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Jember Medical Journal (JMJ)
Published by Universitas Jember
ISSN : -     EISSN : 29630428     DOI : 10.19184
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
ember Medical Journal (JMJ) publishes peer-reviewed original articles, case reports and literature review in basic medical research, clinical research, and applied medical science. This journal is published twice (May and November) by Faculty of Medicine Universitas Jember. Articles are original research that needs to be disseminated and written in English or Indonesia. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication. Jember Medical Journal was issued for the first time in 2022. JMJ recieved the ISSN 2963-0428 for online version in 2022.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 32 Documents
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Limited Sensitivity of Serum Alkaline Phosphatase as an Early Biomarker of Acute Hexavalent Chromium Toxicity Rena, Normasari; Icha, Nadhirotul Izza Afida; Alvin , Alfaaros; Al Munawir
Jember Medical Journal Vol. 5 No. 1 (2026)
Publisher : Fakultas Kedokteran, Universitas Jember

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Abstract

Hexavalent chromium [Cr(VI)] is a highly toxic heavy metal widely used in industrial processes and known to induce multi-organ toxicity. Serum alkaline phosphatase (ALP) is commonly used as a biochemical marker of hepatobiliary and bone dysfunction; however, its sensitivity in detecting early acute Cr(VI) toxicity remains unclear. This study aimed to evaluate serum ALP as an early biomarker of acute hexavalent chromium toxicity in Wistar rats following short-term oral exposure to chromium trioxide (CrO₃). This experimental study employed a post-test-only control-group design with 30 maleWistar rats randomly divided into three groups (n = 10/group): a control group receiving distilled water, a low-dose group receiving CrO₃ at 1 mg/kgBW, and a moderate-dose group receiving CrO₃ at 5 mg/kgBW. Treatments were administered orally for seven consecutive days. Blood samples were collected on day 8, and serum ALP levels were measured using an enzymatic spectrophotometric method at 405 nm. Data were analyzed using one-way ANOVA with a significance level of p < 0.05. Mean serum ALP levels were 236.28 ± 39.46 U/L in the control group, 208.62 ± 50.90 U/L in the 1 mg/kgBWgroup, and 205.20 ± 42.86 U/L in the 5 mg/kgBW group. Although both CrO₃-treated groups showed lower mean ALP levels than controls, statistical analysis revealed no significant difference among groups (p = 0.225). In conclusion, acute oral exposure to Cr(VI) at doses of 1 mg/kgBW and 5 mg/kgBW for seven days did not significantly alter serum ALP levels in Wistar rats. These findings suggest that serum ALP has limited sensitivity as an early biomarker of acute hexavalent chromium toxicity. 
Aktivitas Antikanker Senyawa Androgropholide dari Andrographis paniculata terhadap Kanker Paru: Tinjauan Sistematik Icha , Nadhirotul Izza Afida; Savira, Oktavia Ainiyati
Jember Medical Journal Vol. 5 No. 1 (2026)
Publisher : Fakultas Kedokteran, Universitas Jember

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Abstract

Kanker paru adalah neoplasma ganas yang berasal dari sel epitel saluran pernapasan dan menjadi penyebab utama kematian terkait kanker. Tingginya angka prevalensi kasus ini menunjukkan perlunya upaya pencegahan serta strategi pengobatan yang lebih efektif, seperti menggunakan tanaman obat. Salah satu senyawa dari tanaman obat sebagai calon agen antikanker adalah andrographolide dari sambiloto (Andrographis paniculata) yang diketahui memiliki aktivitas penghambatan proliferasi sel, induksi apoptosis, dan penekanan pertumbuhan tumor. Tujuan dari tinjauan sistematis ini adalah menilai dan menyintesis bukti mengenai efek antikanker andrographolide yang berasal dari Andrographis paniculata terhadap kanker paru-paru. Metode tinjauan sistematis mengikuti pedoman PRISMA yang diperoleh dari empat database meliputi Google Scholar, PuBMed, Science Direct dan Nature. Sebanyak 6 studi yang memenuhi kriteria. Temuan ini menunjukkan jika andrographolide menunjukkan aktivitas antikanker yang signifikan dengan menghambat proliferasi sel, mengurangi pertumbuhan tumor, dan menginduksi apoptosis melalui jalur intrinsik dan ekstrinsik. Senyawa ini jugamendorong penuaan sel dan mengganggu metabolisme kanker dengan memodulasi protein pengatur utama. Oleh karena itu, andrographolide menunjukkan potensinya sebagai agen terapi kanker secara multi-target meskipun masih memerlukan penelitian lebih lanjut untuk mengkonfirmasi keefektivitasan dan keamanan secara klinis. 

Page 4 of 4 | Total Record : 32

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