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Jurnal MIPA dan Pembelajarannya
Published by Universitas Negeri Malang
ISSN : -     EISSN : 27980634     DOI : https://doi.org/10.17977/um067
Core Subject : Science, Education, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Immunology & microbiology Materials Science & Nanotechnology Mathematics
Jurnal MIPA dan Pembelajarannya (JMIPAP) is a publication that focuses on education, particularly in the areas of mathematics and natural sciences. The journal publishes articles, research papers, and other relevant manuscripts related to the teaching and learning of these subjects. It provides a platform for educators, researchers, and scholars to share their ideas, insights, and innovative teaching methods that can enhance the teaching and learning experience of students in mathematics and natural sciences. JMIPAP aims to contribute to the improvement of the quality of education in these fields by providing a space for the exchange of knowledge and ideas among its readers and contributors.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 242 Documents
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Response of Chinese Cabbage (Brassica rapa var. pekinensis) to Zinc Sulfate and Nano Zinc Oxide Fertilization and Their Effects on Growth and Yield Abrar A. Naser; Aws Jawad Kadhim; Ashjan Nazar Kamil; Sabreen Mohammed Lateef; Hayder Bahjat Nasih; Abrar A. Naser; Aws Jawad Kadhim; Ashjan Nazar Kamil; Sabreen Mohammed Lateef; Hayder Bahjat Nasih
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 7 (2026): July
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i72026p1

Abstract

The objective of the study was to evaluate field growth and yield response of ZnO-NPs and ZnSO4 applied at various concentrations on Chinese cabbage during 2024/25. A randomized block design with three replications (8 treatments: selections including 25, 50, 75 and 100 mg/L zinc source concentrations) was employed to evaluate the increasing effect of ZnSO4 treatment as compared to the control in different traits. Among all the treatments, the treatment consisted of CA and MA maintained good vegetative growth on all growth parameters such as average bulb weight (2.86 kg/plant), marketable bulb weight (2.54 kg/plant), bulb circumference (48.7 cm) and number of leaves (19.6 leaves/plant). In addition, it also produced highest total yield (82.4 t·ha⁻¹) and marketable bulb yield (73.2 t·ha⁻¹) compared to the other treatments. This is due to the importance of zinc ions for enzyme activation in chlorophyll biosynthesis. This improves photosynthesis and protein synthesis as a positive effect on vegetative growth and headformation. the other hand, the efficiency of nano-zinc oxide slacking off at higher amounts d which there is probability in aggregation of nanoparticles and thereby obstacle it absorption on the other vital elements. It has been reported that 75 mg·L⁻¹ zinc sulfate might be the best concentration for growth characteristics and yield of Chinese cabbage. This further highlights the significance of choosing an appropriate source of zinc for promoting greater absorption and bestowing positive physiological effects.
Biological Control of Wheat Root Rot Caused by Fusarium SPP Using Microbial Biocontrol Agents Hamzah A. Yasir
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 2 (2026): February
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i22026p2

Abstract

This study aimed to evaluate the ability of the fungus Trichoderma harzianum and the bacteria Bacillus subtilis to resistant disease Wheat root rot caused by the fungus Fusarium culmorum. The pathogenic fungus was isolated from the roots of diseased wheat plants, and the effect of two biological agents on it was tested in vitro and under greenhouse conditions. The laboratory results showed that Trichoderma was superior in inhibiting the growth of the pathogenic fungus 77.29% followed by Bacillus with a rate of 69.64%, while the use of both biocontrol agents showed 82.94% and the average diameter of F.culmorum was 19.3 with T.harzianum, followed by B. subtilis, it was 25.8, while in treatment of both biocontrol agents was 14.5 compared to control treatment which was 85. In greenhouse experiments, the disease severity was 21.4% in plants treated with T.harzianum and the reduction percentage damage was 74.2%, while it was 28.6% in the treatment with Bacillus, and the reduction percentage damage was 65.6%. The treatment with both biocontrol agents was 17.6% and the reduction percentage of damage was 78.8% compared to control (C2) the disease severity was 83.2%. These results suggest that Trichoderma and Bacillus can be used to control wheat root rot instead of chemical pesticides. Field trials are recommended to confirm these findings and to develop biocontrol agents.
A Picard–Integrating Factor Iterative Scheme for Nonlinear Fractional Differential Equations with Error and Convergence Analysis Muayyad Mahmood Khalil
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 7 (2026): July
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i72026p2

