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Herbal Medicine Journal
Published by Sekolah Tinggi Ilmu Kesehatan Senior Medan
ISSN : -     EISSN : 26212625     DOI : https://doi.org/10.58996
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Herbal Medicine Journal menerima artikel penelitian dalam 2 area utama di bidang farmasi: Sains Farmasi dan Farmasi Komunitas dan Klinis. Dalam bidang sains farmasi, artikel penelitian yang diterima meliputi Biologi Farmasi dan Farmakognosi, Kimia Farmasi, Farmasetika, Farmakologi dan Toksikologi, dan juga Bioteknologi. Sedangkan area Farmasi Komunitas dan Klinis mencakup Farmasi Rumah Sakit, Farmasi Klinis, Manajemen Farmasi, dan Farmasi Sosial.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 119 Documents
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Uji Aktivitas Antioksidan Infusa Daun Alpukat (Persea americana Miller) dengan Metode DPPH Maslena Siregar
Herbal Medicine Journal Vol 1 No 1 (2018)
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Avocado leaves (Persea americana Miller) have secondary metabolites such as polyphenols, flavonoids, saponins, tannins. Flavonoid compounds function as antioxidants to the human body. The aim of the study was to determine the antioxidant activity of avocado leaf infusion with extract concentrations of 0 ppm, 250 ppm, 500 ppm, 1000 ppm, 1500 ppm, and Vitamin C with concentrations of 0 ppm, 2.5 ppm, 5 ppm, 10 ppm, and 15 ppm. by the DPPH (1,1-Diphenyl-2-Picrihydrazil) method. The results showed that avocado leaf infusion had very weak antioxidant activity with IC50 value = 1,511.15 ppm, while the measurement results of Vitamin C had very strong antioxidant activity with IC50 value = 9,264 ppm.
Penentuan Nilai SPF Krim Tabir Surya Berbasis Minyak Biji Anggur Wahyuni P
Herbal Medicine Journal Vol 1 No 1 (2018)
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Sunscreen is a cosmetic product that is used on the surface of the skin that works, among others, by absorbing, scattering, or reflecting ultraviolet light. Grape seed oil is a vegetable oil that is rich in vitamin E which acts as an antioxidant and absorbs UV light at wavelengths of 280-320 nm. The purpose of this study was to determine the effect of grape seed oil concentration on SPF values ​​from sunscreen lotion preparations. The sunscreen lotion is made in 5 formulas namely Formula 1 (lotion base), Formula 2 (positive control base), Formula 3 (5% grape seed oil), Formula 4 (10% grape seed oil) and Formula 5 (grapeseed oil) 15%), where Formula 2 to Formula 5 is added with oxybenzone (2%) and octyl methoxycinamate (5%). Determination of SPF value was carried out by Uv-Vis spectrophotometric method. The results showed that the SPF results showed that the higher the concentration of grape seed oil, the higher the SPF value produced. The Formula 1 SPF value is 0.06, Formula 2 is 11.90, Formula 3 is 12.38, Formula 4 is 12.81 and Formula 5 is 13.14. From the results of this study, it was concluded that the addition of various concentrations of grapeseed oil can increase the value of SPF and have good quality.
Uji Aktivitas Penyembuh Luka Bakar dari Gel Getah Jarak Pagar (Jatropha curcas L.) Meri Sayuti
Herbal Medicine Journal Vol 1 No 1 (2018)
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

