyah; Peranginangin, Jason Merari; Purwidyaningrum, Ika
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.752

Abstract

The leaves of the matoa are plants that can be used for hypertension. Matoa leaves were assume to have thought to have hypertensive activity because they contain flavonoids (quercetin-3-O-rhamnosida). Flavonoids can lower blood pressure which is modulated by the Renin-Angiotensin-Aldosterone System (SRAA). Was to fine out about the giving process of matoa leaf extract and fractions in increasing levels of SOD and GPx. This research used the maceration method with 96% ethanol solvent and fractionated by liquid-liquid method using n-hexane fraction solvent, ethyl acetate fraction, and water fraction. In this study, 21 male white rats with Wistar strain were divided into 7 groups, group I named as normal control, group II as negative control (CMC-Na 1%), group III as positive control (Irbesartan), and Group IV. (matoa leaf extract), Group V (n-hexane fraction group VI (ethyl acetate fraction) group VII (water fraction). The data obtained were analyzed with the Shapiro Wilk test, Levene's test and ANOVA. The results showed that the matoa leaf extract a dose 300mg/kg BB lower blood pressure in angiotensin II induced rats incrase SOD and GPx levels in the liver induced by Angiotensin II.
Assessing the Feasibility and Challenges of CRISPR-Cas9 for Treating Genetic Disorders Fernández, Maria; Madriñan, Valmore; Santiago, Palacio; Bermudez, Andrés
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.774

Abstract

This study explores the potential applications of CRISPR-Cas9 technology in treating genetic disorders in Colombia, with a specific focus on thalassemia and sickle cell anemia, which disproportionately affect Afro-Colombians. Given the country’s rich genetic diversity, which includes Afro-Colombians, mestizos, and indigenous populations, the study examines how CRISPR could be tailored to address region-specific genetic mutations and improve health outcomes. The objective of this research is to assess the feasibility, challenges, and strategic implications of CRISPR for genetic disorders in Colombia, considering factors such as healthcare infrastructure, social resistance, and genetic variation. The methodology employed includes a comprehensive review of existing literature, comparative analysis of global CRISPR applications, and a synthesis of data from genetic studies specific to Colombia’s population. The findings indicate that while CRISPR offers significant promise for addressing genetic diseases, challenges such as healthcare accessibility, high costs, and the country’s genetic diversity must be overcome. Furthermore, ethical concerns regarding genetic modification must be addressed through public education and engagement. Future research should focus on expanding genetic databases, particularly for underrepresented populations, and exploring the economic and social implications of CRISPR therapies in Colombia's rural and marginalized communities. These efforts will help ensure that CRISPR technology is effectively and equitably applied to improve public health outcomes.
Ethnopharmacology Study and Therapeutic Potential of Cassia alata for Skin Diseases Khampheng, Vongphachanh; Phoummixay, Nanludet; Sythanonxay, Onmavong
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.775

Abstract

This study explores the ethnopharmacological knowledge of Cassia alata in the treatment of skin diseases in rural Laotian communities. Traditional practices highlight the use of the plant to treat fungal infections, eczema, and other skin conditions, driven by its antimicrobial and anti-inflammatory properties. This study aimed to document and scientifically validate the therapeutic applications of Cassia alata, with a focus on its safety, efficacy, and potential for dermatological product development. A mixed methods approach was used, involving ethnographic interviews with members of a rural Laotian community, laboratory tests to assess antimicrobial activity, and dermatological safety testing. The findings revealed that Cassia alata is widely used in rural areas, with a high degree of confidence in its ability to treat a variety of skin conditions. Microbiological tests confirmed its effectiveness against common pathogens such as Trichophyton and Candida, while dermatological tests demonstrated its safety with minimal side effects. The potential of the plant for dermatological product development is significant, with potential for commercialization and economic benefits to the local community. However, further research is needed to identify active compounds, assess long-term use, and optimize product formulations. This study provides a basis for future research on the global application of Cassia alata as a natural dermatological treatment.
Policies, Progress and Challenges in Addressing Antimicrobial Resistance Torhild, Hilde Juzeniene; Geisler, Andreas; Kirstin, Agnete Olga
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.804

Abstract

Antimicrobial Resistance (AMR) poses a critical challenge to global healthcare systems, including Norway, despite its relatively low antibiotic consumption rate. This study aims to evaluate antibiotic resistance rates, analyze government policies, and explore progress in the development of antibiotics and alternative therapies in Norway. A qualitative descriptive design with a case study approach was used, combining data from policy documents, research articles, and semi-structured interviews with 30 respondents, including microbiologists, healthcare professionals, and policymakers from Oslo, Bergen, and Tromsø. Findings reveal that although Norway’s antibiotic resistance rate is lower than other European countries, certain bacteria, such as MRSA, Enterococcus faecium, and ESBL-producing E. coli, remain problematic in hospitals. The Norwegian government’s strict management policies, including prescription restrictions and diagnostic mandates, have effectively reduced resistance. In addition, research on new antibiotics and alternative therapies, such as phage therapy and probiotics, shows promise but requires further exploration. Challenges such as high R&D costs, resource constraints, and the global spread of resistant bacteria hinder progress. This study highlights the need for international collaboration, innovative funding models, and expanded research into alternative therapies. Future studies should address hospital-specific resistance challenges and strategies to accelerate antibiotic development. Norway’s experience provides valuable insights for global AMR management and policy.

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