Abstract

In this paper, an iterative algorithm, namely Picard–integrating factor, is developed and analyzed for a class of nonlinear fractional differential equations. Fractional models exhibit a nonlocal and memory-dependent structure, which typically does not have an exact closed-form solution, motivating their study. This proposed scheme is based on the Riemann–Liouville fractional integral and the use of an integrating factor in the equivalent fixed-point formulation, together with Picard-type recursive construction. The method is formulated in the presence of the Lipschitz condition on the nonlinear term, and a convergence result is presented in a weighted supremum norm to make the assumptions under which the iteration is a contraction clear. Three nonlinear fractional initial value problems are analyzed: one Riccati-type model, one Bernoulli-type model, and a fourth model, which is considered with a known closed-form solution, to see the true error directly. It presents the numerical results for two cases of Alfa = 1 and Alfa = 0.5. In all examples, the absolute value of the difference between the two Picard approximations and the Picard – integrating factor approximation is tabulated and plotted to visualize their accuracy; residual diagnostics are calculated for Riccati and Bernoulli-type examples, and the true absolute errors are reported for all the examples for which the solution is known. On a quantitative level, for the case, the mean absolute deviation of the respective approximations is minimized when using the Picard–integrating factor approximation, being about 54.4% lower than that of the Picard approximation, while the residual diagnostics present lower endpoint residuals for the nonlinear Riccati and Bernoulli-type tests. The results suggest that the formulation with the integration factor gives a semi-analytical approximation method that is straightforward, structured, and convenient, without requiring the calculation of Adomian polynomials or correction functionals.
Determine The Optimum Conditions for Producing Prodigiosin Pigment from Serratia Marcescens Clinical and Environmental Isolates Aseel Razak Al-Rekaabi
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 2 (2026): February
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i22026p4

Abstract

Serratia marcescens isolates were isolated from various clinical and environmental sources, the 60 sample include 12 isolates were obtained from diverse clinical specimens and environment and all isolates produced prodigiosin. Following multiple screening stages, the local isolate Serratia marcescens SM5 was chosen due to its high prodigiosin dye production. Environmental and clinical samples were cultured on MacConkey agar medium. The media was incubated at 37 °C for 24 hours. The color and shape of the colonies in the culture media, as well as the cell shape and pigmentation in the microscopic examination, were used to determine the phenotypic traits. To confirm the type of isolates, biochemical tests were done. and the Api 20 E. method was used to identify the isolates. The best conditions for producing prodigiosin dye were discovered. The maximum dye output was discovered while employing a peptone-glycerol medium at pH 8 and 30 °C for 72 hours.
Ionizing Electromagnetic Radiation: Its Health Effects and Methods of Prevention Zainab Jawad Jabber
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 7 (2026): July
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i72026p3

Abstract

Here we present a review of the biological effects and prevention of ionizing radiation at doses relevant to acute radiation sickness or cancer as well as contemporary shielding methods and International Commission on Radiological Protection (ICRP) guidelines in order to bridge gaps in understanding potential strategies for health protection against ionizing radiation exposure. This review assessed acute and chronic health impacts, synthesized dCCTP-derived ICRP safety regulations for modern shielding materials, evaluated lead compared to lead-free shielding solutions, and identified advancements in radiation risk mitigation strategies. Methods: We implemented a systematic literature search of clinical, material science, and regulatory research published from 2000 to 2023 in peer-reviewed journals with critical thematic analysis. We summarize below important findings pertaining to this chapter: (a) Acute radiation sickness mechanisms involve complex pathways involving mitosis coupled with cellular damage; (b) cancer risks are highly linear with dose and duration of exposure; (c) modern shielding materials in combination provide comparable attenuation efficacy to traditional metals such as lead but greatly reduce environmental toxicity; (d) historical regulations set out by ICRP have changed substantially since the advent of nuclear technologies, likely leading to greater acceptable occupational doses; and (e) recent innovations aimed at reducing long-term risk include improved dosimetric approaches for personal monitoring and biological countermeasures. Overall, these findings highlight the integration of biology with materials and regulatory aspects, which makes radiation protection complicated. The synthesis will provide guidance for future research directions and aid in the development of radiation protection policies intended to minimize the risk workers and the public face when exposed to ionizing radiation across a broad range of situations.
Radiobiological And Clinical Comparison of Single-Session Versus Hypofractionated Gamma Knife Radiosurgery for Medically Refractory Trigeminal Neuralgia Mohammed Hassan Alewi; Siham Sabah Abdullah; Mohammed Hassan Alewi; Siham Sabah Abdullah; Moneer Khammas Faraj
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 2 (2026): February
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i22026p5