This study uses jatropha resin to treat burns in mice as experimental animals. The researcher conducted a direct experiment to test animals for healing burns from jatropha sap in the form of gel preparations, this can be known from the content of compounds found in jatropha sap that are effective in healing burns. Giving jatropha gel 5%, 10% and 15% (Jatropha curcas Linn.) And giving bioplacenton® 15% gel to the skin of mice (Mus musculus). In this study 25 mice were divided into five groups, namely the group giving bioplacenton® gel (positive control), giving gel base (negative control) and giving jatropha gum gel with various concentrations. The parameters measured in the study were the duration of healing second-degree burns on a daily basis which was marked by a wound that did not appear to be healed (length and width of the wound = 0 cm). The old data on wound healing were analyzed using variance analysis (ANOVA) and continued with the LSD test. It can be concluded that 10% jatropha gum ointment has the potential to accelerate the healing of second degree burns on the skin of mice.
Pengaruh Suhu Pemanasan dan Lama Pemanasan Terhadap Kandungan Vitamin C Beberapa Varietas Nanas Indah Rizka
Herbal Medicine Journal Vol 2 No 1 (2019): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Pineapple (Ananas comosus L.) is a type of tropical plant originating from Brazil, Bolivia and Paraguay. This plant is included in the pineapple-nanasan family (Family Bromeliaceae). The plant is of low stature, with 30 or more long, sharp-tipped leaves arranged in a rosette around a thick stem. Vitamin C or L-ascorbic acid, or ascorbate is an essential nutrient for humans and animals. Vitamin C from nature is commonly found in fruits or vegetables. Examples of local fruits known to be rich in vitamin C are local lemons, limes, guavas, poor apples and pineapples. The purpose of this study was to determine whether the heating temperature had an effect on the vitamin C content in pineapple juice, to determine whether the heating time had an effect on the vitamin C content in pineapple juice. This research was carried out using the ultraviolet spectrophotometric method.The highest vitamin C content in pineapple, namely light green pineapple juice, is higher than honey pineapple juice and regular pineapple juice. Light green pineapple juice with a temperature of 80 ° C in the 60th minute shows a concentration of 9,00529 compared to honey pineapple juice with a concentration of 8,75580 and regular pineapple juice with a concentration of 4,25629. The results of research on vitamin C showed that heating times of 15 minutes, 30 minutes, 45 minutes, and 60 minutes caused a decrease in the vitamin C content of pineapple juice. The results showed that the higher the temperature and duration of heating, the lower the vitamin C produced during heating and using high temperatures would also damage the vitamin C concentration.
Identifikasi Kadar Fenol dan Flavonoid Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) Antonius Purba
Herbal Medicine Journal Vol 2 No 1 (2019): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Turmeric rhizome is an herbal medicine, in herbal medicine, many types of diseases that can be cured such as, inflammatory, tumour, cancer prevention, and others. This study was aimed to determine the total levels of phenols and flavonoids in ethanol extract of turmeric rhizome (Curcuma longa L.). The method for making this extract was done by maceration using 96% ethanol. Qualitative analysis of phenols and flavonoids was performed by UV-Vis Spectrophotometry. Determination of phenol levels using Folin ciocalteau reaction and determination of total flavonoid levels was carried out by the colorimetric method with quercetin comparison. The result showed that phytochemical screening of turmeric rhizome (Curcuma longa L.) contains alkaloids, flavonoids, tannins, and saponins. The results of the determination of levels of turmeric rhizome ethanol extract were obtained a total phenol 229,0894 mg GAE / g and total flavonoid 140,0666 mg QE / g extract.
Antibakteri Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.) Terhadap Escherichia coli Rahmiati Rahmiati
Herbal Medicine Journal Vol 2 No 1 (2019): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Psidium guajava L. is a plant that is widely used and cultivated throughout Indonesia which has a potential as a medicinal plant. The leaves from Psidium guajava L. had been studied and were known the contain secondary metabolites with antibacterial activity, namely flavonoids and tannins. In this study, the antibacterial activity of Psidium guajava L. leaves were tested against Escherichia coli bacteria. The objective of this study was to determine the antibacterial activity of %96 ethanol extracts of Psidium guajava L. leaf against Escherichia coli bacteria. The Psidium guajava L. leaves extracts were prepared by maceration method using % 96 ethanol as solvents. The macerate was evaporated give thick extract. The concentrations of extracts used for the treatment group were 500 mg/ml, 250 mg/ml, 100 mg/ml, 50 mg/ml, 30 mg/ml, 20 mg/ml, 10 mg/ml. Disc diffusion method was used to measure the bacterial inhibition zone and to determine the minimum inhibitory concentration (MIC). The Results of activity %96 ethanol extract of Psidium guajava L. leaf can inhibit the growth of, Esherichia coli bacteria at a concentration of 25 mg/ml with the diameter of inhibition zone 6.88 mm.
Pengaruh Konsentrasi Minyak Jagung (Corn Oil) Terhadap Nilai SPF Krim Tabir Surya Claudia P.A
Herbal Medicine Journal Vol 2 No 2 (2019): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Sunlight generates radiation composed of infrared and visible light as well as ultraviolet light A and B. Excessive UV exposure can lead to premature skin aging and possibly skin cancer. Corn oil is rich in tocopherols (vitamin e) and polyphenols which can reduce free radicals caused by UV rays. The purpose of this study is to see the effect of corn oil addition on SPF effectiveness with the combination of oxybenzone and octyl methoxycinamate sunscreen cream. The cream preparations were made 5 formulas such as Formula 1 (cream base), Formula 2 (positive control base), Formula 3 (corn oil 1%), Formula 4 (corn oil 5%), Formula 5 (corn oil 10%), where Formula 2 to Formula 5 is added oxybenzone 2% and octyl methozycinnamat 5%. Evaluation of sunscreen cream including homogeneity test, pH measurements, determination of emulsion type, irritation test, viscosity measurement, stability observation (shape, smell, and color), and SPF valuation with Uv-Vis spectrophotometry followed by a statistical test using SPSS. The result showed a homogeneous cream, o/w emulsion type, pH 6.77-6.94, non irritating, and stable in storage for 12 weeks. The SPF result showed the higher the concentration of corn oil the higher the SPF value produced. Formula 1 SPF value is 3.82 ± 0.12, Formula 2 is 13.46 ± 0.69, Formula 3 is 17.17 ± 0.10, Formula 4 is 24.10 ± 0.38, Formula 5 is 29.00 ± 1.25. From the research results obtained by the addition of corn oil to sunscreen cream preparations with a combination of oxybenzone and octyl methoxycinnamate can increase the SPF value and have good quality.
Penentuan Kadar Vitamin C Pada Varietas Buah Melon Secara Spektrofotometri Judika Sitinjak
Herbal Medicine Journal Vol 2 No 2 (2019): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Fruits are a type of food that contains nutrients, vitamins and minerals which are generally very good for consumption every day. Vitamin C is one of the vitamins contained in fruits. Vitamin C is a micronutrient that is indispensable for body metabolism. In addition, vitamin C also plays a role in immune function or immune. Various analyzes were carried out to determine the level of vitamin C. This study aims to determine the effect of varieties on the vitamin C content in melon fruits. Examination of vitamin content was carried out using the ultraviolet spectrophotometric method. Determination of vitamin C levels in several melon varieties by ultraviolet spectrophotometry shows that the vitamin C content in green local melons is 1.4528 mg / 100 g and the vitamin C content in orange local melons is 1.6118 mg / 100 g. Higher levels of vitamin C were found in the orange melon fruit varieties compared to the lowest levels of vitamin C in the green melon fruit varieties. This can occur because vitamin C levels are widely distributed in plants, vitamin C levels can vary due to several factors such as the variety of plants, processing, temperature, leaving a long time open to air (oxidation), harvesting time, storage, and the latter is where it grows. There were differences in vitamin C levels in several varieties of melon which was determined by ultraviolet spectrophotometry. The highest vitamin C content is in orange melon.
Efek Virgin Coconut Oil (VCO) Terhadap Pertumbuhan Bakteri Staphylococcus aureus Rahmiati Rahmiati
Herbal Medicine Journal Vol 3 No 2 (2020): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