Abstract

Background: Gamma Knife radiosurgery (GKRS) is a well-established treatment modality for patients with medically refractory trigeminal neuralgia (TN). Although single-fraction treatment remains the conventional standard, recent technological developments have enabled hypofractionated delivery. The biological and clinical implications of these alternative fractionation schedules remain insufficiently characterized. Objective: To compare the radiobiological, dosimetric, and clinical outcomes of single-session and hypofractionated GKRS in patients with medically refractory TN. Methods: A retrospective cohort study was performed involving 62 patients treated with GKRS between January and June 2026. Forty patients underwent conventional single-session treatment (80 Gy in one fraction), while 22 patients received hypofractionated treatment (20 Gy in four fractions). Clinical outcomes were assessed using the Barrow Neurological Institute (BNI) Pain Intensity and Facial Hypesthesia scales at baseline and during 1-, 3-, and 6-month follow-up. Biologically effective dose (BED) and equivalent dose in 2-Gy fractions (EQD2) were calculated using the linear–quadratic model. Results: Both treatment approaches resulted in significant reductions in pain severity during follow-up (p < 0.001). At six months, successful pain control (BNI ≤ IIIb) was achieved in 72.5% of the single-session cohort and 77.3% of the hypofractionated cohort (p = 0.914). Single-session GKRS generated substantially higher target BED and EQD2 values (p < 0.001), whereas hypofractionation significantly reduced brainstem BED and EQD2 (p < 0.001). Despite these radiobiological differences, no significant between-group differences were observed in pain response, complete pain relief, or treatment-related numbness. Conclusions: Hypofractionated GKRS achieved pain outcomes comparable to conventional single-session treatment while significantly decreasing radiobiological exposure to the brainstem. These findings suggest that hypofractionation may provide an effective treatment alternative with enhanced normal tissue sparing. Larger prospective studies with longer follow-up are warranted to validate these observations.
Mathematical Problem-Solving Strategies of Pre-Service Elementary School Teachers in Solving Contextual Problems Refni Adesia Pradiarti
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 8 (2026): August
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i82026p1

Abstract

This study aims to describe the mathematical problem-solving strategies employed by pre-service elementary school teachers in solving contextual problems based on Polya's problem-solving stages. The study adopted a qualitative approach with a descriptive research design. The participants consisted of 32 students from the Elementary School Teacher Education Program at Sunan Gresik University who completed a mathematical problem-solving test. Three participants were purposively selected to represent high-, moderate-, and low-ability groups. Data were collected through a contextual mathematical problem-solving test, semi-structured interviews, and documentation of the participants' written work. Data were analyzed using the Miles and Huberman model, which includes data reduction, data display, and conclusion drawing. The findings indicate that participants in the high-ability group successfully completed all stages of Polya's problem-solving process systematically, employed appropriate strategies, and accurately interpreted the results within the given context. Participants in the moderate-ability group were able to perform the mathematical procedures correctly but experienced difficulties in reflecting on and interpreting their solutions. Meanwhile, participants in the low-ability group encountered difficulties from the initial stage of understanding the problem, resulting in the use of inappropriate strategies and solutions that did not adequately address the problem requirements. These findings suggest that the ability to understand contextual situations, select appropriate strategies, and reflect on the solution process are key factors distinguishing the mathematical problem-solving performance of pre-service elementary school teachers.
Developing Effective Strategies and Innovations Targeting the Scabies Parasite (Sarcoptes Scabiei) Nawar Jaber Hussein Al-asadi
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 7 (2026): July
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i72026p5

Abstract

Scabies, caused by the scabies mite Sarcoptes scabiei, is a major global health challenge due to limited treatment options and increasing parasite resistance. Ag₂O NPs were prepared using an environmentally friendly green manufacturing method that utilized three extracts: lemon peel oil, aloe vera gel, and colocynth seed extract. Their efficacy against scabies in BALB/c mice was investigated. The nanoparticle formulations were used to treat 60 infected mice, divided into groups, and their efficacy was compared to that of the acaricide benzyl benzoate. LO-Ag₂O Nps demonstrated the highest efficacy in eliminating the parasites, and quantitative polymerase chain reaction (qPCR) results showed a significant increase in the cycle threshold (Ct) value ≥ 35 in the treated mouse group. This is consistent with histological examination, which revealed significant skin healing, and microscopic examination of skin scrapings, which showed no parasites. qPCR results for both (CC-Ag2O and AV-Ag2O) NPs samples groups resulting in a (Ct) of less than 35, indicating a lower percentage reduction in parasites compared to LO-Ag₂O and benzyl benzoate. This was further confirmed by microscopic examination and histological examination, which revealed the absence of the parasite in LO-Ag₂O and benzyl benzoate. These results highlight the potential of plant derived Ag2O NPs formulations as safe and effective alternatives to conventional acaricides, and thus their use in initiating scabies control programs in resource limited settings.
Association Of Resistin and Adiponectin Levels with Physiological and Inflammatory Parameters in Women with Rheumatoid Arthritis in Wasit Province, Iraq Nada Hameed Ajam AL-Badri; Nada Hameed Ajam AL-Badri; Eman H. Al-Fadhili
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 8 (2026): August
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i82026p2