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Abstract

Staphylococcus aureus is one of the bacteria that causes pyogenic infections of the skin. Infections caused by Staphylococcus aureus include boils, pimples, and wound infections. Virgin Coconut Oil (VCO) is genuine coconut oil made from fresh coconut raw materials and operates with control and without chemicals. The results of the coconut oil management process can produce essential compounds containing lauric acid, so that pure coconut oil has anti-bacterial properties. The purpose of this study was to see the effect of Virgin Coconut Oil on the growth of Staphylococcus aureus bacteria and to see the potential of Virgin Cococnut Oil as an antibacterial, especially for skin infections. The research method used the dick disc method with various concentrations consisting of 6.25%, 25%, 50%, 75%, 100%. The results showed that VCO had an effect on the growth of Staphylococcus aureus bacteria at a concentration of 100% with an inhibition zone diameter of 10.40 mm in the strong category.
Penetapan Kadar Kloramfenikol dalam Sediaan Kapsul Secara Spektrofotometri Infra Merah Ronauli Ronauli
Herbal Medicine Journal Vol 4 No 2 (2021): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.688 KB) | DOI: 10.58996/hmj.v4i2.63

Abstract

Chloramphenicol is one type of broad-spectrum antibiotic and has been known since 1950 and has been shown to be active against gram negative and positive bacteria. According to Law Number 36 of 2009 concerning Health in paragraph 1 of article 105, it is stated that pharmaceutical preparations in the form of drugs and medicinal raw materials must meet the requirements of Indonesian Pharmacopoeia or other standard books.The purpose of this study was to determine the levels of chloramphenicol in capsules with a trade name and generic and to determine the suitability of the requirements of Indonesian Pharmacopoeia. Determination of chloramphenicol levels by Fourier Transform Infra Red (FTIR) spectrophotometry using methanol solvents in the wave number range 4000 - 650 cm-1. The results showed that chloramphenicol levels in Novachlor® capsules (95.80 ± 0.24)%; colcancetine® capsules (101.63 ± 2.17)%; kalmicetine® capsules (100.80 ± 0.009)%; chlorampenicol capsules (99.01 ± 0.29)%; hufamicetin capsules (102.60 ± 0.16)%. From the method validation, the results of the recovery test were 100.46%, RSD 0.005%, and LOD and LOQ 0.0029 mg / mL and 1.6763 mg / mL, respectively. These results indicate that the method performed shows accurate and precise results. The results of this study concluded that the determination of chloramphenicol levels can be done by Infrared Spectrophotometry and the levels of chloramphenicol capsules have met the requirements.

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