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting the whole body with the presence of constant inflammation at the joints and increased levels of inflammatory mediators while not maintaining normal metabolic homeostasis. The adipokines, such as resistin and adiponectin, secreted by adipose tissue, have been identified as important modulators of inflammatory and immune responses. Their involvement in the RA pathophysiology is not fully understood, especially in Middle Eastern populations. The aim of this study was to evaluate the levels of resistin and adiponectin in the serum of Iraqi women with RA who live in Wasit Province, Iraq, and determine their correlation with inflammatory biomarkers (CRP, ESR, TNF-α, and IL-6), lipid profile (total cholesterol, triglycerides, HDL-C, and LDL-C), and complete blood count (CBC) parameters (Hb, WBC, platelet count, MCV, MCH, and MCHC). The case-control study was carried out at Al-Kut Teaching Hospital and some private clinical laboratories in Al-Kut city, which comprised 60 women with RA (mean age 42.3 ± 8.7 years) and 30 healthy female controls (mean age 40.1 ± 7.9 years). The levels of serum resistin and serum adiponectin were measured using ELISA. Standard laboratory procedures were used to measure inflammatory markers, lipid profiles, and CBC. The Disease Activity Score-28 (DAS28) was used to measure disease activity. Serum resistin was significantly elevated in RA patients (18.6 ± 5.3 ng/mL) compared to controls (7.2 ± 2.1 ng/mL; p<0.001), while adiponectin was significantly reduced (8.4 ± 3.7 vs. 15.9 ± 4.2 μg/mL; p<0.001). Resistin correlated positively with CRP (r=+0.74), ESR (r=+0.68), TNF-α (r=+0.71), IL-6 (r=+0.66), and DAS28 (r=+0.69). Adiponectin inversely correlated with the same parameters. Dyslipidemia (increased LDL-C, triglycerides, decreased HDL-C) and hematological abnormalities were noted in RA patients. Resistin and adiponectin are significantly dysregulated in Iraqi women with RA and closely approximate disease activity and systemic inflammatory load. These adipokines could serve as potential complementary markers for disease severity and metabolic complications of RA.
Essential Oil-Induced Downregulation of Aflatoxin Biosynthetic Genes in Aspergillus Flavus: A Natural Strategy for Reducing Crop Contamination Intesar Ali Mezeal
Jurnal MIPA dan Pembelajarannya Vol. 6 No. 8 (2026): August
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um067v6i82026p3

Abstract

Background: Aspergillus flavus is an important aflatoxigenic fungus associated with contamination of maize, wheat, peanuts and other stored crops. Aflatoxin B1 (AFB1) is a highly toxic and carcinogenic secondary metabolite, and its biosynthesis is controlled by clustered structural and regulatory genes, including aflR, aflS, aflD, aflM, aflP and aflQ. Objective: This study evaluated the inhibitory effects of cinnamon, clove and thyme essential oils on A. flavus growth, AFB1 production and relative expression of selected aflatoxin biosynthetic genes under controlled in vitro conditions. Methods: An aflatoxigenic A. flavus isolate was exposed to essential oils at 0.25, 0.50 and 1.00 µL/mL. Radial growth inhibition was determined on potato dextrose agar, while mycelial dry weight and AFB1 production were evaluated in yeast extract sucrose broth. AFB1 was quantified by HPLC with fluorescence detection. Relative expression of aflR, aflS, aflD, aflM, aflP and aflQ was determined by RT-qPCR using β-tubulin as the reference gene and the 2^-ΔΔCt method. Results: The results showed a concentration-dependent decrease in fungal growth, biomass and AFB1 production. Cinnamon oil produced the strongest inhibition, reducing radial growth by 54.3% and AFB1 production by 81.7% at 1.00 µL/mL. Clove oil reduced AFB1 by 73.4%, whereas thyme oil reduced it by 65.2% at the same concentration. RT-qPCR analysis showed downregulation of all tested biosynthetic genes, with aflR and aflD showing the most consistent suppression. Cinnamon oil reduced aflR expression to 0.24-fold and aflD expression to 0.19-fold compared with the untreated control. Conclusion: The findings demonstrate that essential oils, particularly cinnamon and clove oils, reduced AFB1 production through both growth inhibition and transcriptional suppression of key aflatoxin biosynthetic genes. These results support the use of plant-derived essential oils as natural anti-aflatoxigenic agents in strategies aimed at reducing crop contamination.

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